IMP: Integrative Multi-species Prediction

Drosophila melanogaster

44 known processes

Act88F (Dmel_CG5178)

Actin 88F

(Aliases: E,CG5178,Dmel\CG5178,act88F,Ifm(3)7,Act(88F),rsd,Act88-F,Actin,act 88F,actin,Act88f)

Entrez: 41885
FLYBASE: FBgn0000047
UniProtKB: P83967
UniProtKB: B6IDW7

Process Predictions
Disease Predictions

Act88F biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
sarcomere organization	GO:0045214	26	0.988
myofibril assembly	GO:0030239	36	0.971
actin filament based process	GO:0030029	220	0.904
muscle cell development	GO:0055001	50	0.833
muscle cell differentiation	GO:0042692	103	0.821
actomyosin structure organization	GO:0031032	56	0.819
striated muscle cell development	GO:0055002	50	0.794
cellular component assembly involved in morphogenesis	GO:0010927	151	0.793
striated muscle cell differentiation	GO:0051146	90	0.785
muscle structure development	GO:0061061	224	0.635
somatic muscle development	GO:0007525	66	0.609
organelle assembly	GO:0070925	198	0.604
adult behavior	GO:0030534	137	0.535
adult somatic muscle development	GO:0007527	14	0.453
actin cytoskeleton organization	GO:0030036	206	0.424
eye development	GO:0001654	323	0.421
locomotory behavior	GO:0007626	176	0.378
protein complex assembly	GO:0006461	200	0.360
striated muscle myosin thick filament assembly	GO:0071688	3	0.352
muscle system process	GO:0003012	21	0.313
actin filament organization	GO:0007015	126	0.279
actin mediated cell contraction	GO:0070252	21	0.265
camera type eye development	GO:0043010	4	0.228
cellular protein complex assembly	GO:0043623	71	0.210
carbohydrate derivative metabolic process	GO:1901135	217	0.200
regulation of cellular component biogenesis	GO:0044087	201	0.199
muscle organ development	GO:0007517	127	0.188
nucleoside catabolic process	GO:0009164	112	0.178
imaginal disc derived appendage development	GO:0048737	399	0.175
muscle tissue morphogenesis	GO:0060415	2	0.175
macromolecular complex assembly	GO:0065003	256	0.167
regulation of actin cytoskeleton organization	GO:0032956	42	0.156
regionalization	GO:0003002	416	0.156
cytoskeleton dependent cytokinesis	GO:0061640	81	0.153
organophosphate metabolic process	GO:0019637	195	0.147
adult locomotory behavior	GO:0008344	76	0.135
regulation of actin filament depolymerization	GO:0030834	3	0.135
skeletal muscle adaptation	GO:0043501	1	0.132
skeletal muscle myosin thick filament assembly	GO:0030241	3	0.130
muscle contraction	GO:0006936	13	0.128
response to organophosphorus	GO:0046683	2	0.125
establishment of nucleus localization	GO:0040023	26	0.122
glycerol 3 phosphate metabolic process	GO:0006072	2	0.121
regulation of phosphate metabolic process	GO:0019220	210	0.121
appendage morphogenesis	GO:0035107	397	0.119
flight behavior	GO:0007629	26	0.119
wing disc morphogenesis	GO:0007472	344	0.117
glycosyl compound metabolic process	GO:1901657	127	0.117
post embryonic appendage morphogenesis	GO:0035120	385	0.117
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.117
alditol phosphate metabolic process	GO:0052646	2	0.113
protein complex biogenesis	GO:0070271	201	0.113
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.106
actin filament based movement	GO:0030048	26	0.106
regulation of anatomical structure size	GO:0090066	163	0.106
tissue morphogenesis	GO:0048729	297	0.105
cell motility	GO:0048870	251	0.104
establishment of localization in cell	GO:0051649	402	0.104
myotube cell development	GO:0014904	3	0.101
circulatory system process	GO:0003013	37	0.098
muscle tissue development	GO:0060537	30	0.096
response to reactive oxygen species	GO:0000302	24	0.096
nucleoside triphosphate catabolic process	GO:0009143	108	0.093
cellular catabolic process	GO:0044248	372	0.091
digestive system development	GO:0055123	149	0.088
epithelial cell development	GO:0002064	274	0.088
appendage development	GO:0048736	401	0.087
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.087
visceral muscle development	GO:0007522	14	0.086
cellular macromolecular complex assembly	GO:0034622	153	0.085
circulatory system development	GO:0072359	82	0.084
ribonucleoside metabolic process	GO:0009119	127	0.084
nucleobase containing small molecule metabolic process	GO:0055086	174	0.083
purine nucleoside metabolic process	GO:0042278	127	0.083
mesoderm development	GO:0007498	78	0.083
heart development	GO:0007507	82	0.083
myosin filament assembly	GO:0031034	5	0.082
positive regulation of catabolic process	GO:0009896	105	0.081
cell proliferation	GO:0008283	299	0.081
localization of cell	GO:0051674	257	0.080
organic substance catabolic process	GO:1901575	308	0.080
nucleoside monophosphate catabolic process	GO:0009125	39	0.080
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.075
response to oxygen containing compound	GO:1901700	200	0.075
ribose phosphate metabolic process	GO:0019693	145	0.075
regulation of cellular catabolic process	GO:0031329	157	0.075
imaginal disc derived wing hair organization	GO:0035317	45	0.075
axon development	GO:0061564	297	0.074
protein modification process	GO:0036211	438	0.074
organonitrogen compound metabolic process	GO:1901564	318	0.073
regulation of cytoskeleton organization	GO:0051493	89	0.072
carbohydrate derivative catabolic process	GO:1901136	118	0.071
musculoskeletal movement	GO:0050881	3	0.070
cellular protein modification process	GO:0006464	438	0.070
regulation of actin filament based process	GO:0032970	42	0.069
nucleus localization	GO:0051647	34	0.069
body morphogenesis	GO:0010171	2	0.065
regulation of protein complex disassembly	GO:0043244	29	0.065
regulation of multicellular organismal development	GO:2000026	414	0.062
regulation of cell death	GO:0010941	173	0.062
purine nucleotide metabolic process	GO:0006163	146	0.062
regulation of organelle organization	GO:0033043	196	0.062
purine containing compound metabolic process	GO:0072521	155	0.061
negative regulation of actin filament depolymerization	GO:0030835	2	0.061
purine nucleoside catabolic process	GO:0006152	112	0.061
intracellular transport	GO:0046907	228	0.061
muscle attachment	GO:0016203	36	0.060
organophosphate catabolic process	GO:0046434	112	0.059
regulation of catabolic process	GO:0009894	170	0.059
purine nucleotide catabolic process	GO:0006195	109	0.058
ribonucleoside catabolic process	GO:0042454	112	0.058
glycosyl compound catabolic process	GO:1901658	112	0.058
regulation of system process	GO:0044057	36	0.058
cardiac muscle tissue development	GO:0048738	9	0.057
regulation of apoptotic process	GO:0042981	130	0.057
purine containing compound catabolic process	GO:0072523	112	0.056
organelle fission	GO:0048285	340	0.056
purine ribonucleoside metabolic process	GO:0046128	127	0.055
cell death	GO:0008219	279	0.055
nucleotide catabolic process	GO:0009166	109	0.054
central nervous system development	GO:0007417	201	0.054
negative regulation of cellular metabolic process	GO:0031324	382	0.054
striated muscle tissue development	GO:0014706	27	0.054
intracellular signal transduction	GO:0035556	300	0.054
nucleoside monophosphate metabolic process	GO:0009123	52	0.053
cytokinesis	GO:0000910	90	0.053
tube morphogenesis	GO:0035239	191	0.052
negative regulation of gene expression	GO:0010629	387	0.052
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.052
heart process	GO:0003015	37	0.052
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.052
regulation of nucleoside metabolic process	GO:0009118	50	0.051
tube development	GO:0035295	244	0.051
muscle organ morphogenesis	GO:0048644	7	0.050
regulation of cell proliferation	GO:0042127	163	0.050
growth	GO:0040007	359	0.050
positive regulation of phosphate metabolic process	GO:0045937	139	0.050
cell migration	GO:0016477	238	0.050
skeletal muscle organ development	GO:0060538	48	0.049
embryonic morphogenesis	GO:0048598	206	0.049
regulation of programmed cell death	GO:0043067	152	0.049
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.048
open tracheal system development	GO:0007424	204	0.047
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.046
nucleoside triphosphate metabolic process	GO:0009141	120	0.046
homeostatic process	GO:0042592	199	0.045
positive regulation of catalytic activity	GO:0043085	118	0.045
positive regulation of nucleoside metabolic process	GO:0045979	47	0.045
digestive tract development	GO:0048565	149	0.045
striated muscle contraction	GO:0006941	5	0.045
apoptotic process	GO:0006915	159	0.045
regulation of heart rate	GO:0002027	11	0.044
mitotic cytokinesis	GO:0000281	50	0.044
brain development	GO:0007420	120	0.044
larval somatic muscle development	GO:0007526	19	0.044
ribonucleotide catabolic process	GO:0009261	109	0.043
single organism intracellular transport	GO:1902582	207	0.043
death	GO:0016265	284	0.042
nucleoside phosphate metabolic process	GO:0006753	162	0.042
cardiovascular system development	GO:0072358	82	0.042
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.042
purine ribonucleotide metabolic process	GO:0009150	145	0.041
positive regulation of cellular catabolic process	GO:0031331	95	0.041
apical constriction	GO:0003383	18	0.040
positive regulation of phosphorus metabolic process	GO:0010562	139	0.040
actin filament depolymerization	GO:0030042	5	0.040
nucleotide metabolic process	GO:0009117	161	0.040
cellular protein complex disassembly	GO:0043624	35	0.040
neuron recognition	GO:0008038	101	0.040
heterocycle catabolic process	GO:0046700	166	0.040
head development	GO:0060322	135	0.039
wound healing	GO:0042060	75	0.039
cell division	GO:0051301	248	0.039
regulation of phosphorus metabolic process	GO:0051174	210	0.038
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.037
macromolecular complex disassembly	GO:0032984	37	0.037
positive regulation of molecular function	GO:0044093	136	0.037
striated muscle adaptation	GO:0014888	1	0.036
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.036
organonitrogen compound catabolic process	GO:1901565	128	0.036
reactive oxygen species metabolic process	GO:0072593	22	0.036
regulation of cellular component movement	GO:0051270	42	0.035
regulation of tube architecture open tracheal system	GO:0035152	68	0.035
positive regulation of cellular component biogenesis	GO:0044089	80	0.035
regulation of actin filament length	GO:0030832	27	0.035
cell projection assembly	GO:0030031	94	0.035
regulation of purine nucleotide metabolic process	GO:1900542	62	0.035
multicellular organismal movement	GO:0050879	3	0.034
carbohydrate metabolic process	GO:0005975	82	0.034
neurological system process	GO:0050877	358	0.034
cellular nitrogen compound catabolic process	GO:0044270	165	0.034
regulation of protein complex assembly	GO:0043254	42	0.034
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.034
programmed cell death	GO:0012501	257	0.034
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.034
negative regulation of apoptotic process	GO:0043066	63	0.033
electron transport chain	GO:0022900	14	0.033
aromatic compound catabolic process	GO:0019439	166	0.033
regulation of cell development	GO:0060284	215	0.032
epithelial cell differentiation	GO:0030855	322	0.032
cation homeostasis	GO:0055080	51	0.032
negative regulation of cytoskeleton organization	GO:0051494	30	0.032
regulation of cell substrate adhesion	GO:0010810	2	0.032
phosphorylation	GO:0016310	294	0.031
energy derivation by oxidation of organic compounds	GO:0015980	32	0.031
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.031
embryo development ending in birth or egg hatching	GO:0009792	152	0.031
digestive tract morphogenesis	GO:0048546	127	0.030
multi organism behavior	GO:0051705	175	0.030
regulation of catalytic activity	GO:0050790	185	0.030
tissue migration	GO:0090130	155	0.030
non sensory hair organization	GO:0035316	47	0.029
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.029
biological adhesion	GO:0022610	138	0.029
regulation of localization	GO:0032879	275	0.029
single organism membrane organization	GO:0044802	93	0.029
vesicle mediated transport	GO:0016192	381	0.029
cellular respiration	GO:0045333	26	0.029
nucleobase containing compound catabolic process	GO:0034655	165	0.028
positive regulation of nucleotide catabolic process	GO:0030813	46	0.028
negative regulation of molecular function	GO:0044092	51	0.028
organelle localization	GO:0051640	148	0.028
nucleoside phosphate catabolic process	GO:1901292	110	0.028
respiratory system development	GO:0060541	213	0.028
myosin filament organization	GO:0031033	5	0.028
regulation of hydrolase activity	GO:0051336	97	0.028
regulation of cell differentiation	GO:0045595	302	0.028
catabolic process	GO:0009056	409	0.027
organic cyclic compound catabolic process	GO:1901361	168	0.027
response to hypoxia	GO:0001666	53	0.027
ameboidal type cell migration	GO:0001667	151	0.027
regulation of anatomical structure morphogenesis	GO:0022603	242	0.026
nucleoside metabolic process	GO:0009116	127	0.026
columnar cuboidal epithelial cell development	GO:0002066	249	0.026
protein polymerization	GO:0051258	42	0.026
regulation of muscle contraction	GO:0006937	5	0.025
ovulation	GO:0030728	4	0.025
regulation of growth	GO:0040008	233	0.025
positive regulation of actin filament polymerization	GO:0030838	11	0.025
purine ribonucleotide catabolic process	GO:0009154	109	0.025
epidermis development	GO:0008544	65	0.025
positive regulation of macromolecule metabolic process	GO:0010604	405	0.025
ribonucleotide metabolic process	GO:0009259	145	0.025
detection of chemical stimulus	GO:0009593	93	0.025
mesenchymal cell differentiation	GO:0048762	1	0.024
endocytosis	GO:0006897	310	0.024
single organism carbohydrate metabolic process	GO:0044723	72	0.024
regulation of cellular component size	GO:0032535	98	0.024
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.024
protein localization	GO:0008104	284	0.024
regulation of blood circulation	GO:1903522	21	0.024
hair cell differentiation	GO:0035315	47	0.024
negative regulation of cellular component organization	GO:0051129	108	0.024
imaginal disc derived wing morphogenesis	GO:0007476	337	0.024
anatomical structure homeostasis	GO:0060249	97	0.024
connective tissue development	GO:0061448	3	0.024
anterior posterior pattern specification	GO:0009952	136	0.023
regulation of developmental growth	GO:0048638	174	0.023
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.023
regulation of cell motility	GO:2000145	23	0.023
regulation of epithelial cell proliferation	GO:0050678	4	0.023
positive regulation of hydrolase activity	GO:0051345	78	0.023
cellular lipid metabolic process	GO:0044255	83	0.023
regulation of cellular amine metabolic process	GO:0033238	3	0.023
single organism behavior	GO:0044708	391	0.022
kidney development	GO:0001822	3	0.022
mitochondrial fusion	GO:0008053	7	0.022
oocyte differentiation	GO:0009994	145	0.022
purine ribonucleoside catabolic process	GO:0046130	112	0.022
maintenance of location	GO:0051235	73	0.022
chromosome organization	GO:0051276	360	0.022
lipid metabolic process	GO:0006629	121	0.022
compound eye morphogenesis	GO:0001745	249	0.022
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
actin filament polymerization	GO:0030041	27	0.022
regulation of protein depolymerization	GO:1901879	27	0.022
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.022
developmental growth	GO:0048589	280	0.022
oviposition	GO:0018991	19	0.021
cell cycle arrest	GO:0007050	4	0.021
cellular response to oxygen containing compound	GO:1901701	79	0.021
immune system process	GO:0002376	347	0.021
nuclear division	GO:0000280	332	0.021
sperm mitochondrion organization	GO:0030382	7	0.021
response to nitrogen compound	GO:1901698	90	0.021
regulation of molecular function	GO:0065009	217	0.020
mitotic nuclear division	GO:0007067	213	0.020
heart morphogenesis	GO:0003007	32	0.020
cytoskeleton dependent intracellular transport	GO:0030705	44	0.020
single organism catabolic process	GO:0044712	228	0.020
negative regulation of protein complex disassembly	GO:0043242	23	0.020
gastrulation	GO:0007369	70	0.019
protein modification by small protein conjugation	GO:0032446	79	0.019
epithelial cell morphogenesis involved in gastrulation	GO:0003381	7	0.019
cell adhesion	GO:0007155	136	0.019
positive regulation of lipid metabolic process	GO:0045834	4	0.019
oxidation reduction process	GO:0055114	123	0.019
axonal fasciculation	GO:0007413	12	0.019
epithelial cell migration	GO:0010631	148	0.019
developmental maturation	GO:0021700	172	0.019
hemopoiesis	GO:0030097	46	0.019
small molecule metabolic process	GO:0044281	305	0.019
tripartite regional subdivision	GO:0007351	103	0.018
segmentation	GO:0035282	207	0.018
skeletal myofibril assembly	GO:0014866	6	0.018
positive regulation of cellular biosynthetic process	GO:0031328	316	0.018
negative regulation of cell cycle	GO:0045786	116	0.018
actin polymerization or depolymerization	GO:0008154	31	0.018
positive regulation of rna biosynthetic process	GO:1902680	266	0.018
positive regulation of biosynthetic process	GO:0009891	316	0.017
positive regulation of cell proliferation	GO:0008284	47	0.017
regulation of reproductive process	GO:2000241	54	0.017
positive regulation of cellular component organization	GO:0051130	156	0.017
stress activated mapk cascade	GO:0051403	52	0.017
embryonic pattern specification	GO:0009880	174	0.017
regulation of actin filament polymerization	GO:0030833	25	0.017
negative regulation of cell death	GO:0060548	81	0.017
protein depolymerization	GO:0051261	31	0.017
compound eye development	GO:0048749	307	0.017
positive regulation of rna metabolic process	GO:0051254	271	0.017
skin development	GO:0043588	65	0.016
response to abiotic stimulus	GO:0009628	341	0.016
limb morphogenesis	GO:0035108	1	0.016
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.016
regulation of tube size	GO:0035150	46	0.016
mitochondrion organization	GO:0007005	65	0.016
cell cell junction assembly	GO:0007043	38	0.016
spiracle morphogenesis open tracheal system	GO:0035277	22	0.016
generation of precursor metabolites and energy	GO:0006091	42	0.016
rhythmic process	GO:0048511	106	0.016
embryonic axis specification	GO:0000578	107	0.016
oocyte development	GO:0048599	124	0.016
heart contraction	GO:0060047	26	0.016
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.015
regulation of mrna metabolic process	GO:1903311	72	0.015
response to hexose	GO:0009746	3	0.015
muscle thin filament assembly	GO:0071689	5	0.015
regulation of nucleotide metabolic process	GO:0006140	62	0.015
regulation of transport	GO:0051049	181	0.015
macromolecule catabolic process	GO:0009057	161	0.015
organic substance transport	GO:0071702	257	0.015
outflow tract morphogenesis	GO:0003151	4	0.015
mrna processing	GO:0006397	104	0.015
organelle fusion	GO:0048284	46	0.014
metal ion homeostasis	GO:0055065	44	0.014
response to oxygen levels	GO:0070482	59	0.014
epithelium migration	GO:0090132	148	0.014
immune system development	GO:0002520	57	0.014
regulation of cell projection organization	GO:0031344	92	0.014
protein modification by small protein conjugation or removal	GO:0070647	106	0.014
regulation of multi organism process	GO:0043900	131	0.014
regulation of purine nucleotide catabolic process	GO:0033121	48	0.014
response to monosaccharide	GO:0034284	4	0.014
rna splicing	GO:0008380	83	0.014
ovarian follicle cell development	GO:0030707	248	0.014
mapk cascade	GO:0000165	107	0.014
mesenchymal cell development	GO:0014031	1	0.014
response to oxidative stress	GO:0006979	86	0.014
positive regulation of nucleotide metabolic process	GO:0045981	55	0.014
single organism cellular localization	GO:1902580	180	0.014
cellular potassium ion transport	GO:0071804	18	0.014
muscle adaptation	GO:0043500	1	0.014
regulation of tube length open tracheal system	GO:0035159	24	0.014
leg disc development	GO:0035218	92	0.014
atp catabolic process	GO:0006200	38	0.014
cellular response to organic substance	GO:0071310	132	0.014
negative regulation of phosphorus metabolic process	GO:0010563	45	0.013
feeding behavior	GO:0007631	50	0.013
positive regulation of atp catabolic process	GO:1903291	3	0.013
cardiocyte differentiation	GO:0035051	29	0.013
oocyte maturation	GO:0001556	3	0.013
positive regulation of gtp catabolic process	GO:0033126	43	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
positive regulation of gene expression	GO:0010628	290	0.013
cardiac muscle cell differentiation	GO:0055007	4	0.013
negative regulation of programmed cell death	GO:0043069	72	0.013
cellular protein localization	GO:0034613	160	0.013
positive regulation of multicellular organismal process	GO:0051240	143	0.013
g protein coupled receptor signaling pathway	GO:0007186	136	0.013
response to glucose	GO:0009749	2	0.013
response to extracellular stimulus	GO:0009991	116	0.013
mrna metabolic process	GO:0016071	124	0.013
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.013
epidermal cell differentiation	GO:0009913	51	0.013
transmembrane transport	GO:0055085	139	0.012
cellular carbohydrate catabolic process	GO:0044275	2	0.012
actin filament bundle organization	GO:0061572	28	0.012
positive regulation of proteolysis	GO:0045862	52	0.012
intracellular protein transport	GO:0006886	104	0.012
multicellular organism growth	GO:0035264	46	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.012
sex differentiation	GO:0007548	81	0.012
actin filament capping	GO:0051693	2	0.012
cellular macromolecule localization	GO:0070727	220	0.012
telencephalon development	GO:0021537	2	0.012
stem cell differentiation	GO:0048863	117	0.012
regulation of circadian rhythm	GO:0042752	49	0.012
urogenital system development	GO:0001655	72	0.012
negative regulation of protein polymerization	GO:0032272	7	0.012
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.012
actin filament bundle assembly	GO:0051017	26	0.012
regulation of cellular ketone metabolic process	GO:0010565	3	0.012
receptor clustering	GO:0043113	3	0.012
skeletal muscle fiber development	GO:0048741	3	0.012
cellular response to dna damage stimulus	GO:0006974	223	0.012
regulation of cell migration	GO:0030334	22	0.012
positive regulation of cytoskeleton organization	GO:0051495	21	0.012
cellular response to oxygen levels	GO:0071453	30	0.012
limb development	GO:0060173	1	0.012
pyridine nucleotide metabolic process	GO:0019362	2	0.012
cytoplasmic transport	GO:0016482	130	0.012
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.012
ras protein signal transduction	GO:0007265	88	0.012
cell type specific apoptotic process	GO:0097285	38	0.012
protein phosphorylation	GO:0006468	169	0.011
regulation of nucleotide catabolic process	GO:0030811	48	0.011
regulation of actin polymerization or depolymerization	GO:0008064	27	0.011
transcription from rna polymerase ii promoter	GO:0006366	368	0.011
endoderm formation	GO:0001706	3	0.011
cell recognition	GO:0008037	102	0.011
cellular metal ion homeostasis	GO:0006875	31	0.011
positive regulation of response to stimulus	GO:0048584	323	0.011
hematopoietic progenitor cell differentiation	GO:0002244	1	0.011
response to decreased oxygen levels	GO:0036293	58	0.011
positive regulation of neuron apoptotic process	GO:0043525	1	0.011
positive regulation of protein polymerization	GO:0032273	14	0.011
defense response	GO:0006952	300	0.011
autophagy	GO:0006914	108	0.011
carbohydrate biosynthetic process	GO:0016051	17	0.011
regulation of mrna splicing via spliceosome	GO:0048024	64	0.011
mitotic chromosome condensation	GO:0007076	22	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011
negative regulation of organelle organization	GO:0010639	56	0.011
apical constriction involved in gastrulation	GO:0003384	7	0.011
cellular homeostasis	GO:0019725	80	0.011
regulation of rho protein signal transduction	GO:0035023	20	0.011
rna splicing via transesterification reactions	GO:0000375	73	0.011
protein complex disassembly	GO:0043241	36	0.011
regulation of phosphorylation	GO:0042325	147	0.011
sulfur compound metabolic process	GO:0006790	59	0.011
regulation of response to external stimulus	GO:0032101	115	0.011
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.011
cardiac cell development	GO:0055006	3	0.011
regulation of cellular localization	GO:0060341	136	0.010
regulation of intracellular signal transduction	GO:1902531	236	0.010
regulation of locomotion	GO:0040012	42	0.010
regulation of steroid metabolic process	GO:0019218	2	0.010
stress activated protein kinase signaling cascade	GO:0031098	55	0.010
regulation of ion transport	GO:0043269	39	0.010
multi organism reproductive behavior	GO:0044705	121	0.010
amine metabolic process	GO:0009308	12	0.010
negative regulation of catalytic activity	GO:0043086	42	0.010
positive regulation of cell communication	GO:0010647	250	0.010
response to nutrient levels	GO:0031667	114	0.010
negative regulation of growth	GO:0045926	84	0.010
rhythmic behavior	GO:0007622	76	0.010

Act88F disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.205
cardiovascular system disease	DOID:1287	0.205
dilated cardiomyopathy	DOID:12930	0.111
intrinsic cardiomyopathy	DOID:0060036	0.111
cardiomyopathy	DOID:0050700	0.111
muscular disease	DOID:0080000	0.111
heart disease	DOID:114	0.111
musculoskeletal system disease	DOID:17	0.111
muscle tissue disease	DOID:66	0.111
myopathy	DOID:423	0.111
nervous system disease	DOID:863	0.050
integumentary system disease	DOID:16	0.014
neurodegenerative disease	DOID:1289	0.013
central nervous system disease	DOID:331	0.013
synucleinopathy	DOID:0050890	0.011
parkinson s disease	DOID:14330	0.011
sensory system disease	DOID:0050155	0.011
eye and adnexa disease	DOID:1492	0.011
connective tissue disease	DOID:65	0.010
bone disease	DOID:0080001	0.010

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