Drosophila melanogaster

7 known processes

Nep4 (Dmel_CG4058)

Neprilysin 4

(Aliases: DmeNEP4,Dmel\CG4058,dNEP4,CG4058)

Nep4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to biotic stimulusGO:00096072940.060
immune system processGO:00023763470.057
response to external biotic stimulusGO:00432072930.048
defense responseGO:00069523000.046
lipid metabolic processGO:00066291210.041
appendage morphogenesisGO:00351073970.039
regulation of multicellular organismal developmentGO:20000264140.038
response to other organismGO:00517072930.038
defense response to other organismGO:00985422250.037
muscle structure developmentGO:00610612240.036
single organism behaviorGO:00447083910.035
oxoacid metabolic processGO:00434361030.035
mrna metabolic processGO:00160711240.034
protein modification processGO:00362114380.033
vesicle mediated transportGO:00161923810.033
somatic muscle developmentGO:0007525660.033
positive regulation of response to stimulusGO:00485843230.033
small molecule metabolic processGO:00442813050.032
regulation of rna splicingGO:0043484690.032
positive regulation of macromolecule metabolic processGO:00106044050.029
regionalizationGO:00030024160.029
regulation of phosphate metabolic processGO:00192202100.029
camera type eye developmentGO:004301040.029
regulation of growthGO:00400082330.029
rna processingGO:00063961470.029
spindle organizationGO:00070512530.028
regulation of phosphorus metabolic processGO:00511742100.028
negative regulation of signal transductionGO:00099682060.027
negative regulation of cellular component organizationGO:00511291080.027
response to bacteriumGO:00096171980.027
adult behaviorGO:00305341370.027
cellular lipid metabolic processGO:0044255830.026
negative regulation of multicellular organismal processGO:00512411420.025
regulation of immune responseGO:00507761180.025
body morphogenesisGO:001017120.025
regulation of catalytic activityGO:00507901850.025
immune responseGO:00069552460.025
cellular amine metabolic processGO:0044106120.025
regulation of cellular amine metabolic processGO:003323830.025
single organism biosynthetic processGO:00447112060.024
limb developmentGO:006017310.024
macromolecular complex assemblyGO:00650032560.024
sensory perceptionGO:00076001960.024
cellular catabolic processGO:00442483720.024
positive regulation of cellular biosynthetic processGO:00313283160.024
organic acid metabolic processGO:00060821030.023
organic substance catabolic processGO:19015753080.023
phosphorylationGO:00163102940.023
organic substance transportGO:00717022570.023
catabolic processGO:00090564090.023
regulation of immune system processGO:00026821760.023
protein complex biogenesisGO:00702712010.022
intracellular signal transductionGO:00355563000.022
regulation of response to stressGO:00801342000.022
protein localizationGO:00081042840.022
negative regulation of nitrogen compound metabolic processGO:00511722650.022
embryonic morphogenesisGO:00485982060.022
amine metabolic processGO:0009308120.021
kidney developmentGO:000182230.021
actin filament based processGO:00300292200.021
mrna processingGO:00063971040.021
positive regulation of signal transductionGO:00099672230.021
response to abiotic stimulusGO:00096283410.021
regulation of cellular amino acid metabolic processGO:000652100.021
cellular protein modification processGO:00064644380.021
regulation of alternative mrna splicing via spliceosomeGO:0000381600.021
phagocytosisGO:00069092150.021
neuromuscular junction developmentGO:00075281490.021
organelle fissionGO:00482853400.021
imaginal disc derived appendage developmentGO:00487373990.021
axonogenesisGO:00074092900.021
negative regulation of cellular metabolic processGO:00313243820.021
defense response to bacteriumGO:00427421780.020
ethanolamine containing compound metabolic processGO:004243940.020
regulation of developmental growthGO:00486381740.020
protein complex assemblyGO:00064612000.020
tube morphogenesisGO:00352391910.020
spermatogenesisGO:00072832000.020
eye developmentGO:00016543230.020
Fly
negative regulation of gene expressionGO:00106293870.020
anion homeostasisGO:005508130.020
chemotaxisGO:00069352490.020
positive regulation of cell communicationGO:00106472500.020
camera type eye morphogenesisGO:004859320.020
innate immune responseGO:00450871440.020
regulation of defense responseGO:00313471020.020
retina development in camera type eyeGO:006004140.020
cranial nerve developmentGO:002154510.020
cellular nitrogen compound catabolic processGO:00442701650.019
axon developmentGO:00615642970.019
developmental maturationGO:00217001720.019
regulation of cellular protein metabolic processGO:00322682430.019
regulation of mrna splicing via spliceosomeGO:0048024640.019
wing disc morphogenesisGO:00074723440.019
positive regulation of signalingGO:00230562430.019
organic cyclic compound catabolic processGO:19013611680.019
carboxylic acid metabolic processGO:0019752920.019
synaptic growth at neuromuscular junctionGO:00511241190.018
cellular ketone metabolic processGO:0042180240.018
negative regulation of developmental processGO:00510932010.018
regulation of nervous system developmentGO:00519602480.018
ion transportGO:00068111450.018
forebrain developmentGO:003090020.018
response to temperature stimulusGO:00092661060.018
synaptic transmissionGO:00072682880.018
neurological system processGO:00508773580.018
single organism catabolic processGO:00447122280.018
organonitrogen compound metabolic processGO:19015643180.018
Rat
appendage developmentGO:00487364010.018
post embryonic appendage morphogenesisGO:00351203850.018
negative regulation of nervous system developmentGO:0051961920.018
ras protein signal transductionGO:0007265880.018
chromosome organizationGO:00512763600.018
endocytosisGO:00068973100.017
single organism intracellular transportGO:19025822070.017
negative regulation of cell communicationGO:00106482230.017
protein ubiquitinationGO:0016567700.017
sensory perception of chemical stimulusGO:00076061160.017
regulation of phosphorylationGO:00423251470.017
establishment of localization in cellGO:00516494020.017
regulation of multi organism processGO:00439001310.017
nuclear divisionGO:00002803320.017
positive regulation of gene expressionGO:00106282900.017
regulation of i kappab kinase nf kappab signalingGO:004312220.017
regulation of response to external stimulusGO:00321011150.016
innate immune response activating signal transductionGO:000275820.016
male gamete generationGO:00482322010.016
organic hydroxy compound metabolic processGO:1901615830.016
deathGO:00162652840.016
organonitrogen compound catabolic processGO:19015651280.016
heterocycle catabolic processGO:00467001660.016
imaginal disc derived wing morphogenesisGO:00074763370.016
regulation of intracellular signal transductionGO:19025312360.016
taxisGO:00423303040.016
nucleobase containing small molecule metabolic processGO:00550861740.016
acid secretionGO:004671710.016
cell maturationGO:00484691440.016
positive regulation of nitrogen compound metabolic processGO:00511733540.016
intracellular transportGO:00469072280.016
positive regulation of macromolecule biosynthetic processGO:00105572830.016
regulation of mrna metabolic processGO:1903311720.016
nucleoside catabolic processGO:00091641120.016
nucleobase containing compound catabolic processGO:00346551650.015
negative regulation of response to stimulusGO:00485852580.015
positive regulation of molecular functionGO:00440931360.015
positive regulation of developmental processGO:00510941430.015
alternative mrna splicing via spliceosomeGO:0000380600.015
signal transduction by phosphorylationGO:00230141070.015
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.015
positive regulation of nucleobase containing compound metabolic processGO:00459353320.015
response to lipopolysaccharideGO:003249640.015
regulation of cell developmentGO:00602842150.015
oocyte differentiationGO:00099941450.015
programmed cell deathGO:00125012570.015
protein modification by small protein conjugation or removalGO:00706471060.015
cellular amino acid metabolic processGO:0006520610.015
rna splicing via transesterification reactionsGO:0000375730.015
epithelial cell developmentGO:00020642740.015
developmental growthGO:00485892800.015
single organism cellular localizationGO:19025801800.014
regulation of innate immune responseGO:0045088710.014
limb morphogenesisGO:003510810.014
immune effector processGO:0002252980.014
homeostatic processGO:00425921990.014
regulation of molecular functionGO:00650092170.014
mitotic spindle organizationGO:00070522200.014
regulation of mitotic cell cycleGO:00073461900.014
cellular macromolecule localizationGO:00707272200.014
purine containing compound metabolic processGO:00725211550.014
nucleotide catabolic processGO:00091661090.014
nucleotide metabolic processGO:00091171610.014
negative regulation of growthGO:0045926840.014
immune response regulating signaling pathwayGO:000276420.014
neuron recognitionGO:00080381010.014
cellular macromolecular complex assemblyGO:00346221530.014
photoreceptor cell differentiationGO:00465301700.014
regulation of protein metabolic processGO:00512462560.014
maintenance of locationGO:0051235730.014
defense response to gram negative bacteriumGO:0050829940.014
oocyte constructionGO:00073081120.014
mesoderm developmentGO:0007498780.014
mitotic nuclear divisionGO:00070672130.014
actin cytoskeleton organizationGO:00300362060.014
cellularizationGO:0007349900.014
extrinsic apoptotic signaling pathwayGO:009719110.013
regulation of cellular component biogenesisGO:00440872010.013
response to organic substanceGO:00100332840.013
mapk cascadeGO:00001651070.013
regulation of localizationGO:00328792750.013
regulation of cell cycleGO:00517262910.013
cellular component assembly involved in morphogenesisGO:00109271510.013
negative regulation of cellular biosynthetic processGO:00313272770.013
developmental pigmentationGO:0048066680.013
cellular protein localizationGO:00346131600.013
regulation of mapk cascadeGO:0043408920.013
regulation of programmed cell deathGO:00430671520.013
actin filament organizationGO:00070151260.013
pigmentationGO:0043473750.013
pigment metabolic process involved in developmental pigmentationGO:0043324330.013
response to endogenous stimulusGO:00097191190.013
aromatic compound catabolic processGO:00194391660.013
proteolysisGO:00065081920.013
mrna splicing via spliceosomeGO:0000398730.013
positive regulation of phosphorus metabolic processGO:00105621390.013
axon guidanceGO:00074112330.013
positive regulation of nucleic acid templated transcriptionGO:19035082660.013
positive regulation of multicellular organismal processGO:00512401430.013
segmentationGO:00352822070.013
neutral lipid biosynthetic processGO:004646020.013
regulation of cellular ketone metabolic processGO:001056530.013
small gtpase mediated signal transductionGO:0007264880.013
cellular homeostasisGO:0019725800.013
ribonucleotide metabolic processGO:00092591450.013
organophosphate metabolic processGO:00196371950.013
eye pigmentationGO:0048069430.013
regulation of synapse structure and activityGO:00508031280.013
regulation of synapse assemblyGO:0051963940.013
lipid modificationGO:0030258240.013
negative regulation of developmental growthGO:0048640640.013
membrane organizationGO:00610241120.013
positive regulation of immune responseGO:0050778630.012
protein heterooligomerizationGO:005129140.012
biological adhesionGO:00226101380.012
oocyte developmentGO:00485991240.012
transcription from rna polymerase ii promoterGO:00063663680.012
response to copper ionGO:004668840.012
tissue morphogenesisGO:00487292970.012
kidney epithelium developmentGO:007207330.012
phosphatidylethanolamine metabolic processGO:004633710.012
regulation of cell deathGO:00109411730.012
epithelial cell differentiationGO:00308553220.012
positive regulation of rna metabolic processGO:00512542710.012
digestive system developmentGO:00551231490.012
gland developmentGO:00487321910.012
negative regulation of programmed cell deathGO:0043069720.012
multicellular organismal agingGO:00102591400.012
cognitionGO:00508901410.012
lipid biosynthetic processGO:0008610460.012
blastoderm segmentationGO:00073501590.012
positive regulation of catalytic activityGO:00430851180.012
feeding behaviorGO:0007631500.012
embryonic pattern specificationGO:00098801740.012
regulation of cellular catabolic processGO:00313291570.012
imaginal disc derived appendage morphogenesisGO:00351143950.012
positive regulation of transcription dna templatedGO:00458932660.012
positive regulation of phosphate metabolic processGO:00459371390.012
positive regulation of rna biosynthetic processGO:19026802660.012
neural retina developmentGO:000340740.012
nucleoside phosphate metabolic processGO:00067531620.012
eye morphogenesisGO:00485922600.012
Fly
response to virusGO:0009615280.012
glycosyl compound catabolic processGO:19016581120.012
protein phosphorylationGO:00064681690.012
protein transportGO:00150311550.012
organelle localizationGO:00516401480.012
negative regulation of nucleic acid templated transcriptionGO:19035072400.012
positive regulation of protein metabolic processGO:00512471280.012
organonitrogen compound biosynthetic processGO:19015661170.012
acetate ester metabolic processGO:190061920.012
compound eye photoreceptor cell differentiationGO:00017511400.012
regulation of hydrolase activityGO:0051336970.012
cell motilityGO:00488702510.012
defense response to virusGO:0051607230.012
connective tissue developmentGO:006144830.012
larval developmentGO:00021641040.012
positive regulation of defense responseGO:0031349590.011
cell recognitionGO:00080371020.011
purine ribonucleoside triphosphate catabolic processGO:00092071080.011
growthGO:00400073590.011
purine nucleoside catabolic processGO:00061521120.011
protein modification by small protein conjugationGO:0032446790.011
cellular response to chemical stimulusGO:00708871990.011
vitamin biosynthetic processGO:000911010.011
nucleoside metabolic processGO:00091161270.011
mesenchymal cell differentiationGO:004876210.011
positive regulation of i kappab kinase nf kappab signalingGO:004312310.011
embryonic development via the syncytial blastodermGO:00017001480.011
mesenchymal cell developmentGO:001403110.011
purine nucleotide metabolic processGO:00061631460.011
embryonic axis specificationGO:00005781070.011
dendrite developmentGO:00163582040.011
pattern recognition receptor signaling pathwayGO:000222120.011
cellular response to heatGO:0034605240.011
endomembrane system organizationGO:00102561190.011
negative regulation of nucleobase containing compound metabolic processGO:00459342610.011
rna splicingGO:0008380830.011
regulation of anatomical structure morphogenesisGO:00226032420.011
purine ribonucleoside metabolic processGO:00461281270.011
sensory organ morphogenesisGO:00905962600.011
Fly
ribonucleotide catabolic processGO:00092611090.011
single organism membrane organizationGO:0044802930.011
sterol homeostasisGO:005509240.011
open tracheal system developmentGO:00074242040.011
positive regulation of biosynthetic processGO:00098913160.011
monocarboxylic acid transportGO:001571830.011
carbohydrate derivative catabolic processGO:19011361180.011
phosphatidylcholine metabolic processGO:004647030.011
macromolecule catabolic processGO:00090571610.011
cellular response to radiationGO:0071478520.011
locomotory behaviorGO:00076261760.011
rna localizationGO:00064031150.011
notch signaling pathwayGO:00072191200.011
glycosyl compound metabolic processGO:19016571270.011
morphogenesis of an epitheliumGO:00020092760.011
organelle assemblyGO:00709251980.011
compound eye developmentGO:00487493070.011
Fly
salivary gland morphogenesisGO:00074351450.011
neuromuscular synaptic transmissionGO:0007274670.011
response to organophosphorusGO:004668320.011
negative regulation of defense responseGO:0031348350.011
cellular macromolecule catabolic processGO:00442651360.010
negative regulation of apoptotic processGO:0043066630.010
negative regulation of cell deathGO:0060548810.010
regulation of protein modification processGO:00313991120.010
digestive tract developmentGO:00485651490.010
eye pigment metabolic processGO:0042441330.010
stem cell differentiationGO:00488631170.010
regulation of cell cycle processGO:00105641810.010
immune response activating signal transductionGO:000275720.010
pigment metabolic processGO:0042440840.010
regulation of apoptotic processGO:00429811300.010
cell growthGO:00160491080.010
purine nucleoside triphosphate catabolic processGO:00091461080.010
regulation of cell differentiationGO:00455953020.010
positive regulation of cellular catabolic processGO:0031331950.010
organophosphate catabolic processGO:00464341120.010
regulation of immune effector processGO:0002697520.010
positive regulation of cellular amine metabolic processGO:003324000.010
hindbrain developmentGO:003090220.010
anatomical structure homeostasisGO:0060249970.010
columnar cuboidal epithelial cell differentiationGO:00020652560.010
dendrite morphogenesisGO:00488131990.010
ribonucleoside metabolic processGO:00091191270.010
protein polymerizationGO:0051258420.010
regulation of proteolysisGO:0030162870.010
regulation of response to biotic stimulusGO:0002831630.010
negative regulation of macromolecule biosynthetic processGO:00105582700.010
positive regulation of catabolic processGO:00098961050.010

Nep4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.056
nervous system diseaseDOID:86300.030
cardiovascular system diseaseDOID:128700.020
musculoskeletal system diseaseDOID:1700.019
sensory system diseaseDOID:005015500.019
eye diseaseDOID:561400.019
eye and adnexa diseaseDOID:149200.019
disease of cellular proliferationDOID:1456600.018
cancerDOID:16200.018
organ system cancerDOID:005068600.018
disease of metabolismDOID:001466700.015
Human
carbohydrate metabolism diseaseDOID:005001300.014
acquired metabolic diseaseDOID:006015800.014
diabetes mellitusDOID:935100.014
type 2 diabetes mellitusDOID:935200.014
glucose metabolism diseaseDOID:419400.014
central nervous system diseaseDOID:33100.011
neurodegenerative diseaseDOID:128900.011
hypertensionDOID:1076300.010
artery diseaseDOID:005082800.010
vascular diseaseDOID:17800.010