IMP: Integrative Multi-species Prediction

Drosophila melanogaster

70 known processes

bap (Dmel_CG7902)

bagpipe

(Aliases: Bap,dNK-3,nk-3,bgp,Dmel\CG7902,NK3,CG7902,NK-3)

FLYBASE: FBgn0004862
Entrez: 42537
UniProtKB: P22809
UniProtKB: Q53YH4

Process Predictions
Disease Predictions

bap biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.246
positive regulation of transcription dna templated	GO:0045893	266	0.230
renal tubule development	GO:0061326	64	0.223
embryonic morphogenesis	GO:0048598	206	0.219	Mouse Fly
circadian rhythm	GO:0007623	105	0.203
positive regulation of rna metabolic process	GO:0051254	271	0.196
malpighian tubule morphogenesis	GO:0007443	44	0.191
imaginal disc derived appendage development	GO:0048737	399	0.151
renal tubule morphogenesis	GO:0061333	44	0.147
tissue morphogenesis	GO:0048729	297	0.143	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.140
neurological system process	GO:0050877	358	0.137
hindgut morphogenesis	GO:0007442	58	0.130
negative regulation of transcription dna templated	GO:0045892	237	0.125	Mouse
digestive system development	GO:0055123	149	0.120	Mouse Worm Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.118
vesicle mediated transport	GO:0016192	381	0.117	Worm
malpighian tubule development	GO:0072002	64	0.116
regionalization	GO:0003002	416	0.115
positive regulation of gene expression	GO:0010628	290	0.113
locomotory behavior	GO:0007626	176	0.112
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.109
salivary gland morphogenesis	GO:0007435	145	0.104	Fly
dendrite development	GO:0016358	204	0.103
appendage morphogenesis	GO:0035107	397	0.100
digestive tract development	GO:0048565	149	0.097	Mouse Worm Fly
negative regulation of gene expression	GO:0010629	387	0.093	Mouse
hindgut development	GO:0061525	58	0.090
positive regulation of rna biosynthetic process	GO:1902680	266	0.089
imaginal disc derived wing morphogenesis	GO:0007476	337	0.089
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.089
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.086
transcription from rna polymerase ii promoter	GO:0006366	368	0.086
embryonic organ development	GO:0048568	50	0.084	Mouse Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.084
positive regulation of biosynthetic process	GO:0009891	316	0.082
lateral inhibition	GO:0046331	206	0.080
embryonic development via the syncytial blastoderm	GO:0001700	148	0.080
embryonic hindgut morphogenesis	GO:0048619	48	0.078
neuron fate commitment	GO:0048663	50	0.077
salivary gland development	GO:0007431	162	0.072	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.072
exocrine system development	GO:0035272	162	0.070	Fly
regulation of transport	GO:0051049	181	0.065
rhythmic process	GO:0048511	106	0.065
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.065	Mouse
chorion containing eggshell formation	GO:0007304	105	0.064
digestive tract morphogenesis	GO:0048546	127	0.064	Fly
muscle structure development	GO:0061061	224	0.064	Worm Fly
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.063	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.063	Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.063	Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.061	Mouse
eggshell formation	GO:0030703	105	0.060
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.060
growth	GO:0040007	359	0.058
sensory perception of sound	GO:0007605	56	0.057
apoptotic process	GO:0006915	159	0.056	Mouse
morphogenesis of an epithelium	GO:0002009	276	0.056	Fly
single organism behavior	GO:0044708	391	0.054
anterior posterior pattern specification	GO:0009952	136	0.053
positive regulation of macromolecule metabolic process	GO:0010604	405	0.052
appendage development	GO:0048736	401	0.051
tube development	GO:0035295	244	0.050	Mouse Worm Fly
wing disc morphogenesis	GO:0007472	344	0.050
actomyosin structure organization	GO:0031032	56	0.049
tube morphogenesis	GO:0035239	191	0.049	Fly
endocytosis	GO:0006897	310	0.049	Worm
regulation of developmental growth	GO:0048638	174	0.046
compound eye morphogenesis	GO:0001745	249	0.046
urogenital system development	GO:0001655	72	0.045	Fly
regulation of localization	GO:0032879	275	0.044
photoreceptor cell differentiation	GO:0046530	170	0.043
compound eye development	GO:0048749	307	0.043
death	GO:0016265	284	0.043	Mouse
male courtship behavior veined wing extension	GO:0048065	22	0.042
actin cytoskeleton organization	GO:0030036	206	0.042
organonitrogen compound metabolic process	GO:1901564	318	0.042
muscle organ development	GO:0007517	127	0.040	Worm
gland morphogenesis	GO:0022612	145	0.040	Fly
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.040	Mouse Fly
mesoderm development	GO:0007498	78	0.040
eye photoreceptor cell fate commitment	GO:0042706	37	0.040
epithelial tube morphogenesis	GO:0060562	88	0.040
negative regulation of cellular metabolic process	GO:0031324	382	0.040	Mouse
actin filament based process	GO:0030029	220	0.038
columnar cuboidal epithelial cell development	GO:0002066	249	0.038	Mouse
male courtship behavior veined wing vibration	GO:0016545	21	0.037
eye photoreceptor cell differentiation	GO:0001754	145	0.036
head development	GO:0060322	135	0.036
negative regulation of cellular biosynthetic process	GO:0031327	277	0.036	Mouse
cellular component assembly involved in morphogenesis	GO:0010927	151	0.036
neuron recognition	GO:0008038	101	0.036
eye morphogenesis	GO:0048592	260	0.035
locomotor rhythm	GO:0045475	56	0.035
gastrulation	GO:0007369	70	0.035
photoreceptor cell fate commitment	GO:0046552	41	0.035
negative regulation of biosynthetic process	GO:0009890	277	0.034	Mouse
epithelial cell development	GO:0002064	274	0.034	Mouse
epithelial cell differentiation	GO:0030855	322	0.032	Mouse Fly
gland development	GO:0048732	191	0.032	Fly
regulation of cell proliferation	GO:0042127	163	0.032
response to abiotic stimulus	GO:0009628	341	0.032
negative regulation of rna metabolic process	GO:0051253	251	0.031	Mouse
eye antennal disc development	GO:0035214	60	0.031
camera type eye development	GO:0043010	4	0.030
phagocytosis	GO:0006909	215	0.030
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.030	Mouse
organic substance transport	GO:0071702	257	0.030
negative regulation of developmental process	GO:0051093	201	0.030	Mouse
segmentation	GO:0035282	207	0.029
striated muscle cell development	GO:0055002	50	0.029
gastrulation involving germ band extension	GO:0010004	36	0.029
erbb signaling pathway	GO:0038127	58	0.029
central nervous system development	GO:0007417	201	0.029
renal system development	GO:0072001	72	0.028	Fly
developmental programmed cell death	GO:0010623	138	0.028
striated muscle tissue development	GO:0014706	27	0.028	Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.027	Mouse
g protein coupled receptor signaling pathway	GO:0007186	136	0.027
ovarian follicle cell development	GO:0030707	248	0.026
establishment or maintenance of cell polarity	GO:0007163	167	0.026
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.025
protein modification process	GO:0036211	438	0.025
catabolic process	GO:0009056	409	0.025
secretion	GO:0046903	109	0.025
rhythmic behavior	GO:0007622	76	0.025
gastrulation with mouth forming first	GO:0001703	36	0.025
eye development	GO:0001654	323	0.025
cognition	GO:0050890	141	0.025
muscle tissue development	GO:0060537	30	0.025	Fly
response to nutrient levels	GO:0031667	114	0.025
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.025
cell proliferation	GO:0008283	299	0.024
developmental growth	GO:0048589	280	0.024
negative regulation of cell death	GO:0060548	81	0.024	Mouse
single organism biosynthetic process	GO:0044711	206	0.024
brain development	GO:0007420	120	0.024
leg disc development	GO:0035218	92	0.024
organic substance catabolic process	GO:1901575	308	0.024
body morphogenesis	GO:0010171	2	0.024
compound eye photoreceptor cell differentiation	GO:0001751	140	0.023
immune system process	GO:0002376	347	0.023	Mouse Fly
reproductive behavior	GO:0019098	122	0.023
cell death	GO:0008219	279	0.023	Mouse
regulation of cellular localization	GO:0060341	136	0.023
regulation of anatomical structure size	GO:0090066	163	0.023
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.022
reproductive system development	GO:0061458	74	0.022	Fly
dendrite morphogenesis	GO:0048813	199	0.022
muscle cell development	GO:0055001	50	0.022
memory	GO:0007613	94	0.022
cellular protein modification process	GO:0006464	438	0.022
cell fate commitment involved in pattern specification	GO:0060581	31	0.022
male courtship behavior	GO:0008049	63	0.022
compound eye photoreceptor fate commitment	GO:0001752	36	0.022
negative regulation of rna biosynthetic process	GO:1902679	240	0.022	Mouse
regulation of cell death	GO:0010941	173	0.022	Mouse
neuropeptide signaling pathway	GO:0007218	45	0.021
blastoderm segmentation	GO:0007350	159	0.021
striated muscle cell differentiation	GO:0051146	90	0.021	Fly
regulation of cellular amino acid metabolic process	GO:0006521	0	0.021
negative regulation of cell differentiation	GO:0045596	143	0.021	Mouse
response to oxygen containing compound	GO:1901700	200	0.021
response to lipopolysaccharide	GO:0032496	4	0.020
negative regulation of apoptotic process	GO:0043066	63	0.020	Mouse
detection of light stimulus	GO:0009583	58	0.020
eye antennal disc morphogenesis	GO:0007455	34	0.020
sensory organ precursor cell fate determination	GO:0016360	19	0.020
reproductive structure development	GO:0048608	74	0.020	Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.020	Mouse
carboxylic acid metabolic process	GO:0019752	92	0.020
amine metabolic process	GO:0009308	12	0.020
histolysis	GO:0007559	102	0.020
regulation of cell development	GO:0060284	215	0.020
multi organism behavior	GO:0051705	175	0.020
heart development	GO:0007507	82	0.020	Fly
adult behavior	GO:0030534	137	0.019
sensory perception of mechanical stimulus	GO:0050954	72	0.019
positive regulation of response to stimulus	GO:0048584	323	0.019
negative regulation of signaling	GO:0023057	219	0.019
male courtship behavior veined wing generated song production	GO:0045433	20	0.019
morphogenesis of embryonic epithelium	GO:0016331	94	0.019	Fly
organelle assembly	GO:0070925	198	0.019
cell fate specification	GO:0001708	71	0.018
ventral furrow formation	GO:0007370	17	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
axis specification	GO:0009798	167	0.018
embryonic heart tube development	GO:0035050	22	0.018	Fly
muscle fiber development	GO:0048747	12	0.018
courtship behavior	GO:0007619	68	0.018
cholesterol homeostasis	GO:0042632	3	0.018
organ growth	GO:0035265	56	0.018
mesoderm morphogenesis	GO:0048332	22	0.018
establishment of localization in cell	GO:0051649	402	0.018
muscle cell differentiation	GO:0042692	103	0.018	Fly
cell fate determination involved in pattern specification	GO:0060582	19	0.018
forebrain development	GO:0030900	2	0.017
negative regulation of multicellular organismal process	GO:0051241	142	0.017	Mouse
regulation of cellular amine metabolic process	GO:0033238	3	0.017
response to extracellular stimulus	GO:0009991	116	0.017
sex differentiation	GO:0007548	81	0.017	Fly
positive regulation of cell communication	GO:0010647	250	0.017
larval development	GO:0002164	104	0.017
response to other organism	GO:0051707	293	0.017
regulation of organ morphogenesis	GO:2000027	78	0.017
mesodermal cell fate commitment	GO:0001710	7	0.017
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	17	0.016
formation of anatomical boundary	GO:0048859	37	0.016
negative regulation of cell communication	GO:0010648	223	0.016
positive regulation of signaling	GO:0023056	243	0.016
retina development in camera type eye	GO:0060041	4	0.016
anion homeostasis	GO:0055081	3	0.016
regulation of response to stress	GO:0080134	200	0.016
chemosensory behavior	GO:0007635	106	0.016
cellular amino acid metabolic process	GO:0006520	61	0.016
protein localization	GO:0008104	284	0.016
rna processing	GO:0006396	147	0.016
embryonic pattern specification	GO:0009880	174	0.016
anterior posterior axis specification	GO:0009948	109	0.016
macromolecular complex assembly	GO:0065003	256	0.016
cell recognition	GO:0008037	102	0.016
anterior posterior axis specification embryo	GO:0008595	103	0.015
determination of adult lifespan	GO:0008340	137	0.015
circadian behavior	GO:0048512	76	0.015
oxoacid metabolic process	GO:0043436	103	0.015
oenocyte differentiation	GO:0001742	8	0.015
spindle organization	GO:0007051	253	0.015
response to monosaccharide	GO:0034284	4	0.015
aging	GO:0007568	143	0.015
regulation of growth	GO:0040008	233	0.015
formation of organ boundary	GO:0010160	30	0.015
pharynx development	GO:0060465	1	0.015	Worm
cell fate determination	GO:0001709	91	0.014
membrane organization	GO:0061024	112	0.014
positive regulation of cellular component organization	GO:0051130	156	0.014
organic acid metabolic process	GO:0006082	103	0.014
sensory organ morphogenesis	GO:0090596	260	0.014	Mouse
cellular response to dna damage stimulus	GO:0006974	223	0.014
learning or memory	GO:0007611	141	0.014
regulation of cell shape	GO:0008360	113	0.014
mesodermal cell fate specification	GO:0007501	2	0.014
mating behavior	GO:0007617	106	0.014
antennal development	GO:0007469	25	0.014
response to sterol	GO:0036314	34	0.014
sensory organ boundary specification	GO:0008052	22	0.014
mitotic spindle organization	GO:0007052	220	0.014
sterol homeostasis	GO:0055092	4	0.014
biological adhesion	GO:0022610	138	0.014
positive regulation of lipid storage	GO:0010884	4	0.014
antimicrobial humoral response	GO:0019730	99	0.014
salivary gland histolysis	GO:0035070	88	0.014
morphogenesis of a polarized epithelium	GO:0001738	93	0.014
smoothened signaling pathway	GO:0007224	49	0.014
organ formation	GO:0048645	39	0.014	Mouse
single organism catabolic process	GO:0044712	228	0.014
peptide metabolic process	GO:0006518	80	0.014
regulation of anatomical structure morphogenesis	GO:0022603	242	0.014
regulation of cell cycle	GO:0051726	291	0.014
endomembrane system organization	GO:0010256	119	0.014
regulation of sterol transport	GO:0032371	1	0.013
regulation of molecular function	GO:0065009	217	0.013
multi multicellular organism process	GO:0044706	123	0.013
cellular response to biotic stimulus	GO:0071216	4	0.013
kidney development	GO:0001822	3	0.013
small molecule metabolic process	GO:0044281	305	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.013
gonad development	GO:0008406	50	0.013	Fly
regulation of organelle organization	GO:0033043	196	0.013
localization of cell	GO:0051674	257	0.013	Fly
regulation of cell differentiation	GO:0045595	302	0.013	Mouse
cellular response to organic substance	GO:0071310	132	0.013
detection of stimulus	GO:0051606	156	0.013
imaginal disc pattern formation	GO:0007447	91	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
regulation of multi organism process	GO:0043900	131	0.013
camera type eye morphogenesis	GO:0048593	2	0.013
photoreceptor cell development	GO:0042461	96	0.013
regulation of programmed cell death	GO:0043067	152	0.013	Mouse
regulation of neurogenesis	GO:0050767	158	0.013
segment specification	GO:0007379	33	0.013
mitotic cytokinesis	GO:0000281	50	0.013
regulation of phosphorus metabolic process	GO:0051174	210	0.012
cellular response to molecule of bacterial origin	GO:0071219	3	0.012
positive regulation of cell migration	GO:0030335	2	0.012
positive regulation of signal transduction	GO:0009967	223	0.012
protein complex biogenesis	GO:0070271	201	0.012
positive regulation of transport	GO:0051050	92	0.012
regulation of embryonic development	GO:0045995	68	0.012
cholesterol transport	GO:0030301	2	0.012
nitrogen compound transport	GO:0071705	85	0.012
programmed cell death	GO:0012501	257	0.012	Mouse
aromatic compound catabolic process	GO:0019439	166	0.012
regulation of apoptotic process	GO:0042981	130	0.012	Mouse
cellular macromolecule localization	GO:0070727	220	0.012
cell fate commitment involved in formation of primary germ layer	GO:0060795	10	0.012
neuroblast proliferation	GO:0007405	74	0.012
mesodermal cell differentiation	GO:0048333	7	0.012
ras protein signal transduction	GO:0007265	88	0.012
cellular amine metabolic process	GO:0044106	12	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
negative regulation of cell cycle	GO:0045786	116	0.012
development of primary sexual characteristics	GO:0045137	50	0.012	Fly
immune response activating signal transduction	GO:0002757	2	0.012
cellular response to lipopolysaccharide	GO:0071222	3	0.012
dna metabolic process	GO:0006259	227	0.012
secretion by cell	GO:0032940	101	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.011
positive regulation of developmental process	GO:0051094	143	0.011
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.011
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	17	0.011
protein complex assembly	GO:0006461	200	0.011
dorsal ventral pattern formation	GO:0009953	133	0.011
tripartite regional subdivision	GO:0007351	103	0.011
endodermal cell differentiation	GO:0035987	3	0.011
immune system development	GO:0002520	57	0.011	Mouse Fly
positive regulation of cell motility	GO:2000147	3	0.011
cardiac cell fate commitment	GO:0060911	17	0.011
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.011
response to radiation	GO:0009314	155	0.011
mesoderm formation	GO:0001707	21	0.011
cell motility	GO:0048870	251	0.011	Fly
response to ecdysone	GO:0035075	34	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
cellular lipid metabolic process	GO:0044255	83	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
telencephalon development	GO:0021537	2	0.011
response to organic substance	GO:0010033	284	0.011
response to lipid	GO:0033993	38	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
regulation of cellular protein metabolic process	GO:0032268	243	0.011
chromatin modification	GO:0016568	147	0.011
chromosome organization	GO:0051276	360	0.011
axonogenesis	GO:0007409	290	0.011
positive regulation of phosphate metabolic process	GO:0045937	139	0.011
multicellular organismal aging	GO:0010259	140	0.011
neuromuscular junction development	GO:0007528	149	0.011
establishment of planar polarity	GO:0001736	87	0.011
lipid homeostasis	GO:0055088	33	0.010
oocyte differentiation	GO:0009994	145	0.010
regulation of cellular component size	GO:0032535	98	0.010
cellular catabolic process	GO:0044248	372	0.010
phosphorylation	GO:0016310	294	0.010
skeletal muscle organ development	GO:0060538	48	0.010
immune effector process	GO:0002252	98	0.010
stem cell differentiation	GO:0048863	117	0.010	Fly
negative regulation of growth	GO:0045926	84	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010
germ cell migration	GO:0008354	43	0.010	Fly
cellular response to carbohydrate stimulus	GO:0071322	4	0.010

bap disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.036
inherited metabolic disorder	DOID:655	0.013
lipid metabolism disorder	DOID:3146	0.013
familial hyperlipidemia	DOID:1168	0.013
disease of metabolism	DOID:0014667	0.013
familial combined hyperlipidemia	DOID:13809	0.013
nervous system disease	DOID:863	0.012
carbohydrate metabolism disease	DOID:0050013	0.011
acquired metabolic disease	DOID:0060158	0.011

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