IMP: Integrative Multi-species Prediction

Drosophila melanogaster

372 known processes

p53 (Dmel_CG33336)

CG33336 gene product from transcript CG33336-RB

(Aliases: Dmel\CG33336,Dm-P53,dmp53,CG10873,D-p53,DmP53,prac,Dp53,Dmp53,CG33336,dp53,CG31325)

FLYBASE: FBgn0039044
Entrez: 2768677
UniProtKB: Q8IMZ4
UniProtKB: Q9N6D8

Process Predictions
Disease Predictions

p53 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna metabolic process	GO:0006259	227	0.999
negative regulation of cell cycle	GO:0045786	116	0.997	Human Zebrafish Mouse
intrinsic apoptotic signaling pathway	GO:0097193	16	0.996
negative regulation of cell cycle phase transition	GO:1901988	103	0.995	Human Mouse
chromosome organization	GO:0051276	360	0.994	Human Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.993	Human Zebrafish Mouse
cellular response to dna damage stimulus	GO:0006974	223	0.991
apoptotic signaling pathway	GO:0097190	27	0.991
cellular protein modification process	GO:0006464	438	0.985	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.984
negative regulation of transcription dna templated	GO:0045892	237	0.984	Human Zebrafish Mouse
epithelial cell development	GO:0002064	274	0.982	Mouse
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.977
negative regulation of cellular biosynthetic process	GO:0031327	277	0.977	Human Zebrafish Mouse
response to radiation	GO:0009314	155	0.970
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.967	Human Zebrafish Mouse
mitotic cell cycle phase transition	GO:0044772	138	0.960	Human Mouse
negative regulation of mitotic cell cycle	GO:0045930	109	0.959	Human Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.954
response to organic substance	GO:0010033	284	0.950	Zebrafish Mouse
programmed cell death	GO:0012501	257	0.945
double strand break repair	GO:0006302	26	0.944	Mouse
regulation of cell cycle phase transition	GO:1901987	130	0.936	Human Mouse
negative regulation of cell cycle process	GO:0010948	109	0.928	Human Mouse
regulation of cell cycle	GO:0051726	291	0.927
mitotic cell cycle checkpoint	GO:0007093	88	0.923	Human Mouse
mitotic dna damage checkpoint	GO:0044773	74	0.920	Human Mouse
regulation of endopeptidase activity	GO:0052548	36	0.912
regulation of mitotic cell cycle	GO:0007346	190	0.908	Human Mouse
regulation of protein metabolic process	GO:0051246	256	0.899
axonogenesis	GO:0007409	290	0.895
embryo development ending in birth or egg hatching	GO:0009792	152	0.893	Zebrafish Mouse Worm
response to abiotic stimulus	GO:0009628	341	0.891
negative regulation of rna biosynthetic process	GO:1902679	240	0.888	Human Zebrafish Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.879	Mouse
negative regulation of gene expression	GO:0010629	387	0.875	Human Zebrafish Mouse
neuron death	GO:0070997	27	0.869	Zebrafish Mouse
positive regulation of cellular protein metabolic process	GO:0032270	118	0.861
cell growth	GO:0016049	108	0.857	Human
cellular response to chemical stimulus	GO:0070887	199	0.852	Human Zebrafish Mouse
cellular catabolic process	GO:0044248	372	0.852
telomere organization	GO:0032200	21	0.849
regulation of macroautophagy	GO:0016241	15	0.842
positive regulation of signal transduction	GO:0009967	223	0.841
regulation of gene expression epigenetic	GO:0040029	128	0.837
protein phosphorylation	GO:0006468	169	0.837	Mouse
axon development	GO:0061564	297	0.821
dna packaging	GO:0006323	91	0.815	Human
catabolic process	GO:0009056	409	0.815
positive regulation of macroautophagy	GO:0016239	8	0.804
meiotic chromosome segregation	GO:0045132	59	0.799	Worm
gene silencing	GO:0016458	138	0.796
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.795
ectopic germ cell programmed cell death	GO:0035234	8	0.789
response to organonitrogen compound	GO:0010243	75	0.785
chromatin organization	GO:0006325	207	0.775	Human Mouse
signal transduction in response to dna damage	GO:0042770	3	0.773	Human Zebrafish Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.772	Human Zebrafish Mouse
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.771	Human Mouse
protein modification process	GO:0036211	438	0.771	Mouse
response to light stimulus	GO:0009416	124	0.769
cell cycle phase transition	GO:0044770	140	0.766	Human Mouse
transcription from rna polymerase ii promoter	GO:0006366	368	0.766
cellular response to oxidative stress	GO:0034599	28	0.766	Human
regulation of organelle organization	GO:0033043	196	0.744	Human Mouse
chromatin modification	GO:0016568	147	0.740	Mouse
death	GO:0016265	284	0.736
organelle fission	GO:0048285	340	0.731
establishment of localization in cell	GO:0051649	402	0.728
immune response	GO:0006955	246	0.726	Mouse
autophagy	GO:0006914	108	0.713
mitotic nuclear division	GO:0007067	213	0.705
negative regulation of neuron death	GO:1901215	18	0.700	Mouse
proteolysis	GO:0006508	192	0.697
dna repair	GO:0006281	54	0.682
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.682	Human Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.668
regulation of cellular response to stress	GO:0080135	89	0.666
positive regulation of cysteine type endopeptidase activity	GO:2001056	24	0.657
negative regulation of biosynthetic process	GO:0009890	277	0.653	Human Zebrafish Mouse
telomere maintenance	GO:0000723	21	0.649
cellular response to abiotic stimulus	GO:0071214	58	0.638
mitotic dna integrity checkpoint	GO:0044774	75	0.638	Human Mouse
positive regulation of macromolecule metabolic process	GO:0010604	405	0.634
positive regulation of cellular component organization	GO:0051130	156	0.626	Human Mouse
cellular response to oxygen containing compound	GO:1901701	79	0.624
regulation of multicellular organismal development	GO:2000026	414	0.623
growth	GO:0040007	359	0.622
negative regulation of cell death	GO:0060548	81	0.618	Human Mouse
response to ionizing radiation	GO:0010212	32	0.617
cellular response to organic substance	GO:0071310	132	0.613	Mouse
cellular macromolecule catabolic process	GO:0044265	136	0.608
histone modification	GO:0016570	106	0.603	Mouse
regulation of cell death	GO:0010941	173	0.590
regulation of phosphorylation	GO:0042325	147	0.586
positive regulation of gene expression	GO:0010628	290	0.583
regulation of cell cycle process	GO:0010564	181	0.571	Human Mouse
brain development	GO:0007420	120	0.562	Mouse
dna integrity checkpoint	GO:0031570	81	0.557	Human Zebrafish Mouse
cell death	GO:0008219	279	0.550
regulation of cell division	GO:0051302	72	0.547	Zebrafish Mouse
embryonic development via the syncytial blastoderm	GO:0001700	148	0.544
dna conformation change	GO:0071103	105	0.543	Human
positive regulation of transcription dna templated	GO:0045893	266	0.542
eye morphogenesis	GO:0048592	260	0.541
regulation of neuron apoptotic process	GO:0043523	16	0.539	Zebrafish Mouse
regulation of neuron death	GO:1901214	26	0.536	Zebrafish Mouse
taxis	GO:0042330	304	0.530
organelle localization	GO:0051640	148	0.526
positive regulation of cell communication	GO:0010647	250	0.524
cellular protein catabolic process	GO:0044257	83	0.519
regulation of peptidase activity	GO:0052547	39	0.515
response to uv	GO:0009411	24	0.511
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.505
gliogenesis	GO:0042063	80	0.503
negative regulation of protein metabolic process	GO:0051248	85	0.500	Mouse
macromolecule catabolic process	GO:0009057	161	0.497
immune system process	GO:0002376	347	0.493	Zebrafish Mouse
negative regulation of gene expression epigenetic	GO:0045814	77	0.491
chemotaxis	GO:0006935	249	0.488
positive regulation of response to stimulus	GO:0048584	323	0.487
anatomical structure homeostasis	GO:0060249	97	0.474	Zebrafish
apoptotic process	GO:0006915	159	0.473
cell type specific apoptotic process	GO:0097285	38	0.467	Human Zebrafish Mouse
regulation of chromosome organization	GO:0033044	64	0.465	Mouse
chromatin silencing	GO:0006342	76	0.464
positive regulation of signaling	GO:0023056	243	0.463
ovarian follicle cell development	GO:0030707	248	0.462
eggshell formation	GO:0030703	105	0.455
nuclear division	GO:0000280	332	0.454
regulation of intracellular signal transduction	GO:1902531	236	0.453	Human Mouse
homeostatic process	GO:0042592	199	0.449	Zebrafish Mouse
regulation of cell differentiation	GO:0045595	302	0.447
columnar cuboidal epithelial cell development	GO:0002066	249	0.429
regulation of cellular protein metabolic process	GO:0032268	243	0.427
regulation of catabolic process	GO:0009894	170	0.423
chorion containing eggshell formation	GO:0007304	105	0.423
negative regulation of response to stimulus	GO:0048585	258	0.422	Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.413	Human Zebrafish Mouse
developmental growth	GO:0048589	280	0.412
meiotic cell cycle process	GO:1903046	132	0.398
phosphorylation	GO:0016310	294	0.379
cell cycle checkpoint	GO:0000075	95	0.374	Human Zebrafish Mouse
positive regulation of endopeptidase activity	GO:0010950	26	0.373
negative regulation of intracellular signal transduction	GO:1902532	57	0.372	Mouse
compound eye development	GO:0048749	307	0.372
regulation of transferase activity	GO:0051338	58	0.368
cell cycle arrest	GO:0007050	4	0.368	Human Mouse
regulation of proteolysis	GO:0030162	87	0.366
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.363
negative regulation of cell communication	GO:0010648	223	0.363	Mouse
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.356
cellular response to ionizing radiation	GO:0071479	15	0.353
regulation of response to extracellular stimulus	GO:0032104	18	0.349
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.346	Human Zebrafish Mouse
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	5	0.345
double strand break repair via homologous recombination	GO:0000724	13	0.341
dna damage checkpoint	GO:0000077	78	0.331	Human Zebrafish Mouse
regulation of mitosis	GO:0007088	56	0.327
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.326	Zebrafish
spindle organization	GO:0007051	253	0.322
regulation of phosphorus metabolic process	GO:0051174	210	0.316
positive regulation of organelle organization	GO:0010638	65	0.308	Human Mouse
organic substance catabolic process	GO:1901575	308	0.308
axon guidance	GO:0007411	233	0.306
innate immune response	GO:0045087	144	0.305
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.305	Human Zebrafish Mouse
regulation of cellular catabolic process	GO:0031329	157	0.304
cellular response to nutrient levels	GO:0031669	62	0.304
nucleoside triphosphate catabolic process	GO:0009143	108	0.302
germ cell migration	GO:0008354	43	0.301
translation	GO:0006412	69	0.299
positive regulation of rna biosynthetic process	GO:1902680	266	0.298
positive regulation of proteolysis	GO:0045862	52	0.291
developmental growth involved in morphogenesis	GO:0060560	65	0.289
regulation of dna metabolic process	GO:0051052	34	0.289
regulation of cell proliferation	GO:0042127	163	0.287
mitotic g2 dna damage checkpoint	GO:0007095	69	0.286
cell motility	GO:0048870	251	0.284
recombinational repair	GO:0000725	13	0.280
positive regulation of response to extracellular stimulus	GO:0032106	8	0.280
central nervous system development	GO:0007417	201	0.279	Zebrafish Mouse
negative regulation of organelle organization	GO:0010639	56	0.273
modification dependent protein catabolic process	GO:0019941	78	0.272
regionalization	GO:0003002	416	0.268	Mouse
cellular response to starvation	GO:0009267	61	0.266
cellular response to gamma radiation	GO:0071480	10	0.264
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.262	Human Mouse
negative regulation of phosphorylation	GO:0042326	35	0.260
positive regulation of peptidase activity	GO:0010952	29	0.252
negative regulation of catalytic activity	GO:0043086	42	0.249
response to oxidative stress	GO:0006979	86	0.249	Human Mouse Worm
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.246
cellular response to external stimulus	GO:0071496	66	0.243
protein catabolic process	GO:0030163	101	0.240
neuron apoptotic process	GO:0051402	17	0.238	Zebrafish Mouse
dendrite morphogenesis	GO:0048813	199	0.235
response to nitrogen compound	GO:1901698	90	0.234
cell migration	GO:0016477	238	0.232
regulation of response to stress	GO:0080134	200	0.227
regulation of translation	GO:0006417	56	0.224
centrosome cycle	GO:0007098	137	0.223
eye development	GO:0001654	323	0.223
telomere capping	GO:0016233	11	0.223
positive regulation of protein metabolic process	GO:0051247	128	0.220
defense response	GO:0006952	300	0.219	Mouse
multicellular organismal aging	GO:0010259	140	0.218
dorsal closure	GO:0007391	79	0.216
regulation of transport	GO:0051049	181	0.216
negative regulation of programmed cell death	GO:0043069	72	0.206	Human Mouse
dendrite development	GO:0016358	204	0.206
negative regulation of cellular component organization	GO:0051129	108	0.204
positive regulation of cell death	GO:0010942	69	0.198
locomotory behavior	GO:0007626	176	0.195
cell proliferation	GO:0008283	299	0.194
positive regulation of cellular biosynthetic process	GO:0031328	316	0.193
epithelial cell differentiation	GO:0030855	322	0.191	Mouse
regulation of phosphate metabolic process	GO:0019220	210	0.189
chromosome segregation	GO:0007059	157	0.186	Worm
vesicle mediated transport	GO:0016192	381	0.185
response to oxygen containing compound	GO:1901700	200	0.184
regulation of proteasomal protein catabolic process	GO:0061136	39	0.182
regulation of developmental growth	GO:0048638	174	0.181
regulation of catalytic activity	GO:0050790	185	0.179
neuron projection guidance	GO:0097485	241	0.178
negative regulation of transferase activity	GO:0051348	18	0.177
positive regulation of developmental process	GO:0051094	143	0.177
apoptotic process involved in development	GO:1902742	20	0.176
sensory organ morphogenesis	GO:0090596	260	0.174
organ growth	GO:0035265	56	0.174
cellular response to radiation	GO:0071478	52	0.172
pigmentation	GO:0043473	75	0.171
positive regulation of phosphorylation	GO:0042327	87	0.171	Mouse
positive regulation of response to nutrient levels	GO:0032109	8	0.167
negative regulation of signaling	GO:0023057	219	0.167	Mouse
protein complex assembly	GO:0006461	200	0.165	Human
dna recombination	GO:0006310	32	0.165
aging	GO:0007568	143	0.162
extrinsic apoptotic signaling pathway	GO:0097191	1	0.161
response to x ray	GO:0010165	8	0.161
execution phase of apoptosis	GO:0097194	7	0.158
protein modification by small protein conjugation or removal	GO:0070647	106	0.158
meiotic nuclear division	GO:0007126	151	0.158
localization of cell	GO:0051674	257	0.157
regulation of protein kinase activity	GO:0045859	51	0.157	Mouse
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.156	Human Mouse
negative regulation of neuron apoptotic process	GO:0043524	14	0.155	Mouse
negative regulation of apoptotic process	GO:0043066	63	0.153	Human Mouse
microtubule organizing center organization	GO:0031023	168	0.148
regulation of anatomical structure size	GO:0090066	163	0.145	Mouse
mitotic spindle organization	GO:0007052	220	0.144
regulation of cell growth	GO:0001558	43	0.144	Human
stress activated mapk cascade	GO:0051403	52	0.142	Mouse
developmental programmed cell death	GO:0010623	138	0.142
regulation of response to nutrient levels	GO:0032107	18	0.137
g2 dna damage checkpoint	GO:0031572	69	0.137
regulation of apoptotic process	GO:0042981	130	0.137
response to inorganic substance	GO:0010035	44	0.135
ubiquitin dependent protein catabolic process	GO:0006511	78	0.135
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.134
negative regulation of phosphorus metabolic process	GO:0010563	45	0.134
compound eye morphogenesis	GO:0001745	249	0.132
cellular amide metabolic process	GO:0043603	80	0.131
regulation of autophagy	GO:0010506	62	0.131
development of primary sexual characteristics	GO:0045137	50	0.131
protein modification by small protein conjugation	GO:0032446	79	0.130
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.129
developmental pigmentation	GO:0048066	68	0.128
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.128
regulation of nuclear division	GO:0051783	58	0.128
negative regulation of signal transduction	GO:0009968	206	0.128	Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.126	Mouse
immune response regulating signaling pathway	GO:0002764	2	0.123
dna double strand break processing	GO:0000729	3	0.122
regulation of protein phosphorylation	GO:0001932	64	0.121	Mouse
regulation of innate immune response	GO:0045088	71	0.120
regulation of epithelial cell proliferation	GO:0050678	4	0.119	Mouse
regulation of apoptotic signaling pathway	GO:2001233	10	0.119	Human Mouse
proteasomal protein catabolic process	GO:0010498	59	0.118
regulation of wnt signaling pathway	GO:0030111	68	0.117
protein localization	GO:0008104	284	0.116
jnk cascade	GO:0007254	50	0.114	Mouse
response to endogenous stimulus	GO:0009719	119	0.114	Mouse
regulation of growth	GO:0040008	233	0.113
canonical wnt signaling pathway	GO:0060070	21	0.112
establishment or maintenance of cell polarity	GO:0007163	167	0.112
cellular component assembly involved in morphogenesis	GO:0010927	151	0.111
dna biosynthetic process	GO:0071897	24	0.110
eggshell chorion assembly	GO:0007306	66	0.109
heterocycle catabolic process	GO:0046700	166	0.108
centrosome organization	GO:0051297	163	0.104
regulation of molecular function	GO:0065009	217	0.101
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.101
spermatogenesis	GO:0007283	200	0.100	Zebrafish
regulation of immune response	GO:0050776	118	0.099
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.098
photoreceptor cell differentiation	GO:0046530	170	0.098
signal transduction by p53 class mediator	GO:0072331	6	0.098
cellular nitrogen compound catabolic process	GO:0044270	165	0.096
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.095
negative regulation of kinase activity	GO:0033673	16	0.094
modification dependent macromolecule catabolic process	GO:0043632	79	0.094
cellular response to organonitrogen compound	GO:0071417	36	0.094
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.094
neurological system process	GO:0050877	358	0.094
positive regulation of biosynthetic process	GO:0009891	316	0.092
regulation of anatomical structure morphogenesis	GO:0022603	242	0.091	Zebrafish
regulation of chromatin organization	GO:1902275	32	0.089	Mouse
small molecule metabolic process	GO:0044281	305	0.088
defense response to other organism	GO:0098542	225	0.088
regulation of cellular protein catabolic process	GO:1903362	44	0.086
negative regulation of cellular protein metabolic process	GO:0032269	85	0.086	Mouse
regulation of nervous system development	GO:0051960	248	0.086
protein complex biogenesis	GO:0070271	201	0.085	Human
response to alkaloid	GO:0043279	26	0.085
positive regulation of apoptotic process	GO:0043065	47	0.084
rna splicing	GO:0008380	83	0.083
chromatin remodeling	GO:0006338	72	0.082	Mouse
negative regulation of g1 s transition of mitotic cell cycle	GO:2000134	13	0.081	Human Mouse
oxoacid metabolic process	GO:0043436	103	0.081
camera type eye development	GO:0043010	4	0.080
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.080	Mouse
posttranscriptional regulation of gene expression	GO:0010608	145	0.078
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.078
covalent chromatin modification	GO:0016569	106	0.078	Mouse
compound eye retinal cell programmed cell death	GO:0046667	23	0.078
single organism behavior	GO:0044708	391	0.078
positive regulation of neuron apoptotic process	GO:0043525	1	0.078	Zebrafish Mouse
negative regulation of multicellular organismal process	GO:0051241	142	0.077
aromatic compound catabolic process	GO:0019439	166	0.076
nucleobase containing compound catabolic process	GO:0034655	165	0.076
regulation of programmed cell death	GO:0043067	152	0.075
response to alcohol	GO:0097305	95	0.075
protein acetylation	GO:0006473	39	0.075
determination of adult lifespan	GO:0008340	137	0.073
mitotic sister chromatid segregation	GO:0000070	87	0.073
regulation of localization	GO:0032879	275	0.072
sister chromatid segregation	GO:0000819	92	0.072
protein ubiquitination	GO:0016567	70	0.072
regulation of execution phase of apoptosis	GO:1900117	5	0.071
morphogenesis of embryonic epithelium	GO:0016331	94	0.071	Mouse
regulation of response to biotic stimulus	GO:0002831	63	0.071
endocytosis	GO:0006897	310	0.071
response to starvation	GO:0042594	97	0.071
signal transduction by phosphorylation	GO:0023014	107	0.071	Mouse
regulation of jnk cascade	GO:0046328	40	0.071	Mouse
double strand break repair via synthesis dependent strand annealing	GO:0045003	6	0.070
mitochondrion organization	GO:0007005	65	0.068	Human Mouse
ribose phosphate metabolic process	GO:0019693	145	0.068
regulation of cellular ketone metabolic process	GO:0010565	3	0.068
reproductive system development	GO:0061458	74	0.067	Mouse
cellular response to endogenous stimulus	GO:0071495	80	0.067	Mouse
positive regulation of protein modification process	GO:0031401	58	0.066	Mouse
sex differentiation	GO:0007548	81	0.066	Mouse
phenol containing compound metabolic process	GO:0018958	57	0.065
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.065
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.065
positive regulation of intracellular signal transduction	GO:1902533	116	0.064	Human Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.063	Mouse
intracellular signal transduction	GO:0035556	300	0.063
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.062	Human Mouse
tube morphogenesis	GO:0035239	191	0.062	Mouse
regulation of response to external stimulus	GO:0032101	115	0.062
regulation of organ morphogenesis	GO:2000027	78	0.062
regulation of protein modification process	GO:0031399	112	0.062	Mouse
production of molecular mediator of immune response	GO:0002440	46	0.061
response to superoxide	GO:0000303	3	0.061
stress activated protein kinase signaling cascade	GO:0031098	55	0.060	Mouse
positive regulation of catabolic process	GO:0009896	105	0.060
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.060
purine nucleoside catabolic process	GO:0006152	112	0.060
organonitrogen compound metabolic process	GO:1901564	318	0.060
positive regulation of molecular function	GO:0044093	136	0.060
g1 s transition of mitotic cell cycle	GO:0000082	31	0.060	Human Mouse
organic acid metabolic process	GO:0006082	103	0.059
positive regulation of execution phase of apoptosis	GO:1900119	4	0.059
cell division	GO:0051301	248	0.058	Zebrafish Mouse
positive regulation of catalytic activity	GO:0043085	118	0.058
cellular response to reactive oxygen species	GO:0034614	14	0.058
regulation of cellular amino acid metabolic process	GO:0006521	0	0.057
cellular response to nitrogen compound	GO:1901699	51	0.057
histolysis	GO:0007559	102	0.056
response to organic cyclic compound	GO:0014070	89	0.056
rna processing	GO:0006396	147	0.055
positive regulation of cell differentiation	GO:0045597	64	0.055
negative regulation of neurogenesis	GO:0050768	53	0.054
response to oxygen radical	GO:0000305	3	0.054
response to decreased oxygen levels	GO:0036293	58	0.053	Human Zebrafish Worm
regulation of hydrolase activity	GO:0051336	97	0.053
ribonucleotide metabolic process	GO:0009259	145	0.052
response to purine containing compound	GO:0014074	12	0.052
regulation of cytoskeleton organization	GO:0051493	89	0.052
nuclear migration	GO:0007097	20	0.051
kidney development	GO:0001822	3	0.051
protein heterooligomerization	GO:0051291	4	0.051
secretion	GO:0046903	109	0.051	Mouse
regulation of protein catabolic process	GO:0042176	55	0.049
positive regulation of transferase activity	GO:0051347	26	0.049
neural precursor cell proliferation	GO:0061351	75	0.049
compound eye photoreceptor development	GO:0042051	78	0.049
cellular amine metabolic process	GO:0044106	12	0.049
regulation of cell size	GO:0008361	63	0.048	Mouse
negative regulation of molecular function	GO:0044092	51	0.048
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.048	Mouse
gonad development	GO:0008406	50	0.047
regulation of kinase activity	GO:0043549	53	0.047
cell fate specification	GO:0001708	71	0.047
secretion by cell	GO:0032940	101	0.047
regulation of protein stability	GO:0031647	43	0.047
response to nutrient levels	GO:0031667	114	0.046
positive regulation of autophagy	GO:0010508	21	0.045
positive regulation of protein phosphorylation	GO:0001934	34	0.045	Mouse
purine nucleotide catabolic process	GO:0006195	109	0.045
tube development	GO:0035295	244	0.044	Mouse
digestive tract morphogenesis	GO:0048546	127	0.044	Mouse
carboxylic acid metabolic process	GO:0019752	92	0.044
ribonucleoside metabolic process	GO:0009119	127	0.044
cellular response to insulin stimulus	GO:0032869	28	0.044
regulation of immune system process	GO:0002682	176	0.043
positive regulation of growth	GO:0045927	75	0.043
response to hypoxia	GO:0001666	53	0.043	Human Zebrafish Worm
negative regulation of protein phosphorylation	GO:0001933	17	0.043	Mouse
wnt signaling pathway	GO:0016055	98	0.043
cellular macromolecular complex assembly	GO:0034622	153	0.043
embryonic pattern specification	GO:0009880	174	0.043
regulation of gene silencing	GO:0060968	63	0.042
cellular ketone metabolic process	GO:0042180	24	0.042
cellular response to extracellular stimulus	GO:0031668	64	0.042
mitotic g2 m transition checkpoint	GO:0044818	70	0.042
glial cell migration	GO:0008347	31	0.042
response to transforming growth factor beta	GO:0071559	18	0.042	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.042
regulation of mitotic sister chromatid separation	GO:0010965	28	0.041
regulation of cell development	GO:0060284	215	0.041
organic cyclic compound catabolic process	GO:1901361	168	0.041
regulation of protein transport	GO:0051223	57	0.040
activation of cysteine type endopeptidase activity	GO:0097202	17	0.040
chemical homeostasis	GO:0048878	92	0.039	Mouse
rhythmic process	GO:0048511	106	0.039
multi organism behavior	GO:0051705	175	0.039
negative regulation of chromosome segregation	GO:0051985	14	0.039
respiratory system development	GO:0060541	213	0.039
dorsal appendage formation	GO:0046843	47	0.038
mitochondrial fusion	GO:0008053	7	0.038
positive regulation of hydrolase activity	GO:0051345	78	0.037
response to drug	GO:0042493	17	0.037	Human Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.037
posttranscriptional gene silencing	GO:0016441	46	0.037
response to extracellular stimulus	GO:0009991	116	0.037
g2 m transition of mitotic cell cycle	GO:0000086	19	0.037
posttranscriptional gene silencing by rna	GO:0035194	45	0.037
regulation of cellular response to oxidative stress	GO:1900407	4	0.036
dna replication	GO:0006260	48	0.036	Mouse
negative regulation of protein modification process	GO:0031400	29	0.036	Mouse
germarium derived oocyte fate determination	GO:0007294	26	0.036
mitotic cell cycle embryonic	GO:0045448	38	0.036
cellular response to organic cyclic compound	GO:0071407	32	0.035
nucleotide excision repair	GO:0006289	8	0.035	Human
digestive system development	GO:0055123	149	0.035	Mouse
regulation of stress activated mapk cascade	GO:0032872	41	0.035	Mouse
purine nucleoside metabolic process	GO:0042278	127	0.035
negative regulation of response to oxidative stress	GO:1902883	1	0.034
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.034
spermatid development	GO:0007286	98	0.034
response to gamma radiation	GO:0010332	17	0.033
response to bacterium	GO:0009617	198	0.033
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.033
tripartite regional subdivision	GO:0007351	103	0.033
telencephalon development	GO:0021537	2	0.032	Mouse
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.032	Human Mouse
negative regulation of apoptotic signaling pathway	GO:2001234	5	0.032
single organism cell adhesion	GO:0098602	47	0.032
axis specification	GO:0009798	167	0.032
negative regulation of immune system process	GO:0002683	50	0.032
reactive oxygen species metabolic process	GO:0072593	22	0.032	Human Mouse
secondary metabolic process	GO:0019748	75	0.032
regulation of photoreceptor cell differentiation	GO:0046532	34	0.032
developmental maturation	GO:0021700	172	0.032
positive regulation of wnt signaling pathway	GO:0030177	25	0.031
positive regulation of insulin receptor signaling pathway	GO:0046628	3	0.031
protein autophosphorylation	GO:0046777	15	0.031
response to lipid	GO:0033993	38	0.031
cell adhesion	GO:0007155	136	0.031
response to hormone	GO:0009725	45	0.031
response to acid chemical	GO:0001101	25	0.030
response to other organism	GO:0051707	293	0.030
regulation of epithelial cell differentiation	GO:0030856	4	0.030	Mouse
appendage development	GO:0048736	401	0.030	Mouse
cellular macromolecule localization	GO:0070727	220	0.030

p53 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.120
thoracic cancer	DOID:5093	0.087	Human
organ system cancer	DOID:0050686	0.087	Human
cancer	DOID:162	0.087	Human
disease of cellular proliferation	DOID:14566	0.087	Human
breast cancer	DOID:1612	0.047	Human

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