IMP: Integrative Multi-species Prediction

Drosophila melanogaster

122 known processes

tsu (Dmel_CG8781)

tsunagi

(Aliases: Dmel\CG8781,CG8781,cg8781,Y14/Tsunagi,Y14,Tsu,y14)

FLYBASE: FBgn0033378
Entrez: 35924
UniProtKB: F2FB57
UniProtKB: Q9V535

Process Predictions
Disease Predictions

tsu biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
oocyte axis specification	GO:0007309	108	0.999
oocyte anterior posterior axis specification	GO:0007314	72	0.998
oocyte development	GO:0048599	124	0.997
oocyte differentiation	GO:0009994	145	0.993
pole plasm assembly	GO:0007315	61	0.971
pole plasm rna localization	GO:0007316	52	0.970
segmentation	GO:0035282	207	0.961
pole plasm oskar mrna localization	GO:0045451	46	0.956
intracellular mrna localization	GO:0008298	66	0.922
blastoderm segmentation	GO:0007350	159	0.914
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.910
pole plasm mrna localization	GO:0019094	49	0.899
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.886
embryonic axis specification	GO:0000578	107	0.861
oocyte construction	GO:0007308	112	0.827
embryonic pattern specification	GO:0009880	174	0.818
anterior posterior pattern specification	GO:0009952	136	0.810
developmental maturation	GO:0021700	172	0.783
cytoplasm organization	GO:0007028	64	0.779
cell maturation	GO:0048469	144	0.731
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.698
anterior posterior axis specification embryo	GO:0008595	103	0.692
regionalization	GO:0003002	416	0.660
axis specification	GO:0009798	167	0.622
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.583
rna processing	GO:0006396	147	0.553	Human
nuclear transcribed mrna catabolic process nonsense mediated decay	GO:0000184	8	0.548	Human
negative regulation of gene expression	GO:0010629	387	0.518
mrna splicing via spliceosome	GO:0000398	73	0.511	Human
rna localization	GO:0006403	115	0.444
mrna metabolic process	GO:0016071	124	0.406	Human
pronuclear migration	GO:0035046	4	0.404
apoptotic process	GO:0006915	159	0.329	Worm
single organism cellular localization	GO:1902580	180	0.311
tripartite regional subdivision	GO:0007351	103	0.279
ncrna metabolic process	GO:0034660	43	0.259
morphogenesis of follicular epithelium	GO:0016333	36	0.242
gene silencing	GO:0016458	138	0.212
endomembrane system organization	GO:0010256	119	0.202
rna splicing via transesterification reactions	GO:0000375	73	0.200	Human
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.191	Human
endocytosis	GO:0006897	310	0.185	Worm
peptidyl lysine methylation	GO:0018022	16	0.181
mrna processing	GO:0006397	104	0.170	Human
cellular macromolecular complex assembly	GO:0034622	153	0.168
chromosome organization	GO:0051276	360	0.167
alternative mrna splicing via spliceosome	GO:0000380	60	0.159	Human
anterior posterior axis specification	GO:0009948	109	0.155
embryo development ending in birth or egg hatching	GO:0009792	152	0.154	Worm
heterocycle catabolic process	GO:0046700	166	0.152	Human
regulation of meiosis	GO:0040020	3	0.151
transcription from rna polymerase ii promoter	GO:0006366	368	0.144
positive regulation of rna biosynthetic process	GO:1902680	266	0.141
chromatin organization	GO:0006325	207	0.138
death	GO:0016265	284	0.137	Worm
small gtpase mediated signal transduction	GO:0007264	88	0.137
rna splicing	GO:0008380	83	0.131	Human
peptidyl lysine modification	GO:0018205	57	0.130
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.128
nucleus localization	GO:0051647	34	0.123
positive regulation of phosphate metabolic process	GO:0045937	139	0.119
posttranscriptional gene silencing	GO:0016441	46	0.117
organelle assembly	GO:0070925	198	0.117
establishment of oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0030722	6	0.114
regulation of dna templated transcription elongation	GO:0032784	17	0.113
cell death	GO:0008219	279	0.113	Worm
cellular macromolecule localization	GO:0070727	220	0.110
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.104	Human
covalent chromatin modification	GO:0016569	106	0.096
larval development	GO:0002164	104	0.095	Worm
mrna catabolic process	GO:0006402	33	0.091	Human
ras protein signal transduction	GO:0007265	88	0.089
negative regulation of cell cycle	GO:0045786	116	0.088
body morphogenesis	GO:0010171	2	0.088
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.087
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.085
nucleobase containing compound catabolic process	GO:0034655	165	0.082	Human
ribonucleoside catabolic process	GO:0042454	112	0.077
aromatic compound catabolic process	GO:0019439	166	0.077	Human
establishment of nucleus localization	GO:0040023	26	0.075
histone acetylation	GO:0016573	38	0.075
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.073
cell proliferation	GO:0008283	299	0.073
homeostatic process	GO:0042592	199	0.073
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.073
ribonucleoprotein complex biogenesis	GO:0022613	31	0.072
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.072
negative regulation of cell cycle process	GO:0010948	109	0.068
regulation of cell maturation	GO:1903429	27	0.068
programmed cell death	GO:0012501	257	0.068	Worm
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.065
multicellular organismal aging	GO:0010259	140	0.064
gonad development	GO:0008406	50	0.060	Worm
negative regulation of transcription dna templated	GO:0045892	237	0.058
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.057
cytoplasmic transport	GO:0016482	130	0.057
cellular catabolic process	GO:0044248	372	0.057	Human
regulation of organelle organization	GO:0033043	196	0.057
chromatin modification	GO:0016568	147	0.057
phosphorylation	GO:0016310	294	0.055
regulation of hydrolase activity	GO:0051336	97	0.055
single organism intracellular transport	GO:1902582	207	0.054
negative regulation of gene expression epigenetic	GO:0045814	77	0.053
regulation of cellular localization	GO:0060341	136	0.053
organelle fission	GO:0048285	340	0.052
regulation of apoptotic process	GO:0042981	130	0.052
regulation of ras protein signal transduction	GO:0046578	93	0.051
regulation of catalytic activity	GO:0050790	185	0.050
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.049
meiotic nuclear division	GO:0007126	151	0.049
positive regulation of response to stimulus	GO:0048584	323	0.048
rrna processing	GO:0006364	3	0.047
macromolecular complex assembly	GO:0065003	256	0.046
establishment or maintenance of polarity of follicular epithelium	GO:0016334	26	0.046
reproductive system development	GO:0061458	74	0.045	Worm
development of primary sexual characteristics	GO:0045137	50	0.044	Worm
positive regulation of phosphorus metabolic process	GO:0010562	139	0.044
negative regulation of rna metabolic process	GO:0051253	251	0.043
positive regulation of transcription dna templated	GO:0045893	266	0.043
peptidyl lysine trimethylation	GO:0018023	6	0.043
regulation of mrna splicing via spliceosome	GO:0048024	64	0.043	Human
reproductive structure development	GO:0048608	74	0.041	Worm
purine containing compound metabolic process	GO:0072521	155	0.041
gene silencing by rna	GO:0031047	57	0.041
establishment of localization in cell	GO:0051649	402	0.041
sex differentiation	GO:0007548	81	0.041	Worm
purine ribonucleoside catabolic process	GO:0046130	112	0.040
positive regulation of biosynthetic process	GO:0009891	316	0.040
internal peptidyl lysine acetylation	GO:0018393	38	0.040
regulation of gene expression epigenetic	GO:0040029	128	0.039
protein acylation	GO:0043543	42	0.039
mrna cis splicing via spliceosome	GO:0045292	1	0.039
positive regulation of hydrolase activity	GO:0051345	78	0.039
nucleotide metabolic process	GO:0009117	161	0.038
regulation of cell proliferation	GO:0042127	163	0.038
mitotic cell cycle checkpoint	GO:0007093	88	0.037
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.037
cellular component assembly involved in morphogenesis	GO:0010927	151	0.037
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.036
rna catabolic process	GO:0006401	37	0.036	Human
regulation of meiotic cell cycle	GO:0051445	9	0.036
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.036
regulation of cell cycle process	GO:0010564	181	0.036
rna interference	GO:0016246	27	0.036
peptidyl lysine acetylation	GO:0018394	39	0.035
protein localization	GO:0008104	284	0.035
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.035
regulation of multi organism process	GO:0043900	131	0.034
regulation of cell cycle	GO:0051726	291	0.034
ribonucleotide metabolic process	GO:0009259	145	0.034
vesicle mediated transport	GO:0016192	381	0.034	Worm
cytoplasmic mrna processing body assembly	GO:0033962	10	0.033
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.032
regulation of cellular catabolic process	GO:0031329	157	0.032
single organism catabolic process	GO:0044712	228	0.031
negative regulation of rna biosynthetic process	GO:1902679	240	0.031
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.031
organophosphate metabolic process	GO:0019637	195	0.031
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.030
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.030
activin receptor signaling pathway	GO:0032924	6	0.029
cellular macromolecule catabolic process	GO:0044265	136	0.029	Human
chromatin silencing	GO:0006342	76	0.029
positive regulation of gene expression	GO:0010628	290	0.029
meiotic cell cycle	GO:0051321	171	0.028
nuclear migration	GO:0007097	20	0.028
glycosyl compound catabolic process	GO:1901658	112	0.028
negative regulation of developmental process	GO:0051093	201	0.028
regulation of gene silencing	GO:0060968	63	0.028
ribose phosphate metabolic process	GO:0019693	145	0.028
nucleoside phosphate catabolic process	GO:1901292	110	0.028
regulation of mitotic cell cycle	GO:0007346	190	0.028
cellular nitrogen compound catabolic process	GO:0044270	165	0.027	Human
regulation of localization	GO:0032879	275	0.027
regulation of reproductive process	GO:2000241	54	0.027
dna damage checkpoint	GO:0000077	78	0.027
phagocytosis	GO:0006909	215	0.027
mitotic dna integrity checkpoint	GO:0044774	75	0.027
catabolic process	GO:0009056	409	0.027	Human
response to heat	GO:0009408	63	0.026
genitalia development	GO:0048806	26	0.026	Worm
nucleobase containing small molecule metabolic process	GO:0055086	174	0.026
cellular protein complex assembly	GO:0043623	71	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.025
signal transduction by phosphorylation	GO:0023014	107	0.024
carbohydrate derivative metabolic process	GO:1901135	217	0.024
ribonucleoprotein complex subunit organization	GO:0071826	28	0.024
regulation of cell death	GO:0010941	173	0.024
erbb signaling pathway	GO:0038127	58	0.024
growth	GO:0040007	359	0.024
mitotic g2 m transition checkpoint	GO:0044818	70	0.023
germarium derived egg chamber formation	GO:0007293	101	0.023
small molecule metabolic process	GO:0044281	305	0.023
purine ribonucleotide metabolic process	GO:0009150	145	0.023
posttranscriptional gene silencing by rna	GO:0035194	45	0.023
organic cyclic compound catabolic process	GO:1901361	168	0.023	Human
purine ribonucleotide catabolic process	GO:0009154	109	0.023
cullin deneddylation	GO:0010388	3	0.022
nucleoside phosphate metabolic process	GO:0006753	162	0.022
negative regulation of cell cycle phase transition	GO:1901988	103	0.022
single organism membrane organization	GO:0044802	93	0.022
regulation of cell development	GO:0060284	215	0.022
regulation of catabolic process	GO:0009894	170	0.022
positive regulation of cell communication	GO:0010647	250	0.022
columnar cuboidal epithelial cell development	GO:0002066	249	0.022
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.021
organic substance catabolic process	GO:1901575	308	0.021	Human
purine containing compound catabolic process	GO:0072523	112	0.021
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.021
aging	GO:0007568	143	0.021
negative regulation of mitotic cell cycle	GO:0045930	109	0.021
regulation of intracellular signal transduction	GO:1902531	236	0.021
positive regulation of cellular biosynthetic process	GO:0031328	316	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.020
positive regulation of mapk cascade	GO:0043410	63	0.020
determination of adult lifespan	GO:0008340	137	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020
dna templated transcription initiation	GO:0006352	25	0.020
ribonucleotide catabolic process	GO:0009261	109	0.020
negative regulation of cell differentiation	GO:0045596	143	0.020
cell migration	GO:0016477	238	0.020
immune system process	GO:0002376	347	0.020
organophosphate catabolic process	GO:0046434	112	0.019
cellular homeostasis	GO:0019725	80	0.019
mitotic cell cycle phase transition	GO:0044772	138	0.019
organelle localization	GO:0051640	148	0.019
intracellular transport	GO:0046907	228	0.019
germarium derived female germ line cyst formation	GO:0030727	42	0.019
nuclear transport	GO:0051169	72	0.018
regulation of cellular component biogenesis	GO:0044087	201	0.018
protein complex biogenesis	GO:0070271	201	0.018
regulation of heterochromatin assembly	GO:0031445	8	0.018
purine ribonucleoside metabolic process	GO:0046128	127	0.018
positive regulation of catabolic process	GO:0009896	105	0.018
protein localization to plasma membrane	GO:0072659	13	0.018
regulation of cell division	GO:0051302	72	0.018
regulation of cell differentiation	GO:0045595	302	0.017
spindle organization	GO:0007051	253	0.017
protein acetylation	GO:0006473	39	0.017
modification dependent macromolecule catabolic process	GO:0043632	79	0.017
erk1 and erk2 cascade	GO:0070371	39	0.017
regulation of programmed cell death	GO:0043067	152	0.017
purine nucleotide catabolic process	GO:0006195	109	0.016
lateral inhibition	GO:0046331	206	0.016
cellular protein localization	GO:0034613	160	0.016
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.016
positive regulation of phosphorylation	GO:0042327	87	0.016
positive regulation of ras protein signal transduction	GO:0046579	43	0.016
positive regulation of signaling	GO:0023056	243	0.016
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.016
imaginal disc derived wing vein specification	GO:0007474	48	0.015
oocyte dorsal ventral axis specification	GO:0007310	34	0.015
regulation of molecular function	GO:0065009	217	0.015
negative regulation of neuron projection development	GO:0010977	9	0.015
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.015
negative regulation of apoptotic process	GO:0043066	63	0.015
negative regulation of multicellular organismal process	GO:0051241	142	0.015
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.015
multi organism behavior	GO:0051705	175	0.015
regulation of multicellular organismal development	GO:2000026	414	0.015
membrane organization	GO:0061024	112	0.014
cell cycle phase transition	GO:0044770	140	0.014
nucleoside metabolic process	GO:0009116	127	0.014
mitotic nuclear division	GO:0007067	213	0.014
nucleoside catabolic process	GO:0009164	112	0.014
negative regulation of programmed cell death	GO:0043069	72	0.014
regulation of mapk cascade	GO:0043408	92	0.014
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.014
negative regulation of signal transduction	GO:0009968	206	0.014
histone modification	GO:0016570	106	0.013
organonitrogen compound metabolic process	GO:1901564	318	0.013
hatching	GO:0035188	4	0.013
negative regulation of response to stimulus	GO:0048585	258	0.013
positive regulation of signal transduction	GO:0009967	223	0.013
cell cycle checkpoint	GO:0000075	95	0.013
phospholipid transport	GO:0015914	2	0.013
regulation of reactive oxygen species biosynthetic process	GO:1903426	0	0.013
intracellular signal transduction	GO:0035556	300	0.013
protein modification by small protein removal	GO:0070646	28	0.013
mitotic dna damage checkpoint	GO:0044773	74	0.013
positive regulation of cellular catabolic process	GO:0031331	95	0.013
regulation of nuclear division	GO:0051783	58	0.012
histone h2a ubiquitination	GO:0033522	2	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012
muscle structure development	GO:0061061	224	0.012
organic substance transport	GO:0071702	257	0.012
mitotic g2 dna damage checkpoint	GO:0007095	69	0.012
nucleotide catabolic process	GO:0009166	109	0.012
protein modification process	GO:0036211	438	0.012
chromatin remodeling	GO:0006338	72	0.012
regulation of rna splicing	GO:0043484	69	0.011	Human
regulation of intracellular transport	GO:0032386	64	0.011
protein deneddylation	GO:0000338	8	0.011
nuclear division	GO:0000280	332	0.011
g2 dna damage checkpoint	GO:0031572	69	0.011
response to temperature stimulus	GO:0009266	106	0.011
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
rho protein signal transduction	GO:0007266	14	0.011
molting cycle	GO:0042303	56	0.011
regulation of response to stress	GO:0080134	200	0.011
negative regulation of epithelial cell proliferation	GO:0050680	4	0.011
ribonucleoside metabolic process	GO:0009119	127	0.011
olfactory learning	GO:0008355	56	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
regulation of synapse organization	GO:0050807	110	0.010
protein modification by small protein conjugation or removal	GO:0070647	106	0.010
response to organic substance	GO:0010033	284	0.010
protein localization to organelle	GO:0033365	82	0.010
negative regulation of cellular metabolic process	GO:0031324	382	0.010
germ line cyst formation	GO:0048134	44	0.010
positive regulation of intracellular signal transduction	GO:1902533	116	0.010
ribonucleoprotein complex assembly	GO:0022618	23	0.010
regulation of cell cycle phase transition	GO:1901987	130	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010
eggshell chorion assembly	GO:0007306	66	0.010
taxis	GO:0042330	304	0.010

tsu disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.026
	chromosomal disease	DOID:0080014	0	0.015	Human

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