Drosophila melanogaster

4 known processes

Spn2 (Dmel_CG8137)

Serine protease inhibitor 2

(Aliases: Dmel\CG8137,Sp2,CG8137,sp2,Spn28F)

Spn2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cholesterol homeostasisGO:004263230.173
sterol homeostasisGO:005509240.138
inseminationGO:0007320220.119
sperm competitionGO:0046692210.093
oxoacid metabolic processGO:00434361030.056
vesicle mediated transportGO:00161923810.054
sperm storageGO:0046693100.048
lateral inhibitionGO:00463312060.043
endocytosisGO:00068973100.042
response to abiotic stimulusGO:00096283410.039
organic acid metabolic processGO:00060821030.039
carboxylic acid metabolic processGO:0019752920.039
homeostatic processGO:00425921990.038
protein hydroxylationGO:001812610.036
appendage developmentGO:00487364010.036
imaginal disc derived appendage developmentGO:00487373990.036
multi organism behaviorGO:00517051750.034
small molecule metabolic processGO:00442813050.034
organonitrogen compound metabolic processGO:19015643180.033
Fly
single organism behaviorGO:00447083910.033
chemical homeostasisGO:0048878920.032
phagocytosisGO:00069092150.031
multicellular organismal reproductive behaviorGO:00330571100.031
response to other organismGO:00517072930.031
Fly
negative regulation of cellular metabolic processGO:00313243820.030
Rat Fly
organic hydroxy compound metabolic processGO:1901615830.030
anion homeostasisGO:005508130.030
positive regulation of response to stimulusGO:00485843230.030
protein modification processGO:00362114380.029
negative regulation of gene expressionGO:00106293870.029
Rat Fly
lipid metabolic processGO:00066291210.029
body morphogenesisGO:001017120.029
multi multicellular organism processGO:00447061230.029
cell cell signaling involved in cell fate commitmentGO:00451682100.028
positive regulation of cell communicationGO:00106472500.028
post embryonic appendage morphogenesisGO:00351203850.028
cellular protein modification processGO:00064644380.027
response to biotic stimulusGO:00096072940.027
Fly
immune system processGO:00023763470.027
Fly
compound eye developmentGO:00487493070.027
acylglycerol catabolic processGO:004646430.027
positive regulation of nitrogen compound metabolic processGO:00511733540.026
neutral lipid biosynthetic processGO:004646020.026
defense response to other organismGO:00985422250.026
Fly
regulation of localizationGO:00328792750.026
organic substance transportGO:00717022570.026
triglyceride catabolic processGO:001943330.026
lipid homeostasisGO:0055088330.026
mating behaviorGO:00076171060.026
catabolic processGO:00090564090.025
female mating behaviorGO:0060180300.025
positive regulation of cellular biosynthetic processGO:00313283160.025
cellular amino acid metabolic processGO:0006520610.025
negative regulation of nitrogen compound metabolic processGO:00511722650.025
Fly
positive regulation of nucleic acid templated transcriptionGO:19035082660.025
oxidation reduction processGO:00551141230.024
defense response to bacteriumGO:00427421780.024
Fly
defense responseGO:00069523000.024
Rat Fly
imaginal disc derived appendage morphogenesisGO:00351143950.024
wing disc morphogenesisGO:00074723440.024
phospholipid homeostasisGO:005509110.024
transcription from rna polymerase ii promoterGO:00063663680.024
eye developmentGO:00016543230.024
negative regulation of macromolecule biosynthetic processGO:00105582700.024
cellular lipid metabolic processGO:0044255830.024
neurological system processGO:00508773580.024
regulation of female receptivityGO:0045924240.024
regulation of transcription from rna polymerase ii promoterGO:00063573780.023
peptidyl proline hydroxylationGO:001951110.023
salivary gland developmentGO:00074311620.023
adult behaviorGO:00305341370.023
kidney developmentGO:000182230.023
negative regulation of signal transductionGO:00099682060.023
Fly
response to external biotic stimulusGO:00432072930.023
Fly
matingGO:00076181200.023
forebrain developmentGO:003090020.022
negative regulation of signalingGO:00230572190.022
Fly
cellular catabolic processGO:00442483720.022
macromolecular complex assemblyGO:00650032560.022
exocrine system developmentGO:00352721620.022
ethanolamine containing compound metabolic processGO:004243940.022
triglyceride biosynthetic processGO:001943220.022
courtship behaviorGO:0007619680.022
appendage morphogenesisGO:00351073970.022
immune responseGO:00069552460.022
Fly
positive regulation of biosynthetic processGO:00098913160.022
positive regulation of signalingGO:00230562430.022
imaginal disc derived wing morphogenesisGO:00074763370.022
camera type eye developmentGO:004301040.022
compound eye morphogenesisGO:00017452490.022
salivary gland morphogenesisGO:00074351450.021
regulation of immune system processGO:00026821760.021
Fly
positive regulation of signal transductionGO:00099672230.021
cell proliferationGO:00082832990.021
organic substance catabolic processGO:19015753080.021
positive regulation of nucleobase containing compound metabolic processGO:00459353320.021
positive regulation of transcription dna templatedGO:00458932660.021
positive regulation of rna biosynthetic processGO:19026802660.021
regulation of protein metabolic processGO:00512462560.021
Rat Fly
regionalizationGO:00030024160.021
cell deathGO:00082192790.021
segmentationGO:00352822070.021
protein localizationGO:00081042840.021
tube morphogenesisGO:00352391910.020
negative regulation of cell communicationGO:00106482230.020
Fly
regulation of multicellular organismal developmentGO:20000264140.020
single organism biosynthetic processGO:00447112060.020
positive regulation of rna metabolic processGO:00512542710.020
cell divisionGO:00513012480.020
positive regulation of macromolecule metabolic processGO:00106044050.020
eye morphogenesisGO:00485922600.020
growthGO:00400073590.020
Rat
acylglycerol biosynthetic processGO:004646320.020
deathGO:00162652840.020
gland morphogenesisGO:00226121450.020
positive regulation of macromolecule biosynthetic processGO:00105572830.020
negative regulation of nucleic acid templated transcriptionGO:19035072400.020
peptidyl proline modificationGO:001820830.019
morphogenesis of an epitheliumGO:00020092760.019
proteolysisGO:00065081920.019
Rat Fly
regulation of response to stressGO:00801342000.019
Rat
carbohydrate derivative metabolic processGO:19011352170.019
sensory organ morphogenesisGO:00905962600.019
single organism catabolic processGO:00447122280.019
glycerolipid catabolic processGO:004650330.019
positive regulation of gene expressionGO:00106282900.019
response to nutrient levelsGO:00316671140.018
Rat
response to radiationGO:00093141550.018
establishment of localization in cellGO:00516494020.018
amine metabolic processGO:0009308120.018
reproductive behaviorGO:00190981220.018
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.018
negative regulation of developmental processGO:00510932010.018
embryonic pattern specificationGO:00098801740.018
developmental growthGO:00485892800.018
Rat
regulation of gene expression epigeneticGO:00400291280.018
regulation of transportGO:00510491810.018
response to organic substanceGO:00100332840.018
blastoderm segmentationGO:00073501590.018
regulation of cell cycleGO:00517262910.018
compound eye photoreceptor cell differentiationGO:00017511400.018
spindle organizationGO:00070512530.018
cellular amine metabolic processGO:0044106120.018
antimicrobial peptide productionGO:0002775460.017
Fly
response to temperature stimulusGO:00092661060.017
protein complex biogenesisGO:00702712010.017
negative regulation of biosynthetic processGO:00098902770.017
gland developmentGO:00487321910.017
axis specificationGO:00097981670.017
positive regulation of cell migrationGO:003033520.017
regulation of cellular amine metabolic processGO:003323830.017
gene silencingGO:00164581380.017
humoral immune responseGO:00069591170.017
Fly
response to lipopolysaccharideGO:003249640.017
anterior posterior pattern specificationGO:00099521360.017
negative regulation of nucleobase containing compound metabolic processGO:00459342610.017
regulation of sequestering of triglycerideGO:001088930.017
embryonic morphogenesisGO:00485982060.017
rna processingGO:00063961470.017
response to extracellular stimulusGO:00099911160.017
Rat
cellular response to dna damage stimulusGO:00069742230.017
positive regulation of cell motilityGO:200014730.017
developmental maturationGO:00217001720.017
open tracheal system developmentGO:00074242040.016
very long chain fatty acid metabolic processGO:000003840.016
protein complex assemblyGO:00064612000.016
phosphorylationGO:00163102940.016
programmed cell deathGO:00125012570.016
agingGO:00075681430.016
negative regulation of response to stimulusGO:00485852580.016
Rat Fly
developmental programmed cell deathGO:00106231380.016
tissue morphogenesisGO:00487292970.016
negative regulation of cellular biosynthetic processGO:00313272770.016
digestive tract developmentGO:00485651490.016
peptide metabolic processGO:0006518800.016
Fly
regulation of cellular protein metabolic processGO:00322682430.016
Rat Fly
mitotic spindle organizationGO:00070522200.016
connective tissue developmentGO:006144830.016
mitotic nuclear divisionGO:00070672130.016
regulation of molecular functionGO:00650092170.016
Rat Fly
anterior posterior axis specification embryoGO:00085951030.016
nuclear divisionGO:00002803320.016
single organism intracellular transportGO:19025822070.015
limb developmentGO:006017310.015
organelle fissionGO:00482853400.015
response to copper ionGO:004668840.015
regulation of cellular response to stressGO:0080135890.015
regulation of sterol transportGO:003237110.015
chemosensory behaviorGO:00076351060.015
cellular ketone metabolic processGO:0042180240.015
regulation of female receptivity post matingGO:0046008170.015
digestive system developmentGO:00551231490.015
triglyceride homeostasisGO:0070328180.015
regulation of immune responseGO:00507761180.015
Fly
cholesterol transportGO:003030120.015
embryonic axis specificationGO:00005781070.015
cell cycle phase transitionGO:00447701400.015
response to bacteriumGO:00096171980.015
Fly
g protein coupled receptor signaling pathwayGO:00071861360.015
retina development in camera type eyeGO:006004140.015
regulation of mitotic cell cycle phase transitionGO:19019901300.015
response to hexoseGO:000974630.015
antimicrobial humoral responseGO:0019730990.015
Fly
tube developmentGO:00352952440.015
negative regulation of gene expression epigeneticGO:0045814770.015
positive regulation of sequestering of triglycerideGO:001089010.015
negative regulation of rna biosynthetic processGO:19026792400.015
intracellular signal transductionGO:00355563000.015
innate immune responseGO:00450871440.015
mitotic cell cycle phase transitionGO:00447721380.015
photoreceptor cell differentiationGO:00465301700.015
negative regulation of multicellular organismal processGO:00512411420.015
tripartite regional subdivisionGO:00073511030.015
regulation of mitotic cell cycleGO:00073461900.015
regulation of cellular amino acid metabolic processGO:000652100.015
negative regulation of rna metabolic processGO:00512532510.015
eye photoreceptor cell differentiationGO:00017541450.014
embryonic development via the syncytial blastodermGO:00017001480.014
enzyme linked receptor protein signaling pathwayGO:00071671790.014
regulation of catalytic activityGO:00507901850.014
Rat Fly
multi organism reproductive behaviorGO:00447051210.014
regulation of multi organism processGO:00439001310.014
Fly
epithelial cell differentiationGO:00308553220.014
anterior posterior axis specificationGO:00099481090.014
telencephalon developmentGO:002153720.014
rna localizationGO:00064031150.014
dna metabolic processGO:00062592270.014
cellular response to chemical stimulusGO:00708871990.014
regulation of production of molecular mediator of immune responseGO:0002700440.014
Fly
intracellular transportGO:00469072280.014
regulation of antimicrobial peptide productionGO:0002784440.014
Fly
response to monosaccharideGO:003428440.014
central nervous system developmentGO:00074172010.014
digestive tract morphogenesisGO:00485461270.014
regulation of cellular ketone metabolic processGO:001056530.014
male courtship behaviorGO:0008049630.014
steroid catabolic processGO:000670610.014
response to organophosphorusGO:004668320.014
establishment of protein localizationGO:00451841630.014
rhythmic processGO:00485111060.014
regulation of lipid transportGO:003236830.014
sensory perceptionGO:00076001960.014
response to oxygen containing compoundGO:19017002000.014
regulation of phosphorus metabolic processGO:00511742100.014
small gtpase mediated signal transductionGO:0007264880.014
mesenchymal cell differentiationGO:004876210.014
notch signaling pathwayGO:00072191200.014
taxisGO:00423303040.014
endomembrane system organizationGO:00102561190.014
positive regulation of lipid storageGO:001088440.014
regulation of cell cycle phase transitionGO:19019871300.014
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.014
steroid metabolic processGO:0008202200.014
tissue deathGO:00162711020.014
multicellular organismal agingGO:00102591400.014
negative regulation of transcription dna templatedGO:00458922370.014
olfactory behaviorGO:0042048970.014
adult locomotory behaviorGO:0008344760.014
chromatin organizationGO:00063252070.014
embryo development ending in birth or egg hatchingGO:00097921520.013
chromatin remodelingGO:0006338720.013
regulation of intracellular signal transductionGO:19025312360.013
carbohydrate derivative biosynthetic processGO:1901137850.013
phosphatidic acid metabolic processGO:004647310.013
respiratory system developmentGO:00605412130.013
phosphatidylethanolamine metabolic processGO:004633710.013
cellular macromolecule localizationGO:00707272200.013
regulation of cell cycle processGO:00105641810.013
regulation of cell deathGO:00109411730.013
photoreceptor cell developmentGO:0042461960.013
regulation of cellular component biogenesisGO:00440872010.013
cytokinesisGO:0000910900.013
response to organic cyclic compoundGO:0014070890.013
regulation of epithelial cell proliferationGO:005067840.013
protein phosphorylationGO:00064681690.013
regulation of cell differentiationGO:00455953020.013
camera type eye morphogenesisGO:004859320.013
positive regulation of cellular amine metabolic processGO:003324000.013
cellular nitrogen compound catabolic processGO:00442701650.013
cytoplasmic transportGO:00164821300.013
mapk cascadeGO:00001651070.013
ras protein signal transductionGO:0007265880.013
synaptic transmissionGO:00072682880.013
kidney epithelium developmentGO:007207330.013
wnt signaling pathwayGO:0016055980.013
aromatic compound catabolic processGO:00194391660.013
organic cyclic compound catabolic processGO:19013611680.013
somatic muscle developmentGO:0007525660.013
l amino acid importGO:004309220.013
cellular macromolecule catabolic processGO:00442651360.013
regulation of anatomical structure morphogenesisGO:00226032420.012
neuropeptide signaling pathwayGO:0007218450.012
oocyte constructionGO:00073081120.012
detection of stimulusGO:00516061560.012
cytoskeleton dependent cytokinesisGO:0061640810.012
posttranscriptional regulation of gene expressionGO:00106081450.012
immune response activating signal transductionGO:000275720.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
limb morphogenesisGO:003510810.012
production of molecular mediator of immune responseGO:0002440460.012
Fly
localization of cellGO:00516742570.012
regulation of proteolysisGO:0030162870.012
Rat Fly
cellular response to organic substanceGO:00713101320.012
mesenchymal cell developmentGO:001403110.012
immune effector processGO:0002252980.012
Fly
organophosphate metabolic processGO:00196371950.012
sterol metabolic processGO:0016125120.012
epithelial cell developmentGO:00020642740.012
regulation of mapk cascadeGO:0043408920.012
organelle assemblyGO:00709251980.012
negative regulation of female receptivityGO:0007621140.012
response to endogenous stimulusGO:00097191190.012
regulation of catabolic processGO:00098941700.012
protein transportGO:00150311550.012
chromosome organizationGO:00512763600.012
positive regulation of multicellular organismal processGO:00512401430.012
nephron developmentGO:007200630.012
cellular response to carbohydrate stimulusGO:007132240.012
histolysisGO:00075591020.012
regulation of cellular localizationGO:00603411360.012
signal transduction by phosphorylationGO:00230141070.012
mitochondrion organizationGO:0007005650.012
protein maturationGO:0051604710.012
Fly
heterocycle catabolic processGO:00467001660.012
salivary gland histolysisGO:0035070880.012
macromolecule catabolic processGO:00090571610.012
muscle structure developmentGO:00610612240.012
negative regulation of cellular protein metabolic processGO:0032269850.012
Rat Fly
regulation of notch signaling pathwayGO:00085931000.012
regulation of nervous system developmentGO:00519602480.012
imaginal disc derived leg morphogenesisGO:0007480800.012
regulation of epithelial cell differentiationGO:003085640.012
regulation of humoral immune responseGO:0002920510.012
Fly
dendrite developmentGO:00163582040.012
cell migrationGO:00164772380.012
spinal cord developmentGO:002151010.012
mrna metabolic processGO:00160711240.012
organophosphate catabolic processGO:00464341120.012
chromosome segregationGO:00070591570.012
compound eye photoreceptor developmentGO:0042051780.012
defense response to fungusGO:0050832480.011
Fly
response to fungusGO:0009620500.011
Fly
oocyte axis specificationGO:00073091080.011
nephron tubule developmentGO:007208030.011
nephron morphogenesisGO:007202830.011
locomotory behaviorGO:00076261760.011
immune response regulating signaling pathwayGO:000276420.011
establishment or maintenance of cell polarityGO:00071631670.011
positive regulation of transportGO:0051050920.011
regulation of cell developmentGO:00602842150.011
neuron projection guidanceGO:00974852410.011
determination of adult lifespanGO:00083401370.011
morphogenesis of embryonic epitheliumGO:0016331940.011
regulation of cholesterol transportGO:003237410.011
maternal determination of anterior posterior axis embryoGO:0008358740.011
detection of stimulus involved in sensory perceptionGO:0050906920.011
nucleoside phosphate metabolic processGO:00067531620.011
sensory perception of chemical stimulusGO:00076061160.011
negative regulation of cell differentiationGO:00455961430.011
cell maturationGO:00484691440.011
dorsal ventral pattern formationGO:00099531330.011
hormone catabolic processGO:004244730.011
regulation of organelle organizationGO:00330431960.011
cell cycle checkpointGO:0000075950.011
defense response to gram negative bacteriumGO:0050829940.011
Fly
oocyte differentiationGO:00099941450.011
cellular macromolecular complex assemblyGO:00346221530.011
hindbrain developmentGO:003090220.011
rrna processingGO:000636430.011
regulation of programmed cell deathGO:00430671520.011
mrna processingGO:00063971040.011
peptide biosynthetic processGO:0043043420.011
regulation of wnt signaling pathwayGO:0030111680.011
nitrogen compound transportGO:0071705850.011
modification dependent protein catabolic processGO:0019941780.011
regulation of defense responseGO:00313471020.011
Rat
nephron tubule morphogenesisGO:007207830.011
transmembrane transportGO:00550851390.011
chromatin silencingGO:0006342760.011
peptidyl amino acid modificationGO:00181931050.011
regulation of synapse structure and activityGO:00508031280.011
regulation of response to external stimulusGO:00321011150.011
Rat Fly
actin cytoskeleton organizationGO:00300362060.011
chemotaxisGO:00069352490.011
protein catabolic processGO:00301631010.011
salivary gland cell autophagic cell deathGO:0035071830.011
alditol phosphate metabolic processGO:005264620.011
male mating behaviorGO:0060179700.011
dendrite morphogenesisGO:00488131990.011
maintenance of locationGO:0051235730.011
negative regulation of protein metabolic processGO:0051248850.011
Rat Fly
vitamin metabolic processGO:000676620.011
cellular response to biotic stimulusGO:007121640.011
mesoderm developmentGO:0007498780.011
dna integrity checkpointGO:0031570810.011
membrane organizationGO:00610241120.011
cellular response to lipopolysaccharideGO:007122230.010
chaeta developmentGO:0022416970.010
cellular homeostasisGO:0019725800.010
response to oxidative stressGO:0006979860.010
positive regulation of production of molecular mediator of immune responseGO:0002702280.010
response to nitrogen compoundGO:1901698900.010
vitamin biosynthetic processGO:000911010.010
muscle organ developmentGO:00075171270.010
autophagic cell deathGO:0048102830.010
synapse organizationGO:00508081960.010
regulation of protein localizationGO:0032880760.010
chromatin modificationGO:00165681470.010
response to glucoseGO:000974920.010
response to light stimulusGO:00094161240.010
endodermal cell differentiationGO:003598730.010
polyol biosynthetic processGO:004617330.010
regulation of phosphorylationGO:00423251470.010
ameboidal type cell migrationGO:00016671510.010
positive regulation of intracellular signal transductionGO:19025331160.010
regulation of phosphate metabolic processGO:00192202100.010
negative regulation of mitotic cell cycleGO:00459301090.010
hematopoietic progenitor cell differentiationGO:000224410.010
cell motilityGO:00488702510.010
l glutamate importGO:005193810.010
regulation of cell substrate adhesionGO:001081020.010
ion transmembrane transportGO:00342201220.010
glycoprotein metabolic processGO:0009100410.010
dna damage checkpointGO:0000077780.010
negative regulation of cell cycle processGO:00109481090.010
mitotic sister chromatid segregationGO:0000070870.010
phosphate ion transportGO:000681740.010
pigment metabolic processGO:0042440840.010
organonitrogen compound biosynthetic processGO:19015661170.010
regulation of developmental growthGO:00486381740.010

Spn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.052
disease of metabolismDOID:001466700.028
acquired metabolic diseaseDOID:006015800.028
inherited metabolic disorderDOID:65500.025
nervous system diseaseDOID:86300.023
carbohydrate metabolism diseaseDOID:005001300.021
hypotrichosisDOID:453500.019
hair diseaseDOID:42100.019
integumentary system diseaseDOID:1600.019
diabetes mellitusDOID:935100.018
type 2 diabetes mellitusDOID:935200.018
glucose metabolism diseaseDOID:419400.018
lipid metabolism disorderDOID:314600.015
familial hypertriglyceridemiaDOID:005052700.015
cardiovascular system diseaseDOID:128700.015
familial combined hyperlipidemiaDOID:1380900.013
familial hyperlipidemiaDOID:116800.013
eye and adnexa diseaseDOID:149200.013
sensory system diseaseDOID:005015500.013
eye diseaseDOID:561400.012
vascular diseaseDOID:17800.012
musculoskeletal system diseaseDOID:1700.011
hypertensionDOID:1076300.011
artery diseaseDOID:005082800.011
disease of cellular proliferationDOID:1456600.011
familial lipoprotein lipase deficiencyDOID:1411800.011
cancerDOID:16200.011
organ system cancerDOID:005068600.010