IMP: Integrative Multi-species Prediction

Drosophila melanogaster

138 known processes

LamC (Dmel_CG10119)

Lamin C

(Aliases: lamC,G-IF,CG10119,pG-IF,Dmel\CG10119,LAMC)

FLYBASE: FBgn0010397
Entrez: 36615
UniProtKB: Q03427

Process Predictions
Disease Predictions

LamC biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of anatomical structure morphogenesis	GO:0022603	242	0.902
immune response	GO:0006955	246	0.829
syncytium formation by plasma membrane fusion	GO:0000768	43	0.691
substrate adhesion dependent cell spreading	GO:0034446	2	0.632
protein localization	GO:0008104	284	0.620
myoblast fusion	GO:0007520	43	0.620
morphogenesis of an epithelium	GO:0002009	276	0.620	Fly
myotube differentiation	GO:0014902	46	0.587
cellular macromolecule localization	GO:0070727	220	0.570
regulation of immune system process	GO:0002682	176	0.567
tissue morphogenesis	GO:0048729	297	0.520
regulation of cell proliferation	GO:0042127	163	0.513	Worm
muscle attachment	GO:0016203	36	0.509
immune system process	GO:0002376	347	0.489
tube development	GO:0035295	244	0.486	Fly
striated muscle cell differentiation	GO:0051146	90	0.469	Mouse Worm
syncytium formation	GO:0006949	43	0.450
organic substance transport	GO:0071702	257	0.449	Mouse
apoptotic process	GO:0006915	159	0.408	Mouse
kidney morphogenesis	GO:0060993	3	0.402
post embryonic appendage morphogenesis	GO:0035120	385	0.400
vesicle mediated transport	GO:0016192	381	0.391	Worm
muscle structure development	GO:0061061	224	0.387
growth	GO:0040007	359	0.385	Worm
defense response	GO:0006952	300	0.378
cell adhesion	GO:0007155	136	0.374
regulation of wnt signaling pathway	GO:0030111	68	0.371
response to endogenous stimulus	GO:0009719	119	0.364
regulation of growth	GO:0040008	233	0.363	Worm
biological adhesion	GO:0022610	138	0.355
muscle cell differentiation	GO:0042692	103	0.334	Mouse Worm
cellular response to organic substance	GO:0071310	132	0.332
body morphogenesis	GO:0010171	2	0.328	Worm
response to organic substance	GO:0010033	284	0.324
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.312	Mouse
cell proliferation	GO:0008283	299	0.311	Worm
cell motility	GO:0048870	251	0.302	Mouse
regulation of mitotic cell cycle	GO:0007346	190	0.299	Worm
regulation of cell differentiation	GO:0045595	302	0.293
regulation of programmed cell death	GO:0043067	152	0.287	Mouse
homeostatic process	GO:0042592	199	0.273
regulation of multicellular organismal development	GO:2000026	414	0.271
cellular response to chemical stimulus	GO:0070887	199	0.270	Human
organic substance catabolic process	GO:1901575	308	0.268	Worm
cellular response to oxidative stress	GO:0034599	28	0.262
organelle assembly	GO:0070925	198	0.260	Worm
cellular catabolic process	GO:0044248	372	0.258
regulation of cellular component biogenesis	GO:0044087	201	0.256
regulation of apoptotic process	GO:0042981	130	0.252	Mouse
positive regulation of cell communication	GO:0010647	250	0.252
imaginal disc derived appendage development	GO:0048737	399	0.250
regulation of cell death	GO:0010941	173	0.248	Mouse
cellular response to hormone stimulus	GO:0032870	44	0.243
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.240
regulation of intracellular signal transduction	GO:1902531	236	0.240
response to wounding	GO:0009611	94	0.237
nuclear transport	GO:0051169	72	0.234	Mouse
eye development	GO:0001654	323	0.233	Fly
negative regulation of gene expression	GO:0010629	387	0.232
muscle organ development	GO:0007517	127	0.229
actin filament based process	GO:0030029	220	0.224
regulation of blood circulation	GO:1903522	21	0.223
cell cycle phase transition	GO:0044770	140	0.221
positive regulation of signaling	GO:0023056	243	0.219
death	GO:0016265	284	0.216	Mouse
catabolic process	GO:0009056	409	0.215	Worm
macromolecular complex assembly	GO:0065003	256	0.211
negative regulation of cell cycle	GO:0045786	116	0.209	Worm
wnt signaling pathway	GO:0016055	98	0.202
programmed cell death	GO:0012501	257	0.196	Mouse
cell migration	GO:0016477	238	0.195	Mouse
response to temperature stimulus	GO:0009266	106	0.194
appendage morphogenesis	GO:0035107	397	0.193
response to inorganic substance	GO:0010035	44	0.189
protein catabolic process	GO:0030163	101	0.188	Worm
innate immune response	GO:0045087	144	0.185
outflow tract morphogenesis	GO:0003151	4	0.185
regulation of organelle organization	GO:0033043	196	0.184
anatomical structure homeostasis	GO:0060249	97	0.183
negative regulation of response to stimulus	GO:0048585	258	0.182	Mouse
response to reactive oxygen species	GO:0000302	24	0.180
negative regulation of biosynthetic process	GO:0009890	277	0.179
positive regulation of multicellular organismal process	GO:0051240	143	0.178	Worm
regulation of cell shape	GO:0008360	113	0.176
positive regulation of developmental process	GO:0051094	143	0.172	Human Worm
macromolecule catabolic process	GO:0009057	161	0.170	Worm
actin cytoskeleton organization	GO:0030036	206	0.168
response to nitrogen compound	GO:1901698	90	0.166
single organism nuclear import	GO:1902593	51	0.164	Mouse
molting cycle chitin based cuticle	GO:0007591	56	0.159
regulation of muscle cell differentiation	GO:0051147	8	0.158
establishment of protein localization	GO:0045184	163	0.157	Mouse
appendage development	GO:0048736	401	0.156
cellular component assembly involved in morphogenesis	GO:0010927	151	0.154	Worm
cellular response to oxygen containing compound	GO:1901701	79	0.154
regulation of myotube differentiation	GO:0010830	6	0.153
branching morphogenesis of an epithelial tube	GO:0048754	45	0.153	Fly
cytoplasmic transport	GO:0016482	130	0.151	Mouse
protein complex assembly	GO:0006461	200	0.150
nuclear import	GO:0051170	51	0.150	Mouse
response to drug	GO:0042493	17	0.148
establishment of localization in cell	GO:0051649	402	0.142	Mouse Fly
negative regulation of developmental process	GO:0051093	201	0.141
developmental growth	GO:0048589	280	0.140	Worm
regulation of catabolic process	GO:0009894	170	0.137
extracellular matrix assembly	GO:0085029	13	0.136
positive regulation of developmental growth	GO:0048639	62	0.136	Worm
proteolysis	GO:0006508	192	0.134
carboxylic acid metabolic process	GO:0019752	92	0.134
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.133
synapse assembly	GO:0007416	143	0.133
defense response to other organism	GO:0098542	225	0.132
nucleocytoplasmic transport	GO:0006913	72	0.130	Mouse
dendrite morphogenesis	GO:0048813	199	0.128
regulation of protein metabolic process	GO:0051246	256	0.128
extracellular structure organization	GO:0043062	46	0.127
response to abiotic stimulus	GO:0009628	341	0.126	Human
negative regulation of signaling	GO:0023057	219	0.125	Mouse
regulation of developmental growth	GO:0048638	174	0.121	Worm
cellular response to endogenous stimulus	GO:0071495	80	0.121
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.120	Mouse
cellular macromolecular complex assembly	GO:0034622	153	0.119
positive regulation of signal transduction	GO:0009967	223	0.118
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.117
muscle cell development	GO:0055001	50	0.117	Mouse Worm
imaginal disc derived wing morphogenesis	GO:0007476	337	0.114
protein localization to organelle	GO:0033365	82	0.114	Mouse Fly
nuclear division	GO:0000280	332	0.114	Worm
positive regulation of macromolecule metabolic process	GO:0010604	405	0.113	Mouse
positive regulation of growth	GO:0045927	75	0.111	Worm
response to metal ion	GO:0010038	23	0.109
positive regulation of cellular component organization	GO:0051130	156	0.107
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.105
response to organonitrogen compound	GO:0010243	75	0.105
organic acid metabolic process	GO:0006082	103	0.105
intracellular signal transduction	GO:0035556	300	0.105
integrin mediated signaling pathway	GO:0007229	3	0.105
actomyosin structure organization	GO:0031032	56	0.104	Worm
small molecule metabolic process	GO:0044281	305	0.103
positive regulation of cell proliferation	GO:0008284	47	0.101	Worm
respiratory system development	GO:0060541	213	0.100	Fly
regulation of cytoplasmic transport	GO:1903649	47	0.100
regulation of syncytium formation by plasma membrane fusion	GO:0060142	6	0.099
organonitrogen compound metabolic process	GO:1901564	318	0.097
neuron projection guidance	GO:0097485	241	0.096
somatic muscle development	GO:0007525	66	0.096
cellular response to organonitrogen compound	GO:0071417	36	0.095
skeletal muscle organ development	GO:0060538	48	0.093
skeletal muscle fiber development	GO:0048741	3	0.093
single organism intracellular transport	GO:1902582	207	0.093	Mouse
intracellular transport	GO:0046907	228	0.093	Mouse
regulation of localization	GO:0032879	275	0.092	Mouse
cellular ketone metabolic process	GO:0042180	24	0.092
regulation of immune response	GO:0050776	118	0.092
protein phosphorylation	GO:0006468	169	0.090
establishment of protein localization to organelle	GO:0072594	62	0.090	Mouse
cell aging	GO:0007569	2	0.089	Human Zebrafish Fly
positive regulation of response to stimulus	GO:0048584	323	0.088
regulation of cellular ketone metabolic process	GO:0010565	3	0.088
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.088
regulation of nervous system development	GO:0051960	248	0.087
lamellipodium organization	GO:0097581	21	0.087
morphogenesis of a branching epithelium	GO:0061138	45	0.087	Fly
wing disc morphogenesis	GO:0007472	344	0.086
cellular protein localization	GO:0034613	160	0.083
negative regulation of cellular component organization	GO:0051129	108	0.083	Mouse
positive regulation of molecular function	GO:0044093	136	0.082
single organism cell adhesion	GO:0098602	47	0.081
protein complex biogenesis	GO:0070271	201	0.081
negative regulation of rna metabolic process	GO:0051253	251	0.081
regulation of cell morphogenesis	GO:0022604	163	0.081
response to oxygen containing compound	GO:1901700	200	0.081
atp metabolic process	GO:0046034	49	0.080
protein localization to nucleus	GO:0034504	55	0.080	Mouse Fly
response to extracellular stimulus	GO:0009991	116	0.080
positive regulation of rna biosynthetic process	GO:1902680	266	0.079	Mouse
pupal development	GO:0035209	11	0.079
positive regulation of cell migration	GO:0030335	2	0.079
positive regulation of gene expression	GO:0010628	290	0.079	Mouse
protein targeting to nucleus	GO:0044744	51	0.078	Mouse
regulation of dendrite morphogenesis	GO:0048814	28	0.078
single organism biosynthetic process	GO:0044711	206	0.078
cellular amino acid metabolic process	GO:0006520	61	0.076
negative regulation of mitotic cell cycle	GO:0045930	109	0.076
epithelial tube morphogenesis	GO:0060562	88	0.075	Fly
regulation of cellular catabolic process	GO:0031329	157	0.074
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.074	Mouse
negative regulation of signal transduction	GO:0009968	206	0.074	Mouse
kidney development	GO:0001822	3	0.074
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.073	Mouse
negative regulation of cellular protein metabolic process	GO:0032269	85	0.073
dendrite development	GO:0016358	204	0.072
ribonucleoside catabolic process	GO:0042454	112	0.072
cuticle pigmentation	GO:0048067	22	0.071
regulation of actin filament based process	GO:0032970	42	0.071
response to organic cyclic compound	GO:0014070	89	0.071
protein import into nucleus	GO:0006606	51	0.070	Mouse
wound healing	GO:0042060	75	0.070
regulation of catalytic activity	GO:0050790	185	0.070
ion transmembrane transport	GO:0034220	122	0.070
localization of cell	GO:0051674	257	0.069	Mouse
positive regulation of cell death	GO:0010942	69	0.069
response to virus	GO:0009615	28	0.069
notch signaling pathway	GO:0007219	120	0.068
organic hydroxy compound metabolic process	GO:1901615	83	0.068
heterocycle catabolic process	GO:0046700	166	0.067
neuron apoptotic process	GO:0051402	17	0.067
cell death	GO:0008219	279	0.067	Mouse
metal ion homeostasis	GO:0055065	44	0.066
regulation of cytoskeleton organization	GO:0051493	89	0.066
response to toxic substance	GO:0009636	22	0.065
cellular homeostasis	GO:0019725	80	0.065
positive regulation of cell motility	GO:2000147	3	0.065
positive regulation of biosynthetic process	GO:0009891	316	0.065	Mouse
regulation of synapse assembly	GO:0051963	94	0.065
purine nucleoside metabolic process	GO:0042278	127	0.064
myofibril assembly	GO:0030239	36	0.064	Worm
striated muscle cell development	GO:0055002	50	0.063	Mouse Worm
regulation of cell cycle process	GO:0010564	181	0.062
negative regulation of neuron death	GO:1901215	18	0.062
regulation of cell cycle	GO:0051726	291	0.062	Worm
nephron tubule development	GO:0072080	3	0.062
single organism catabolic process	GO:0044712	228	0.062
circulatory system process	GO:0003013	37	0.060	Zebrafish
aging	GO:0007568	143	0.059	Human Zebrafish Worm Fly
regulation of ras protein signal transduction	GO:0046578	93	0.059
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.058
cellular cation homeostasis	GO:0030003	38	0.058
small gtpase mediated signal transduction	GO:0007264	88	0.057
response to external biotic stimulus	GO:0043207	293	0.057
synaptic growth at neuromuscular junction	GO:0051124	119	0.057
response to other organism	GO:0051707	293	0.056
mitotic nuclear division	GO:0007067	213	0.056	Worm
regulation of cell cycle phase transition	GO:1901987	130	0.056
heart contraction	GO:0060047	26	0.056	Zebrafish
posttranscriptional regulation of gene expression	GO:0010608	145	0.056
regulation of cell development	GO:0060284	215	0.056
positive regulation of intracellular signal transduction	GO:1902533	116	0.056
response to oxidative stress	GO:0006979	86	0.056
myotube cell development	GO:0014904	3	0.056
positive regulation of wnt signaling pathway	GO:0030177	25	0.056
cellular protein modification process	GO:0006464	438	0.055
establishment or maintenance of cell polarity	GO:0007163	167	0.055	Mouse
positive regulation of rna metabolic process	GO:0051254	271	0.055	Mouse
purine nucleotide metabolic process	GO:0006163	146	0.054
basement membrane organization	GO:0071711	10	0.054
mitotic cell cycle phase transition	GO:0044772	138	0.054
defense response to gram negative bacterium	GO:0050829	94	0.054
transcription from rna polymerase ii promoter	GO:0006366	368	0.053
nephron tubule morphogenesis	GO:0072078	3	0.053
response to lipid	GO:0033993	38	0.053
regulation of epithelial cell proliferation	GO:0050678	4	0.053
mapk cascade	GO:0000165	107	0.053
regulation of striated muscle cell differentiation	GO:0051153	8	0.052
regulation of anatomical structure size	GO:0090066	163	0.052
peptide metabolic process	GO:0006518	80	0.052
nucleotide metabolic process	GO:0009117	161	0.052
striated muscle myosin thick filament assembly	GO:0071688	3	0.051	Worm
cation homeostasis	GO:0055080	51	0.051
sensory perception	GO:0007600	196	0.051
nephron epithelium morphogenesis	GO:0072088	3	0.051
response to decreased oxygen levels	GO:0036293	58	0.050	Human
negative regulation of immune system process	GO:0002683	50	0.050
regulation of proteolysis	GO:0030162	87	0.049
actin filament organization	GO:0007015	126	0.049
regulation of actin cytoskeleton organization	GO:0032956	42	0.049
ribonucleoside metabolic process	GO:0009119	127	0.049
cellular protein catabolic process	GO:0044257	83	0.049
endosomal transport	GO:0016197	44	0.048
single organismal cell cell adhesion	GO:0016337	45	0.047
positive regulation of catabolic process	GO:0009896	105	0.047
purine ribonucleoside catabolic process	GO:0046130	112	0.047
regulation of myoblast fusion	GO:1901739	6	0.047
cognition	GO:0050890	141	0.046
negative regulation of cellular metabolic process	GO:0031324	382	0.046
purine ribonucleoside metabolic process	GO:0046128	127	0.046
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.046
purine nucleotide catabolic process	GO:0006195	109	0.046
morphogenesis of embryonic epithelium	GO:0016331	94	0.046
single organism cellular localization	GO:1902580	180	0.045
regulation of notch signaling pathway	GO:0008593	100	0.045
ion homeostasis	GO:0050801	55	0.045
regulation of locomotion	GO:0040012	42	0.044	Mouse
response to organophosphorus	GO:0046683	2	0.044
positive regulation of phosphate metabolic process	GO:0045937	139	0.044
glycosyl compound metabolic process	GO:1901657	127	0.043
sensory perception of chemical stimulus	GO:0007606	116	0.043
negative regulation of multicellular organismal process	GO:0051241	142	0.043
epithelial cell development	GO:0002064	274	0.042
response to hormone	GO:0009725	45	0.042
positive regulation of catalytic activity	GO:0043085	118	0.042
response to hexose	GO:0009746	3	0.042
protein targeting	GO:0006605	64	0.041	Mouse
sarcomere organization	GO:0045214	26	0.041
negative regulation of nervous system development	GO:0051961	92	0.041
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.041
phosphorylation	GO:0016310	294	0.041
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.041
response to nutrient levels	GO:0031667	114	0.041
ribonucleotide metabolic process	GO:0009259	145	0.041
phagocytosis	GO:0006909	215	0.041
guanosine containing compound metabolic process	GO:1901068	74	0.040
digestive system development	GO:0055123	149	0.040	Fly
morphogenesis of a branching structure	GO:0001763	45	0.040	Fly
regulation of molecular function	GO:0065009	217	0.040
regulation of protein import into nucleus	GO:0042306	28	0.040
gastrulation	GO:0007369	70	0.039
cellular macromolecule catabolic process	GO:0044265	136	0.039
purine nucleoside catabolic process	GO:0006152	112	0.039
mesenchymal cell differentiation	GO:0048762	1	0.039
learning	GO:0007612	75	0.039
regulation of purine nucleotide metabolic process	GO:1900542	62	0.039
response to radiation	GO:0009314	155	0.039
positive regulation of cellular biosynthetic process	GO:0031328	316	0.039	Mouse
cellular ion homeostasis	GO:0006873	39	0.039
nucleobase containing compound catabolic process	GO:0034655	165	0.039
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.038
chemical homeostasis	GO:0048878	92	0.038
cellular response to peptide	GO:1901653	28	0.038
regulation of cellular amino acid metabolic process	GO:0006521	0	0.038
leg disc development	GO:0035218	92	0.038
protein transport	GO:0015031	155	0.037	Mouse
reactive oxygen species metabolic process	GO:0072593	22	0.037
negative regulation of synapse assembly	GO:0051964	39	0.037
taxis	GO:0042330	304	0.036
protein import	GO:0017038	55	0.036	Mouse
positive regulation of cellular protein metabolic process	GO:0032270	118	0.036
muscle system process	GO:0003012	21	0.036
regulation of synapse organization	GO:0050807	110	0.036
positive regulation of phosphorus metabolic process	GO:0010562	139	0.036
neuromuscular junction development	GO:0007528	149	0.036
negative regulation of protein complex disassembly	GO:0043242	23	0.035
blood circulation	GO:0008015	26	0.035	Zebrafish
secondary metabolic process	GO:0019748	75	0.035
ribose phosphate metabolic process	GO:0019693	145	0.035
tube morphogenesis	GO:0035239	191	0.035	Fly
organelle fission	GO:0048285	340	0.035	Worm
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.035	Mouse
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.035
regulation of intracellular transport	GO:0032386	64	0.034
response to bacterium	GO:0009617	198	0.034
connective tissue development	GO:0061448	3	0.034
ion transport	GO:0006811	145	0.034
negative regulation of neuron apoptotic process	GO:0043524	14	0.034
purine ribonucleotide metabolic process	GO:0009150	145	0.033
organic cyclic compound catabolic process	GO:1901361	168	0.032
regionalization	GO:0003002	416	0.032
regulation of hydrolase activity	GO:0051336	97	0.032
regulation of lamellipodium organization	GO:1902743	15	0.032
regulation of nucleocytoplasmic transport	GO:0046822	35	0.032
stem cell development	GO:0048864	79	0.032
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.032
heterotypic cell cell adhesion	GO:0034113	1	0.032
neuronal action potential	GO:0019228	10	0.032
signal transduction by phosphorylation	GO:0023014	107	0.032
defense response to bacterium	GO:0042742	178	0.032
response to purine containing compound	GO:0014074	12	0.031
response to growth factor	GO:0070848	31	0.031
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.031
nephron morphogenesis	GO:0072028	3	0.031
renal tubule morphogenesis	GO:0061333	44	0.031
regulation of cell adhesion	GO:0030155	27	0.031
endoderm formation	GO:0001706	3	0.031
cell cycle checkpoint	GO:0000075	95	0.031
regulation of cellular amine metabolic process	GO:0033238	3	0.031
positive regulation of programmed cell death	GO:0043068	62	0.030
negative regulation of cell communication	GO:0010648	223	0.030	Mouse
metal ion transport	GO:0030001	74	0.030
epithelial cell proliferation	GO:0050673	15	0.030
organophosphate catabolic process	GO:0046434	112	0.030
positive regulation of apoptotic process	GO:0043065	47	0.030
endodermal cell differentiation	GO:0035987	3	0.030
glycosyl compound catabolic process	GO:1901658	112	0.030
cellular response to hypoxia	GO:0071456	28	0.029	Human
oxoacid metabolic process	GO:0043436	103	0.029
response to heat	GO:0009408	63	0.029
response to hypoxia	GO:0001666	53	0.029	Human
immune system development	GO:0002520	57	0.029
positive regulation of hydrolase activity	GO:0051345	78	0.029
columnar cuboidal epithelial cell development	GO:0002066	249	0.029
camera type eye development	GO:0043010	4	0.029
positive regulation of gtpase activity	GO:0043547	43	0.029
reproductive structure development	GO:0048608	74	0.029	Worm Fly
chemotaxis	GO:0006935	249	0.029
regulation of cell projection organization	GO:0031344	92	0.029
modification dependent macromolecule catabolic process	GO:0043632	79	0.029
negative regulation of protein metabolic process	GO:0051248	85	0.028
positive regulation of cellular amine metabolic process	GO:0033240	0	0.028
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.028
circulatory system development	GO:0072359	82	0.028	Mouse
nephron epithelium development	GO:0072009	3	0.028
negative regulation of cellular biosynthetic process	GO:0031327	277	0.028
toxin metabolic process	GO:0009404	2	0.028
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.028
ubiquitin dependent protein catabolic process	GO:0006511	78	0.027
nucleoside metabolic process	GO:0009116	127	0.027
molting cycle process	GO:0022404	29	0.027
kidney epithelium development	GO:0072073	3	0.027
regulation of mapk cascade	GO:0043408	92	0.027
regulation of translation	GO:0006417	56	0.027
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.027
lamellipodium assembly	GO:0030032	21	0.027
nucleotide catabolic process	GO:0009166	109	0.026
circadian behavior	GO:0048512	76	0.026
muscle tissue morphogenesis	GO:0060415	2	0.026
apoptotic signaling pathway	GO:0097190	27	0.026	Mouse
cellular response to growth factor stimulus	GO:0071363	30	0.026
cation transport	GO:0006812	110	0.026
single organism carbohydrate metabolic process	GO:0044723	72	0.026
negative regulation of transcription dna templated	GO:0045892	237	0.025
negative regulation of molecular function	GO:0044092	51	0.025
nucleoside triphosphate catabolic process	GO:0009143	108	0.025
nucleoside triphosphate metabolic process	GO:0009141	120	0.025
regulation of cellular localization	GO:0060341	136	0.025	Mouse
establishment of organelle localization	GO:0051656	122	0.025	Fly
intracellular protein transport	GO:0006886	104	0.025	Mouse
regulation of cell substrate adhesion	GO:0010810	2	0.025
cellular response to organic cyclic compound	GO:0071407	32	0.025
negative regulation of wnt signaling pathway	GO:0030178	28	0.025
salivary gland development	GO:0007431	162	0.024
negative regulation of cytoskeleton organization	GO:0051494	30	0.024
developmental maturation	GO:0021700	172	0.024
cellular response to nitrogen compound	GO:1901699	51	0.024
regulation of purine nucleotide catabolic process	GO:0033121	48	0.024
regulation of neuron apoptotic process	GO:0043523	16	0.024
transforming growth factor beta receptor signaling pathway	GO:0007179	16	0.024
forebrain development	GO:0030900	2	0.024
regulation of establishment of protein localization	GO:0070201	61	0.024
gonad development	GO:0008406	50	0.024	Worm Fly
nucleoside catabolic process	GO:0009164	112	0.023
positive regulation of cell projection organization	GO:0031346	29	0.023
response to hydrogen peroxide	GO:0042542	11	0.023
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	18	0.023
lipid biosynthetic process	GO:0008610	46	0.023
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.023	Mouse
multicellular organismal homeostasis	GO:0048871	41	0.023
memory	GO:0007613	94	0.023
protein maturation	GO:0051604	71	0.023
synapse organization	GO:0050808	196	0.022
regulation of endopeptidase activity	GO:0052548	36	0.022
cellular amine metabolic process	GO:0044106	12	0.022
bmp signaling pathway	GO:0030509	27	0.022
tissue homeostasis	GO:0001894	36	0.022
purine ribonucleotide catabolic process	GO:0009154	109	0.022
regulation of phosphorus metabolic process	GO:0051174	210	0.022
regulation of protein localization to nucleus	GO:1900180	29	0.022	Mouse
secretion by cell	GO:0032940	101	0.022
eggshell formation	GO:0030703	105	0.021
axon guidance	GO:0007411	233	0.021
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.021
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.021
negative regulation of epithelial cell proliferation	GO:0050680	4	0.021
endocytosis	GO:0006897	310	0.021	Worm
cellular chemical homeostasis	GO:0055082	40	0.021
positive regulation of transcription dna templated	GO:0045893	266	0.021	Mouse
cellular nitrogen compound catabolic process	GO:0044270	165	0.021
regulation of map kinase activity	GO:0043405	17	0.021
spermatogenesis	GO:0007283	200	0.021	Rat Fly
peptide hormone processing	GO:0016486	2	0.021
regulation of phosphorylation	GO:0042325	147	0.021
transmembrane transport	GO:0055085	139	0.021
regulation of nucleoside metabolic process	GO:0009118	50	0.021
axonogenesis	GO:0007409	290	0.020
regulation of synapse structure and activity	GO:0050803	128	0.020
negative regulation of protein depolymerization	GO:1901880	23	0.020
regulation of erbb signaling pathway	GO:1901184	42	0.020
regulation of mitosis	GO:0007088	56	0.020
heart process	GO:0003015	37	0.020	Zebrafish
embryo development ending in birth or egg hatching	GO:0009792	152	0.020	Worm
regulation of membrane potential	GO:0042391	35	0.020
nephron development	GO:0072006	3	0.020
cellular response to reactive oxygen species	GO:0034614	14	0.020
regulation of cellular protein metabolic process	GO:0032268	243	0.020
negative regulation of programmed cell death	GO:0043069	72	0.020	Mouse
regulation of transport	GO:0051049	181	0.019
response to sterol	GO:0036314	34	0.019
determination of adult lifespan	GO:0008340	137	0.019	Worm
positive regulation of cellular catabolic process	GO:0031331	95	0.019
regulation of nucleotide metabolic process	GO:0006140	62	0.019
cellular response to decreased oxygen levels	GO:0036294	30	0.019	Human
larval development	GO:0002164	104	0.019	Worm
spindle organization	GO:0007051	253	0.019
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.019
ovarian follicle cell development	GO:0030707	248	0.018
negative regulation of cell cycle process	GO:0010948	109	0.018
nucleoside phosphate catabolic process	GO:1901292	110	0.018
negative regulation of protein phosphorylation	GO:0001933	17	0.018
peptidyl amino acid modification	GO:0018193	105	0.018
response to monosaccharide	GO:0034284	4	0.018
positive regulation of organelle organization	GO:0010638	65	0.018
cellular response to peptide hormone stimulus	GO:0071375	28	0.018
protein secretion	GO:0009306	45	0.018
regulation of heart morphogenesis	GO:2000826	3	0.018

LamC disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.245	Human
musculoskeletal system disease	DOID:17	0.037	Human
muscular disease	DOID:0080000	0.020	Human
muscle tissue disease	DOID:66	0.020	Human

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