Drosophila melanogaster

0 known processes

bru-3 (Dmel_CG12478)

bruno-3

(Aliases: Dm Bru-3,Dmel\CG12478,CG10046,Bru-3,cg10046,cg12478,CG12478)

bru-3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cuticle developmentGO:0042335860.083
vesicle mediated transportGO:00161923810.075
body morphogenesisGO:001017120.071
establishment of localization in cellGO:00516494020.061
regulation of multicellular organismal developmentGO:20000264140.058
regulation of sequestering of triglycerideGO:001088930.058
protein modification processGO:00362114380.057
immune system processGO:00023763470.056
imaginal disc derived appendage developmentGO:00487373990.053
endocytosisGO:00068973100.049
single organism biosynthetic processGO:00447112060.049
sensory perceptionGO:00076001960.048
cell deathGO:00082192790.046
response to monosaccharideGO:003428440.046
appendage developmentGO:00487364010.045
phagocytosisGO:00069092150.043
glycoprotein biosynthetic processGO:0009101410.043
regulation of cell differentiationGO:00455953020.043
pigment metabolic processGO:0042440840.043
camera type eye developmentGO:004301040.043
regulation of nervous system developmentGO:00519602480.042
imaginal disc derived wing morphogenesisGO:00074763370.042
protein localizationGO:00081042840.042
post embryonic appendage morphogenesisGO:00351203850.042
negative regulation of nucleobase containing compound metabolic processGO:00459342610.042
molting cycle chitin based cuticleGO:0007591560.041
regulation of anatomical structure morphogenesisGO:00226032420.040
synapse organizationGO:00508081960.040
imaginal disc derived appendage morphogenesisGO:00351143950.040
regulation of cell developmentGO:00602842150.039
small molecule metabolic processGO:00442813050.039
positive regulation of cellular biosynthetic processGO:00313283160.038
regulation of cell projection organizationGO:0031344920.038
wing disc morphogenesisGO:00074723440.038
regulation of cellular component biogenesisGO:00440872010.038
response to other organismGO:00517072930.038
transcription from rna polymerase ii promoterGO:00063663680.038
regulation of synapse structure and activityGO:00508031280.038
regulation of chitin based cuticle tanningGO:0007564140.038
regulation of epithelial cell proliferationGO:005067840.038
oxoacid metabolic processGO:00434361030.038
positive regulation of biosynthetic processGO:00098913160.038
negative regulation of response to stimulusGO:00485852580.037
intracellular signal transductionGO:00355563000.037
regulation of cellular amine metabolic processGO:003323830.037
cellular catabolic processGO:00442483720.036
neurological system processGO:00508773580.036
chitin based cuticle sclerotizationGO:0007593190.036
organic substance transportGO:00717022570.035
cation transportGO:00068121100.035
sensory perception of chemical stimulusGO:00076061160.035
cellular component assembly involved in morphogenesisGO:00109271510.035
deathGO:00162652840.035
immune responseGO:00069552460.035
lipopolysaccharide mediated signaling pathwayGO:003166310.034
regulation of transportGO:00510491810.034
defense responseGO:00069523000.034
regulation of adult chitin containing cuticle pigmentationGO:0048082130.034
epiboly involved in wound healingGO:009050520.034
negative regulation of gene expressionGO:00106293870.034
negative regulation of cellular biosynthetic processGO:00313272770.033
organonitrogen compound metabolic processGO:19015643180.033
nephron developmentGO:007200630.033
regulation of localizationGO:00328792750.033
carboxylic acid metabolic processGO:0019752920.033
response to lipopolysaccharideGO:003249640.033
protein transportGO:00150311550.033
organic acid metabolic processGO:00060821030.033
positive regulation of cell migrationGO:003033520.033
positive regulation of macromolecule metabolic processGO:00106044050.033
adult chitin containing cuticle pigmentationGO:0048085160.032
intracellular transportGO:00469072280.032
negative regulation of signalingGO:00230572190.032
response to hexoseGO:000974630.032
positive regulation of transportGO:0051050920.032
regulation of cellular ketone metabolic processGO:001056530.031
wound healing spreading of epidermal cellsGO:003531310.031
single organism cellular localizationGO:19025801800.031
positive regulation of nitrogen compound metabolic processGO:00511733540.031
segmentationGO:00352822070.031
epithelial cell developmentGO:00020642740.031
positive regulation of cellular amine metabolic processGO:003324000.030
axon developmentGO:00615642970.030
kidney developmentGO:000182230.030
regulation of phosphate metabolic processGO:00192202100.030
programmed cell deathGO:00125012570.030
positive regulation of response to stimulusGO:00485843230.030
lipid metabolic processGO:00066291210.030
homeostatic processGO:00425921990.030
axonogenesisGO:00074092900.029
catabolic processGO:00090564090.029
ras protein signal transductionGO:0007265880.029
regulation of transcription from rna polymerase ii promoterGO:00063573780.029
regulation of cellular amino acid metabolic processGO:000652100.029
kidney epithelium developmentGO:007207330.029
dna metabolic processGO:00062592270.029
chitin based cuticle developmentGO:0040003490.029
nephron tubule developmentGO:007208030.029
nephron epithelium developmentGO:007200930.029
forebrain developmentGO:003090020.029
secretionGO:00469031090.029
carbohydrate derivative metabolic processGO:19011352170.029
transmembrane transportGO:00550851390.029
anatomical structure homeostasisGO:0060249970.029
phosphorylationGO:00163102940.028
negative regulation of cellular metabolic processGO:00313243820.028
carbohydrate derivative biosynthetic processGO:1901137850.028
paracrine signalingGO:003800170.028
regulation of cell cycleGO:00517262910.028
single organism intracellular transportGO:19025822070.028
single organism catabolic processGO:00447122280.028
nephron morphogenesisGO:007202830.027
axon guidanceGO:00074112330.027
ion transportGO:00068111450.027
cell proliferationGO:00082832990.027
response to organophosphorusGO:004668320.027
negative regulation of biosynthetic processGO:00098902770.027
regulation of synapse organizationGO:00508071100.027
amine metabolic processGO:0009308120.027
positive regulation of signalingGO:00230562430.027
positive regulation of cell communicationGO:00106472500.027
muscle attachmentGO:0016203360.026
regulation of cuticle pigmentationGO:0048079160.026
negative regulation of rna biosynthetic processGO:19026792400.026
apoptotic process involved in morphogenesisGO:006056130.026
regulation of cellular catabolic processGO:00313291570.026
chromatin organizationGO:00063252070.026
regulation of neuron differentiationGO:00456641030.026
growthGO:00400073590.026
somatic muscle developmentGO:0007525660.026
nephron epithelium morphogenesisGO:007208830.026
oocyte microtubule cytoskeleton organizationGO:0016325350.026
developmental maturationGO:00217001720.026
cellular amino acid metabolic processGO:0006520610.025
cellular macromolecule localizationGO:00707272200.025
regulation of immune responseGO:00507761180.025
cellular protein modification processGO:00064644380.025
gland developmentGO:00487321910.025
melanin metabolic processGO:0006582470.025
single organism carbohydrate metabolic processGO:0044723720.025
response to biotic stimulusGO:00096072940.025
molting cycle processGO:0022404290.025
defense response to bacteriumGO:00427421780.025
amide biosynthetic processGO:0043604420.025
cellular amine metabolic processGO:0044106120.025
ion transmembrane transportGO:00342201220.025
regulation of neurogenesisGO:00507671580.024
cation transmembrane transportGO:0098655880.024
negative regulation of macromolecule biosynthetic processGO:00105582700.024
developmental growthGO:00485892800.024
protein complex biogenesisGO:00702712010.024
adult behaviorGO:00305341370.024
regionalizationGO:00030024160.024
negative regulation of signal transductionGO:00099682060.024
oocyte dorsal ventral axis specificationGO:0007310340.024
secretion by cellGO:00329401010.024
positive regulation of phosphate metabolic processGO:00459371390.024
organelle assemblyGO:00709251980.024
peptide biosynthetic processGO:0043043420.024
small gtpase mediated signal transductionGO:0007264880.023
synaptic transmissionGO:00072682880.023
positive regulation of macromolecule biosynthetic processGO:00105572830.023
appendage morphogenesisGO:00351073970.023
neuromuscular junction developmentGO:00075281490.023
response to abiotic stimulusGO:00096283410.023
regulation of developmental growthGO:00486381740.023
histolysisGO:00075591020.023
cell divisionGO:00513012480.023
acylglycerol catabolic processGO:004646430.023
learning or memoryGO:00076111410.023
positive regulation of cellular amino acid metabolic processGO:004576400.023
retina development in camera type eyeGO:006004140.023
glycoprotein metabolic processGO:0009100410.023
hindbrain developmentGO:003090220.023
regulation of response to stressGO:00801342000.023
regulation of cell cycle processGO:00105641810.023
mapk cascadeGO:00001651070.023
gene silencingGO:00164581380.023
protein heterooligomerizationGO:005129140.023
defense response to other organismGO:00985422250.023
l amino acid importGO:004309220.023
neurotransmitter secretionGO:0007269350.023
neuron projection guidanceGO:00974852410.023
developmental programmed cell deathGO:00106231380.022
positive regulation of rna biosynthetic processGO:19026802660.022
regulation of cell morphogenesisGO:00226041630.022
response to organic substanceGO:00100332840.022
negative regulation of nucleic acid templated transcriptionGO:19035072400.022
positive regulation of cell motilityGO:200014730.022
regulation of protein metabolic processGO:00512462560.022
eye developmentGO:00016543230.022
organic substance catabolic processGO:19015753080.022
chromatin assembly or disassemblyGO:0006333520.022
macromolecular complex assemblyGO:00650032560.022
neurotransmitter metabolic processGO:004213320.022
cell projection assemblyGO:0030031940.022
connective tissue developmentGO:006144830.022
establishment of protein localizationGO:00451841630.022
positive regulation of rna metabolic processGO:00512542710.022
lateral inhibitionGO:00463312060.022
regulation of intracellular signal transductionGO:19025312360.022
kidney morphogenesisGO:006099330.022
innate immune responseGO:00450871440.022
response to bacteriumGO:00096171980.022
negative regulation of cell communicationGO:00106482230.021
positive regulation of gene expressionGO:00106282900.021
response to glucoseGO:000974920.021
cuticle pigmentationGO:0048067220.021
cell recognitionGO:00080371020.021
positive regulation of signal transductionGO:00099672230.021
cell cell signaling involved in cell fate commitmentGO:00451682100.021
axis specificationGO:00097981670.021
neuron recognitionGO:00080381010.021
positive regulation of axonogenesisGO:005077220.021
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.021
positive regulation of mitotic cell cycleGO:0045931340.021
negative regulation of multicellular organismal processGO:00512411420.021
embryonic hindgut morphogenesisGO:0048619480.021
regulation of phosphorylationGO:00423251470.020
carbohydrate metabolic processGO:0005975820.020
positive regulation of developmental processGO:00510941430.020
cell growthGO:00160491080.020
activation of innate immune responseGO:000221840.020
humoral immune responseGO:00069591170.020
synaptic growth at neuromuscular junctionGO:00511241190.020
telencephalon developmentGO:002153720.020
regulation of phosphorus metabolic processGO:00511742100.020
epibolyGO:009050420.020
positive regulation of phosphorus metabolic processGO:00105621390.020
response to alcoholGO:0097305950.020
regulation of synapse assemblyGO:0051963940.020
regulation of cellular localizationGO:00603411360.020
regulation of catalytic activityGO:00507901850.020
extrinsic apoptotic signaling pathwayGO:009719110.019
enzyme linked receptor protein signaling pathwayGO:00071671790.019
positive regulation of transcription dna templatedGO:00458932660.019
behavioral response to painGO:004826630.019
positive regulation of nervous system developmentGO:0051962690.019
protein dna complex subunit organizationGO:0071824860.019
mitotic cell cycle phase transitionGO:00447721380.019
regulation of developmental pigmentationGO:0048070240.019
triglyceride catabolic processGO:001943330.019
positive regulation of synapse assemblyGO:0051965290.019
mesoderm developmentGO:0007498780.019
nucleotide metabolic processGO:00091171610.019
synapse assemblyGO:00074161430.019
phenol containing compound metabolic processGO:0018958570.019
organophosphate metabolic processGO:00196371950.019
nephron tubule morphogenesisGO:007207830.019
monocarboxylic acid transportGO:001571830.019
maintenance of locationGO:0051235730.019
gland morphogenesisGO:00226121450.019
negative regulation of rna metabolic processGO:00512532510.019
head developmentGO:00603221350.019
dna conformation changeGO:00711031050.019
positive regulation of lipid metabolic processGO:004583440.019
chromosome organizationGO:00512763600.019
exocrine system developmentGO:00352721620.019
muscle organ developmentGO:00075171270.019
chemotaxisGO:00069352490.019
positive regulation of reactive oxygen species metabolic processGO:200037900.019
salivary gland developmentGO:00074311620.019
response to oxygen containing compoundGO:19017002000.018
spiracle morphogenesis open tracheal systemGO:0035277220.018
regulation of immune system processGO:00026821760.018
signal transduction by phosphorylationGO:00230141070.018
sarcomere organizationGO:0045214260.018
columnar cuboidal epithelial cell differentiationGO:00020652560.018
dendrite developmentGO:00163582040.018
defense response to gram negative bacteriumGO:0050829940.018
protein targetingGO:0006605640.018
actin filament based processGO:00300292200.018
compound eye morphogenesisGO:00017452490.018
regulation of mitotic cell cycleGO:00073461900.018
autophagic cell deathGO:0048102830.018
positive regulation of catabolic processGO:00098961050.018
regulation of cell deathGO:00109411730.018
regulation of stem cell proliferationGO:0072091400.018
cellular macromolecular complex assemblyGO:00346221530.018
actin cytoskeleton organizationGO:00300362060.018
stem cell divisionGO:0017145690.018
eye photoreceptor cell developmentGO:0042462810.018
establishment of tissue polarityGO:0007164870.017
cellular amide metabolic processGO:0043603800.017
tissue deathGO:00162711020.017
substrate dependent cell migrationGO:000692930.017
regulation of molecular functionGO:00650092170.017
detection of stimulusGO:00516061560.017
regulation of catabolic processGO:00098941700.017
regulation of cellular protein metabolic processGO:00322682430.017
pigmentationGO:0043473750.017
regulation of gene silencingGO:0060968630.017
cellular response to transforming growth factor beta stimulusGO:0071560180.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.017
hematopoietic progenitor cell differentiationGO:000224410.017
intracellular protein transportGO:00068861040.017
metal ion transportGO:0030001740.017
regulation of cell morphogenesis involved in differentiationGO:0010769610.017
malpighian tubule morphogenesisGO:0007443440.017
positive regulation of nucleobase containing compound metabolic processGO:00459353320.017
regulation of protein deacetylationGO:009031120.017
tissue morphogenesisGO:00487292970.017
negative regulation of nitrogen compound metabolic processGO:00511722650.017
proteolysisGO:00065081920.017
regulation of defense responseGO:00313471020.017
regulation of anatomical structure sizeGO:00900661630.017
negative regulation of transcription dna templatedGO:00458922370.017
single organism behaviorGO:00447083910.017
regulation of synaptic growth at neuromuscular junctionGO:0008582890.017
photoreceptor cell developmentGO:0042461960.017
cellular homeostasisGO:0019725800.017
protein complex assemblyGO:00064612000.017
male courtship behavior veined wing vibrationGO:0016545210.017
ribose phosphate metabolic processGO:00196931450.017
cell cycle checkpointGO:0000075950.016
chemical homeostasisGO:0048878920.016
muscle structure developmentGO:00610612240.016
pigment biosynthetic processGO:0046148360.016
response to radiationGO:00093141550.016
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.016
cellular protein localizationGO:00346131600.016
developmental pigmentationGO:0048066680.016
notch signaling pathwayGO:00072191200.016
regulation of organelle organizationGO:00330431960.016
cellular carbohydrate catabolic processGO:004427520.016
post embryonic hemopoiesisGO:0035166170.016
sterol homeostasisGO:005509240.016
mitotic nuclear divisionGO:00070672130.016
regulation of cell cycle phase transitionGO:19019871300.016
positive regulation of histone deacetylationGO:003106520.016
chemosensory behaviorGO:00076351060.016
regulation of cell shapeGO:00083601130.016
response to light stimulusGO:00094161240.016
purine ribonucleotide metabolic processGO:00091501450.016
columnar cuboidal epithelial cell developmentGO:00020662490.016
cellular response to ionizing radiationGO:0071479150.016
salivary gland cell autophagic cell deathGO:0035071830.016
cellular ketone metabolic processGO:0042180240.016
apoptotic processGO:00069151590.016
neurotransmitter transportGO:0006836370.016
localization of cellGO:00516742570.016
specification of organ identityGO:001009230.016
response to ionizing radiationGO:0010212320.016
positive regulation of cellular component organizationGO:00511301560.016
regulation of cell proliferationGO:00421271630.016
salivary gland histolysisGO:0035070880.016
response to painGO:004826530.016
blastoderm segmentationGO:00073501590.015
triglyceride biosynthetic processGO:001943220.015
positive regulation of immune system processGO:0002684680.015
salivary gland morphogenesisGO:00074351450.015
regulation of i kappab kinase nf kappab signalingGO:004312220.015
peptide metabolic processGO:0006518800.015
cellular response to chemical stimulusGO:00708871990.015
taxisGO:00423303040.015
multi organism behaviorGO:00517051750.015
embryonic morphogenesisGO:00485982060.015
regulation of ras protein signal transductionGO:0046578930.015
positive regulation of nucleic acid templated transcriptionGO:19035082660.015
dna integrity checkpointGO:0031570810.015
cellular response to molecule of bacterial originGO:007121930.015
purine nucleoside triphosphate metabolic processGO:00091441190.015
purine containing compound metabolic processGO:00725211550.015
cellular lipid metabolic processGO:0044255830.015
regulation of embryonic developmentGO:0045995680.015
hindgut morphogenesisGO:0007442580.015
segment specificationGO:0007379330.015
organonitrogen compound biosynthetic processGO:19015661170.015
neural retina developmentGO:000340740.015
tube developmentGO:00352952440.015
regulation of multi organism processGO:00439001310.015
central nervous system developmentGO:00074172010.015
cytoplasmic transportGO:00164821300.015
aromatic compound catabolic processGO:00194391660.015
organelle fissionGO:00482853400.015
regulation of phospholipase activityGO:001051720.015
positive regulation of catalytic activityGO:00430851180.015
cellular response to hexose stimulusGO:007133110.015
cell cycle phase transitionGO:00447701400.015
collateral sproutingGO:004866830.015
rna processingGO:00063961470.015
wound healingGO:0042060750.015
reproductive behaviorGO:00190981220.015
secondary metabolite biosynthetic processGO:0044550240.015
wound healing spreading of cellsGO:004431920.015
eye photoreceptor cell differentiationGO:00017541450.015
embryonic axis specificationGO:00005781070.015
regulation of response to oxidative stressGO:190288240.015
positive regulation of phosphorylationGO:0042327870.015
negative regulation of small gtpase mediated signal transductionGO:0051058130.015
purine nucleotide metabolic processGO:00061631460.015
neutral lipid biosynthetic processGO:004646020.015
negative regulation of cell deathGO:0060548810.014
regulation of growthGO:00400082330.014
regulation of innate immune responseGO:0045088710.014
positive regulation of intracellular signal transductionGO:19025331160.014
ethanolamine containing compound metabolic processGO:004243940.014
mitotic spindle organizationGO:00070522200.014
protein localization to nucleusGO:0034504550.014
regulation of mitotic cell cycle phase transitionGO:19019901300.014
regulation of small gtpase mediated signal transductionGO:0051056930.014
neuromuscular synaptic transmissionGO:0007274670.014
malpighian tubule developmentGO:0072002640.014
detection of external stimulusGO:0009581660.014
morphogenesis of an epitheliumGO:00020092760.014
molting cycleGO:0042303560.014
sensory perception of painGO:001923340.014
dna damage checkpointGO:0000077780.014
response to external biotic stimulusGO:00432072930.014
cell cell adhesionGO:0098609260.014
regulation of cyclin dependent protein serine threonine kinase activityGO:000007930.014
filopodium assemblyGO:0046847330.014
negative regulation of nervous system developmentGO:0051961920.014
rna localizationGO:00064031150.014
digestive tract morphogenesisGO:00485461270.014
brain developmentGO:00074201200.014
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.014
negative regulation of cellular protein metabolic processGO:0032269850.014
anion homeostasisGO:005508130.014
detection of stimulus involved in sensory perceptionGO:0050906920.014
response to endogenous stimulusGO:00097191190.014
nucleoside phosphate metabolic processGO:00067531620.014
posttranscriptional regulation of gene expressionGO:00106081450.014
positive regulation of peptidyl tyrosine phosphorylationGO:005073140.014
embryonic development via the syncytial blastodermGO:00017001480.014
germarium derived egg chamber formationGO:00072931010.014
multi organism reproductive behaviorGO:00447051210.014
cell surface receptor signaling pathway involved in heart developmentGO:006131130.014
synaptic target recognitionGO:0008039450.014
positive regulation of developmental growthGO:0048639620.014
embryonic hemopoiesisGO:0035162260.014
neutral lipid catabolic processGO:004646130.014
positive regulation of hydrolase activityGO:0051345780.014
protein hydroxylationGO:001812610.014
heterocycle catabolic processGO:00467001660.014
positive regulation of molecular functionGO:00440931360.014
cellular response to biotic stimulusGO:007121640.014
inter male aggressive behaviorGO:0002121600.014
axon cargo transportGO:0008088290.014
chromosome separationGO:0051304420.014
open tracheal system developmentGO:00074242040.014
photoreceptor cell differentiationGO:00465301700.014
protein targeting to nucleusGO:0044744510.014
receptor clusteringGO:004311330.014
cell maturationGO:00484691440.013
camera type eye morphogenesisGO:004859320.013
mesenchymal cell developmentGO:001403110.013
protein localization to organelleGO:0033365820.013
respiratory system developmentGO:00605412130.013
negative regulation of immune responseGO:0050777390.013
cellular transition metal ion homeostasisGO:004691690.013
regulation of mitosisGO:0007088560.013
cuticle pattern formationGO:0035017270.013
rrna processingGO:000636430.013
establishment or maintenance of microtubule cytoskeleton polarityGO:0030951410.013
response to nitrogen compoundGO:1901698900.013
regulation of reproductive processGO:2000241540.013
oocyte axis specificationGO:00073091080.013
regulation of cellular response to stressGO:0080135890.013
g protein coupled receptor signaling pathwayGO:00071861360.013
eye morphogenesisGO:00485922600.013
regulation of meiosisGO:004002030.013
regulation of imaginal disc derived wing sizeGO:0044719200.013
negative regulation of cell cycle processGO:00109481090.013
pigment metabolic process involved in developmental pigmentationGO:0043324330.013
mitotic cell cycle embryonicGO:0045448380.013
pattern recognition receptor signaling pathwayGO:000222120.013
response to ecdysoneGO:0035075340.013
morphogenesis of embryonic epitheliumGO:0016331940.013
hindgut developmentGO:0061525580.013
regulation of gene expression epigeneticGO:00400291280.013
positive regulation of cellular protein metabolic processGO:00322701180.013
sensory organ morphogenesisGO:00905962600.013
regulation of histone deacetylationGO:003106320.013
cell motilityGO:00488702510.013
cellular nitrogen compound catabolic processGO:00442701650.013
response to woundingGO:0009611940.013
nucleoside triphosphate metabolic processGO:00091411200.013
organic hydroxy compound metabolic processGO:1901615830.013
imaginal disc pattern formationGO:0007447910.013
establishment of planar polarityGO:0001736870.013
mesenchymal cell differentiationGO:004876210.013

bru-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.046
disease of metabolismDOID:001466700.043
inherited metabolic disorderDOID:65500.030
nervous system diseaseDOID:86300.027
glucose metabolism diseaseDOID:419400.024
acquired metabolic diseaseDOID:006015800.024
type 2 diabetes mellitusDOID:935200.024
diabetes mellitusDOID:935100.024
carbohydrate metabolism diseaseDOID:005001300.024
disease of cellular proliferationDOID:1456600.023
cancerDOID:16200.018
organ system cancerDOID:005068600.017
musculoskeletal system diseaseDOID:1700.013
connective tissue diseaseDOID:6500.013