IMP: Integrative Multi-species Prediction

Drosophila melanogaster

87 known processes

NiPp1 (Dmel_CG8980)

Nuclear inhibitor of Protein phosphatase 1

(Aliases: NiPp-1,NIPP-1Dm,NIPP1,NIPP1Dm,CG8980,Dmel\CG8980,nipp1)

FLYBASE: FBgn0026402
Entrez: 44748
UniProtKB: Q9V7W9

Process Predictions
Disease Predictions

NiPp1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chromosome segregation	GO:0007059	157	0.750
organelle fission	GO:0048285	340	0.447
spindle assembly	GO:0051225	80	0.386
spindle assembly involved in mitosis	GO:0090307	50	0.312
meiotic nuclear division	GO:0007126	151	0.288
sister chromatid segregation	GO:0000819	92	0.242
chromosome organization	GO:0051276	360	0.234
mitotic spindle organization	GO:0007052	220	0.210
mitotic sister chromatid segregation	GO:0000070	87	0.205
protein complex biogenesis	GO:0070271	201	0.201
locomotory behavior	GO:0007626	176	0.196
cellular response to dna damage stimulus	GO:0006974	223	0.196
meiotic cell cycle	GO:0051321	171	0.193
dna conformation change	GO:0071103	105	0.190
axon development	GO:0061564	297	0.187
cellular protein modification process	GO:0006464	438	0.167
organelle assembly	GO:0070925	198	0.165
axonogenesis	GO:0007409	290	0.156
meiotic chromosome segregation	GO:0045132	59	0.138
protein dephosphorylation	GO:0006470	27	0.135
regulation of cell cycle	GO:0051726	291	0.130
macromolecular complex assembly	GO:0065003	256	0.127
female meiotic division	GO:0007143	70	0.123
axon guidance	GO:0007411	233	0.114
rna processing	GO:0006396	147	0.111
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.106
nuclear division	GO:0000280	332	0.106
regulation of intracellular signal transduction	GO:1902531	236	0.105
mitotic chromosome condensation	GO:0007076	22	0.103
cellular catabolic process	GO:0044248	372	0.102
central nervous system development	GO:0007417	201	0.102
regulation of sister chromatid segregation	GO:0033045	28	0.102
multi multicellular organism process	GO:0044706	123	0.100
dna metabolic process	GO:0006259	227	0.098
meiotic cell cycle process	GO:1903046	132	0.090
regulation of mapk cascade	GO:0043408	92	0.090
dna packaging	GO:0006323	91	0.086
reproductive behavior	GO:0019098	122	0.081
columnar cuboidal epithelial cell development	GO:0002066	249	0.080
cell migration	GO:0016477	238	0.079
regulation of cellular protein metabolic process	GO:0032268	243	0.079
spindle organization	GO:0007051	253	0.077
mitotic sister chromatid separation	GO:0051306	30	0.077
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.073
negative regulation of phosphate metabolic process	GO:0045936	45	0.071
regulation of protein dephosphorylation	GO:0035304	5	0.069
regulation of organelle organization	GO:0033043	196	0.069
protein complex assembly	GO:0006461	200	0.066
regulation of cellular component biogenesis	GO:0044087	201	0.065
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.065
circadian rhythm	GO:0007623	105	0.063
dna replication	GO:0006260	48	0.062
macromolecule catabolic process	GO:0009057	161	0.061
dna dependent dna replication maintenance of fidelity	GO:0045005	0	0.061
chromosome separation	GO:0051304	42	0.060
cell proliferation	GO:0008283	299	0.059	Mouse
regulation of protein metabolic process	GO:0051246	256	0.059
regulation of phosphate metabolic process	GO:0019220	210	0.058
neurological system process	GO:0050877	358	0.057
spindle assembly involved in female meiosis i	GO:0007057	5	0.057
carbohydrate derivative metabolic process	GO:1901135	217	0.057
chemotaxis	GO:0006935	249	0.055
intracellular signal transduction	GO:0035556	300	0.055
positive regulation of signal transduction	GO:0009967	223	0.055
organic substance catabolic process	GO:1901575	308	0.054
circadian behavior	GO:0048512	76	0.054
protein modification process	GO:0036211	438	0.052
mitotic nuclear division	GO:0007067	213	0.051
dephosphorylation	GO:0016311	51	0.050
negative regulation of cell communication	GO:0010648	223	0.050
multi organism reproductive behavior	GO:0044705	121	0.050
mrna metabolic process	GO:0016071	124	0.050
regulation of mitotic sister chromatid separation	GO:0010965	28	0.048
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.048
mrna processing	GO:0006397	104	0.047
negative regulation of organelle organization	GO:0010639	56	0.047
heterocycle catabolic process	GO:0046700	166	0.045
centrosome organization	GO:0051297	163	0.045
brain development	GO:0007420	120	0.045
metaphase anaphase transition of cell cycle	GO:0044784	28	0.044
establishment or maintenance of cell polarity	GO:0007163	167	0.042
protein complex disassembly	GO:0043241	36	0.041
erk1 and erk2 cascade	GO:0070371	39	0.040
taxis	GO:0042330	304	0.040
regulation of circadian rhythm	GO:0042752	49	0.039
regulation of transport	GO:0051049	181	0.039
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.039
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.039
centrosome duplication	GO:0051298	121	0.039
ras protein signal transduction	GO:0007265	88	0.039
dna damage checkpoint	GO:0000077	78	0.039
regulation of protein catabolic process	GO:0042176	55	0.038
axis specification	GO:0009798	167	0.038
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.038
negative regulation of cellular protein metabolic process	GO:0032269	85	0.038
dendrite development	GO:0016358	204	0.037
regulation of immune response	GO:0050776	118	0.036
endocytosis	GO:0006897	310	0.036
regulation of molecular function	GO:0065009	217	0.036
covalent chromatin modification	GO:0016569	106	0.035
chromosome condensation	GO:0030261	41	0.035
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.035
phosphorylation	GO:0016310	294	0.035
immune response	GO:0006955	246	0.035
nucleobase containing small molecule metabolic process	GO:0055086	174	0.035
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.035
establishment of chromosome localization	GO:0051303	20	0.034
dendrite morphogenesis	GO:0048813	199	0.034
chromatin organization	GO:0006325	207	0.034
negative regulation of cellular component organization	GO:0051129	108	0.034
modification dependent protein catabolic process	GO:0019941	78	0.033
cellularization	GO:0007349	90	0.033
epithelial cell differentiation	GO:0030855	322	0.033
positive regulation of signaling	GO:0023056	243	0.032
cellular macromolecular complex assembly	GO:0034622	153	0.032
cellular protein complex assembly	GO:0043623	71	0.032
hindgut morphogenesis	GO:0007442	58	0.032
chromatin modification	GO:0016568	147	0.032
regulation of cytoskeleton organization	GO:0051493	89	0.031
histone modification	GO:0016570	106	0.031
regulation of phosphorylation	GO:0042325	147	0.031
positive regulation of cell communication	GO:0010647	250	0.031
regulation of erk1 and erk2 cascade	GO:0070372	39	0.031
microtubule organizing center organization	GO:0031023	168	0.030
respiratory system development	GO:0060541	213	0.030
negative regulation of signal transduction	GO:0009968	206	0.030
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.030
embryonic pattern specification	GO:0009880	174	0.030
regulation of phosphorus metabolic process	GO:0051174	210	0.029
regulation of protein modification process	GO:0031399	112	0.029
positive regulation of cellular protein metabolic process	GO:0032270	118	0.029
dna integrity checkpoint	GO:0031570	81	0.029
regulation of microtubule polymerization or depolymerization	GO:0031110	27	0.029
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.029
regulation of cell division	GO:0051302	72	0.029
energy derivation by oxidation of organic compounds	GO:0015980	32	0.028
cellular macromolecule catabolic process	GO:0044265	136	0.028
multicellular organismal reproductive behavior	GO:0033057	110	0.028
protein polymerization	GO:0051258	42	0.028
neuron projection guidance	GO:0097485	241	0.027
organelle localization	GO:0051640	148	0.027
multi organism behavior	GO:0051705	175	0.027
defense response to other organism	GO:0098542	225	0.027
secretion	GO:0046903	109	0.025
sensory perception of mechanical stimulus	GO:0050954	72	0.025
regulation of proteasomal protein catabolic process	GO:0061136	39	0.025
catabolic process	GO:0009056	409	0.025
negative regulation of cellular metabolic process	GO:0031324	382	0.025
rhythmic process	GO:0048511	106	0.025
negative regulation of catalytic activity	GO:0043086	42	0.025
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.025
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.024
cell division	GO:0051301	248	0.024
telomere capping	GO:0016233	11	0.024
meiosis i	GO:0007127	59	0.024
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.024
small gtpase mediated signal transduction	GO:0007264	88	0.023
localization of cell	GO:0051674	257	0.023
single organism behavior	GO:0044708	391	0.023
positive regulation of protein metabolic process	GO:0051247	128	0.023
transcription from rna polymerase ii promoter	GO:0006366	368	0.023
sensory perception	GO:0007600	196	0.023
negative regulation of protein metabolic process	GO:0051248	85	0.023
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.023
regulation of chromosome organization	GO:0033044	64	0.023
positive regulation of biosynthetic process	GO:0009891	316	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023
regulation of cell death	GO:0010941	173	0.023
regulation of dna metabolic process	GO:0051052	34	0.022
negative regulation of gene expression	GO:0010629	387	0.022
organonitrogen compound metabolic process	GO:1901564	318	0.022
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.022
sister chromatid cohesion	GO:0007062	18	0.022
dna dependent dna replication	GO:0006261	17	0.022
positive regulation of phosphorylation	GO:0042327	87	0.021
negative regulation of chromosome segregation	GO:0051985	14	0.021
macromolecular complex disassembly	GO:0032984	37	0.021
positive regulation of cellular component biogenesis	GO:0044089	80	0.021
regulation of localization	GO:0032879	275	0.021
intracellular transport	GO:0046907	228	0.021
microtubule based movement	GO:0007018	51	0.021
regulation of ras protein signal transduction	GO:0046578	93	0.021
cellular component assembly involved in morphogenesis	GO:0010927	151	0.020
regulation of protein complex disassembly	GO:0043244	29	0.020
regulation of catalytic activity	GO:0050790	185	0.020
development of primary sexual characteristics	GO:0045137	50	0.020
appendage development	GO:0048736	401	0.020
cognition	GO:0050890	141	0.020
regulation of proteolysis	GO:0030162	87	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
segmentation	GO:0035282	207	0.019
erbb signaling pathway	GO:0038127	58	0.019
reproductive system development	GO:0061458	74	0.019
ovarian follicle cell development	GO:0030707	248	0.019
proteolysis	GO:0006508	192	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.019
negative regulation of mitotic sister chromatid segregation	GO:0033048	13	0.019
microtubule bundle formation	GO:0001578	27	0.019
regulation of immune system process	GO:0002682	176	0.018
phagocytosis	GO:0006909	215	0.018
regulation of wnt signaling pathway	GO:0030111	68	0.018
regulation of protein polymerization	GO:0032271	28	0.018
negative regulation of biosynthetic process	GO:0009890	277	0.017
negative regulation of signaling	GO:0023057	219	0.017
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.017
establishment of localization in cell	GO:0051649	402	0.017
protein depolymerization	GO:0051261	31	0.017
sex differentiation	GO:0007548	81	0.017
negative regulation of sister chromatid segregation	GO:0033046	13	0.016
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.016
positive regulation of intracellular signal transduction	GO:1902533	116	0.016
positive regulation of rna biosynthetic process	GO:1902680	266	0.016
mitotic cell cycle phase transition	GO:0044772	138	0.016
appendage morphogenesis	GO:0035107	397	0.016
embryonic hindgut morphogenesis	GO:0048619	48	0.016
organic substance transport	GO:0071702	257	0.016
immune response activating signal transduction	GO:0002757	2	0.016
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.016
regulation of nuclear division	GO:0051783	58	0.016
dna replication checkpoint	GO:0000076	8	0.016
reciprocal meiotic recombination	GO:0007131	19	0.016
negative regulation of cell cycle	GO:0045786	116	0.016
negative regulation of neuron death	GO:1901215	18	0.015
mitotic cytokinesis	GO:0000281	50	0.015
protein localization	GO:0008104	284	0.015
protein catabolic process	GO:0030163	101	0.015
response to external biotic stimulus	GO:0043207	293	0.015
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.015
positive regulation of response to stimulus	GO:0048584	323	0.015
dna double strand break processing	GO:0000729	3	0.015
mapk cascade	GO:0000165	107	0.015
gliogenesis	GO:0042063	80	0.015
signal transduction by phosphorylation	GO:0023014	107	0.015
dna repair	GO:0006281	54	0.015
maintenance of location	GO:0051235	73	0.015
negative regulation of cellular biosynthetic process	GO:0031327	277	0.014
purine ribonucleoside metabolic process	GO:0046128	127	0.014
pole cell formation	GO:0007279	19	0.014
establishment of rna localization	GO:0051236	47	0.014
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.014
regulation of chromosome segregation	GO:0051983	32	0.014
larval development	GO:0002164	104	0.014
stem cell division	GO:0017145	69	0.014
negative regulation of mitotic metaphase anaphase transition	GO:0045841	13	0.014
regulation of catabolic process	GO:0009894	170	0.014
cellular protein catabolic process	GO:0044257	83	0.014
positive regulation of transcription dna templated	GO:0045893	266	0.014
positive regulation of protein catabolic process	GO:0045732	34	0.014
generation of precursor metabolites and energy	GO:0006091	42	0.014
regulation of protein depolymerization	GO:1901879	27	0.014
post embryonic appendage morphogenesis	GO:0035120	385	0.013
cytoskeleton dependent intracellular transport	GO:0030705	44	0.013
positive regulation of ras protein signal transduction	GO:0046579	43	0.013
glycosyl compound metabolic process	GO:1901657	127	0.013
proteasomal protein catabolic process	GO:0010498	59	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
regulation of nervous system development	GO:0051960	248	0.013
purine ribonucleotide metabolic process	GO:0009150	145	0.013
nitrogen compound transport	GO:0071705	85	0.013
imaginal disc derived appendage development	GO:0048737	399	0.013
mitotic spindle checkpoint	GO:0071174	11	0.013
cell death	GO:0008219	279	0.013
aromatic compound catabolic process	GO:0019439	166	0.013
negative regulation of phosphorus metabolic process	GO:0010563	45	0.013
nucleocytoplasmic transport	GO:0006913	72	0.013
response to other organism	GO:0051707	293	0.012
small molecule metabolic process	GO:0044281	305	0.012
negative regulation of cell division	GO:0051782	17	0.012
epithelial cell development	GO:0002064	274	0.012
signal transduction in response to dna damage	GO:0042770	3	0.012
mitotic g2 m transition checkpoint	GO:0044818	70	0.012
embryonic axis specification	GO:0000578	107	0.012
organophosphate metabolic process	GO:0019637	195	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012
regulation of apoptotic process	GO:0042981	130	0.012
microtubule polymerization or depolymerization	GO:0031109	39	0.012
hindgut development	GO:0061525	58	0.012
embryo development ending in birth or egg hatching	GO:0009792	152	0.012
protein acylation	GO:0043543	42	0.012
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.012
mitotic spindle assembly checkpoint	GO:0007094	11	0.012
negative regulation of mitotic cell cycle	GO:0045930	109	0.012
modification dependent macromolecule catabolic process	GO:0043632	79	0.012
negative regulation of intracellular signal transduction	GO:1902532	57	0.012
single organism biosynthetic process	GO:0044711	206	0.012
learning or memory	GO:0007611	141	0.012
regulation of neuron projection development	GO:0010975	69	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
vesicle mediated transport	GO:0016192	381	0.011
cell maturation	GO:0048469	144	0.011
cell motility	GO:0048870	251	0.011
positive regulation of phosphorus metabolic process	GO:0010562	139	0.011
negative regulation of protein modification process	GO:0031400	29	0.011
camera type eye development	GO:0043010	4	0.011
response to light stimulus	GO:0009416	124	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
mitotic spindle elongation	GO:0000022	81	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011
cell cycle arrest	GO:0007050	4	0.011
cellular protein complex disassembly	GO:0043624	35	0.011
regulation of cellular protein catabolic process	GO:1903362	44	0.011
positive regulation of immune response	GO:0050778	63	0.011
negative regulation of proteolysis	GO:0045861	31	0.011
wing disc morphogenesis	GO:0007472	344	0.011
atp dependent chromatin remodeling	GO:0043044	22	0.011
meiotic dna double strand break formation involved in reciprocal meiotic recombination	GO:0010780	1	0.011
single organism catabolic process	GO:0044712	228	0.011
positive regulation of cellular component organization	GO:0051130	156	0.010
cellular response to chemical stimulus	GO:0070887	199	0.010
nucleotide metabolic process	GO:0009117	161	0.010
protein phosphorylation	GO:0006468	169	0.010
ubiquitin dependent protein catabolic process	GO:0006511	78	0.010
nuclear transport	GO:0051169	72	0.010

NiPp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.026
disease of anatomical entity	DOID:7	0.026
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
sensory system disease	DOID:0050155	0.012

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