IMP: Integrative Multi-species Prediction

Drosophila melanogaster

18 known processes

eIF4E-4 (Dmel_CG10124)

CG10124 gene product from transcript CG10124-RA

(Aliases: NEST:bs04e06,Dmel\CG10124,CT28485,eIF4E,BEST:GH01027,CG10124)

FLYBASE: FBgn0035709
Entrez: 38743
UniProtKB: Q9VRY0

Process Predictions
Disease Predictions

eIF4E-4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organic acid metabolic process	GO:0006082	103	0.067
small molecule metabolic process	GO:0044281	305	0.053
organonitrogen compound metabolic process	GO:1901564	318	0.051
oxoacid metabolic process	GO:0043436	103	0.043
carboxylic acid metabolic process	GO:0019752	92	0.033
response to organic substance	GO:0010033	284	0.031
spermatogenesis	GO:0007283	200	0.030	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.029
pyridine containing compound metabolic process	GO:0072524	3	0.029
vesicle mediated transport	GO:0016192	381	0.027
cellular amino acid metabolic process	GO:0006520	61	0.026
single organism biosynthetic process	GO:0044711	206	0.026
endocytosis	GO:0006897	310	0.025
catabolic process	GO:0009056	409	0.024
organic substance catabolic process	GO:1901575	308	0.024
response to oxygen containing compound	GO:1901700	200	0.023
response to abiotic stimulus	GO:0009628	341	0.023
positive regulation of cellular biosynthetic process	GO:0031328	316	0.023	Fly
phagocytosis	GO:0006909	215	0.023
positive regulation of macromolecule metabolic process	GO:0010604	405	0.022	Fly
response to biotic stimulus	GO:0009607	294	0.022
lipid metabolic process	GO:0006629	121	0.021
cellular response to chemical stimulus	GO:0070887	199	0.021
pyridine nucleotide metabolic process	GO:0019362	2	0.021
response to other organism	GO:0051707	293	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.020	Fly
positive regulation of rna metabolic process	GO:0051254	271	0.020
cellular response to organic substance	GO:0071310	132	0.020
kidney development	GO:0001822	3	0.020
positive regulation of signal transduction	GO:0009967	223	0.020
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.019
cell proliferation	GO:0008283	299	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.019	Fly
response to external biotic stimulus	GO:0043207	293	0.018
nucleoside phosphate metabolic process	GO:0006753	162	0.018
growth	GO:0040007	359	0.018
ion transport	GO:0006811	145	0.018
mitotic spindle organization	GO:0007052	220	0.018
chromatin organization	GO:0006325	207	0.018
macromolecular complex assembly	GO:0065003	256	0.018
cellular ketone metabolic process	GO:0042180	24	0.017
cellular catabolic process	GO:0044248	372	0.017
response to lipopolysaccharide	GO:0032496	4	0.017
protein modification process	GO:0036211	438	0.017
positive regulation of response to stimulus	GO:0048584	323	0.017
protein complex biogenesis	GO:0070271	201	0.017
cellular macromolecular complex assembly	GO:0034622	153	0.017
single organism catabolic process	GO:0044712	228	0.017
regulation of localization	GO:0032879	275	0.017
l amino acid import	GO:0043092	2	0.017
oxidation reduction process	GO:0055114	123	0.017
single organism intracellular transport	GO:1902582	207	0.016
spermatid development	GO:0007286	98	0.016
transcription from rna polymerase ii promoter	GO:0006366	368	0.016
cell death	GO:0008219	279	0.016	Fly
compound eye development	GO:0048749	307	0.016
positive regulation of cell communication	GO:0010647	250	0.016
nucleotide metabolic process	GO:0009117	161	0.016
organic substance transport	GO:0071702	257	0.016
positive regulation of gene expression	GO:0010628	290	0.015	Fly
chromosome organization	GO:0051276	360	0.015
cellular protein modification process	GO:0006464	438	0.015
spindle organization	GO:0007051	253	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.015
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
regulation of transport	GO:0051049	181	0.014
male gamete generation	GO:0048232	201	0.014	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.014
microtubule organizing center organization	GO:0031023	168	0.014
chaeta development	GO:0022416	97	0.014
positive regulation of transcription dna templated	GO:0045893	266	0.014
cellularization	GO:0007349	90	0.013
cell projection assembly	GO:0030031	94	0.013
intracellular signal transduction	GO:0035556	300	0.013
eye photoreceptor cell differentiation	GO:0001754	145	0.013
single organism behavior	GO:0044708	391	0.013
cellular component assembly involved in morphogenesis	GO:0010927	151	0.013
oxidoreduction coenzyme metabolic process	GO:0006733	2	0.013
positive regulation of signaling	GO:0023056	243	0.012
nicotinamide nucleotide metabolic process	GO:0046496	2	0.012
positive regulation of cell motility	GO:2000147	3	0.012
gene silencing	GO:0016458	138	0.012
regionalization	GO:0003002	416	0.012
regulation of intracellular signal transduction	GO:1902531	236	0.012
embryonic pattern specification	GO:0009880	174	0.012
defense response	GO:0006952	300	0.012
nadh metabolic process	GO:0006734	1	0.012
cellular protein complex assembly	GO:0043623	71	0.012
protein modification by small protein conjugation	GO:0032446	79	0.011
gland morphogenesis	GO:0022612	145	0.011	Fly
exocrine system development	GO:0035272	162	0.011	Fly
cellular macromolecule catabolic process	GO:0044265	136	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
intracellular transport	GO:0046907	228	0.011
macromolecule catabolic process	GO:0009057	161	0.011
organic hydroxy compound metabolic process	GO:1901615	83	0.011
amine metabolic process	GO:0009308	12	0.011
tube development	GO:0035295	244	0.011	Rat
protein modification by small protein conjugation or removal	GO:0070647	106	0.011
response to oxygen levels	GO:0070482	59	0.011
gland development	GO:0048732	191	0.011	Fly
segmentation	GO:0035282	207	0.011
organonitrogen compound biosynthetic process	GO:1901566	117	0.011
sensory organ morphogenesis	GO:0090596	260	0.011
negative regulation of response to stimulus	GO:0048585	258	0.011
determination of adult lifespan	GO:0008340	137	0.010
actin cytoskeleton organization	GO:0030036	206	0.010
regulation of cellular ketone metabolic process	GO:0010565	3	0.010
cytoplasmic transport	GO:0016482	130	0.010
epithelial cell development	GO:0002064	274	0.010
forebrain development	GO:0030900	2	0.010
protein ubiquitination	GO:0016567	70	0.010
nitrogen compound transport	GO:0071705	85	0.010
cellular lipid metabolic process	GO:0044255	83	0.010
regulation of cellular amine metabolic process	GO:0033238	3	0.010
multicellular organismal aging	GO:0010259	140	0.010
organelle assembly	GO:0070925	198	0.010
regulation of cell cycle process	GO:0010564	181	0.010
chemotaxis	GO:0006935	249	0.010

eIF4E-4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.021
	musculoskeletal system disease	DOID:17	0	0.013

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