Drosophila melanogaster

117 known processes

E(spl) (Dmel_CG8365)

Enhancer of split

(Aliases: clone 1.71,l(3)96Fd,e(spl),Hes,E(spl)M8,Su(H)[[m8]],E(spl)-m8,m8,E(spl)bHLH,E(spl)m8,E(spl)-C,En(spl),HLHm8,En(spl)-C,E(spl) m8,CG8365,bHLHb36,anon-EST:Liang-1.71,M8,Dmel\CG8365)

E(spl) biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
sensory organ precursor cell fate determinationGO:0016360191.000
neuron fate determinationGO:004866411.000
Mouse
cell fate determination involved in pattern specificationGO:0060582191.000
formation of organ boundaryGO:0010160301.000
cell fate determinationGO:0001709911.000
sensory organ boundary specificationGO:0008052221.000
cell fate commitment involved in pattern specificationGO:0060581311.000
eye photoreceptor cell differentiationGO:00017541450.999
Fly
eye morphogenesisGO:00485922600.998
Fly
stem cell maintenanceGO:0019827670.998
Human Mouse Rat
r7 cell differentiationGO:0045466430.998
Fly
negative regulation of cellular biosynthetic processGO:00313272770.998
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.998
Mouse
compound eye morphogenesisGO:00017452490.998
Fly
compound eye developmentGO:00487493070.998
negative regulation of nucleic acid templated transcriptionGO:19035072400.998
head developmentGO:00603221350.997
Zebrafish Mouse Rat Fly
morphogenesis of an epitheliumGO:00020092760.997
Mouse
r1 r6 cell differentiationGO:004805240.996
Fly
organ formationGO:0048645390.996
forebrain developmentGO:003090020.996
Mouse Rat
brain developmentGO:00074201200.995
Zebrafish Mouse Rat Fly
positive regulation of bmp signaling pathwayGO:003051350.995
Mouse
nephron epithelium morphogenesisGO:007208830.995
Mouse
tube morphogenesisGO:00352391910.994
Mouse Fly
sensory organ morphogenesisGO:00905962600.994
Fly
positive regulation of transcription dna templatedGO:00458932660.994
Mouse
notch signaling pathwayGO:00072191200.993
Human Zebrafish Mouse Fly
regulation of cell differentiationGO:00455953020.993
Human Zebrafish Mouse Rat Fly
glial cell fate commitmentGO:002178130.993
Mouse
compound eye photoreceptor cell differentiationGO:00017511400.992
Fly
regulation of cell developmentGO:00602842150.991
Zebrafish Mouse Rat Fly
negative regulation of nitrogen compound metabolic processGO:00511722650.991
negative regulation of cell developmentGO:0010721620.991
Zebrafish Mouse Rat
tissue morphogenesisGO:00487292970.990
Mouse
negative regulation of rna biosynthetic processGO:19026792400.990
axon developmentGO:00615642970.989
Zebrafish
positive regulation of rna metabolic processGO:00512542710.989
Mouse
negative regulation of nucleobase containing compound metabolic processGO:00459342610.989
regulation of neural precursor cell proliferationGO:2000177350.989
Fly
formation of anatomical boundaryGO:0048859370.989
mesoderm developmentGO:0007498780.988
regulation of nervous system developmentGO:00519602480.988
Zebrafish Mouse Rat Fly
eye developmentGO:00016543230.986
negative regulation of gene expressionGO:00106293870.986
cranial nerve developmentGO:002154510.986
Mouse
regionalizationGO:00030024160.985
renal tubule morphogenesisGO:0061333440.984
Mouse
regulation of transcription from rna polymerase ii promoterGO:00063573780.984
nerve developmentGO:002167560.984
Mouse
regulation of mitosisGO:0007088560.984
Fly
regulation of notch signaling pathwayGO:00085931000.984
Mouse
gliogenesisGO:0042063800.983
Zebrafish Mouse Rat
renal system developmentGO:0072001720.982
Mouse
regulation of glial cell differentiationGO:004568510.982
Mouse
glial cell differentiationGO:0010001350.981
Mouse Rat
negative regulation of transcription dna templatedGO:00458922370.978
negative regulation of rna metabolic processGO:00512532510.975
renal tubule developmentGO:0061326640.975
Mouse
neuroblast proliferationGO:0007405740.974
Fly
dosage compensationGO:0007549160.974
Fly
chaeta morphogenesisGO:0008407420.971
kidney epithelium developmentGO:007207330.970
Mouse
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.970
axonogenesisGO:00074092900.970
Zebrafish
negative regulation of macromolecule biosynthetic processGO:00105582700.970
regulation of timing of cell differentiationGO:004850510.968
Mouse
regulation of gliogenesisGO:0014013110.966
Mouse
glial cell developmentGO:0021782270.966
Mouse
primary sex determination somaGO:000753920.965
Fly
positive regulation of developmental processGO:00510941430.964
Fly
negative regulation of stem cell differentiationGO:200073780.964
Human
rhythmic processGO:00485111060.964
Mouse
positive regulation of rna biosynthetic processGO:19026802660.962
Mouse
telencephalon developmentGO:002153720.961
Mouse
nephron developmentGO:007200630.960
Mouse
stem cell fate commitmentGO:0048865250.959
epidermal cell differentiationGO:0009913510.958
Mouse Worm
malpighian tubule morphogenesisGO:0007443440.956
regulation of neuroblast proliferationGO:1902692340.955
Fly
cell fate specificationGO:0001708710.952
Worm
tube developmentGO:00352952440.952
Zebrafish Mouse Fly
negative regulation of cellular metabolic processGO:00313243820.952
central nervous system developmentGO:00074172010.951
Zebrafish Mouse Rat Fly
stem cell proliferationGO:0072089880.951
Fly
positive regulation of nucleic acid templated transcriptionGO:19035082660.950
Mouse
negative regulation of multicellular organismal processGO:00512411420.950
Zebrafish Mouse Rat
columnar cuboidal epithelial cell differentiationGO:00020652560.949
cell divisionGO:00513012480.947
Fly
negative regulation of biosynthetic processGO:00098902770.947
locomotory behaviorGO:00076261760.946
Fly
embryonic hindgut morphogenesisGO:0048619480.943
dendrite morphogenesisGO:00488131990.942
regulation of neuron differentiationGO:00456641030.942
Mouse Rat
hair cell differentiationGO:0035315470.939
Mouse
regulation of neurogenesisGO:00507671580.939
Zebrafish Mouse Rat Fly
positive regulation of macromolecule metabolic processGO:00106044050.937
Zebrafish Mouse
sex determinationGO:0007530180.936
Fly
dendrite developmentGO:00163582040.935
epidermis developmentGO:0008544650.933
Mouse Worm
regulation of cell morphogenesisGO:00226041630.932
photoreceptor cell differentiationGO:00465301700.932
Fly
bolwig s organ developmentGO:005503480.931
kidney morphogenesisGO:006099330.931
Mouse
regulation of stem cell differentiationGO:2000736140.929
Human
eye photoreceptor cell fate commitmentGO:0042706370.924
negative regulation of nervous system developmentGO:0051961920.922
Zebrafish Mouse Rat
kidney developmentGO:000182230.921
Mouse
gland morphogenesisGO:00226121450.918
Fly
negative regulation of cell differentiationGO:00455961430.917
Human Zebrafish Mouse Rat
exocrine system developmentGO:00352721620.916
Fly
camera type eye developmentGO:004301040.915
Mouse
regulation of hematopoietic progenitor cell differentiationGO:190153210.913
Rat
regulation of gene expression epigeneticGO:00400291280.908
Fly
positive regulation of cellular biosynthetic processGO:00313283160.908
Mouse
negative regulation of gliogenesisGO:001401460.906
Mouse
regulation of tyrosine phosphorylation of stat proteinGO:004250910.904
Mouse
epithelial tube morphogenesisGO:0060562880.901
Mouse
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.899
positive regulation of macromolecule biosynthetic processGO:00105572830.899
Mouse
gland developmentGO:00487321910.893
Fly
mitotic nuclear divisionGO:00070672130.886
Fly
positive regulation of cell proliferationGO:0008284470.885
Human Fly
hindbrain developmentGO:003090220.884
Mouse
neuroepithelial cell differentiationGO:006056360.884
neuron fate commitmentGO:0048663500.882
Mouse
positive regulation of neurogenesisGO:0050769410.879
Fly
neuronal stem cell maintenanceGO:009715040.878
Human Mouse Rat
organelle fissionGO:00482853400.874
Fly
regulation of multicellular organismal developmentGO:20000264140.874
Zebrafish Mouse Rat Fly
neuroblast fate specificationGO:001401820.873
nephron tubule morphogenesisGO:007207830.870
Mouse
positive regulation of nitrogen compound metabolic processGO:00511733540.868
Mouse
cell maturationGO:00484691440.867
Mouse
neuron projection guidanceGO:00974852410.867
nephron epithelium developmentGO:007200930.864
Mouse
neuron fate specificationGO:0048665120.862
protein complex assemblyGO:00064612000.860
Mouse
regulation of cellular ketone metabolic processGO:001056530.860
biological adhesionGO:00226101380.856
Mouse
regulation of mitotic cell cycleGO:00073461900.853
Fly
stem cell fate specificationGO:004886620.845
hindgut morphogenesisGO:0007442580.844
regulation of glial cell proliferationGO:0060251110.841
positive regulation of cellular amino acid metabolic processGO:004576400.838
negative regulation of developmental processGO:00510932010.836
Human Zebrafish Mouse Rat
positive regulation of neural precursor cell proliferationGO:200017980.836
Fly
nuclear divisionGO:00002803320.836
Fly
cellular response to dna damage stimulusGO:00069742230.831
Fly
immune system processGO:00023763470.830
Rat
respiratory system developmentGO:00605412130.829
Fly
regulation of stem cell proliferationGO:0072091400.826
Fly
positive regulation of biosynthetic processGO:00098913160.823
Mouse
regulation of cell morphogenesis involved in differentiationGO:0010769610.822
salivary gland developmentGO:00074311620.819
Fly
epithelial cell differentiationGO:00308553220.818
Mouse Worm
regulation of bmp signaling pathwayGO:0030510230.796
Mouse
positive regulation of nervous system developmentGO:0051962690.793
Fly
neuroblast fate determinationGO:0007400120.793
compound eye photoreceptor fate commitmentGO:0001752360.790
axon ensheathment in central nervous systemGO:003229130.788
Mouse
neural precursor cell proliferationGO:0061351750.785
Fly
nephron tubule formationGO:007207930.779
Mouse
nephron morphogenesisGO:007202830.777
Mouse
nephron tubule developmentGO:007208030.774
Mouse
chaeta developmentGO:0022416970.770
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.766
Mouse
cellular protein modification processGO:00064644380.764
Zebrafish Mouse
sex determination establishment of x a ratioGO:000754010.757
Fly
somatic sex determinationGO:001899320.747
Fly
bolwig s organ morphogenesisGO:000174680.730
negative regulation of notch signaling pathwayGO:0045746410.730
positive regulation of cell developmentGO:0010720610.713
Fly
urogenital system developmentGO:0001655720.709
Mouse
digestive tract morphogenesisGO:00485461270.707
embryonic organ developmentGO:0048568500.705
Zebrafish
regulation of axonogenesisGO:0050770320.692
morphogenesis of embryonic epitheliumGO:0016331940.691
Mouse
positive regulation of cellular amine metabolic processGO:003324000.691
neuroblast fate commitmentGO:0014017190.689
epithelial cell proliferation involved in malpighian tubule morphogenesisGO:0061331110.687
skin developmentGO:0043588650.677
Mouse Worm
segment specificationGO:0007379330.674
Zebrafish Mouse
positive regulation of gene expressionGO:00106282900.673
Mouse
regulation of cell proliferationGO:00421271630.672
Human Fly
transcription from rna polymerase ii promoterGO:00063663680.669
brain morphogenesisGO:0048854160.668
Fly
lateral inhibitionGO:00463312060.662
startle responseGO:0001964160.659
Fly
protein phosphorylationGO:00064681690.656
Zebrafish Mouse
regulation of cellular protein metabolic processGO:00322682430.653
Zebrafish Mouse
protein modification processGO:00362114380.650
Zebrafish Mouse
stem cell developmentGO:0048864790.646
Human Mouse Rat
connective tissue developmentGO:006144830.644
Human Mouse
imaginal disc pattern formationGO:0007447910.642
Fly
positive regulation of neuroblast proliferationGO:000205270.638
Fly
protein complex biogenesisGO:00702712010.636
Mouse
central nervous system neuron differentiationGO:002195380.629
Rat
bmp signaling pathwayGO:0030509270.622
Mouse
regulation of axon guidanceGO:1902667100.620
peripheral nervous system neuron differentiationGO:004893480.619
Zebrafish
positive regulation of cellular protein metabolic processGO:00322701180.616
Zebrafish Mouse
regulation of peptidyl tyrosine phosphorylationGO:0050730100.613
Mouse
positive regulation of notch signaling pathwayGO:0045747340.594
Mouse
positive regulation of multicellular organismal processGO:00512401430.590
Fly
negative regulation of glial cell proliferationGO:006025360.587
tyrosine phosphorylation of stat proteinGO:000726010.573
Mouse
regulation of axon extension involved in axon guidanceGO:004884140.571
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010090.569
Mouse
regulation of organelle organizationGO:00330431960.568
Fly
segmentationGO:00352822070.561
Zebrafish Mouse
dorsal ventral pattern formationGO:00099531330.561
Fly
positive regulation of neuron differentiationGO:0045666260.557
positive regulation of nucleobase containing compound metabolic processGO:00459353320.555
Mouse
localization of cellGO:00516742570.555
regulation of cell divisionGO:0051302720.553
Fly
regulation of cellular amine metabolic processGO:003323830.551
salivary gland morphogenesisGO:00074351450.550
Fly
hematopoietic progenitor cell differentiationGO:000224410.549
Rat
regulation of response to dna damage stimulusGO:2001020230.543
Fly
compound eye cone cell fate commitmentGO:004267650.538
response to organic substanceGO:00100332840.537
negative regulation of neurogenesisGO:0050768530.536
Zebrafish Mouse Rat
regulation of cyclin dependent protein serine threonine kinase activityGO:000007930.531
Zebrafish
stem cell fate determinationGO:0048867150.530
enzyme linked receptor protein signaling pathwayGO:00071671790.529
Mouse
cellular amine metabolic processGO:0044106120.525
negative regulation of immune system processGO:0002683500.517
Rat
positive regulation of cell differentiationGO:0045597640.512
Fly
cellular amino acid metabolic processGO:0006520610.507
regulation of neuron projection developmentGO:0010975690.504
regulation of epithelial cell differentiationGO:003085640.501
regulation of protein metabolic processGO:00512462560.499
Zebrafish Mouse
positive regulation of response to stimulusGO:00485843230.485
Mouse
circadian rhythmGO:00076231050.485
regulation of phosphate metabolic processGO:00192202100.484
Zebrafish Mouse
cell proliferationGO:00082832990.481
Human Fly
regulation of cell cycleGO:00517262910.476
Zebrafish Fly
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.476
Mouse
macromolecular complex assemblyGO:00650032560.475
Mouse
positive regulation of cell cycleGO:0045787430.470
Zebrafish Fly
organonitrogen compound metabolic processGO:19015643180.470
courtship behaviorGO:0007619680.468
regulation of cellular amino acid metabolic processGO:000652100.467
hematopoietic or lymphoid organ developmentGO:0048534570.463
Rat
oenocyte developmentGO:000743880.463
regulation of nuclear divisionGO:0051783580.454
Fly
stem cell differentiationGO:00488631170.448
Human Mouse Rat
proximal distal pattern formationGO:0009954150.439
Mouse
cell deathGO:00082192790.434
axon guidanceGO:00074112330.422
cellular ketone metabolic processGO:0042180240.422
response to abiotic stimulusGO:00096283410.421
Fly
cell fate commitment involved in formation of primary germ layerGO:0060795100.419
humoral immune responseGO:00069591170.417
r8 cell fate commitmentGO:000746060.414
anterior posterior pattern specificationGO:00099521360.412
Zebrafish Mouse Worm
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.407
Mouse
adult behaviorGO:00305341370.406
Fly
neuroblast differentiationGO:0014016290.406
regulation of cell cycle processGO:00105641810.405
Fly
peripheral nervous system neuron developmentGO:004893580.400
Zebrafish
glial cell proliferationGO:0014009130.399
regulation of protein modification processGO:00313991120.392
Zebrafish Mouse
embryonic morphogenesisGO:00485982060.379
Zebrafish Mouse
digestive system developmentGO:00551231490.378
cell cell signaling involved in cell fate commitmentGO:00451682100.370
axon extension involved in axon guidanceGO:0048846100.366
positive regulation of cellular component organizationGO:00511301560.360
Fly
peptidyl tyrosine phosphorylationGO:0018108240.356
Mouse
epithelial cell developmentGO:00020642740.355
regulation of axon extensionGO:003051680.355
locomotor rhythmGO:0045475560.352
response to external biotic stimulusGO:00432072930.352
smoothened signaling pathwayGO:0007224490.351
Mouse
response to hypoxiaGO:0001666530.347
Fly
positive regulation of stem cell proliferationGO:200064880.347
Fly
immune responseGO:00069552460.346
positive regulation of protein metabolic processGO:00512471280.341
Zebrafish Mouse
neuron projection extensionGO:1990138320.337
epithelial cell proliferation involved in renal tubule morphogenesisGO:2001013110.333
regulation of anatomical structure morphogenesisGO:00226032420.333
Mouse
positive regulation of signal transductionGO:00099672230.332
Mouse
cell adhesionGO:00071551360.327
Mouse
larval behaviorGO:0030537420.325
Fly
wing disc pattern formationGO:0035222660.323
Fly
epithelial tube formationGO:007217570.318
Mouse
immune system developmentGO:0002520570.317
Rat
positive regulation of molecular functionGO:00440931360.317
Zebrafish
regulation of phosphorylationGO:00423251470.317
Zebrafish Mouse
mesodermal cell differentiationGO:004833370.316
chromosome organizationGO:00512763600.310
amine metabolic processGO:0009308120.306
embryonic epithelial tube formationGO:000183860.306
Mouse
developmental maturationGO:00217001720.300
Mouse
somatic stem cell maintenanceGO:0035019140.299
hemopoiesisGO:0030097460.296
Rat
regulation of immune system processGO:00026821760.293
Rat
regulation of localizationGO:00328792750.292
single organism behaviorGO:00447083910.289
Fly
peripheral nervous system developmentGO:0007422520.287
Zebrafish
transmission of nerve impulseGO:0019226120.287
Mouse
formation of primary germ layerGO:0001704240.285
small molecule metabolic processGO:00442813050.281
compound eye cone cell differentiationGO:0042675130.278
central nervous system neuron developmentGO:002195480.277
mesodermal cell fate commitmentGO:000171070.276
negative regulation of cell cycle processGO:00109481090.268
intracellular signal transductionGO:00355563000.268
Mouse
photoreceptor cell fate commitmentGO:0046552410.263
glandular epithelial cell differentiationGO:000206710.262
wing disc dorsal ventral pattern formationGO:0048190470.255
Fly
neuromuscular processGO:0050905210.255
Fly
actin cytoskeleton organizationGO:00300362060.251
negative regulation of neuron differentiationGO:0045665160.248
Mouse Rat
morphogenesis of a polarized epitheliumGO:0001738930.246
medulla oblongata developmentGO:002155020.244
chromatin organizationGO:00063252070.244
spinal cord patterningGO:002151110.241
response to growth factorGO:0070848310.239
taxisGO:00423303040.238
gastrulation involving germ band extensionGO:0010004360.234
oxoacid metabolic processGO:00434361030.232
regulation of protein phosphorylationGO:0001932640.231
Zebrafish Mouse
larval developmentGO:00021641040.228
regulation of phosphorus metabolic processGO:00511742100.228
Zebrafish Mouse
appendage developmentGO:00487364010.224
carboxylic acid metabolic processGO:0019752920.223
regulation of molecular functionGO:00650092170.221
Zebrafish
embryonic organ morphogenesisGO:004856250.220
Zebrafish
spinal cord developmentGO:002151010.219
open tracheal system developmentGO:00074242040.219
Fly
cell migrationGO:00164772380.217
negative regulation of cell proliferationGO:0008285690.217
regulation of cell projection organizationGO:0031344920.216
regulation of intracellular signal transductionGO:19025312360.216
Mouse
negative regulation of signalingGO:00230572190.207
cellular response to chemical stimulusGO:00708871990.205
camera type eye photoreceptor cell differentiationGO:006021920.204
organic acid metabolic processGO:00060821030.204
regulation of epidermal cell differentiationGO:004560430.203
camera type eye morphogenesisGO:004859320.203
tube formationGO:0035148210.203
Mouse
negative regulation of signal transductionGO:00099682060.200
jak stat cascadeGO:0007259490.200
Mouse
cellular response to organic substanceGO:00713101320.197
actin filament based processGO:00300292200.196
negative regulation of programmed cell deathGO:0043069720.195
peptidyl amino acid modificationGO:00181931050.191
Mouse
positive regulation of signalingGO:00230562430.186
Mouse
developmental cell growthGO:0048588520.185
neuron migrationGO:000176450.183
regulation of cell sizeGO:0008361630.182
apoptotic processGO:00069151590.182
positive regulation of mitotic cell cycleGO:0045931340.181
Fly
neural retina developmentGO:000340740.180
multi organism behaviorGO:00517051750.177
adult locomotory behaviorGO:0008344760.176
Fly
deathGO:00162652840.175
regulation of compound eye cone cell fate specificationGO:004268240.174
regulation of dendrite morphogenesisGO:0048814280.163
regulation of catalytic activityGO:00507901850.162
Zebrafish
appendage morphogenesisGO:00351073970.161
peptidyl tyrosine modificationGO:0018212240.160
Mouse
mesenchymal cell differentiationGO:004876210.158
retinal cone cell differentiationGO:004267020.158
mesoderm morphogenesisGO:0048332220.157
immune effector processGO:0002252980.155
retina morphogenesis in camera type eyeGO:006004220.154
regulation of response to external stimulusGO:00321011150.153
regulation of cellular response to stressGO:0080135890.152
Fly
malpighian tubule tip cell differentiationGO:006138290.152
muscle cell differentiationGO:00426921030.147
neurological system processGO:00508773580.145
Mouse Fly
spinal cord dorsal ventral patterningGO:002151310.145
response to biotic stimulusGO:00096072940.143
larval locomotory behaviorGO:0008345270.143
Fly
developmental growthGO:00485892800.142
sensory perception of soundGO:0007605560.141
regulation of cellular component movementGO:0051270420.141
antennal developmentGO:0007469250.141
negative regulation of cellular component organizationGO:00511291080.140
epithelial cell proliferationGO:0050673150.140
regulation of muscle organ developmentGO:0048634130.139
growthGO:00400073590.138
gastrulation with mouth forming firstGO:0001703360.138
defense responseGO:00069523000.136
regulation of growthGO:00400082330.135
gastrulationGO:0007369700.135
programmed cell deathGO:00125012570.133
positive regulation of organelle organizationGO:0010638650.131
Fly
positive regulation of protein modification processGO:0031401580.130
Zebrafish Mouse
positive regulation of cell divisionGO:0051781160.129
Fly
eye antennal disc developmentGO:0035214600.128
muscle organ developmentGO:00075171270.127
male courtship behavior veined wing generated song productionGO:0045433200.124
negative regulation of cell communicationGO:00106482230.121
positive regulation of intracellular signal transductionGO:19025331160.120
Mouse
phosphorylationGO:00163102940.120
Zebrafish Mouse
dorsal ventral pattern formation imaginal discGO:0007450510.119
Fly
digestive tract developmentGO:00485651490.119
imaginal disc derived appendage morphogenesisGO:00351143950.117
positive regulation of protein serine threonine kinase activityGO:0071902150.117
Zebrafish
regulation of ovipositionGO:0046662140.116
aggressive behaviorGO:0002118630.116
negative regulation of mitotic cell cycleGO:00459301090.115
regulation of protein kinase activityGO:0045859510.115
Zebrafish
antennal joint developmentGO:004809850.114
regulation of developmental growthGO:00486381740.112
response to other organismGO:00517072930.110
positive regulation of cell communicationGO:00106472500.109
Mouse
regulation of cell fate specificationGO:0042659270.108
neuronal action potentialGO:0019228100.106
Mouse
cell growthGO:00160491080.105
negative regulation of cell deathGO:0060548810.105
body morphogenesisGO:001017120.103
regulation of kinase activityGO:0043549530.103
Zebrafish
muscle structure developmentGO:00610612240.103
multi organism reproductive behaviorGO:00447051210.103
regulation of transferase activityGO:0051338580.102
Zebrafish
male courtship behavior veined wing extensionGO:0048065220.101
establishment of tissue polarityGO:0007164870.100
apoptotic process involved in morphogenesisGO:006056130.100
imaginal disc derived appendage developmentGO:00487373990.099
establishment of planar polarityGO:0001736870.098
mesoderm formationGO:0001707210.097
response to decreased oxygen levelsGO:0036293580.096
Fly
neuron apoptotic processGO:0051402170.095
cellular response to endogenous stimulusGO:0071495800.094
ensheathment of neuronsGO:0007272100.094
Mouse
muscle cell developmentGO:0055001500.093
circadian behaviorGO:0048512760.092
negative regulation of cell cycleGO:00457861160.091
regulation of behaviorGO:0050795750.090
positive regulation of phosphate metabolic processGO:00459371390.089
Zebrafish Mouse
oenocyte differentiationGO:000174280.089
response to endogenous stimulusGO:00097191190.089
regulation of programmed cell deathGO:00430671520.088
regulation of response to stressGO:00801342000.086
Fly
regulation of organ morphogenesisGO:2000027780.086
limb developmentGO:006017310.085
response to woundingGO:0009611940.085
rhythmic behaviorGO:0007622760.084
axon extensionGO:0048675320.084
mesodermal cell fate specificationGO:000750120.084
regulation of r7 cell differentiationGO:0045676150.083
regulation of extent of cell growthGO:006138780.082
retina development in camera type eyeGO:006004140.079
positive regulation of kinase activityGO:0033674250.079
Zebrafish
regulation of immune effector processGO:0002697520.078
cell motilityGO:00488702510.077
positive regulation of epithelial cell differentiationGO:003085810.076
positive regulation of phosphorylationGO:0042327870.075
Zebrafish Mouse
positive regulation of catalytic activityGO:00430851180.075
Zebrafish
response to oxygen levelsGO:0070482590.073
Fly
positive regulation of gliogenesisGO:001401550.073
cell type specific apoptotic processGO:0097285380.071
negative regulation of cell divisionGO:0051782170.070
antimicrobial humoral responseGO:0019730990.069
regulation of antimicrobial peptide biosynthetic processGO:0002805380.069
regulation of cell deathGO:00109411730.068
adult chitin based cuticle pattern formationGO:003501810.068
establishment of ommatidial planar polarityGO:0042067490.068
positive regulation of protein phosphorylationGO:0001934340.067
Zebrafish Mouse
regulation of immune responseGO:00507761180.067
neuron projection extension involved in neuron projection guidanceGO:1902284100.067
malpighian tubule developmentGO:0072002640.067
renal filtration cell differentiationGO:0061318120.065
positive regulation of transferase activityGO:0051347260.063
Zebrafish
developmental growth involved in morphogenesisGO:0060560650.063
imaginal disc derived wing vein specificationGO:0007474480.063
negative regulation of organelle organizationGO:0010639560.062
regenerationGO:0031099160.062
cell recognitionGO:00080371020.060
striated muscle cell differentiationGO:0051146900.059
r8 cell differentiationGO:0045465130.059
multicellular organismal reproductive behaviorGO:00330571100.058
positive regulation of cell cycle processGO:0090068280.057
Fly
male courtship behavior veined wing vibrationGO:0016545210.056
peptide metabolic processGO:0006518800.054
regulation of reproductive processGO:2000241540.053
mesenchymal cell developmentGO:001403110.053
striated muscle tissue developmentGO:0014706270.052
cellular response to growth factor stimulusGO:0071363300.051
regulation of chemotaxisGO:0050920120.051
ommatidial rotationGO:0016318200.051
regulation of cellular amide metabolic processGO:0034248390.051
regulation of cellular component sizeGO:0032535980.050
adult chitin based cuticle developmentGO:000836520.049
wing disc morphogenesisGO:00074723440.049
positive regulation of protein kinase activityGO:0045860250.049
Zebrafish
chemotaxisGO:00069352490.048

E(spl) disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.974
Human
spondylocostal dysostosisDOID:005056800.974
Human
bone development diseaseDOID:008000600.974
Human
bone diseaseDOID:008000100.974
Human
disease of anatomical entityDOID:700.974
Human
connective tissue diseaseDOID:6500.974
Human
dysostosisDOID:193400.974
Human