IMP: Integrative Multi-species Prediction

Drosophila melanogaster

49 known processes

mit(1)15 (Dmel_CG9900)

mitotic 15

(Aliases: abe,CG9900,l(1)zw10,Dmel\CG9900,EG:BACR7C10.3,mit(l)15,zw10,l(1)3Af,Zw10,l(1)6-99,ZW-10,ZW10,zw-10,dZW10)

Entrez: 47874
FLYBASE: FBgn0004643
UniProtKB: Q9W4X9

Process Predictions
Disease Predictions

mit(1)15 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
male meiosis cytokinesis	GO:0007112	26	1.000
nuclear division	GO:0000280	332	0.999
organelle fission	GO:0048285	340	0.998
meiotic nuclear division	GO:0007126	151	0.997
meiotic cell cycle process	GO:1903046	132	0.957
male meiosis	GO:0007140	52	0.894
male gamete generation	GO:0048232	201	0.820
dna conformation change	GO:0071103	105	0.709
cytoskeleton dependent cytokinesis	GO:0061640	81	0.695
establishment of localization in cell	GO:0051649	402	0.621	Worm
regulation of neurogenesis	GO:0050767	158	0.605
spermatogenesis	GO:0007283	200	0.593
developmental growth	GO:0048589	280	0.591
cell division	GO:0051301	248	0.532
mitotic nuclear division	GO:0007067	213	0.532
cytokinesis	GO:0000910	90	0.502
cytokinetic process	GO:0032506	27	0.456
meiotic cell cycle	GO:0051321	171	0.445
cell maturation	GO:0048469	144	0.440
embryo development ending in birth or egg hatching	GO:0009792	152	0.382	Worm
regulation of localization	GO:0032879	275	0.380
regionalization	GO:0003002	416	0.368
dna metabolic process	GO:0006259	227	0.355
protein modification by small protein conjugation	GO:0032446	79	0.332
larval development	GO:0002164	104	0.327	Worm
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.327
neuroblast proliferation	GO:0007405	74	0.311
negative regulation of rna metabolic process	GO:0051253	251	0.298
chromosome organization	GO:0051276	360	0.291
dna biosynthetic process	GO:0071897	24	0.289
cellular macromolecule localization	GO:0070727	220	0.285
eye photoreceptor cell differentiation	GO:0001754	145	0.268
maintenance of location	GO:0051235	73	0.259
regulation of developmental growth	GO:0048638	174	0.246
dorsal ventral pattern formation	GO:0009953	133	0.244
dna packaging	GO:0006323	91	0.239
protein complex assembly	GO:0006461	200	0.232
centrosome organization	GO:0051297	163	0.223
regulation of cell cycle phase transition	GO:1901987	130	0.192
meiotic chromosome segregation	GO:0045132	59	0.186
rna localization	GO:0006403	115	0.180
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.175
intracellular transport	GO:0046907	228	0.175
cytoplasmic transport	GO:0016482	130	0.172
negative regulation of biosynthetic process	GO:0009890	277	0.169
photoreceptor cell differentiation	GO:0046530	170	0.169
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.167
protein modification by small protein conjugation or removal	GO:0070647	106	0.157
sister chromatid segregation	GO:0000819	92	0.145
meiotic spindle organization	GO:0000212	36	0.141
axis specification	GO:0009798	167	0.140
chromosome segregation	GO:0007059	157	0.139
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.138
meiotic cytokinesis	GO:0033206	33	0.136
mitotic cell cycle phase transition	GO:0044772	138	0.135
tube development	GO:0035295	244	0.132
purine containing compound catabolic process	GO:0072523	112	0.132
negative regulation of mitotic cell cycle	GO:0045930	109	0.130
cellular catabolic process	GO:0044248	372	0.125
double strand break repair	GO:0006302	26	0.120
photoreceptor cell development	GO:0042461	96	0.117
protein localization to organelle	GO:0033365	82	0.117
regulation of cell cycle process	GO:0010564	181	0.115
positive regulation of developmental process	GO:0051094	143	0.110
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.107
compound eye photoreceptor cell differentiation	GO:0001751	140	0.105
organophosphate metabolic process	GO:0019637	195	0.105
cell motility	GO:0048870	251	0.099
single organism intracellular transport	GO:1902582	207	0.098
maintenance of location in cell	GO:0051651	28	0.096
spindle assembly involved in meiosis	GO:0090306	20	0.094
oocyte development	GO:0048599	124	0.093
maintenance of protein location	GO:0045185	28	0.093
cellular protein catabolic process	GO:0044257	83	0.090
dendrite development	GO:0016358	204	0.089
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.088
regulation of cell cycle	GO:0051726	291	0.088
nucleobase containing small molecule metabolic process	GO:0055086	174	0.087
cellular protein localization	GO:0034613	160	0.087
positive regulation of multicellular organismal process	GO:0051240	143	0.086
organelle fusion	GO:0048284	46	0.086
positive regulation of response to stimulus	GO:0048584	323	0.083
spermatocyte division	GO:0048137	13	0.083
regulation of hemocyte proliferation	GO:0035206	37	0.082
positive regulation of cell communication	GO:0010647	250	0.080
endocytosis	GO:0006897	310	0.078	Worm
vesicle mediated transport	GO:0016192	381	0.077	Worm
cell proliferation	GO:0008283	299	0.076
negative regulation of cell cycle	GO:0045786	116	0.076
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.073
protein ubiquitination	GO:0016567	70	0.071
modification dependent macromolecule catabolic process	GO:0043632	79	0.070
autophagy	GO:0006914	108	0.069
single organism cellular localization	GO:1902580	180	0.067
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.066
spindle assembly	GO:0051225	80	0.066
cell cycle phase transition	GO:0044770	140	0.065
imaginal disc derived appendage development	GO:0048737	399	0.064
purine ribonucleoside catabolic process	GO:0046130	112	0.063
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.063
organonitrogen compound metabolic process	GO:1901564	318	0.062
negative regulation of gene expression	GO:0010629	387	0.062
proteasomal protein catabolic process	GO:0010498	59	0.062
compound eye development	GO:0048749	307	0.061
lipid storage	GO:0019915	38	0.060
regulation of cell division	GO:0051302	72	0.060
ribonucleotide metabolic process	GO:0009259	145	0.059
epithelial cell differentiation	GO:0030855	322	0.059
microtubule organizing center organization	GO:0031023	168	0.058
anterior posterior axis specification	GO:0009948	109	0.058
single organism biosynthetic process	GO:0044711	206	0.057
protein catabolic process	GO:0030163	101	0.056
macromolecular complex assembly	GO:0065003	256	0.056
regulation of cell morphogenesis	GO:0022604	163	0.056
purine ribonucleoside metabolic process	GO:0046128	127	0.055
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.055
negative regulation of transcription dna templated	GO:0045892	237	0.054
heterocycle catabolic process	GO:0046700	166	0.054
muscle structure development	GO:0061061	224	0.053
maintenance of protein location in cell	GO:0032507	26	0.053
protein localization	GO:0008104	284	0.053
regulation of organelle organization	GO:0033043	196	0.052
purine nucleoside catabolic process	GO:0006152	112	0.052
nucleus organization	GO:0006997	45	0.052
nucleobase containing compound catabolic process	GO:0034655	165	0.051
negative regulation of cellular metabolic process	GO:0031324	382	0.051
regulation of neuron projection development	GO:0010975	69	0.051
protein import	GO:0017038	55	0.050
regulation of viral genome replication	GO:0045069	4	0.049
positive regulation of ribosome biogenesis	GO:0090070	3	0.048
glycosyl compound catabolic process	GO:1901658	112	0.047
protein targeting to nucleus	GO:0044744	51	0.046
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.045
death	GO:0016265	284	0.044	Worm
regulation of proteasomal protein catabolic process	GO:0061136	39	0.044
organic substance catabolic process	GO:1901575	308	0.044
digestive system development	GO:0055123	149	0.043
regulation of intracellular transport	GO:0032386	64	0.043
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.043
positive regulation of signal transduction	GO:0009967	223	0.041
modification dependent protein catabolic process	GO:0019941	78	0.040
ubiquitin dependent protein catabolic process	GO:0006511	78	0.040
eye morphogenesis	GO:0048592	260	0.040
regulation of meiosis	GO:0040020	3	0.040
chromatin organization	GO:0006325	207	0.039
regulation of ras protein signal transduction	GO:0046578	93	0.039
positive regulation of signaling	GO:0023056	243	0.038
dendrite morphogenesis	GO:0048813	199	0.038
oocyte differentiation	GO:0009994	145	0.037
cellular response to chemical stimulus	GO:0070887	199	0.037
mitotic cell cycle checkpoint	GO:0007093	88	0.036
nucleoside triphosphate catabolic process	GO:0009143	108	0.036
cellular macromolecule catabolic process	GO:0044265	136	0.035
ribose phosphate metabolic process	GO:0019693	145	0.035
endomembrane system organization	GO:0010256	119	0.035
cell death	GO:0008219	279	0.034	Worm
proteolysis	GO:0006508	192	0.034
carbohydrate derivative metabolic process	GO:1901135	217	0.034
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.033
regulation of cytoskeleton organization	GO:0051493	89	0.032
centrosome cycle	GO:0007098	137	0.032
positive regulation of cellular component organization	GO:0051130	156	0.032
stress granule disassembly	GO:0035617	1	0.032
cellular response to organic substance	GO:0071310	132	0.031
ribonucleotide catabolic process	GO:0009261	109	0.031
regulation of nervous system development	GO:0051960	248	0.031
regulation of cellular localization	GO:0060341	136	0.031
regulation of dna metabolic process	GO:0051052	34	0.031
nucleotide metabolic process	GO:0009117	161	0.030
regulation of mitotic cell cycle	GO:0007346	190	0.030
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.030
regulation of catalytic activity	GO:0050790	185	0.029
eye photoreceptor cell development	GO:0042462	81	0.029
positive regulation of macromolecule metabolic process	GO:0010604	405	0.029
oocyte dorsal ventral axis specification	GO:0007310	34	0.029
spindle assembly involved in mitosis	GO:0090307	50	0.028
regulation of cellular catabolic process	GO:0031329	157	0.028
protein targeting	GO:0006605	64	0.028
oocyte construction	GO:0007308	112	0.027
positive regulation of hydrolase activity	GO:0051345	78	0.027
microtubule anchoring	GO:0034453	11	0.026
single organism catabolic process	GO:0044712	228	0.026
mitotic cytokinesis	GO:0000281	50	0.026
programmed cell death	GO:0012501	257	0.026	Worm
positive regulation of neurogenesis	GO:0050769	41	0.026
establishment of protein localization	GO:0045184	163	0.026
digestive tract development	GO:0048565	149	0.025
carbohydrate derivative catabolic process	GO:1901136	118	0.025
ribonucleoside catabolic process	GO:0042454	112	0.025
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.025
nucleotide catabolic process	GO:0009166	109	0.025
purine ribonucleotide catabolic process	GO:0009154	109	0.025
mitotic sister chromatid segregation	GO:0000070	87	0.025
spermatid development	GO:0007286	98	0.024
axon guidance	GO:0007411	233	0.024
developmental maturation	GO:0021700	172	0.024
regulation of cell development	GO:0060284	215	0.024
macromolecule catabolic process	GO:0009057	161	0.024
regulation of protein localization	GO:0032880	76	0.023
negative regulation of rna biosynthetic process	GO:1902679	240	0.023
regulation of chromatin silencing	GO:0031935	36	0.023
organic acid metabolic process	GO:0006082	103	0.023
oocyte morphogenesis	GO:0048601	3	0.022
sex differentiation	GO:0007548	81	0.022
axon development	GO:0061564	297	0.022
dendrite regeneration	GO:0031104	2	0.022
actin filament based process	GO:0030029	220	0.022
meiosis i	GO:0007127	59	0.022
compound eye photoreceptor development	GO:0042051	78	0.022
organelle assembly	GO:0070925	198	0.021
positive regulation of developmental growth	GO:0048639	62	0.021
positive regulation of stem cell maintenance	GO:1902459	1	0.021
purine containing compound metabolic process	GO:0072521	155	0.021
catabolic process	GO:0009056	409	0.021
zygotic specification of dorsal ventral axis	GO:0007352	3	0.021
axonogenesis	GO:0007409	290	0.021
nucleoside triphosphate metabolic process	GO:0009141	120	0.021
aromatic compound catabolic process	GO:0019439	166	0.021
regulation of neuron differentiation	GO:0045664	103	0.020
small molecule metabolic process	GO:0044281	305	0.020
response to light stimulus	GO:0009416	124	0.020
organophosphate catabolic process	GO:0046434	112	0.020
cellular nitrogen compound catabolic process	GO:0044270	165	0.020
nucleoside catabolic process	GO:0009164	112	0.020
regulation of chromosome organization	GO:0033044	64	0.020
purine nucleoside metabolic process	GO:0042278	127	0.020
anterior posterior pattern specification	GO:0009952	136	0.020
growth	GO:0040007	359	0.019
eye development	GO:0001654	323	0.019
positive regulation of cellular amine metabolic process	GO:0033240	0	0.019
regulation of nucleotide metabolic process	GO:0006140	62	0.019
dna repair	GO:0006281	54	0.019
cell migration	GO:0016477	238	0.019
negative regulation of cell cycle process	GO:0010948	109	0.019
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.019
maternal determination of dorsal ventral axis ovarian follicular epithelium soma encoded	GO:0008071	1	0.019
neuron projection guidance	GO:0097485	241	0.018
nucleoside monophosphate catabolic process	GO:0009125	39	0.018
body morphogenesis	GO:0010171	2	0.018
positive regulation of transport	GO:0051050	92	0.018
secretion	GO:0046903	109	0.018	Worm
ras protein signal transduction	GO:0007265	88	0.018
protein maturation	GO:0051604	71	0.018
response to external biotic stimulus	GO:0043207	293	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.018
transmembrane transport	GO:0055085	139	0.017
regulation of planar cell polarity pathway involved in axis elongation	GO:2000040	2	0.017
negative regulation of terminal cell fate specification open tracheal system	GO:0035155	2	0.017
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.017
cellular response to dna damage stimulus	GO:0006974	223	0.017
regulation of establishment of protein localization	GO:0070201	61	0.017
regulation of intracellular signal transduction	GO:1902531	236	0.017
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.017
cell cycle checkpoint	GO:0000075	95	0.017
positive regulation of neuron projection regeneration	GO:0070572	3	0.017
digestive tract morphogenesis	GO:0048546	127	0.017
purine nucleotide metabolic process	GO:0006163	146	0.016
ncrna metabolic process	GO:0034660	43	0.016
protein localization to nucleus	GO:0034504	55	0.016
positive regulation of rna biosynthetic process	GO:1902680	266	0.016
mitotic spindle organization	GO:0007052	220	0.016
oocyte maturation	GO:0001556	3	0.016
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.016
amine metabolic process	GO:0009308	12	0.016
wing disc morphogenesis	GO:0007472	344	0.016
positive regulation of growth	GO:0045927	75	0.016
regulation of cell size	GO:0008361	63	0.016
nucleoside phosphate metabolic process	GO:0006753	162	0.016
negative regulation of developmental process	GO:0051093	201	0.016
negative regulation of cell communication	GO:0010648	223	0.016
negative regulation of signal transduction by p53 class mediator	GO:1901797	1	0.016
positive regulation of cdc42 gtpase activity	GO:0043089	2	0.015
activation of anaphase promoting complex activity	GO:0051488	1	0.015
carboxylic acid metabolic process	GO:0019752	92	0.015
cell cycle g1 s phase transition	GO:0044843	31	0.015
organelle localization	GO:0051640	148	0.015
nucleoside metabolic process	GO:0009116	127	0.015
asymmetric cell division	GO:0008356	37	0.014
cellular macromolecular complex assembly	GO:0034622	153	0.014
response to organic substance	GO:0010033	284	0.014
regulation of purine nucleotide metabolic process	GO:1900542	62	0.014
negative regulation of cell differentiation	GO:0045596	143	0.014
pronuclear migration	GO:0035046	4	0.014
dorsal closure leading edge cell differentiation	GO:0046663	2	0.014
response to radiation	GO:0009314	155	0.014
female meiotic division	GO:0007143	70	0.014
tissue morphogenesis	GO:0048729	297	0.014
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
regulation of intracellular protein transport	GO:0033157	46	0.013
regulation of cell cycle checkpoint	GO:1901976	2	0.013
biological adhesion	GO:0022610	138	0.013
appendage development	GO:0048736	401	0.013
nucleoside phosphate catabolic process	GO:1901292	110	0.013
positive regulation of multicellular organism growth	GO:0040018	21	0.013
intracellular protein transport	GO:0006886	104	0.013
anterior posterior axis specification follicular epithelium	GO:0030714	2	0.013
regulation of postsynaptic membrane potential	GO:0060078	5	0.013
multicellular organismal aging	GO:0010259	140	0.013
icosanoid biosynthetic process	GO:0046456	1	0.013
regulation of transport	GO:0051049	181	0.013
cellular protein modification process	GO:0006464	438	0.013
response to biotic stimulus	GO:0009607	294	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
morphogenesis of an epithelium	GO:0002009	276	0.013
genitalia development	GO:0048806	26	0.013
positive regulation of epidermal growth factor activated receptor activity	GO:0045741	1	0.013
negative regulation of developmental pigmentation	GO:0048086	1	0.012
oxoacid metabolic process	GO:0043436	103	0.012
regulation of cell proliferation involved in compound eye morphogenesis	GO:2000495	2	0.012
sirna loading onto risc involved in rna interference	GO:0035087	4	0.012
positive regulation of viral process	GO:0048524	2	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
single organism membrane organization	GO:0044802	93	0.012
response to inorganic substance	GO:0010035	44	0.012
rhabdomere development	GO:0042052	38	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.012
embryonic development via the syncytial blastoderm	GO:0001700	148	0.012
negative regulation of signaling	GO:0023057	219	0.012
dna integrity checkpoint	GO:0031570	81	0.012
mrna cleavage	GO:0006379	2	0.012
purine nucleotide catabolic process	GO:0006195	109	0.012
nuclear import	GO:0051170	51	0.011
positive regulation of cell proliferation	GO:0008284	47	0.011
negative regulation of gene expression epigenetic	GO:0045814	77	0.011
compound eye morphogenesis	GO:0001745	249	0.011
cystoblast division	GO:0007282	10	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
negative regulation of nucleotide catabolic process	GO:0030812	1	0.011
regulation of spindle checkpoint	GO:0090231	2	0.011
respiratory system development	GO:0060541	213	0.011
aging	GO:0007568	143	0.011
positive regulation of nervous system development	GO:0051962	69	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
regulation of protein metabolic process	GO:0051246	256	0.011
protein import into nucleus	GO:0006606	51	0.011
meiotic spindle checkpoint	GO:0044779	1	0.011
oocyte fate commitment	GO:0048600	2	0.011
phagocytosis	GO:0006909	215	0.011
regulation of calcium ion transmembrane transport	GO:1903169	2	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
pole cell migration	GO:0007280	13	0.011
oocyte axis specification	GO:0007309	108	0.010
anterior head segmentation	GO:0035288	3	0.010

mit(1)15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
benign neoplasm	DOID:0060072	0.016
disease of cellular proliferation	DOID:14566	0.016
chromosomal disease	DOID:0080014	0.014
gonadal dysgenesis	DOID:14447	0.014
cancer	DOID:162	0.013
organ system cancer	DOID:0050686	0.013
head and neck cancer	DOID:11934	0.013

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