IMP: Integrative Multi-species Prediction

Drosophila melanogaster

148 known processes

put (Dmel_CG7904)

punt

(Aliases: pun,l(3)j5A5,Act-r,AtrII,CG7904,Dmel\CG7904,l(3)10460,Tgf-r,atrII,Punt,Atr,TGF-beta,Atr88CD,Put,dlhC,Atr-II,STK-C,TGF-B)

FLYBASE: FBgn0003169
Entrez: 41772
UniProtKB: Q24468

Process Predictions
Disease Predictions

put biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
axonogenesis	GO:0007409	290	1.000
axon development	GO:0061564	297	0.999
localization of cell	GO:0051674	257	0.999	Fly
neuron projection guidance	GO:0097485	241	0.998
forebrain development	GO:0030900	2	0.997
taxis	GO:0042330	304	0.994
axon guidance	GO:0007411	233	0.993
cell migration	GO:0016477	238	0.992	Fly
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.986
cell motility	GO:0048870	251	0.982	Fly
cellular protein modification process	GO:0006464	438	0.981
regulation of multicellular organismal development	GO:2000026	414	0.981	Fly
cell fate specification	GO:0001708	71	0.970	Fly
positive regulation of macromolecule metabolic process	GO:0010604	405	0.960	Worm Fly
intracellular signal transduction	GO:0035556	300	0.955
embryonic organ development	GO:0048568	50	0.947
synaptic growth at neuromuscular junction	GO:0051124	119	0.940	Fly
ameboidal type cell migration	GO:0001667	151	0.940
neurological system process	GO:0050877	358	0.938
morphogenesis of an epithelium	GO:0002009	276	0.935
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.934	Fly
death	GO:0016265	284	0.931
negative regulation of cell communication	GO:0010648	223	0.930	Worm Fly
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.912	Fly
lipid metabolic process	GO:0006629	121	0.910
regulation of cell cycle	GO:0051726	291	0.908	Fly
urogenital system development	GO:0001655	72	0.908
mesoderm development	GO:0007498	78	0.904
regulation of intracellular signal transduction	GO:1902531	236	0.902
negative regulation of neurogenesis	GO:0050768	53	0.900
apoptotic process	GO:0006915	159	0.898
gliogenesis	GO:0042063	80	0.893
hematopoietic or lymphoid organ development	GO:0048534	57	0.890
cellular response to organic substance	GO:0071310	132	0.882
regulation of growth	GO:0040008	233	0.877	Worm Fly
response to bacterium	GO:0009617	198	0.876	Fly
actin filament based process	GO:0030029	220	0.873	Fly
organ growth	GO:0035265	56	0.868	Fly
regulation of neuron differentiation	GO:0045664	103	0.865
regulation of developmental growth	GO:0048638	174	0.856	Worm Fly
protein modification process	GO:0036211	438	0.855
negative regulation of apoptotic process	GO:0043066	63	0.855
lipid localization	GO:0010876	54	0.855
respiratory system development	GO:0060541	213	0.854
negative regulation of nervous system development	GO:0051961	92	0.853
chemotaxis	GO:0006935	249	0.852
immune system process	GO:0002376	347	0.850	Worm Fly
stem cell development	GO:0048864	79	0.844
cellular response to chemical stimulus	GO:0070887	199	0.843
regulation of neurogenesis	GO:0050767	158	0.835
negative regulation of cellular metabolic process	GO:0031324	382	0.832	Fly
regulation of immune system process	GO:0002682	176	0.824	Fly
stem cell maintenance	GO:0019827	67	0.820
programmed cell death	GO:0012501	257	0.810
learning or memory	GO:0007611	141	0.799
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.791
growth	GO:0040007	359	0.780	Worm Fly
positive regulation of cell communication	GO:0010647	250	0.774	Worm Fly
synapse assembly	GO:0007416	143	0.765	Fly
kidney epithelium development	GO:0072073	3	0.763
heart development	GO:0007507	82	0.752
cognition	GO:0050890	141	0.749
epithelial cell differentiation	GO:0030855	322	0.748	Fly
response to organic substance	GO:0010033	284	0.747
response to oxygen containing compound	GO:1901700	200	0.731
regulation of anatomical structure morphogenesis	GO:0022603	242	0.725	Worm
regulation of cell differentiation	GO:0045595	302	0.725
heart morphogenesis	GO:0003007	32	0.707
regulation of apoptotic process	GO:0042981	130	0.685
appendage morphogenesis	GO:0035107	397	0.682	Fly
central nervous system development	GO:0007417	201	0.678	Fly
negative regulation of developmental process	GO:0051093	201	0.675
germ cell migration	GO:0008354	43	0.674	Fly
regulation of protein metabolic process	GO:0051246	256	0.664	Fly
positive regulation of developmental growth	GO:0048639	62	0.664	Worm Fly
cellular lipid metabolic process	GO:0044255	83	0.660
immune system development	GO:0002520	57	0.660
stem cell differentiation	GO:0048863	117	0.660
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.659
epithelial tube morphogenesis	GO:0060562	88	0.655
positive regulation of transcription dna templated	GO:0045893	266	0.649	Worm
cell elongation involved in imaginal disc derived wing morphogenesis	GO:0090254	5	0.648	Fly
regulation of programmed cell death	GO:0043067	152	0.645
innate immune response	GO:0045087	144	0.635	Worm Fly
regulation of muscle organ development	GO:0048634	13	0.635	Fly
tube development	GO:0035295	244	0.629
positive regulation of signaling	GO:0023056	243	0.619	Worm Fly
epithelial cell development	GO:0002064	274	0.608	Fly
regulation of cell proliferation	GO:0042127	163	0.595
small gtpase mediated signal transduction	GO:0007264	88	0.594
morphogenesis of a branching structure	GO:0001763	45	0.571
gland development	GO:0048732	191	0.565
epithelial cell migration	GO:0010631	148	0.564
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.563	Worm
telencephalon development	GO:0021537	2	0.559
regulation of cellular component biogenesis	GO:0044087	201	0.555	Fly
cell death	GO:0008219	279	0.546
regulation of phosphorus metabolic process	GO:0051174	210	0.544	Fly
branching involved in open tracheal system development	GO:0060446	45	0.538
signal transduction by phosphorylation	GO:0023014	107	0.537
ras protein signal transduction	GO:0007265	88	0.528
positive regulation of rna metabolic process	GO:0051254	271	0.521	Worm
retinal ganglion cell axon guidance	GO:0031290	12	0.520
response to endogenous stimulus	GO:0009719	119	0.517
negative regulation of intracellular signal transduction	GO:1902532	57	0.507
positive regulation of pathway restricted smad protein phosphorylation	GO:0010862	1	0.502	Fly
appendage development	GO:0048736	401	0.501	Fly
tissue morphogenesis	GO:0048729	297	0.500
regulation of cellular protein metabolic process	GO:0032268	243	0.489	Fly
phosphorylation	GO:0016310	294	0.489
hemopoiesis	GO:0030097	46	0.477
spermatogenesis	GO:0007283	200	0.464
negative regulation of rna metabolic process	GO:0051253	251	0.460
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.456	Worm
cellular response to endogenous stimulus	GO:0071495	80	0.450
actin cytoskeleton organization	GO:0030036	206	0.449	Fly
regulation of nervous system development	GO:0051960	248	0.441	Fly
apoptotic signaling pathway	GO:0097190	27	0.425
eye antennal disc development	GO:0035214	60	0.425	Fly
regulation of organ morphogenesis	GO:2000027	78	0.416
protein phosphorylation	GO:0006468	169	0.413
glial cell differentiation	GO:0010001	35	0.412
multicellular organismal reproductive behavior	GO:0033057	110	0.412	Worm
carboxylic acid metabolic process	GO:0019752	92	0.412
embryonic heart tube development	GO:0035050	22	0.403
positive regulation of phosphate metabolic process	GO:0045937	139	0.400	Fly
cell growth	GO:0016049	108	0.399	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.397
mushroom body development	GO:0016319	70	0.396	Fly
regulation of epithelial cell proliferation	GO:0050678	4	0.394
negative regulation of cellular biosynthetic process	GO:0031327	277	0.391
positive regulation of protein metabolic process	GO:0051247	128	0.388	Fly
malpighian tubule development	GO:0072002	64	0.385
regulation of cell development	GO:0060284	215	0.384
regulation of protein phosphorylation	GO:0001932	64	0.384	Fly
regulation of cytoplasmic transport	GO:1903649	47	0.376
positive regulation of signal transduction	GO:0009967	223	0.371	Worm Fly
columnar cuboidal epithelial cell development	GO:0002066	249	0.369	Fly
single organism biosynthetic process	GO:0044711	206	0.363
mesenchymal cell differentiation	GO:0048762	1	0.362
macromolecular complex assembly	GO:0065003	256	0.358
morphogenesis of a branching epithelium	GO:0061138	45	0.358
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.344
body morphogenesis	GO:0010171	2	0.343
positive regulation of phosphorus metabolic process	GO:0010562	139	0.342	Fly
tissue migration	GO:0090130	155	0.337
regulation of protein modification process	GO:0031399	112	0.335	Fly
organic acid metabolic process	GO:0006082	103	0.331
cardiovascular system development	GO:0072358	82	0.328
regulation of cell death	GO:0010941	173	0.323
regulation of molecular function	GO:0065009	217	0.323
negative regulation of response to stimulus	GO:0048585	258	0.310	Worm Fly
open tracheal system development	GO:0007424	204	0.309
regulation of epithelial cell migration	GO:0010632	12	0.308
segmentation	GO:0035282	207	0.306	Fly
immune effector process	GO:0002252	98	0.303
renal tubule development	GO:0061326	64	0.302
positive regulation of response to stimulus	GO:0048584	323	0.301	Worm Fly
biological adhesion	GO:0022610	138	0.299	Fly
determination of adult lifespan	GO:0008340	137	0.297	Fly
nephron development	GO:0072006	3	0.296
response to growth factor	GO:0070848	31	0.293
cellular catabolic process	GO:0044248	372	0.292	Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.289	Fly
cellular response to growth factor stimulus	GO:0071363	30	0.286
positive regulation of cell migration	GO:0030335	2	0.285
neuromuscular junction development	GO:0007528	149	0.284	Fly
regulation of pathway restricted smad protein phosphorylation	GO:0060393	1	0.283	Fly
meiotic cell cycle	GO:0051321	171	0.282
anterior posterior pattern specification	GO:0009952	136	0.281	Fly
negative regulation of transforming growth factor beta receptor signaling pathway	GO:0030512	4	0.278	Fly
kidney development	GO:0001822	3	0.277
negative regulation of rna biosynthetic process	GO:1902679	240	0.273
regulation of neuron projection development	GO:0010975	69	0.271
nucleobase containing compound catabolic process	GO:0034655	165	0.267
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.265	Worm Fly
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.264
positive regulation of gene expression	GO:0010628	290	0.260	Worm
wing disc anterior posterior pattern formation	GO:0048100	5	0.260	Fly
developmental growth	GO:0048589	280	0.258	Worm Fly
catabolic process	GO:0009056	409	0.253	Fly
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.253
sulfur compound metabolic process	GO:0006790	59	0.252
hindbrain development	GO:0030902	2	0.252
establishment of localization in cell	GO:0051649	402	0.250
regulation of phosphorylation	GO:0042325	147	0.247	Fly
negative regulation of signaling	GO:0023057	219	0.245	Worm Fly
head development	GO:0060322	135	0.245	Fly
endodermal cell fate commitment	GO:0001711	3	0.244	Fly
regionalization	GO:0003002	416	0.238
circulatory system development	GO:0072359	82	0.238
developmental growth involved in morphogenesis	GO:0060560	65	0.237	Fly
male gamete generation	GO:0048232	201	0.237
embryonic pattern specification	GO:0009880	174	0.236	Fly
cardiac muscle tissue development	GO:0048738	9	0.232
positive regulation of cellular component biogenesis	GO:0044089	80	0.231	Fly
connective tissue development	GO:0061448	3	0.231
response to radiation	GO:0009314	155	0.230	Fly
motor neuron axon guidance	GO:0008045	58	0.229
cation transport	GO:0006812	110	0.227
negative regulation of autophagy	GO:0010507	16	0.227	Fly
positive regulation of cellular biosynthetic process	GO:0031328	316	0.226	Worm
tor signaling	GO:0031929	32	0.226
aging	GO:0007568	143	0.223	Fly
regulation of localization	GO:0032879	275	0.222
muscle organ development	GO:0007517	127	0.221	Fly
branching morphogenesis of an epithelial tube	GO:0048754	45	0.211
regulation of epithelial cell differentiation	GO:0030856	4	0.209
response to biotic stimulus	GO:0009607	294	0.206	Worm Fly
oxoacid metabolic process	GO:0043436	103	0.206
organic substance catabolic process	GO:1901575	308	0.205
cell cycle phase transition	GO:0044770	140	0.203
positive regulation of cellular protein metabolic process	GO:0032270	118	0.203	Fly
ovarian follicle cell development	GO:0030707	248	0.203	Fly
mesodermal cell fate specification	GO:0007501	2	0.200
positive regulation of cell proliferation	GO:0008284	47	0.195
photoreceptor cell differentiation	GO:0046530	170	0.190
positive regulation of growth	GO:0045927	75	0.187	Worm Fly
exocrine system development	GO:0035272	162	0.183
camera type eye development	GO:0043010	4	0.182
sex differentiation	GO:0007548	81	0.179
skeletal muscle fiber development	GO:0048741	3	0.177
eye development	GO:0001654	323	0.177	Fly
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.176
organic cyclic compound catabolic process	GO:1901361	168	0.176
negative regulation of neuron differentiation	GO:0045665	16	0.173
positive regulation of multicellular organism growth	GO:0040018	21	0.173	Worm
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.171	Worm
positive regulation of rna biosynthetic process	GO:1902680	266	0.171	Worm
histone modification	GO:0016570	106	0.171
determination of dorsal ventral asymmetry	GO:0048262	3	0.171
brain development	GO:0007420	120	0.171	Fly
gland morphogenesis	GO:0022612	145	0.170
chromatin organization	GO:0006325	207	0.168
positive regulation of catalytic activity	GO:0043085	118	0.167
nephron tubule morphogenesis	GO:0072078	3	0.165
negative regulation of signal transduction	GO:0009968	206	0.165	Worm Fly
regulation of bmp signaling pathway	GO:0030510	23	0.165	Worm Fly
regulation of cell migration	GO:0030334	22	0.157
muscle tissue development	GO:0060537	30	0.155
border follicle cell migration	GO:0007298	113	0.155
heterocycle catabolic process	GO:0046700	166	0.153
response to wounding	GO:0009611	94	0.152
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.151
positive regulation of nervous system development	GO:0051962	69	0.151	Fly
regulation of phosphate metabolic process	GO:0019220	210	0.150	Fly
anterior posterior axis specification embryo	GO:0008595	103	0.149	Fly
receptor mediated endocytosis	GO:0006898	21	0.149
cellular amine metabolic process	GO:0044106	12	0.147
memory	GO:0007613	94	0.144
tube morphogenesis	GO:0035239	191	0.143
transcription from rna polymerase ii promoter	GO:0006366	368	0.143	Worm Fly
cellular response to nitrogen compound	GO:1901699	51	0.143
negative regulation of cell differentiation	GO:0045596	143	0.142
epithelium migration	GO:0090132	148	0.142
regulation of cellular localization	GO:0060341	136	0.140
cytoplasmic transport	GO:0016482	130	0.140
organophosphate metabolic process	GO:0019637	195	0.139
cellular response to oxygen containing compound	GO:1901701	79	0.139
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.137	Worm Fly
cell migration involved in gastrulation	GO:0042074	9	0.136
positive regulation of multicellular organismal process	GO:0051240	143	0.134	Worm Fly
embryonic hindgut morphogenesis	GO:0048619	48	0.133
cellular nitrogen compound catabolic process	GO:0044270	165	0.132
protein localization to nucleus	GO:0034504	55	0.131
axon extension	GO:0048675	32	0.130
dorsal ventral pattern formation	GO:0009953	133	0.129
renal system development	GO:0072001	72	0.128
erbb signaling pathway	GO:0038127	58	0.128
regulation of mitotic cell cycle	GO:0007346	190	0.128	Fly
multicellular organism growth	GO:0035264	46	0.126	Worm
determination of ventral identity	GO:0048264	1	0.126
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.124
regulation of axonogenesis	GO:0050770	32	0.123
regulation of cell cycle process	GO:0010564	181	0.123
regulation of innate immune response	GO:0045088	71	0.121	Fly
single organism catabolic process	GO:0044712	228	0.120
negative regulation of cell development	GO:0010721	62	0.120
response to external biotic stimulus	GO:0043207	293	0.119	Worm Fly
synapse organization	GO:0050808	196	0.119	Fly
embryonic morphogenesis	GO:0048598	206	0.119
negative regulation of synapse assembly	GO:0051964	39	0.118
gastrulation	GO:0007369	70	0.118	Fly
dendrite morphogenesis	GO:0048813	199	0.118
positive regulation of molecular function	GO:0044093	136	0.115
embryo development ending in birth or egg hatching	GO:0009792	152	0.114
negative regulation of phosphorylation	GO:0042326	35	0.114
establishment of protein localization	GO:0045184	163	0.113
mesenchymal cell development	GO:0014031	1	0.113
regulation of protein transport	GO:0051223	57	0.112
renal tubule morphogenesis	GO:0061333	44	0.112
homeostatic process	GO:0042592	199	0.111
purine nucleotide metabolic process	GO:0006163	146	0.110
spermatid development	GO:0007286	98	0.110
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.109	Worm Fly
regulation of erbb signaling pathway	GO:1901184	42	0.107
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.106
negative regulation of epithelial cell migration	GO:0010633	1	0.106
regulation of synapse organization	GO:0050807	110	0.106	Fly
response to abiotic stimulus	GO:0009628	341	0.105	Fly
germ line stem cell division	GO:0042078	25	0.105
cellular component assembly involved in morphogenesis	GO:0010927	151	0.104
regulation of cell adhesion	GO:0030155	27	0.103	Fly
transmembrane transport	GO:0055085	139	0.102
epithelial cell proliferation	GO:0050673	15	0.102
hematopoietic progenitor cell differentiation	GO:0002244	1	0.102
regulation of glial cell differentiation	GO:0045685	1	0.101
dendrite development	GO:0016358	204	0.099
ion transport	GO:0006811	145	0.098
small molecule metabolic process	GO:0044281	305	0.098
regulation of photoreceptor cell differentiation	GO:0046532	34	0.098
mapk cascade	GO:0000165	107	0.098
unidimensional cell growth	GO:0009826	15	0.098	Fly
peptidyl amino acid modification	GO:0018193	105	0.096
regulation of cell motility	GO:2000145	23	0.096
larval development	GO:0002164	104	0.094	Worm
kidney morphogenesis	GO:0060993	3	0.093
single organism behavior	GO:0044708	391	0.092
positive regulation of neurogenesis	GO:0050769	41	0.092
maintenance of location	GO:0051235	73	0.092
metal ion transport	GO:0030001	74	0.092
positive regulation of nucleotide catabolic process	GO:0030813	46	0.092
aromatic compound catabolic process	GO:0019439	166	0.091
regulation of meiosis	GO:0040020	3	0.091
wnt signaling pathway	GO:0016055	98	0.089
ovarian follicle cell migration	GO:0007297	121	0.089
carbohydrate derivative catabolic process	GO:1901136	118	0.087
single organismal cell cell adhesion	GO:0016337	45	0.086	Fly
cellular response to dna damage stimulus	GO:0006974	223	0.086
defense response	GO:0006952	300	0.084	Worm Fly
regulation of immune response	GO:0050776	118	0.084	Fly
tripartite regional subdivision	GO:0007351	103	0.084	Fly
nucleoside metabolic process	GO:0009116	127	0.083
regulation of cellular amine metabolic process	GO:0033238	3	0.082
anion transport	GO:0006820	41	0.082
protein targeting to nucleus	GO:0044744	51	0.081
malpighian tubule morphogenesis	GO:0007443	44	0.080
reproductive structure development	GO:0048608	74	0.080
limb morphogenesis	GO:0035108	1	0.079
muscle cell differentiation	GO:0042692	103	0.079
meiotic nuclear envelope disassembly	GO:0051078	2	0.078
nephron epithelium development	GO:0072009	3	0.077
secretion	GO:0046903	109	0.077
negative regulation of multicellular organismal process	GO:0051241	142	0.076
muscle structure development	GO:0061061	224	0.075	Fly
nephron tubule development	GO:0072080	3	0.075
striated muscle tissue development	GO:0014706	27	0.075
mesenchyme development	GO:0060485	9	0.074
neuroblast proliferation	GO:0007405	74	0.074	Fly
cell activation	GO:0001775	9	0.072
regulation of cell size	GO:0008361	63	0.072
purine ribonucleotide metabolic process	GO:0009150	145	0.071
lipid storage	GO:0019915	38	0.071
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.070
regulation of synapse structure and activity	GO:0050803	128	0.070	Fly
wound healing	GO:0042060	75	0.069
mitotic cell cycle phase transition	GO:0044772	138	0.069
multicellular organismal aging	GO:0010259	140	0.068	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.067	Worm
purine ribonucleotide catabolic process	GO:0009154	109	0.066
compound eye morphogenesis	GO:0001745	249	0.065	Fly
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.065
cellular response to hormone stimulus	GO:0032870	44	0.064
regulation of embryonic development	GO:0045995	68	0.064
oocyte morphogenesis	GO:0048601	3	0.064
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.063	Fly
response to lipopolysaccharide	GO:0032496	4	0.062
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.061
protein localization to organelle	GO:0033365	82	0.061
morphogenesis of larval imaginal disc epithelium	GO:0016335	5	0.061
endocytosis	GO:0006897	310	0.061
eye morphogenesis	GO:0048592	260	0.061	Fly
reproductive system development	GO:0061458	74	0.061
convergent extension	GO:0060026	2	0.060
regulation of wnt signaling pathway	GO:0030111	68	0.060
amine metabolic process	GO:0009308	12	0.059
regulation of intracellular protein transport	GO:0033157	46	0.059
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.058
posttranscriptional regulation of gene expression	GO:0010608	145	0.058
maintenance of protein location	GO:0045185	28	0.057
negative regulation of phosphate metabolic process	GO:0045936	45	0.057
limb development	GO:0060173	1	0.056
dorsal closure	GO:0007391	79	0.056
positive regulation of biosynthetic process	GO:0009891	316	0.056	Worm
locomotory behavior	GO:0007626	176	0.056
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.055
negative regulation of programmed cell death	GO:0043069	72	0.055
sensory organ morphogenesis	GO:0090596	260	0.055	Fly
ion homeostasis	GO:0050801	55	0.054
positive regulation of transport	GO:0051050	92	0.054
regulation of cell growth	GO:0001558	43	0.054
positive regulation of protein localization to plasma membrane	GO:1903078	3	0.053
regulation of vesicle mediated transport	GO:0060627	59	0.053
regulation of cell projection organization	GO:0031344	92	0.053
divalent inorganic cation transport	GO:0072511	30	0.053
nephron epithelium morphogenesis	GO:0072088	3	0.053
developmental maturation	GO:0021700	172	0.053
positive regulation of cellular component organization	GO:0051130	156	0.053	Fly
cellular protein localization	GO:0034613	160	0.052
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.052
regulation of dendrite development	GO:0050773	37	0.052
cell cycle g1 s phase transition	GO:0044843	31	0.051
gtp metabolic process	GO:0046039	72	0.050
cardiac cell fate commitment	GO:0060911	17	0.050
cellular response to peptide	GO:1901653	28	0.049
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.049
macromolecule catabolic process	GO:0009057	161	0.049
axis specification	GO:0009798	167	0.048	Fly
regulation of establishment of protein localization	GO:0070201	61	0.048
positive regulation of cell motility	GO:2000147	3	0.048
regulation of protein localization	GO:0032880	76	0.048
response to insulin	GO:0032868	29	0.047
digestive tract development	GO:0048565	149	0.047
organonitrogen compound metabolic process	GO:1901564	318	0.047
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.046
central nervous system morphogenesis	GO:0021551	8	0.046
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.046
salivary gland morphogenesis	GO:0007435	145	0.046
response to organic cyclic compound	GO:0014070	89	0.046
dephosphorylation	GO:0016311	51	0.046
response to hormone	GO:0009725	45	0.046
somatic muscle development	GO:0007525	66	0.045
skeletal muscle organ development	GO:0060538	48	0.045
trunk segmentation	GO:0035290	8	0.044
multi organism behavior	GO:0051705	175	0.044	Worm
collateral sprouting	GO:0048668	3	0.044
negative regulation of cell proliferation	GO:0008285	69	0.044
negative regulation of cell death	GO:0060548	81	0.044
monocarboxylic acid metabolic process	GO:0032787	29	0.044
cellular response to insulin stimulus	GO:0032869	28	0.043
chromosome organization	GO:0051276	360	0.043
r7 cell differentiation	GO:0045466	43	0.043
bmp signaling pathway involved in malpighian tubule cell chemotaxis	GO:0061353	3	0.043
negative regulation of cell cycle phase transition	GO:1901988	103	0.043
regulation of cellular ketone metabolic process	GO:0010565	3	0.042
positive regulation of nucleoside metabolic process	GO:0045979	47	0.042
digestive system development	GO:0055123	149	0.042
regulation of protein kinase activity	GO:0045859	51	0.041
cell adhesion	GO:0007155	136	0.041	Fly
ribose phosphate metabolic process	GO:0019693	145	0.041
regulation of cellular amino acid metabolic process	GO:0006521	0	0.041
cellular response to organic cyclic compound	GO:0071407	32	0.040
negative regulation of protein metabolic process	GO:0051248	85	0.040
divalent metal ion transport	GO:0070838	26	0.040
positive regulation of cell differentiation	GO:0045597	64	0.040
compound eye photoreceptor cell differentiation	GO:0001751	140	0.040
regulation of mapk cascade	GO:0043408	92	0.040
dendrite regeneration	GO:0031104	2	0.040
developmental cell growth	GO:0048588	52	0.040
spermatid differentiation	GO:0048515	114	0.039
regulation of behavior	GO:0050795	75	0.039
regulation of cell cell adhesion	GO:0022407	21	0.039	Fly
anterior posterior axis specification	GO:0009948	109	0.038	Fly
cell type specific apoptotic process	GO:0097285	38	0.038
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.038
regulation of catalytic activity	GO:0050790	185	0.038
positive regulation of intracellular signal transduction	GO:1902533	116	0.038
positive regulation of protein phosphorylation	GO:0001934	34	0.037	Fly
negative regulation of cell cycle	GO:0045786	116	0.037
positive regulation of phosphorylation	GO:0042327	87	0.037	Fly
oocyte fate commitment	GO:0048600	2	0.036
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.036
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.036
defense response to fungus	GO:0050832	48	0.035	Worm
negative regulation of cellular protein metabolic process	GO:0032269	85	0.035
protein import	GO:0017038	55	0.035
cellular macromolecular complex assembly	GO:0034622	153	0.035
response to alcohol	GO:0097305	95	0.034
negative regulation of transcription dna templated	GO:0045892	237	0.034
morphogenesis of embryonic epithelium	GO:0016331	94	0.034
carbohydrate derivative metabolic process	GO:1901135	217	0.034
regulation of cell morphogenesis	GO:0022604	163	0.034	Worm
digestive tract morphogenesis	GO:0048546	127	0.034
cardiocyte differentiation	GO:0035051	29	0.033
meiotic spindle checkpoint	GO:0044779	1	0.033
regulation of synapse assembly	GO:0051963	94	0.033	Fly
regulation of cell fate commitment	GO:0010453	29	0.033
regulation of transport	GO:0051049	181	0.033
leg disc morphogenesis	GO:0007478	80	0.033
regulation of actin cytoskeleton organization	GO:0032956	42	0.033
wing disc morphogenesis	GO:0007472	344	0.033	Fly
protein acetylation	GO:0006473	39	0.032
cellular macromolecule catabolic process	GO:0044265	136	0.032
reproductive behavior	GO:0019098	122	0.032	Worm

put disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
musculoskeletal system disease	DOID:17	0.154
connective tissue disease	DOID:65	0.154
disease of anatomical entity	DOID:7	0.154
gastrointestinal system cancer	DOID:3119	0.095
large intestine cancer	DOID:5672	0.095
intestinal cancer	DOID:10155	0.095
cancer	DOID:162	0.095
colorectal cancer	DOID:9256	0.095
disease of cellular proliferation	DOID:14566	0.095
organ system cancer	DOID:0050686	0.095
neuroma	DOID:2001	0.052
benign neoplasm	DOID:0060072	0.052
nervous system benign neoplasm	DOID:0060115	0.052
organ system benign neoplasm	DOID:0060085	0.052

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