IMP: Integrative Multi-species Prediction

Drosophila melanogaster

103 known processes

Thor (Dmel_CG8846)

CG8846 gene product from transcript CG8846-RA

(Aliases: d4E-BP,Dmel\CG8846,4EBP,d4eBP,thor,4E-BP,4e-bp,l(2)k13517,CG8846,4eBP,4E-BP1,d4E-BP1,BcDNA:HL08053,eIF4E-BP,Dm 4E-BP,pp20,BcDNA.HL08053,153432_at,d4e-bp,l(2)k07736,CT8705,Phas1,4ebp,43-BP,l(2)06270,d4EBP,anon-WO0172774.158)

Entrez: 33569
FLYBASE: FBgn0261560
UniProtKB: Q9XZ56

Process Predictions
Disease Predictions

Thor biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
aging	GO:0007568	143	0.965
regulation of translation	GO:0006417	56	0.964
myoblast fusion	GO:0007520	43	0.958
muscle structure development	GO:0061061	224	0.952
syncytium formation	GO:0006949	43	0.947
regulation of response to stress	GO:0080134	200	0.907
negative regulation of biosynthetic process	GO:0009890	277	0.886
muscle cell differentiation	GO:0042692	103	0.853
multicellular organismal aging	GO:0010259	140	0.822
syncytium formation by plasma membrane fusion	GO:0000768	43	0.806
myotube differentiation	GO:0014902	46	0.796
striated muscle cell differentiation	GO:0051146	90	0.793
negative regulation of cellular metabolic process	GO:0031324	382	0.786
response to nitrogen compound	GO:1901698	90	0.778
regulation of protein metabolic process	GO:0051246	256	0.764
translation	GO:0006412	69	0.730
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.726
posttranscriptional regulation of gene expression	GO:0010608	145	0.723
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.705
negative regulation of gene expression	GO:0010629	387	0.700
determination of adult lifespan	GO:0008340	137	0.655
regulation of cell differentiation	GO:0045595	302	0.636
response to organonitrogen compound	GO:0010243	75	0.627
growth	GO:0040007	359	0.608
regulation of cellular protein metabolic process	GO:0032268	243	0.597
regulation of cellular response to stress	GO:0080135	89	0.587
response to nutrient levels	GO:0031667	114	0.569
response to oxidative stress	GO:0006979	86	0.568
wing disc morphogenesis	GO:0007472	344	0.528
positive regulation of protein metabolic process	GO:0051247	128	0.523
regulation of lipid metabolic process	GO:0019216	15	0.512
cellular catabolic process	GO:0044248	372	0.441
neuron death	GO:0070997	27	0.418
negative regulation of response to stimulus	GO:0048585	258	0.406
regulation of immune system process	GO:0002682	176	0.405
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.404
defense response	GO:0006952	300	0.400
cellular response to nutrient levels	GO:0031669	62	0.400
morphogenesis of an epithelium	GO:0002009	276	0.395
defense response to bacterium	GO:0042742	178	0.394
negative regulation of cellular biosynthetic process	GO:0031327	277	0.391
cellular response to oxidative stress	GO:0034599	28	0.384
stress activated mapk cascade	GO:0051403	52	0.381
translational initiation	GO:0006413	11	0.380
appendage morphogenesis	GO:0035107	397	0.380
immune response	GO:0006955	246	0.368
catabolic process	GO:0009056	409	0.362
response to extracellular stimulus	GO:0009991	116	0.357
imaginal disc derived wing morphogenesis	GO:0007476	337	0.356
carboxylic acid metabolic process	GO:0019752	92	0.352
response to oxygen containing compound	GO:1901700	200	0.347
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.345
response to organic cyclic compound	GO:0014070	89	0.332
negative regulation of signaling	GO:0023057	219	0.330
imaginal disc derived appendage development	GO:0048737	399	0.328
regulation of molecular function	GO:0065009	217	0.316
positive regulation of catabolic process	GO:0009896	105	0.314
apoptotic process	GO:0006915	159	0.307
lipid metabolic process	GO:0006629	121	0.306
cellular response to extracellular stimulus	GO:0031668	64	0.305
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.305
metal ion homeostasis	GO:0055065	44	0.297
ribonucleotide metabolic process	GO:0009259	145	0.296
skeletal muscle organ development	GO:0060538	48	0.286
oxoacid metabolic process	GO:0043436	103	0.282
positive regulation of cell migration	GO:0030335	2	0.280
oxidation reduction process	GO:0055114	123	0.279
immune system process	GO:0002376	347	0.275
regulation of cell death	GO:0010941	173	0.265
positive regulation of biosynthetic process	GO:0009891	316	0.258
tissue morphogenesis	GO:0048729	297	0.256
organonitrogen compound metabolic process	GO:1901564	318	0.253
carbohydrate derivative metabolic process	GO:1901135	217	0.249
response to starvation	GO:0042594	97	0.244
death	GO:0016265	284	0.243
regulation of macroautophagy	GO:0016241	15	0.242
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.241
circadian rhythm	GO:0007623	105	0.240
response to temperature stimulus	GO:0009266	106	0.237
positive regulation of lipid metabolic process	GO:0045834	4	0.233
response to monosaccharide	GO:0034284	4	0.231
response to biotic stimulus	GO:0009607	294	0.230
positive regulation of transcription dna templated	GO:0045893	266	0.229
cellular response to reactive oxygen species	GO:0034614	14	0.219
cellular component assembly involved in morphogenesis	GO:0010927	151	0.218
vesicle mediated transport	GO:0016192	381	0.212
response to organic substance	GO:0010033	284	0.210
cellular response to dna damage stimulus	GO:0006974	223	0.210
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.210
transcription from rna polymerase ii promoter	GO:0006366	368	0.209
cellular response to peptide hormone stimulus	GO:0071375	28	0.208
heart development	GO:0007507	82	0.206
muscle attachment	GO:0016203	36	0.203
post embryonic appendage morphogenesis	GO:0035120	385	0.202
cell death	GO:0008219	279	0.192
regulation of intracellular signal transduction	GO:1902531	236	0.190
positive regulation of cell motility	GO:2000147	3	0.186
positive regulation of multicellular organismal process	GO:0051240	143	0.184
regulation of insulin receptor signaling pathway	GO:0046626	17	0.183
small molecule metabolic process	GO:0044281	305	0.183
single organism behavior	GO:0044708	391	0.181
regionalization	GO:0003002	416	0.175
chemotaxis	GO:0006935	249	0.172
regulation of nervous system development	GO:0051960	248	0.172
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.172
regulation of defense response	GO:0031347	102	0.171
tube development	GO:0035295	244	0.169
regulation of phosphate metabolic process	GO:0019220	210	0.169
response to insulin	GO:0032868	29	0.169
regulation of developmental growth	GO:0048638	174	0.168
larval development	GO:0002164	104	0.167
cellular response to starvation	GO:0009267	61	0.165
inositol lipid mediated signaling	GO:0048017	4	0.164
positive regulation of gene expression	GO:0010628	290	0.163
hematopoietic or lymphoid organ development	GO:0048534	57	0.161
positive regulation of response to stimulus	GO:0048584	323	0.159
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.159
negative regulation of programmed cell death	GO:0043069	72	0.159
purine ribonucleoside metabolic process	GO:0046128	127	0.158
cellular response to peptide	GO:1901653	28	0.154
response to glucose	GO:0009749	2	0.154
cellular response to external stimulus	GO:0071496	66	0.152
response to hexose	GO:0009746	3	0.149
cellular response to organonitrogen compound	GO:0071417	36	0.149
autophagic vacuole assembly	GO:0000045	2	0.149
regulation of catalytic activity	GO:0050790	185	0.148
regulation of phosphorus metabolic process	GO:0051174	210	0.148
positive regulation of signal transduction	GO:0009967	223	0.147
epithelial cell development	GO:0002064	274	0.147
regulation of anatomical structure morphogenesis	GO:0022603	242	0.146
dopamine receptor signaling pathway	GO:0007212	4	0.144
regulation of cell motility	GO:2000145	23	0.144
regulation of cellular component biogenesis	GO:0044087	201	0.143
maintenance of location	GO:0051235	73	0.143
cellular response to oxygen containing compound	GO:1901701	79	0.141
response to peptide hormone	GO:0043434	29	0.140
positive regulation of response to external stimulus	GO:0032103	44	0.140
lipid storage	GO:0019915	38	0.139
regulation of cell development	GO:0060284	215	0.138
regulation of growth	GO:0040008	233	0.138
regulation of cell cycle	GO:0051726	291	0.135
embryonic morphogenesis	GO:0048598	206	0.135
cellular response to nitrogen compound	GO:1901699	51	0.134
regulation of multicellular organismal development	GO:2000026	414	0.134
appendage development	GO:0048736	401	0.134
phosphorylation	GO:0016310	294	0.134
cellular response to insulin stimulus	GO:0032869	28	0.133
phosphatidylinositol mediated signaling	GO:0048015	4	0.133
stress activated protein kinase signaling cascade	GO:0031098	55	0.132
regulation of hydrolase activity	GO:0051336	97	0.130
regulation of stress activated mapk cascade	GO:0032872	41	0.129
positive regulation of macromolecule metabolic process	GO:0010604	405	0.125
positive regulation of rna metabolic process	GO:0051254	271	0.125
regulation of response to extracellular stimulus	GO:0032104	18	0.125
glial cell differentiation	GO:0010001	35	0.124
negative regulation of cellular protein metabolic process	GO:0032269	85	0.122
organic acid metabolic process	GO:0006082	103	0.122
cell motility	GO:0048870	251	0.119
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.117
synaptic transmission	GO:0007268	288	0.117
negative regulation of cell communication	GO:0010648	223	0.117
response to bacterium	GO:0009617	198	0.115
actin filament based process	GO:0030029	220	0.114
response to reactive oxygen species	GO:0000302	24	0.113
regulation of cellular catabolic process	GO:0031329	157	0.112
response to other organism	GO:0051707	293	0.112
defense response to gram negative bacterium	GO:0050829	94	0.112
regulation of apoptotic process	GO:0042981	130	0.111
response to organophosphorus	GO:0046683	2	0.108
positive regulation of cellular component biogenesis	GO:0044089	80	0.108
anatomical structure homeostasis	GO:0060249	97	0.104
negative regulation of protein metabolic process	GO:0051248	85	0.104
regulation of mitotic cell cycle	GO:0007346	190	0.103
autophagy	GO:0006914	108	0.102
embryo development ending in birth or egg hatching	GO:0009792	152	0.101
response to external biotic stimulus	GO:0043207	293	0.101
regulation of organelle organization	GO:0033043	196	0.098
positive regulation of rna biosynthetic process	GO:1902680	266	0.097
neuron projection guidance	GO:0097485	241	0.097
single organism catabolic process	GO:0044712	228	0.094
nucleotide metabolic process	GO:0009117	161	0.094
regulation of dna metabolic process	GO:0051052	34	0.094
gland development	GO:0048732	191	0.094
telomere organization	GO:0032200	21	0.092
neuromuscular synaptic transmission	GO:0007274	67	0.092
intracellular signal transduction	GO:0035556	300	0.091
negative regulation of cell death	GO:0060548	81	0.091
positive regulation of cell size	GO:0045793	21	0.090
positive regulation of organelle organization	GO:0010638	65	0.090
macroautophagy	GO:0016236	42	0.090
lipid biosynthetic process	GO:0008610	46	0.088
cellular response to chemical stimulus	GO:0070887	199	0.088
immune system development	GO:0002520	57	0.088
skeletal muscle adaptation	GO:0043501	1	0.088
single organism carbohydrate metabolic process	GO:0044723	72	0.088
positive regulation of cellular catabolic process	GO:0031331	95	0.087
purine nucleoside metabolic process	GO:0042278	127	0.086
proteolysis	GO:0006508	192	0.086
negative regulation of translation	GO:0017148	28	0.085
cellular ketone metabolic process	GO:0042180	24	0.083
regulation of protein complex assembly	GO:0043254	42	0.082
cellular protein modification process	GO:0006464	438	0.082
positive regulation of macroautophagy	GO:0016239	8	0.082
negative regulation of growth	GO:0045926	84	0.082
nuclear import	GO:0051170	51	0.082
positive regulation of phosphate metabolic process	GO:0045937	139	0.081
regulation of localization	GO:0032879	275	0.081
positive regulation of lipid catabolic process	GO:0050996	1	0.080
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.079
intracellular transport	GO:0046907	228	0.079
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.079
regulation of autophagy	GO:0010506	62	0.079
adult behavior	GO:0030534	137	0.078
regulation of neuron death	GO:1901214	26	0.077
response to mechanical stimulus	GO:0009612	28	0.076
regulation of mapk cascade	GO:0043408	92	0.075
nucleobase containing small molecule metabolic process	GO:0055086	174	0.074
cellular homeostasis	GO:0019725	80	0.073
signal transduction by phosphorylation	GO:0023014	107	0.073
organic hydroxy compound metabolic process	GO:1901615	83	0.073
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.073
ovarian follicle cell development	GO:0030707	248	0.072
gland morphogenesis	GO:0022612	145	0.072
organic substance catabolic process	GO:1901575	308	0.071
regulation of cellular response to insulin stimulus	GO:1900076	17	0.071
regulation of protein polymerization	GO:0032271	28	0.071
organelle fission	GO:0048285	340	0.069
somatic muscle development	GO:0007525	66	0.069
negative regulation of intracellular signal transduction	GO:1902532	57	0.069
endocytosis	GO:0006897	310	0.069
regulation of locomotion	GO:0040012	42	0.069
regulation of response to nutrient levels	GO:0032107	18	0.069
regulation of lipid kinase activity	GO:0043550	2	0.069
response to peptide	GO:1901652	29	0.068
myotube cell development	GO:0014904	3	0.068
regulation of protein import into nucleus	GO:0042306	28	0.068
regulation of cellular ketone metabolic process	GO:0010565	3	0.068
dna metabolic process	GO:0006259	227	0.067
extrinsic apoptotic signaling pathway	GO:0097191	1	0.067
nuclear division	GO:0000280	332	0.066
regulation of cell migration	GO:0030334	22	0.066
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.066
columnar cuboidal epithelial cell development	GO:0002066	249	0.065
defense response to other organism	GO:0098542	225	0.065
response to wounding	GO:0009611	94	0.064
positive regulation of programmed cell death	GO:0043068	62	0.064
hemopoiesis	GO:0030097	46	0.064
cellular protein complex assembly	GO:0043623	71	0.063
regulation of anatomical structure size	GO:0090066	163	0.063
cell adhesion	GO:0007155	136	0.063
positive regulation of translation	GO:0045727	12	0.062
protein catabolic process	GO:0030163	101	0.062
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.062
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.062
larval feeding behavior	GO:0030536	15	0.062
negative regulation of apoptotic process	GO:0043066	63	0.061
biological adhesion	GO:0022610	138	0.060
reactive oxygen species metabolic process	GO:0072593	22	0.060
cellular macromolecular complex assembly	GO:0034622	153	0.060
protein modification process	GO:0036211	438	0.060
regulation of phosphorylation	GO:0042325	147	0.060
chemical homeostasis	GO:0048878	92	0.059
muscle organ development	GO:0007517	127	0.059
nucleoside phosphate metabolic process	GO:0006753	162	0.058
chorion containing eggshell formation	GO:0007304	105	0.057
regulation of proteolysis	GO:0030162	87	0.056
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.056
dendrite development	GO:0016358	204	0.056
actin filament organization	GO:0007015	126	0.056
programmed cell death	GO:0012501	257	0.055
positive regulation of cellular protein metabolic process	GO:0032270	118	0.055
circulatory system development	GO:0072359	82	0.055
positive regulation of protein complex assembly	GO:0031334	22	0.055
developmental growth	GO:0048589	280	0.054
positive regulation of molecular function	GO:0044093	136	0.054
regulation of cytoplasmic transport	GO:1903649	47	0.054
regulation of response to oxidative stress	GO:1902882	4	0.053
ribose phosphate metabolic process	GO:0019693	145	0.053
cellular response to hormone stimulus	GO:0032870	44	0.052
organelle assembly	GO:0070925	198	0.052
lipid localization	GO:0010876	54	0.052
regulation of neurogenesis	GO:0050767	158	0.051
regulation of catabolic process	GO:0009894	170	0.050
carbohydrate metabolic process	GO:0005975	82	0.050
protein complex assembly	GO:0006461	200	0.050
carbohydrate biosynthetic process	GO:0016051	17	0.049
positive regulation of phosphorylation	GO:0042327	87	0.049
regulation of immune response	GO:0050776	118	0.049
organophosphate metabolic process	GO:0019637	195	0.048
salivary gland development	GO:0007431	162	0.048
purine containing compound metabolic process	GO:0072521	155	0.048
regulation of myoblast fusion	GO:1901739	6	0.047
actin cytoskeleton organization	GO:0030036	206	0.047
response to transition metal nanoparticle	GO:1990267	9	0.047
cardiovascular system development	GO:0072358	82	0.047
response to hormone	GO:0009725	45	0.047
regulation of innate immune response	GO:0045088	71	0.047
eggshell chorion assembly	GO:0007306	66	0.046
protein localization to nucleus	GO:0034504	55	0.046
positive regulation of developmental process	GO:0051094	143	0.046
mitochondrial fission	GO:0000266	8	0.046
cellular response to ionizing radiation	GO:0071479	15	0.046
actomyosin structure organization	GO:0031032	56	0.046
cell cycle phase transition	GO:0044770	140	0.045
eye development	GO:0001654	323	0.045
generation of precursor metabolites and energy	GO:0006091	42	0.045
negative regulation of rna biosynthetic process	GO:1902679	240	0.045
ameboidal type cell migration	GO:0001667	151	0.045
positive regulation of phosphorus metabolic process	GO:0010562	139	0.045
negative regulation of signal transduction	GO:0009968	206	0.044
homeostatic process	GO:0042592	199	0.044
jnk cascade	GO:0007254	50	0.044
positive regulation of developmental growth	GO:0048639	62	0.044
pyruvate metabolic process	GO:0006090	7	0.044
negative regulation of developmental process	GO:0051093	201	0.044
regulation of lipid biosynthetic process	GO:0046890	6	0.044
positive regulation of cellular component organization	GO:0051130	156	0.044
regulation of actin cytoskeleton organization	GO:0032956	42	0.043
cellular amine metabolic process	GO:0044106	12	0.043
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.043
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.043
negative regulation of cell cycle	GO:0045786	116	0.043
positive regulation of mitochondrion organization	GO:0010822	8	0.043
negative regulation of rna metabolic process	GO:0051253	251	0.043
purine nucleotide metabolic process	GO:0006163	146	0.043
eggshell formation	GO:0030703	105	0.042
response to abiotic stimulus	GO:0009628	341	0.042
nucleoside triphosphate metabolic process	GO:0009141	120	0.042
single organism intracellular transport	GO:1902582	207	0.041
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.041
rna processing	GO:0006396	147	0.041
regulation of nucleoside metabolic process	GO:0009118	50	0.041
mrna metabolic process	GO:0016071	124	0.041
secretion	GO:0046903	109	0.040
nuclear transport	GO:0051169	72	0.040
morphogenesis of a branching structure	GO:0001763	45	0.040
macromolecular complex assembly	GO:0065003	256	0.039
positive regulation of cell differentiation	GO:0045597	64	0.039
single organism biosynthetic process	GO:0044711	206	0.039
telomere maintenance	GO:0000723	21	0.039
response to alkaloid	GO:0043279	26	0.039
skeletal muscle fiber development	GO:0048741	3	0.038
regulation of jnk cascade	GO:0046328	40	0.038
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.038
response to inorganic substance	GO:0010035	44	0.038
amine metabolic process	GO:0009308	12	0.038
positive regulation of cell communication	GO:0010647	250	0.037
macromolecule catabolic process	GO:0009057	161	0.037
cellular response to organic substance	GO:0071310	132	0.037
compound eye development	GO:0048749	307	0.037
antimicrobial humoral response	GO:0019730	99	0.037
carbohydrate catabolic process	GO:0016052	7	0.036
positive regulation of apoptotic process	GO:0043065	47	0.036
cell aging	GO:0007569	2	0.036
negative regulation of mitotic cell cycle	GO:0045930	109	0.036
organonitrogen compound catabolic process	GO:1901565	128	0.035
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.035
peptidyl amino acid modification	GO:0018193	105	0.035
entry into diapause	GO:0055115	1	0.034
intracellular protein transport	GO:0006886	104	0.034
embryonic ectodermal digestive tract morphogenesis	GO:0048613	4	0.034
nucleoside metabolic process	GO:0009116	127	0.034
single organism nuclear import	GO:1902593	51	0.034
positive regulation of autophagy	GO:0010508	21	0.034
cell junction organization	GO:0034330	57	0.033
regulation of cellular component movement	GO:0051270	42	0.033
cellular response to hydrogen peroxide	GO:0070301	7	0.033
striated muscle tissue development	GO:0014706	27	0.033
regulation of nucleocytoplasmic transport	GO:0046822	35	0.033
exocrine system development	GO:0035272	162	0.033
nucleocytoplasmic transport	GO:0006913	72	0.033
female germ line stem cell maintenance	GO:0036099	8	0.032
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.032
humoral immune response	GO:0006959	117	0.032
dendrite morphogenesis	GO:0048813	199	0.032
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.032
protein complex biogenesis	GO:0070271	201	0.032
female meiosis chromosome segregation	GO:0016321	33	0.032
regulation of cellular localization	GO:0060341	136	0.031
positive regulation of protein import into nucleus	GO:0042307	21	0.031
cell proliferation	GO:0008283	299	0.031
protein targeting to nucleus	GO:0044744	51	0.031
tor signaling	GO:0031929	32	0.031
positive regulation of mapk cascade	GO:0043410	63	0.031
purine nucleotide catabolic process	GO:0006195	109	0.030
regulation of programmed cell death	GO:0043067	152	0.030
single organism cellular localization	GO:1902580	180	0.030
germ line stem cell maintenance	GO:0030718	50	0.030
protein phosphorylation	GO:0006468	169	0.030
nucleobase containing compound catabolic process	GO:0034655	165	0.030
positive regulation of intracellular signal transduction	GO:1902533	116	0.030
glycosyl compound metabolic process	GO:1901657	127	0.030
response to ionizing radiation	GO:0010212	32	0.029
retina development in camera type eye	GO:0060041	4	0.029
regulation of response to wounding	GO:1903034	19	0.029
mapk cascade	GO:0000165	107	0.029
insulin receptor signaling pathway	GO:0008286	25	0.029
glucan biosynthetic process	GO:0009250	2	0.029
positive regulation of cellular response to insulin stimulus	GO:1900078	4	0.029
regulation of protein modification process	GO:0031399	112	0.028
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.028
regulation of cellular component size	GO:0032535	98	0.028
apoptotic signaling pathway	GO:0097190	27	0.028
regulation of behavior	GO:0050795	75	0.028
locomotor rhythm	GO:0045475	56	0.028
cellular nitrogen compound catabolic process	GO:0044270	165	0.028
digestive system development	GO:0055123	149	0.028
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.028
regulation of protein localization to nucleus	GO:1900180	29	0.028
protein import into nucleus	GO:0006606	51	0.027
positive regulation of transport	GO:0051050	92	0.027
positive regulation of signaling	GO:0023056	243	0.027
organ growth	GO:0035265	56	0.027
cellular response to molecule of bacterial origin	GO:0071219	3	0.027
gliogenesis	GO:0042063	80	0.027
rhythmic process	GO:0048511	106	0.026
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.026
embryonic heart tube development	GO:0035050	22	0.026
purine ribonucleotide catabolic process	GO:0009154	109	0.026
regulation of cellular amino acid metabolic process	GO:0006521	0	0.026
localization of cell	GO:0051674	257	0.026
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.026
striated muscle cell development	GO:0055002	50	0.026
negative regulation of sequestering of calcium ion	GO:0051283	2	0.026
leg disc morphogenesis	GO:0007478	80	0.026
regulation of endopeptidase activity	GO:0052548	36	0.026
dorsal closure	GO:0007391	79	0.026
embryonic organ development	GO:0048568	50	0.026
cell type specific apoptotic process	GO:0097285	38	0.025
carbohydrate derivative biosynthetic process	GO:1901137	85	0.025
cellular response to mechanical stimulus	GO:0071260	2	0.025
cellular response to radiation	GO:0071478	52	0.025
regulation of peptidase activity	GO:0052547	39	0.025
long term memory	GO:0007616	62	0.025
cellular amino acid metabolic process	GO:0006520	61	0.025
cell migration	GO:0016477	238	0.025
positive regulation of cell adhesion	GO:0045785	10	0.025
telencephalon development	GO:0021537	2	0.024
leg disc development	GO:0035218	92	0.024
epidermis development	GO:0008544	65	0.024
feeding behavior	GO:0007631	50	0.024
body morphogenesis	GO:0010171	2	0.024
regulation of cell substrate adhesion	GO:0010810	2	0.024
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.024
regulation of epithelial cell differentiation	GO:0030856	4	0.024
regulation of response to biotic stimulus	GO:0002831	63	0.023
cellular amide metabolic process	GO:0043603	80	0.023
skeletal muscle tissue development	GO:0007519	13	0.023
salivary gland morphogenesis	GO:0007435	145	0.023
regulation of transport	GO:0051049	181	0.023
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.023
steroid metabolic process	GO:0008202	20	0.023
regulation of cell adhesion	GO:0030155	27	0.023
activation of mapk activity	GO:0000187	9	0.023
regulation of lipid storage	GO:0010883	22	0.023
response to endogenous stimulus	GO:0009719	119	0.023
hexose metabolic process	GO:0019318	8	0.022
striated muscle myosin thick filament assembly	GO:0071688	3	0.022
negative regulation of molecular function	GO:0044092	51	0.022
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.022
positive regulation of cellular biosynthetic process	GO:0031328	316	0.022
innate immune response	GO:0045087	144	0.022
positive regulation of cellular amine metabolic process	GO:0033240	0	0.022
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.022
regulation of neuron apoptotic process	GO:0043523	16	0.021
regulation of cellular response to oxidative stress	GO:1900407	4	0.021
response to ethanol	GO:0045471	59	0.021
response to heat	GO:0009408	63	0.021
negative regulation of cell size	GO:0045792	19	0.021
cuticle development	GO:0042335	86	0.021
cellular response to inorganic substance	GO:0071241	8	0.021
spermatogenesis	GO:0007283	200	0.021
cardiac muscle tissue development	GO:0048738	9	0.021
regulation of vesicle mediated transport	GO:0060627	59	0.021
cellular response to gamma radiation	GO:0071480	10	0.021
regulation of cytoskeleton organization	GO:0051493	89	0.020
hydrogen peroxide catabolic process	GO:0042744	6	0.020
muscle cell migration	GO:0014812	3	0.020
regulation of cell size	GO:0008361	63	0.020
positive regulation of intracellular protein transport	GO:0090316	30	0.020
regulation of cell shape	GO:0008360	113	0.020
regulation of cell proliferation	GO:0042127	163	0.020
cytoplasmic transport	GO:0016482	130	0.020
positive regulation of response to nutrient levels	GO:0032109	8	0.020
divalent inorganic cation homeostasis	GO:0072507	29	0.020
carbohydrate derivative catabolic process	GO:1901136	118	0.019
protein kinase b signaling	GO:0043491	1	0.019
modification dependent macromolecule catabolic process	GO:0043632	79	0.019
negative regulation of defense response	GO:0031348	35	0.019
regulation of establishment of protein localization	GO:0070201	61	0.019
positive regulation of antifungal peptide biosynthetic process	GO:0006967	5	0.019

Thor disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.056
disease of cellular proliferation	DOID:14566	0.056
musculoskeletal system disease	DOID:17	0.032
disease of anatomical entity	DOID:7	0.032
muscular disease	DOID:0080000	0.032
organ system cancer	DOID:0050686	0.030
muscle tissue disease	DOID:66	0.021
cardiovascular system disease	DOID:1287	0.020

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