IMP: Integrative Multi-species Prediction

Drosophila melanogaster

40 known processes

HmgD (Dmel_CG17950)

High mobility group protein D

(Aliases: Dm-HMG-D100,hmg-D,dHMG-D,HMGD,CG17950,HMG-D,anon-EST:Liang-1.9,clone 1.9,Hmg-D,Dmel\CG17950,HMG-D100,HMG D)

Entrez: 37481
FLYBASE: FBgn0004362
UniProtKB: Q05783
UniProtKB: C0MJA0

Process Predictions
Disease Predictions

HmgD biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
chromatin silencing	GO:0006342	76	0.815
negative regulation of gene expression epigenetic	GO:0045814	77	0.730
negative regulation of cellular biosynthetic process	GO:0031327	277	0.646
protein complex biogenesis	GO:0070271	201	0.550
regulation of gene expression epigenetic	GO:0040029	128	0.511
macromolecular complex assembly	GO:0065003	256	0.434
negative regulation of rna metabolic process	GO:0051253	251	0.377
negative regulation of gene expression	GO:0010629	387	0.348
negative regulation of rna biosynthetic process	GO:1902679	240	0.343
mrna metabolic process	GO:0016071	124	0.334
mitotic spindle organization	GO:0007052	220	0.332
chromatin organization	GO:0006325	207	0.299
gene silencing	GO:0016458	138	0.292
cellular macromolecular complex assembly	GO:0034622	153	0.291
chromosome organization	GO:0051276	360	0.276
dna metabolic process	GO:0006259	227	0.270
dna conformation change	GO:0071103	105	0.264
protein complex assembly	GO:0006461	200	0.245
organelle fission	GO:0048285	340	0.240
single organism behavior	GO:0044708	391	0.232
mitotic cell cycle embryonic	GO:0045448	38	0.230
response to abiotic stimulus	GO:0009628	341	0.215
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.209
mitotic nuclear division	GO:0007067	213	0.195
mitotic cell cycle phase transition	GO:0044772	138	0.192
regulation of gene silencing	GO:0060968	63	0.185
dna packaging	GO:0006323	91	0.166
cellular protein complex assembly	GO:0043623	71	0.153
mrna processing	GO:0006397	104	0.147
chromatin assembly	GO:0031497	48	0.144
heterochromatin organization	GO:0070828	25	0.137
dna repair	GO:0006281	54	0.135
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.133
tissue morphogenesis	GO:0048729	297	0.132
organonitrogen compound metabolic process	GO:1901564	318	0.132
regulation of cytoskeleton organization	GO:0051493	89	0.129
negative regulation of cellular metabolic process	GO:0031324	382	0.124
regulation of multicellular organismal development	GO:2000026	414	0.122
regulation of mitotic cell cycle	GO:0007346	190	0.118
regulation of organelle organization	GO:0033043	196	0.117
protein polymerization	GO:0051258	42	0.115
rna processing	GO:0006396	147	0.115
actin nucleation	GO:0045010	8	0.115
intracellular transport	GO:0046907	228	0.114
cellular response to abiotic stimulus	GO:0071214	58	0.112
positive regulation of protein metabolic process	GO:0051247	128	0.110
response to temperature stimulus	GO:0009266	106	0.104
regulation of cellular component biogenesis	GO:0044087	201	0.103
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.102
negative regulation of biosynthetic process	GO:0009890	277	0.100
embryo development ending in birth or egg hatching	GO:0009792	152	0.100
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.096
cell cycle phase transition	GO:0044770	140	0.093
oxoacid metabolic process	GO:0043436	103	0.089
protein modification process	GO:0036211	438	0.088
actin filament organization	GO:0007015	126	0.087
cellular response to dna damage stimulus	GO:0006974	223	0.084
spindle organization	GO:0007051	253	0.083
mitotic sister chromatid segregation	GO:0000070	87	0.083
rna splicing via transesterification reactions	GO:0000375	73	0.082
learning	GO:0007612	75	0.079
gland development	GO:0048732	191	0.078
positive regulation of proteolysis	GO:0045862	52	0.076
negative regulation of cellular component organization	GO:0051129	108	0.076
organic acid metabolic process	GO:0006082	103	0.071
positive regulation of developmental process	GO:0051094	143	0.070
positive regulation of macromolecule metabolic process	GO:0010604	405	0.068
regulation of protein complex assembly	GO:0043254	42	0.068
nucleobase containing small molecule metabolic process	GO:0055086	174	0.067
regulation of chromatin silencing	GO:0031935	36	0.067
muscle organ development	GO:0007517	127	0.066
organic substance catabolic process	GO:1901575	308	0.062
adult behavior	GO:0030534	137	0.062
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.061
regulation of protein metabolic process	GO:0051246	256	0.060
sensory organ morphogenesis	GO:0090596	260	0.059
sister chromatid segregation	GO:0000819	92	0.058
regulation of cell cycle process	GO:0010564	181	0.057
alternative mrna splicing via spliceosome	GO:0000380	60	0.057
multicellular organismal reproductive behavior	GO:0033057	110	0.056
chromatin assembly or disassembly	GO:0006333	52	0.056
taxis	GO:0042330	304	0.056
nucleoside phosphate metabolic process	GO:0006753	162	0.055
carboxylic acid metabolic process	GO:0019752	92	0.055
mrna splicing via spliceosome	GO:0000398	73	0.055
histolysis	GO:0007559	102	0.054
regulation of mrna processing	GO:0050684	71	0.053
cellular response to sterol depletion	GO:0071501	3	0.051
positive regulation of catalytic activity	GO:0043085	118	0.050
g1 s transition of mitotic cell cycle	GO:0000082	31	0.050
gland morphogenesis	GO:0022612	145	0.049
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.049
salivary gland morphogenesis	GO:0007435	145	0.049
positive regulation of biosynthetic process	GO:0009891	316	0.047
regulation of transport	GO:0051049	181	0.047
protein localization	GO:0008104	284	0.046
macromolecule methylation	GO:0043414	45	0.044
regulation of cell cycle	GO:0051726	291	0.042
nuclear division	GO:0000280	332	0.041
regulation of mrna splicing via spliceosome	GO:0048024	64	0.041
regulation of mitotic cell cycle embryonic	GO:0009794	11	0.040
cellular amino acid metabolic process	GO:0006520	61	0.039
feeding behavior	GO:0007631	50	0.038
positive regulation of cellular component organization	GO:0051130	156	0.038
positive regulation of cellular protein metabolic process	GO:0032270	118	0.037
locomotory behavior	GO:0007626	176	0.037
autophagic cell death	GO:0048102	83	0.036
nitrogen compound transport	GO:0071705	85	0.036
arp2 3 complex mediated actin nucleation	GO:0034314	3	0.036
guanosine containing compound catabolic process	GO:1901069	74	0.036
rna splicing	GO:0008380	83	0.036
regulation of intracellular signal transduction	GO:1902531	236	0.036
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.036
actin filament polymerization	GO:0030041	27	0.035
muscle structure development	GO:0061061	224	0.035
protein complex localization	GO:0031503	4	0.034
small molecule metabolic process	GO:0044281	305	0.034
dorsal ventral pattern formation imaginal disc	GO:0007450	51	0.034
organic cyclic compound catabolic process	GO:1901361	168	0.034
microtubule organizing center organization	GO:0031023	168	0.034
wing disc dorsal ventral pattern formation	GO:0048190	47	0.033
methylation	GO:0032259	47	0.033
nucleoside triphosphate metabolic process	GO:0009141	120	0.033
protein methylation	GO:0006479	43	0.033
regulation of actin cytoskeleton organization	GO:0032956	42	0.033
salivary gland cell autophagic cell death	GO:0035071	83	0.033
chromatin modification	GO:0016568	147	0.032
compound eye development	GO:0048749	307	0.032
wing disc pattern formation	GO:0035222	66	0.032
olfactory behavior	GO:0042048	97	0.032
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.031
posttranscriptional gene silencing	GO:0016441	46	0.031
regulation of cellular protein metabolic process	GO:0032268	243	0.031
spindle assembly	GO:0051225	80	0.031
regulation of apoptotic process	GO:0042981	130	0.030
lateral inhibition	GO:0046331	206	0.030
ribose phosphate metabolic process	GO:0019693	145	0.030
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.029
cell division	GO:0051301	248	0.029
intracellular signal transduction	GO:0035556	300	0.029
cellular protein modification process	GO:0006464	438	0.029
meiotic cell cycle	GO:0051321	171	0.028
nucleotide metabolic process	GO:0009117	161	0.028
eye morphogenesis	GO:0048592	260	0.028
regulation of embryonic development	GO:0045995	68	0.028
response to organic substance	GO:0010033	284	0.028
organic substance transport	GO:0071702	257	0.028
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.028
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.027
regulation of cellular amine metabolic process	GO:0033238	3	0.027
carbohydrate derivative metabolic process	GO:1901135	217	0.027
positive regulation of actin filament polymerization	GO:0030838	11	0.026
regionalization	GO:0003002	416	0.026
regulation of hydrolase activity	GO:0051336	97	0.026
negative regulation of response to external stimulus	GO:0032102	22	0.025
negative regulation of transcription dna templated	GO:0045892	237	0.025
salivary gland development	GO:0007431	162	0.025
protein modification by small protein conjugation or removal	GO:0070647	106	0.024
eye development	GO:0001654	323	0.024
reproductive structure development	GO:0048608	74	0.024
purine ribonucleotide metabolic process	GO:0009150	145	0.024
histone methylation	GO:0016571	40	0.024
mesenchymal cell differentiation	GO:0048762	1	0.023
positive regulation of organelle organization	GO:0010638	65	0.023
negative regulation of cell cycle	GO:0045786	116	0.023
regulation of synapse assembly	GO:0051963	94	0.023
regulation of actin filament based process	GO:0032970	42	0.023
neuron migration	GO:0001764	5	0.023
actin cytoskeleton organization	GO:0030036	206	0.023
regulation of catalytic activity	GO:0050790	185	0.023
dorsal ventral pattern formation	GO:0009953	133	0.023
positive regulation of gene expression	GO:0010628	290	0.022
transcription from rna polymerase ii promoter	GO:0006366	368	0.022
mesenchymal cell development	GO:0014031	1	0.022
protein alkylation	GO:0008213	43	0.022
cellular response to chemical stimulus	GO:0070887	199	0.022
regulation of cellular response to stress	GO:0080135	89	0.022
photoreceptor cell differentiation	GO:0046530	170	0.022
positive regulation of multicellular organismal process	GO:0051240	143	0.021
regulation of ras protein signal transduction	GO:0046578	93	0.021
histone lysine methylation	GO:0034968	32	0.021
establishment of localization in cell	GO:0051649	402	0.021
establishment of mitotic spindle localization	GO:0040001	17	0.021
response to nitrogen compound	GO:1901698	90	0.020
regulation of response to stress	GO:0080134	200	0.020
rna localization	GO:0006403	115	0.020
salivary gland histolysis	GO:0035070	88	0.020
cellular ketone metabolic process	GO:0042180	24	0.020
purine ribonucleoside metabolic process	GO:0046128	127	0.020
positive regulation of intracellular signal transduction	GO:1902533	116	0.020
regulation of cellular amino acid metabolic process	GO:0006521	0	0.019
response to extracellular stimulus	GO:0009991	116	0.019
telencephalon development	GO:0021537	2	0.019
apoptotic process	GO:0006915	159	0.019
regulation of cellular localization	GO:0060341	136	0.019
cell cycle g1 s phase transition	GO:0044843	31	0.019
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.019
regulation of actin filament polymerization	GO:0030833	25	0.019
golgi organization	GO:0007030	66	0.019
glutamine metabolic process	GO:0006541	4	0.019
central nervous system development	GO:0007417	201	0.019
ribonucleotide metabolic process	GO:0009259	145	0.018
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.018
reproductive system development	GO:0061458	74	0.018
tissue death	GO:0016271	102	0.018
ribonucleotide catabolic process	GO:0009261	109	0.018
regulation of mrna metabolic process	GO:1903311	72	0.018
death	GO:0016265	284	0.018
positive regulation of developmental growth	GO:0048639	62	0.018
nucleotide catabolic process	GO:0009166	109	0.018
aromatic compound catabolic process	GO:0019439	166	0.018
organonitrogen compound catabolic process	GO:1901565	128	0.018
response to organic cyclic compound	GO:0014070	89	0.017
nucleobase containing compound catabolic process	GO:0034655	165	0.017
cilium morphogenesis	GO:0060271	39	0.017
ncrna metabolic process	GO:0034660	43	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.017
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.017
positive regulation of protein complex assembly	GO:0031334	22	0.017
regulation of phosphorus metabolic process	GO:0051174	210	0.017
regulation of cell development	GO:0060284	215	0.017
nucleosome assembly	GO:0006334	35	0.017
negative regulation of cell cycle process	GO:0010948	109	0.017
single organism intracellular transport	GO:1902582	207	0.016
centrosome organization	GO:0051297	163	0.016
regulation of phosphate metabolic process	GO:0019220	210	0.016
camera type eye development	GO:0043010	4	0.016
regulation of localization	GO:0032879	275	0.016
positive regulation of cell development	GO:0010720	61	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
developmental programmed cell death	GO:0010623	138	0.016
regulation of actin polymerization or depolymerization	GO:0008064	27	0.016
retina development in camera type eye	GO:0060041	4	0.016
body morphogenesis	GO:0010171	2	0.016
regulation of proteasomal protein catabolic process	GO:0061136	39	0.016
purine nucleoside metabolic process	GO:0042278	127	0.015
dephosphorylation	GO:0016311	51	0.015
cell death	GO:0008219	279	0.015
positive regulation of rna metabolic process	GO:0051254	271	0.015
response to radiation	GO:0009314	155	0.015
negative regulation of signaling	GO:0023057	219	0.015
positive regulation of signaling	GO:0023056	243	0.015
positive regulation of protein modification process	GO:0031401	58	0.015
neuron projection guidance	GO:0097485	241	0.015
catabolic process	GO:0009056	409	0.014
heterocycle catabolic process	GO:0046700	166	0.014
brain development	GO:0007420	120	0.014
regulation of programmed cell death	GO:0043067	152	0.014
negative regulation of response to stimulus	GO:0048585	258	0.014
larval behavior	GO:0030537	42	0.014
phosphorylation	GO:0016310	294	0.014
sex differentiation	GO:0007548	81	0.014
cellular response to organic substance	GO:0071310	132	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.013
larval locomotory behavior	GO:0008345	27	0.013
wnt signaling pathway	GO:0016055	98	0.013
regulation of nervous system development	GO:0051960	248	0.013
regulation of protein polymerization	GO:0032271	28	0.013
epithelial cell differentiation	GO:0030855	322	0.013
protein dna complex assembly	GO:0065004	63	0.013
positive regulation of rna biosynthetic process	GO:1902680	266	0.013
regulation of chromosome organization	GO:0033044	64	0.013
peptidyl lysine dimethylation	GO:0018027	3	0.013
proteasomal protein catabolic process	GO:0010498	59	0.013
regulation of multicellular organism growth	GO:0040014	40	0.013
amine metabolic process	GO:0009308	12	0.013
dendrite development	GO:0016358	204	0.013
multi organism reproductive behavior	GO:0044705	121	0.013
positive regulation of neurogenesis	GO:0050769	41	0.013
establishment of rna localization	GO:0051236	47	0.013
actin polymerization or depolymerization	GO:0008154	31	0.013
hematopoietic progenitor cell differentiation	GO:0002244	1	0.013
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.013
negative regulation of organelle organization	GO:0010639	56	0.012
positive regulation of transcription dna templated	GO:0045893	266	0.012
chromatin remodeling	GO:0006338	72	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
regulation of glial cell differentiation	GO:0045685	1	0.012
regulation of cell cycle phase transition	GO:1901987	130	0.012
regulation of hemocyte proliferation	GO:0035206	37	0.012
negative regulation of developmental process	GO:0051093	201	0.012
positive regulation of signal transduction	GO:0009967	223	0.012
positive regulation of cytoskeleton organization	GO:0051495	21	0.012
protein phosphorylation	GO:0006468	169	0.012
mitotic dna integrity checkpoint	GO:0044774	75	0.012
regulation of protein catabolic process	GO:0042176	55	0.012
nucleic acid transport	GO:0050657	46	0.011
covalent chromatin modification	GO:0016569	106	0.011
response to oxygen levels	GO:0070482	59	0.011
compound eye photoreceptor cell differentiation	GO:0001751	140	0.011
genitalia development	GO:0048806	26	0.011
regulation of dna metabolic process	GO:0051052	34	0.011
ribonucleoside metabolic process	GO:0009119	127	0.011
establishment of spindle localization	GO:0051293	22	0.011
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.011
retina morphogenesis in camera type eye	GO:0060042	2	0.011
respiratory system development	GO:0060541	213	0.011
cellular response to endogenous stimulus	GO:0071495	80	0.011
head development	GO:0060322	135	0.011
recombinational repair	GO:0000725	13	0.011
reactive oxygen species biosynthetic process	GO:1903409	0	0.010
spindle assembly involved in mitosis	GO:0090307	50	0.010
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.010
endocytosis	GO:0006897	310	0.010
response to nutrient levels	GO:0031667	114	0.010
protein modification by small protein conjugation	GO:0032446	79	0.010
ribonucleoside catabolic process	GO:0042454	112	0.010
reproductive behavior	GO:0019098	122	0.010
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.010

HmgD disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.028
disease of anatomical entity	DOID:7	0.025
motor neuron disease	DOID:231	0.023
neurodegenerative disease	DOID:1289	0.023
central nervous system disease	DOID:331	0.023
nervous system disease	DOID:863	0.023
cancer	DOID:162	0.010
muscular disease	DOID:0080000	0.010
musculoskeletal system disease	DOID:17	0.010

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