IMP: Integrative Multi-species Prediction

Drosophila melanogaster

62 known processes

inx2 (Dmel_CG4590)

innexin 2

(Aliases: l(1)G0035,Dmel\CG4590,Inx2,prp33,l(1)G0059,l(1)G0364,CG4590,Dm-inx,l(1)G0157,l(1)G0118,l(1)G0317,Dm-inx2,l(1)G0036,kropf,l(1)G0043,Ix2,inx-2,D-inx-2,INX-2)

Entrez: 31646
FLYBASE: FBgn0027108
UniProtKB: E1JJF3
UniProtKB: Q9V427

Process Predictions
Disease Predictions

inx2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
digestive tract development	GO:0048565	149	0.914
digestive system development	GO:0055123	149	0.802
g protein coupled receptor signaling pathway	GO:0007186	136	0.779
positive regulation of transcription dna templated	GO:0045893	266	0.671
morphogenesis of embryonic epithelium	GO:0016331	94	0.646
tube development	GO:0035295	244	0.626
epithelial cell migration	GO:0010631	148	0.604
olfactory behavior	GO:0042048	97	0.555
multi multicellular organism process	GO:0044706	123	0.514
positive regulation of rna metabolic process	GO:0051254	271	0.488
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.485
regulation of nervous system development	GO:0051960	248	0.482
embryonic morphogenesis	GO:0048598	206	0.436
branching involved in open tracheal system development	GO:0060446	45	0.419
sensory perception of smell	GO:0007608	80	0.409
cell projection assembly	GO:0030031	94	0.393
digestive tract morphogenesis	GO:0048546	127	0.372
positive regulation of gene expression	GO:0010628	290	0.361
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.360
tube morphogenesis	GO:0035239	191	0.341
embryonic development via the syncytial blastoderm	GO:0001700	148	0.337
stem cell differentiation	GO:0048863	117	0.330
positive regulation of signaling	GO:0023056	243	0.327
mating	GO:0007618	120	0.316
regulation of cell morphogenesis	GO:0022604	163	0.306
positive regulation of rna biosynthetic process	GO:1902680	266	0.294
multi organism behavior	GO:0051705	175	0.293
associative learning	GO:0008306	65	0.284
cognition	GO:0050890	141	0.281
cell cell junction organization	GO:0045216	55	0.280	Fly
axon development	GO:0061564	297	0.274
regulation of cell differentiation	GO:0045595	302	0.258	Worm
actin filament bundle organization	GO:0061572	28	0.258
protein complex biogenesis	GO:0070271	201	0.251
tissue migration	GO:0090130	155	0.248
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.247
regulation of response to stress	GO:0080134	200	0.245
memory	GO:0007613	94	0.236
actin cytoskeleton organization	GO:0030036	206	0.226
female germ line stem cell asymmetric division	GO:0048132	14	0.210
dopamine biosynthetic process	GO:0042416	3	0.203
detection of stimulus	GO:0051606	156	0.202	Fly
chitin based cuticle sclerotization	GO:0007593	19	0.185
wing disc morphogenesis	GO:0007472	344	0.184
long term memory	GO:0007616	62	0.181
germ line stem cell maintenance	GO:0030718	50	0.179
chromosome organization	GO:0051276	360	0.178
intercellular transport	GO:0010496	2	0.176
multi organism reproductive behavior	GO:0044705	121	0.176
tissue morphogenesis	GO:0048729	297	0.165
cellular component assembly involved in morphogenesis	GO:0010927	151	0.164
response to external biotic stimulus	GO:0043207	293	0.163
regulation of multicellular organismal development	GO:2000026	414	0.162
cuticle development	GO:0042335	86	0.161
cell migration	GO:0016477	238	0.157
head involution	GO:0008258	35	0.156
locomotory behavior	GO:0007626	176	0.154	Fly
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.142
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.138
homeostatic process	GO:0042592	199	0.137	Fly
chemosensory behavior	GO:0007635	106	0.136
post embryonic appendage morphogenesis	GO:0035120	385	0.135
regulation of intracellular signal transduction	GO:1902531	236	0.123
localization of cell	GO:0051674	257	0.123
embryo development ending in birth or egg hatching	GO:0009792	152	0.120	Worm
germarium derived female germ line cyst formation	GO:0030727	42	0.120
chromatin organization	GO:0006325	207	0.119
positive regulation of response to stimulus	GO:0048584	323	0.117
epithelial cell differentiation	GO:0030855	322	0.117
regulation of response to external stimulus	GO:0032101	115	0.114
cellular protein modification process	GO:0006464	438	0.113
epithelial cell cell adhesion	GO:0090136	6	0.110
regulation of cellular component biogenesis	GO:0044087	201	0.106
gliogenesis	GO:0042063	80	0.105
ovarian follicle cell development	GO:0030707	248	0.104
peptidyl amino acid modification	GO:0018193	105	0.104
single organism behavior	GO:0044708	391	0.104
organelle localization	GO:0051640	148	0.102
molting cycle process	GO:0022404	29	0.101
reproductive behavior	GO:0019098	122	0.098
glial cell migration	GO:0008347	31	0.096
regulation of immune response	GO:0050776	118	0.095
foregut morphogenesis	GO:0007440	10	0.092
negative regulation of cell differentiation	GO:0045596	143	0.092	Worm
actin filament based process	GO:0030029	220	0.091
cell motility	GO:0048870	251	0.090
positive regulation of cell communication	GO:0010647	250	0.089
cortical actin cytoskeleton organization	GO:0030866	24	0.088
cell adhesion	GO:0007155	136	0.087
actin filament bundle assembly	GO:0051017	26	0.086
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.084
regulation of cell shape	GO:0008360	113	0.083
molting cycle chitin based cuticle	GO:0007591	56	0.081
reproductive system development	GO:0061458	74	0.080
positive regulation of biosynthetic process	GO:0009891	316	0.079
regulation of phosphorylation	GO:0042325	147	0.079
macromolecular complex assembly	GO:0065003	256	0.079
regulation of protein metabolic process	GO:0051246	256	0.078
cuticle pigmentation	GO:0048067	22	0.074
columnar cuboidal epithelial cell development	GO:0002066	249	0.073
reproductive structure development	GO:0048608	74	0.072
stem cell maintenance	GO:0019827	67	0.072
positive regulation of cellular component biogenesis	GO:0044089	80	0.071
organonitrogen compound metabolic process	GO:1901564	318	0.070
ameboidal type cell migration	GO:0001667	151	0.067
malpighian tubule morphogenesis	GO:0007443	44	0.067
negative regulation of transcription dna templated	GO:0045892	237	0.066
negative regulation of nervous system development	GO:0051961	92	0.065
actin filament organization	GO:0007015	126	0.065
regulation of membrane potential	GO:0042391	35	0.064	Fly
regulation of cytoskeleton organization	GO:0051493	89	0.064
protein modification process	GO:0036211	438	0.063
detection of stimulus involved in sensory perception	GO:0050906	92	0.061
regulation of anatomical structure morphogenesis	GO:0022603	242	0.060
dorsal closure	GO:0007391	79	0.060
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.060
initiation of dorsal closure	GO:0007392	12	0.058
sensory perception of chemical stimulus	GO:0007606	116	0.058
aromatic amino acid family metabolic process	GO:0009072	3	0.056
neurological system process	GO:0050877	358	0.055
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.055
ovarian follicle cell migration	GO:0007297	121	0.054
open tracheal system development	GO:0007424	204	0.054
forebrain development	GO:0030900	2	0.053
positive regulation of cellular biosynthetic process	GO:0031328	316	0.053
germline stem cell asymmetric division	GO:0098728	15	0.052
positive regulation of cell migration	GO:0030335	2	0.052
central nervous system development	GO:0007417	201	0.052
sensory perception	GO:0007600	196	0.052
female germ line stem cell maintenance	GO:0036099	8	0.051
male mating behavior	GO:0060179	70	0.051
circulatory system development	GO:0072359	82	0.051
cellular catabolic process	GO:0044248	372	0.051
protein complex assembly	GO:0006461	200	0.051
regulation of phosphorus metabolic process	GO:0051174	210	0.050
hindgut morphogenesis	GO:0007442	58	0.049
regulation of embryonic cell shape	GO:0016476	30	0.049
axonogenesis	GO:0007409	290	0.048
establishment of tissue polarity	GO:0007164	87	0.048
periodic partitioning	GO:0007365	29	0.048
sensory organ morphogenesis	GO:0090596	260	0.048
organic substance catabolic process	GO:1901575	308	0.048
striated muscle cell differentiation	GO:0051146	90	0.048
photoreceptor cell differentiation	GO:0046530	170	0.048
asymmetric cell division	GO:0008356	37	0.048
intracellular signal transduction	GO:0035556	300	0.048
mating behavior	GO:0007617	106	0.047
female germ line cyst formation	GO:0048135	42	0.047
gonad development	GO:0008406	50	0.047
chromatin assembly	GO:0031497	48	0.045
germarium derived female germ line cyst encapsulation	GO:0030708	8	0.045
establishment of organelle localization	GO:0051656	122	0.045
compound eye development	GO:0048749	307	0.044
regulation of cellular protein metabolic process	GO:0032268	243	0.044
cell growth	GO:0016049	108	0.044
dorsal closure spreading of leading edge cells	GO:0007395	4	0.043
apical junction assembly	GO:0043297	32	0.043
cellular macromolecular complex assembly	GO:0034622	153	0.043
phosphorylation	GO:0016310	294	0.043
hindgut development	GO:0061525	58	0.042
dopamine metabolic process	GO:0042417	7	0.042
neuroblast division	GO:0055057	35	0.042
positive regulation of signal transduction	GO:0009967	223	0.041
appendage morphogenesis	GO:0035107	397	0.041
morphogenesis of an epithelium	GO:0002009	276	0.041
chorion containing eggshell formation	GO:0007304	105	0.041
germ band extension	GO:0007377	11	0.040
taxis	GO:0042330	304	0.040
organelle fission	GO:0048285	340	0.039
convergent extension involved in gastrulation	GO:0060027	2	0.038
muscle attachment	GO:0016203	36	0.038
positive regulation of macromolecule metabolic process	GO:0010604	405	0.038
morphogenesis of a polarized epithelium	GO:0001738	93	0.038
multicellular organismal reproductive behavior	GO:0033057	110	0.037
positive regulation of cell cycle	GO:0045787	43	0.037
glial cell differentiation	GO:0010001	35	0.037
segmentation	GO:0035282	207	0.036
cellular protein complex assembly	GO:0043623	71	0.036
epithelium migration	GO:0090132	148	0.036
response to other organism	GO:0051707	293	0.036
positive regulation of protein metabolic process	GO:0051247	128	0.035
positive regulation of phosphate metabolic process	GO:0045937	139	0.035
cell junction organization	GO:0034330	57	0.035	Fly
regulation of cell development	GO:0060284	215	0.035	Worm
tricarboxylic acid metabolic process	GO:0072350	1	0.035
gastrulation involving germ band extension	GO:0010004	36	0.034
actin filament based movement	GO:0030048	26	0.034
epithelial tube morphogenesis	GO:0060562	88	0.033
chromosome segregation	GO:0007059	157	0.033
sex differentiation	GO:0007548	81	0.033
regulation of wound healing	GO:0061041	13	0.033
oocyte axis specification	GO:0007309	108	0.032
imaginal disc derived appendage development	GO:0048737	399	0.032
ubiquitin dependent protein catabolic process	GO:0006511	78	0.032
neuroblast fate commitment	GO:0014017	19	0.032
alpha amino acid metabolic process	GO:1901605	20	0.031
response to abiotic stimulus	GO:0009628	341	0.031	Fly
regulation of cell projection organization	GO:0031344	92	0.031
regulation of catalytic activity	GO:0050790	185	0.031
appendage development	GO:0048736	401	0.031
nucleobase containing compound catabolic process	GO:0034655	165	0.030
posttranscriptional regulation of gene expression	GO:0010608	145	0.030
serotonin metabolic process	GO:0042428	2	0.030
oviposition	GO:0018991	19	0.030
imaginal disc derived female genitalia development	GO:0007486	6	0.030
macromolecule catabolic process	GO:0009057	161	0.030
synapse assembly	GO:0007416	143	0.029
cellular amide metabolic process	GO:0043603	80	0.029
response to carbon dioxide	GO:0010037	4	0.029
primary amino compound biosynthetic process	GO:1901162	2	0.029
protein catabolic process	GO:0030163	101	0.029
rhythmic process	GO:0048511	106	0.029
striated muscle cell development	GO:0055002	50	0.029
regulation of innate immune response	GO:0045088	71	0.029
chemotaxis	GO:0006935	249	0.029
cellular amine metabolic process	GO:0044106	12	0.028
oocyte development	GO:0048599	124	0.028	Worm
ventral cord development	GO:0007419	16	0.028
cell cell junction assembly	GO:0007043	38	0.028	Fly
cell migration involved in gastrulation	GO:0042074	9	0.028
negative regulation of cellular metabolic process	GO:0031324	382	0.027
gastrulation with mouth forming first	GO:0001703	36	0.027
germarium derived egg chamber formation	GO:0007293	101	0.027
purine ribonucleotide metabolic process	GO:0009150	145	0.027
stem cell division	GO:0017145	69	0.026
embryonic hindgut morphogenesis	GO:0048619	48	0.026
genital disc development	GO:0035215	44	0.026
developmental maturation	GO:0021700	172	0.026	Worm
determination of adult lifespan	GO:0008340	137	0.026	Worm
regulation of chitin based cuticle tanning	GO:0007564	14	0.026
regulation of epithelial cell proliferation	GO:0050678	4	0.025
stem cell development	GO:0048864	79	0.025
epithelial cell migration open tracheal system	GO:0007427	32	0.025
segment polarity determination	GO:0007367	25	0.025
gastrulation	GO:0007369	70	0.025
carboxylic acid metabolic process	GO:0019752	92	0.024
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.024
axon extension	GO:0048675	32	0.024
eggshell chorion assembly	GO:0007306	66	0.024
detection of light stimulus	GO:0009583	58	0.024	Fly
catabolic process	GO:0009056	409	0.024
regulation of organelle organization	GO:0033043	196	0.024
positive regulation of defense response	GO:0031349	59	0.024
regulation of developmental pigmentation	GO:0048070	24	0.023
amine metabolic process	GO:0009308	12	0.023
regulation of gene expression epigenetic	GO:0040029	128	0.023
eye morphogenesis	GO:0048592	260	0.023
regulation of behavior	GO:0050795	75	0.022
development of primary sexual characteristics	GO:0045137	50	0.022
learning or memory	GO:0007611	141	0.022
cell proliferation	GO:0008283	299	0.022
growth	GO:0040007	359	0.022
positive regulation of gtp catabolic process	GO:0033126	43	0.021
organic cyclic compound catabolic process	GO:1901361	168	0.021
rna processing	GO:0006396	147	0.021
carbohydrate derivative catabolic process	GO:1901136	118	0.021
spermatogenesis	GO:0007283	200	0.021
dorsal closure elongation of leading edge cells	GO:0007394	10	0.021
positive regulation of intracellular signal transduction	GO:1902533	116	0.021
aging	GO:0007568	143	0.021	Worm
regulation of malpighian tubule diameter	GO:0035297	3	0.020
mitotic sister chromatid separation	GO:0051306	30	0.020
oocyte construction	GO:0007308	112	0.020
defense response to gram negative bacterium	GO:0050829	94	0.020
establishment of vesicle localization	GO:0051650	51	0.020
heterocycle catabolic process	GO:0046700	166	0.020
response to wounding	GO:0009611	94	0.020
blastoderm segmentation	GO:0007350	159	0.020
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.020
apical constriction involved in gastrulation	GO:0003384	7	0.020
motor neuron axon guidance	GO:0008045	58	0.019
imaginal disc derived wing morphogenesis	GO:0007476	337	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.019
adherens junction organization	GO:0034332	27	0.019
branch fusion open tracheal system	GO:0035147	17	0.019
regulation of phosphate metabolic process	GO:0019220	210	0.019
mrna metabolic process	GO:0016071	124	0.019
nuclear division	GO:0000280	332	0.018
positive regulation of phosphorus metabolic process	GO:0010562	139	0.018
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.018
dorsal appendage formation	GO:0046843	47	0.018
positive regulation of kinase activity	GO:0033674	25	0.018
nucleotide catabolic process	GO:0009166	109	0.018
axon choice point recognition	GO:0016198	26	0.018
asymmetric stem cell division	GO:0098722	49	0.018
apical constriction	GO:0003383	18	0.018
protein phosphorylation	GO:0006468	169	0.017
germ line cyst formation	GO:0048134	44	0.017
circadian behavior	GO:0048512	76	0.017
chromatin modification	GO:0016568	147	0.017
embryonic pattern specification	GO:0009880	174	0.016
establishment of spindle orientation	GO:0051294	18	0.016
actomyosin structure organization	GO:0031032	56	0.016
meiotic cell cycle	GO:0051321	171	0.016
regulation of locomotion	GO:0040012	42	0.016
cell junction assembly	GO:0034329	42	0.016	Fly
chromatin assembly or disassembly	GO:0006333	52	0.016
regulation of neuron differentiation	GO:0045664	103	0.016
regulation of membrane depolarization	GO:0003254	1	0.016	Fly
regulation of defense response	GO:0031347	102	0.016
regulation of molecular function	GO:0065009	217	0.016
negative regulation of epithelial cell proliferation	GO:0050680	4	0.016
branching morphogenesis of an epithelial tube	GO:0048754	45	0.015
positive regulation of response to wounding	GO:1903036	15	0.015
programmed cell death	GO:0012501	257	0.015	Worm
response to ethanol	GO:0045471	59	0.015
oxoacid metabolic process	GO:0043436	103	0.015
positive regulation of molecular function	GO:0044093	136	0.015
cell fate determination	GO:0001709	91	0.015
death	GO:0016265	284	0.015	Worm
neuron recognition	GO:0008038	101	0.015
regulation of anatomical structure size	GO:0090066	163	0.015
cell maturation	GO:0048469	144	0.015	Worm
regulation of cell cycle	GO:0051726	291	0.015
molting cycle	GO:0042303	56	0.015
positive regulation of phosphorylation	GO:0042327	87	0.015
citrate metabolic process	GO:0006101	0	0.014
mitotic nuclear division	GO:0007067	213	0.014
female germ line cyst encapsulation	GO:0048139	8	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
fusome organization	GO:0045478	13	0.014
cardiocyte differentiation	GO:0035051	29	0.014
r7 cell fate commitment	GO:0007465	12	0.014
small molecule metabolic process	GO:0044281	305	0.014
filopodium assembly	GO:0046847	33	0.014
epithelial cell development	GO:0002064	274	0.013
vesicle localization	GO:0051648	55	0.013
histone modification	GO:0016570	106	0.013
regulation of tube diameter	GO:0035296	14	0.013
regulation of immune system process	GO:0002682	176	0.013
genitalia development	GO:0048806	26	0.013
determination of digestive tract left right asymmetry	GO:0071907	6	0.013
wound healing	GO:0042060	75	0.013
indole containing compound biosynthetic process	GO:0042435	4	0.013
oocyte differentiation	GO:0009994	145	0.013	Worm
germ line cyst encapsulation	GO:0048138	8	0.013
nucleus organization	GO:0006997	45	0.013
neurotransmitter transport	GO:0006836	37	0.013
morphogenesis of follicular epithelium	GO:0016333	36	0.012
cardiovascular system development	GO:0072358	82	0.012
skeletal muscle organ development	GO:0060538	48	0.012
negative regulation of protein processing	GO:0010955	31	0.012
anterior posterior axis specification embryo	GO:0008595	103	0.012
body morphogenesis	GO:0010171	2	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
border follicle cell migration	GO:0007298	113	0.012
regulation of cell growth	GO:0001558	43	0.012
compound eye retinal cell programmed cell death	GO:0046667	23	0.012
eye development	GO:0001654	323	0.012
cell substrate adhesion	GO:0031589	10	0.012
negative regulation of cellular component organization	GO:0051129	108	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
regulation of tube size open tracheal system	GO:0035151	43	0.012
regulation of actin filament based process	GO:0032970	42	0.012
eye photoreceptor cell fate commitment	GO:0042706	37	0.012
rho protein signal transduction	GO:0007266	14	0.012
proteasomal protein catabolic process	GO:0010498	59	0.012
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.011
regulation of actin cytoskeleton organization	GO:0032956	42	0.011
germarium derived oocyte fate determination	GO:0007294	26	0.011
establishment of planar polarity	GO:0001736	87	0.011
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	23	0.011
morphogenesis of a branching epithelium	GO:0061138	45	0.011
neuroblast development	GO:0014019	13	0.011
feeding behavior	GO:0007631	50	0.011
apoptotic process	GO:0006915	159	0.011	Worm
negative regulation of cell development	GO:0010721	62	0.011	Worm
response to nutrient levels	GO:0031667	114	0.011
meiotic cell cycle phase transition	GO:0044771	4	0.011
photoreceptor cell fate commitment	GO:0046552	41	0.011
neuron projection guidance	GO:0097485	241	0.011
catechol containing compound metabolic process	GO:0009712	10	0.011
rna splicing	GO:0008380	83	0.011
biological adhesion	GO:0022610	138	0.011
striated muscle myosin thick filament assembly	GO:0071688	3	0.011
regulation of reproductive process	GO:2000241	54	0.011	Worm
response to organic cyclic compound	GO:0014070	89	0.011
regulation of hydrolase activity	GO:0051336	97	0.011
genitalia morphogenesis	GO:0035112	16	0.011
negative regulation of gene expression	GO:0010629	387	0.011
dna endoreduplication	GO:0042023	22	0.011
response to light stimulus	GO:0009416	124	0.011	Fly
compound eye photoreceptor cell differentiation	GO:0001751	140	0.011
multicellular organismal aging	GO:0010259	140	0.011	Worm
asymmetric neuroblast division	GO:0055059	33	0.011
signal transduction by phosphorylation	GO:0023014	107	0.010
positive regulation of cellular protein metabolic process	GO:0032270	118	0.010
regulation of cell substrate adhesion	GO:0010810	2	0.010
circadian rhythm	GO:0007623	105	0.010
regulation of mapk cascade	GO:0043408	92	0.010
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.010
spiracle morphogenesis open tracheal system	GO:0035277	22	0.010
detection of external stimulus	GO:0009581	66	0.010	Fly
axis elongation	GO:0003401	3	0.010
intracellular receptor signaling pathway	GO:0030522	19	0.010
imaginal disc derived wing vein specification	GO:0007474	48	0.010

inx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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