IMP: Integrative Multi-species Prediction

Drosophila melanogaster

12 known processes

EfTuM (Dmel_CG6050)

Elongation factor Tu mitochondrial

(Aliases: mtEF-Tu,eftu-M,CG6050,Dmel\CG6050,l(3)L4569)

FLYBASE: FBgn0024556
Entrez: 44438
UniProtKB: A1Z9E3

Process Predictions
Disease Predictions

EfTuM biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
small molecule metabolic process	GO:0044281	305	0.585
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.238
embryo development ending in birth or egg hatching	GO:0009792	152	0.154
oxoacid metabolic process	GO:0043436	103	0.145
cellular amino acid metabolic process	GO:0006520	61	0.118
single organism biosynthetic process	GO:0044711	206	0.114
intracellular signal transduction	GO:0035556	300	0.108
cell division	GO:0051301	248	0.093
carboxylic acid metabolic process	GO:0019752	92	0.090
catabolic process	GO:0009056	409	0.089
body morphogenesis	GO:0010171	2	0.081
larval development	GO:0002164	104	0.078
localization of cell	GO:0051674	257	0.077
cellular catabolic process	GO:0044248	372	0.074
ribonucleoside monophosphate biosynthetic process	GO:0009156	3	0.071
phagocytosis	GO:0006909	215	0.068
mitochondrion organization	GO:0007005	65	0.064
ribonucleoside metabolic process	GO:0009119	127	0.063
purine containing compound metabolic process	GO:0072521	155	0.060
oxidative phosphorylation	GO:0006119	9	0.059
nucleobase containing small molecule metabolic process	GO:0055086	174	0.057
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.056
organic acid metabolic process	GO:0006082	103	0.051
cytoplasmic microtubule organization	GO:0031122	22	0.051
glycosyl compound biosynthetic process	GO:1901659	3	0.047
nucleoside phosphate metabolic process	GO:0006753	162	0.047
vesicle mediated transport	GO:0016192	381	0.046
atp synthesis coupled electron transport	GO:0042773	8	0.045
response to abiotic stimulus	GO:0009628	341	0.044
positive regulation of cell death	GO:0010942	69	0.042
mitotic spindle organization	GO:0007052	220	0.039
negative regulation of gene expression	GO:0010629	387	0.039
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.038
positive regulation of cell communication	GO:0010647	250	0.037
positive regulation of response to stimulus	GO:0048584	323	0.037
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.036
organic substance catabolic process	GO:1901575	308	0.036
positive regulation of endopeptidase activity	GO:0010950	26	0.036
atp metabolic process	GO:0046034	49	0.035
purine nucleoside biosynthetic process	GO:0042451	3	0.033
eye development	GO:0001654	323	0.032
nucleoside monophosphate metabolic process	GO:0009123	52	0.032
gland development	GO:0048732	191	0.032
endocytosis	GO:0006897	310	0.031
nucleoside triphosphate metabolic process	GO:0009141	120	0.031
nucleoside monophosphate biosynthetic process	GO:0009124	4	0.030
spermatid development	GO:0007286	98	0.030
apoptotic process	GO:0006915	159	0.029
atp biosynthetic process	GO:0006754	2	0.029
regulation of response to stress	GO:0080134	200	0.029
regulation of protein metabolic process	GO:0051246	256	0.029	Fly
regulation of defense response	GO:0031347	102	0.029
organonitrogen compound metabolic process	GO:1901564	318	0.028
trna aminoacylation for protein translation	GO:0006418	2	0.028
immune system process	GO:0002376	347	0.028
regulation of molecular function	GO:0065009	217	0.028
growth	GO:0040007	359	0.026
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.026
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.025
positive regulation of proteolysis	GO:0045862	52	0.025
response to temperature stimulus	GO:0009266	106	0.025
glycosyl compound metabolic process	GO:1901657	127	0.025
response to decreased oxygen levels	GO:0036293	58	0.024
purine nucleoside metabolic process	GO:0042278	127	0.024
cell death	GO:0008219	279	0.023
organonitrogen compound biosynthetic process	GO:1901566	117	0.023
ribose phosphate biosynthetic process	GO:0046390	28	0.023
response to hypoxia	GO:0001666	53	0.022
chromosome organization	GO:0051276	360	0.022
open tracheal system development	GO:0007424	204	0.021
spermatid differentiation	GO:0048515	114	0.021
ribonucleotide biosynthetic process	GO:0009260	28	0.021
purine nucleotide metabolic process	GO:0006163	146	0.021
carbohydrate derivative metabolic process	GO:1901135	217	0.021
alpha amino acid metabolic process	GO:1901605	20	0.020
reproductive structure development	GO:0048608	74	0.020
response to oxygen levels	GO:0070482	59	0.020
negative regulation of cell communication	GO:0010648	223	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	3	0.019
nucleoside biosynthetic process	GO:0009163	3	0.019
small molecule catabolic process	GO:0044282	21	0.019
response to ecdysone	GO:0035075	34	0.019
cell motility	GO:0048870	251	0.018
protein complex assembly	GO:0006461	200	0.018
development of primary sexual characteristics	GO:0045137	50	0.018
immune response	GO:0006955	246	0.018
purine ribonucleotide biosynthetic process	GO:0009152	28	0.018
proton transport	GO:0015992	7	0.018
response to cold	GO:0009409	13	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
ribose phosphate metabolic process	GO:0019693	145	0.017
microtubule organizing center organization	GO:0031023	168	0.017
response to organic substance	GO:0010033	284	0.017
purine nucleoside monophosphate biosynthetic process	GO:0009127	3	0.017
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.017
purine containing compound biosynthetic process	GO:0072522	30	0.016
nucleoside metabolic process	GO:0009116	127	0.016
protein complex biogenesis	GO:0070271	201	0.016
cellular respiration	GO:0045333	26	0.016
spindle organization	GO:0007051	253	0.016
negative regulation of nucleoside metabolic process	GO:0045978	1	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
organophosphate metabolic process	GO:0019637	195	0.016
regulation of immune system process	GO:0002682	176	0.016
programmed cell death	GO:0012501	257	0.016
regulation of phosphorus metabolic process	GO:0051174	210	0.016
response to radiation	GO:0009314	155	0.016
nucleotide metabolic process	GO:0009117	161	0.016
eye morphogenesis	GO:0048592	260	0.016
organonitrogen compound catabolic process	GO:1901565	128	0.016
cell recognition	GO:0008037	102	0.015
single organism catabolic process	GO:0044712	228	0.015
regulation of innate immune response	GO:0045088	71	0.015
reproductive system development	GO:0061458	74	0.015
cellular response to chemical stimulus	GO:0070887	199	0.015
mitotic nuclear division	GO:0007067	213	0.015
response to oxygen containing compound	GO:1901700	200	0.015
positive regulation of programmed cell death	GO:0043068	62	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
ribonucleoside biosynthetic process	GO:0042455	3	0.015
connective tissue development	GO:0061448	3	0.014
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.014
positive regulation of catalytic activity	GO:0043085	118	0.014
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.014
imaginal disc derived appendage development	GO:0048737	399	0.014
defense response	GO:0006952	300	0.014
sister chromatid segregation	GO:0000819	92	0.014
purine ribonucleotide metabolic process	GO:0009150	145	0.014
oxidation reduction process	GO:0055114	123	0.014
purine nucleotide biosynthetic process	GO:0006164	29	0.014
gonad development	GO:0008406	50	0.014
cell proliferation	GO:0008283	299	0.014
translation	GO:0006412	69	0.013	Fly
purine ribonucleoside biosynthetic process	GO:0046129	3	0.013
epithelial tube morphogenesis	GO:0060562	88	0.013
regulation of immune response	GO:0050776	118	0.013
developmental growth	GO:0048589	280	0.013
phosphorylation	GO:0016310	294	0.013
kidney development	GO:0001822	3	0.013
carboxylic acid catabolic process	GO:0046395	16	0.012
proteolysis	GO:0006508	192	0.012
death	GO:0016265	284	0.012
transcription from rna polymerase ii promoter	GO:0006366	368	0.012
head development	GO:0060322	135	0.012
chromosome segregation	GO:0007059	157	0.011
positive regulation of molecular function	GO:0044093	136	0.011
genitalia development	GO:0048806	26	0.011
positive regulation of multicellular organismal process	GO:0051240	143	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
nephron epithelium development	GO:0072009	3	0.011
response to biotic stimulus	GO:0009607	294	0.011
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
embryonic morphogenesis	GO:0048598	206	0.010
lipid localization	GO:0010876	54	0.010
sex differentiation	GO:0007548	81	0.010
negative regulation of rna biosynthetic process	GO:1902679	240	0.010

EfTuM disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.081
inherited metabolic disorder	DOID:655	0.058
disease of anatomical entity	DOID:7	0.047

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