IMP: Integrative Multi-species Prediction

Drosophila melanogaster

115 known processes

ird5 (Dmel_CG4201)

immune response deficient 5

(Aliases: Ikkbeta,DIK,ird5/DmIkk[beta],Dmel\CG4201,Dmikkbeta,IKKb,DmIKKb,Ird-5,dIKK,IKKbeta,Lak,dIKK-beta,Ird5,DmIKKbeta,DmIkkbeta,IKKB,IKK,ird,IKK-beta,DLAK,DmIKK,IK,DmIKKBeta,ikk,anon-89Bd,IRD-5,LRK,dLak,CG4201,Ik,dmIKKbeta)

FLYBASE: FBgn0024222
Entrez: 44432
UniProtKB: Q9VEZ5

Process Predictions
Disease Predictions

ird5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002816	3	0.997
humoral immune response	GO:0006959	117	0.993
antibacterial humoral response	GO:0019731	44	0.991
positive regulation of defense response to virus by host	GO:0002230	10	0.970
immune response	GO:0006955	246	0.966
positive regulation of antibacterial peptide production	GO:0002803	20	0.962
regulation of defense response to virus by host	GO:0050691	10	0.958
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002813	14	0.952
positive regulation of antimicrobial humoral response	GO:0002760	28	0.950
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.930
antibacterial peptide production	GO:0002778	22	0.925
regulation of defense response to virus	GO:0050688	14	0.924
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	20	0.923
antimicrobial peptide production	GO:0002775	46	0.923
immune system process	GO:0002376	347	0.918
positive regulation of antimicrobial peptide production	GO:0002225	28	0.917
regulation of defense response to bacterium	GO:1900424	30	0.908
antimicrobial humoral response	GO:0019730	99	0.906
defense response to virus	GO:0051607	23	0.904
antibacterial peptide biosynthetic process	GO:0002780	22	0.903
regulation of antibacterial peptide production	GO:0002786	22	0.900
antifungal peptide production	GO:0002781	7	0.894
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0006964	12	0.876
biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002812	14	0.851
defense response to bacterium	GO:0042742	178	0.851
regulation of response to external stimulus	GO:0032101	115	0.840
peptidoglycan recognition protein signaling pathway	GO:0061057	16	0.838
immune effector process	GO:0002252	98	0.834
defense response to other organism	GO:0098542	225	0.825
peptide metabolic process	GO:0006518	80	0.819
regulation of antimicrobial peptide production	GO:0002784	44	0.815
positive regulation of humoral immune response	GO:0002922	28	0.792
antifungal humoral response	GO:0019732	12	0.761
response to peptidoglycan	GO:0032494	2	0.749
regulation of response to biotic stimulus	GO:0002831	63	0.738
positive regulation of response to biotic stimulus	GO:0002833	31	0.737
regulation of immune effector process	GO:0002697	52	0.722
regulation of humoral immune response	GO:0002920	51	0.716
regulation of multi organism process	GO:0043900	131	0.716
response to external biotic stimulus	GO:0043207	293	0.715
cellular amide metabolic process	GO:0043603	80	0.685
positive regulation of immune effector process	GO:0002699	28	0.677
regulation of antimicrobial humoral response	GO:0002759	50	0.661
biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002815	3	0.658
regulation of cellular amide metabolic process	GO:0034248	39	0.649
positive regulation of antifungal peptide biosynthetic process	GO:0006967	5	0.641
response to biotic stimulus	GO:0009607	294	0.632
regulation of production of molecular mediator of immune response	GO:0002700	44	0.631
response to bacterium	GO:0009617	198	0.628
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.625
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.623
defense response	GO:0006952	300	0.607
positive regulation of response to external stimulus	GO:0032103	44	0.605
regulation of immune response	GO:0050776	118	0.600
antimicrobial peptide biosynthetic process	GO:0002777	38	0.594
defense response to gram negative bacterium	GO:0050829	94	0.585
response to other organism	GO:0051707	293	0.574
response to virus	GO:0009615	28	0.566
production of molecular mediator of immune response	GO:0002440	46	0.526
negative regulation of peptidoglycan recognition protein signaling pathway	GO:0061060	3	0.427
regulation of defense response	GO:0031347	102	0.401
positive regulation of cellular amide metabolic process	GO:0034250	26	0.320
cellular protein modification process	GO:0006464	438	0.313
positive regulation of defense response to bacterium	GO:1900426	23	0.302
amide biosynthetic process	GO:0043604	42	0.282
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0006965	3	0.280
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.280
positive regulation of defense response	GO:0031349	59	0.274
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.266	Zebrafish Mouse
positive regulation of immune response	GO:0050778	63	0.228
activation of innate immune response	GO:0002218	4	0.210
regulation of peptidoglycan recognition protein signaling pathway	GO:0061058	4	0.207
regulation of antifungal peptide production	GO:0002788	6	0.199
regulation of endopeptidase activity	GO:0052548	36	0.191	Fly
regulation of innate immune response	GO:0045088	71	0.190
positive regulation of endopeptidase activity	GO:0010950	26	0.189	Fly
regulation of antifungal peptide biosynthetic process	GO:0002810	5	0.189
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.189	Fly
cellular response to external stimulus	GO:0071496	66	0.185
cellular response to extracellular stimulus	GO:0031668	64	0.183
regulation of immune system process	GO:0002682	176	0.183
innate immune response	GO:0045087	144	0.181
positive regulation of multi organism process	GO:0043902	40	0.181
negative regulation of gene expression	GO:0010629	387	0.175
peptide biosynthetic process	GO:0043043	42	0.173
organonitrogen compound metabolic process	GO:1901564	318	0.166
gene silencing by rna	GO:0031047	57	0.161
positive regulation of biosynthetic process	GO:0009891	316	0.159
cognition	GO:0050890	141	0.155
organonitrogen compound biosynthetic process	GO:1901566	117	0.151
antifungal peptide biosynthetic process	GO:0002783	5	0.149
establishment of localization in cell	GO:0051649	402	0.147	Fly
protein localization	GO:0008104	284	0.145
response to extracellular stimulus	GO:0009991	116	0.143
cell cycle checkpoint	GO:0000075	95	0.136
regulation of response to stress	GO:0080134	200	0.136
chromosome organization	GO:0051276	360	0.132
immune response regulating signaling pathway	GO:0002764	2	0.132
establishment of protein localization	GO:0045184	163	0.129
intracellular signal transduction	GO:0035556	300	0.129	Zebrafish Mouse
cellular response to mechanical stimulus	GO:0071260	2	0.128
regulation of defense response to fungus	GO:1900150	6	0.127
pigmentation	GO:0043473	75	0.126
positive regulation of antifungal peptide production	GO:0002804	6	0.125
response to nutrient levels	GO:0031667	114	0.122
regulation of cell cycle	GO:0051726	291	0.121
dendrite morphogenesis	GO:0048813	199	0.121
single organism intracellular transport	GO:1902582	207	0.120	Fly
mitotic dna integrity checkpoint	GO:0044774	75	0.120
defense response to gram positive bacterium	GO:0050830	41	0.119
negative regulation of defense response to bacterium	GO:1900425	7	0.113
cellularization	GO:0007349	90	0.110
negative regulation of cellular metabolic process	GO:0031324	382	0.109
death	GO:0016265	284	0.108	Zebrafish Rat Fly
negative regulation of cell cycle phase transition	GO:1901988	103	0.107
small rna loading onto risc	GO:0070922	6	0.106
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.106
regulation of cellular protein metabolic process	GO:0032268	243	0.105	Fly
posttranscriptional regulation of gene expression	GO:0010608	145	0.104
response to lipopolysaccharide	GO:0032496	4	0.104
immune response activating signal transduction	GO:0002757	2	0.104
response to starvation	GO:0042594	97	0.104
positive regulation of immune system process	GO:0002684	68	0.101
organelle assembly	GO:0070925	198	0.098
programmed cell death	GO:0012501	257	0.097	Zebrafish Fly
catabolic process	GO:0009056	409	0.093
activation of cysteine type endopeptidase activity involved in apoptotic process	GO:0006919	16	0.093
reactive oxygen species metabolic process	GO:0072593	22	0.092
internal peptidyl lysine acetylation	GO:0018393	38	0.090
heterochromatin organization	GO:0070828	25	0.088
innate immune response activating signal transduction	GO:0002758	2	0.088
positive regulation of response to stimulus	GO:0048584	323	0.086
rna interference	GO:0016246	27	0.085
gene silencing	GO:0016458	138	0.085
regulation of intracellular signal transduction	GO:1902531	236	0.085	Human Zebrafish Mouse
cell death	GO:0008219	279	0.081	Zebrafish Rat Fly
negative regulation of stem cell proliferation	GO:2000647	30	0.081
cytoplasmic transport	GO:0016482	130	0.079
dna metabolic process	GO:0006259	227	0.078
signal transduction in response to dna damage	GO:0042770	3	0.077
regulation of cell differentiation	GO:0045595	302	0.077
negative regulation of cell communication	GO:0010648	223	0.076	Zebrafish
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.075	Fly
chromatin organization	GO:0006325	207	0.074
activation of cysteine type endopeptidase activity	GO:0097202	17	0.074
melanization defense response	GO:0035006	45	0.072
cellular macromolecule localization	GO:0070727	220	0.072
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.071
response to organophosphorus	GO:0046683	2	0.071
regulation of cell death	GO:0010941	173	0.071	Zebrafish Rat Fly
regulation of macroautophagy	GO:0016241	15	0.070
dna integrity checkpoint	GO:0031570	81	0.070
developmental maturation	GO:0021700	172	0.070	Fly
nuclear transport	GO:0051169	72	0.069
regulation of programmed cell death	GO:0043067	152	0.068	Zebrafish Fly
regulation of protein metabolic process	GO:0051246	256	0.068	Fly
cellular catabolic process	GO:0044248	372	0.067
maintenance of protein location in cell	GO:0032507	26	0.066
response to abiotic stimulus	GO:0009628	341	0.065
positive regulation of cellular biosynthetic process	GO:0031328	316	0.064
positive regulation of cell death	GO:0010942	69	0.064	Rat Fly
protein transport	GO:0015031	155	0.064
secondary metabolic process	GO:0019748	75	0.063
single organism catabolic process	GO:0044712	228	0.062
fat soluble vitamin metabolic process	GO:0006775	1	0.062
zymogen activation	GO:0031638	20	0.061
negative regulation of signaling	GO:0023057	219	0.060	Zebrafish
cellular protein localization	GO:0034613	160	0.059
pigment metabolic process	GO:0042440	84	0.059
negative regulation of mitotic cell cycle	GO:0045930	109	0.059
i kappab kinase nf kappab signaling	GO:0007249	6	0.058	Zebrafish Mouse
mitotic spindle organization	GO:0007052	220	0.057
pattern recognition receptor signaling pathway	GO:0002221	2	0.057
benzene containing compound metabolic process	GO:0042537	3	0.056
positive regulation of multicellular organismal process	GO:0051240	143	0.055
regulation of peptidase activity	GO:0052547	39	0.054	Fly
cardiovascular system development	GO:0072358	82	0.053
internal protein amino acid acetylation	GO:0006475	38	0.053
dendrite development	GO:0016358	204	0.053
protein localization to nucleus	GO:0034504	55	0.053
regulation of gene expression epigenetic	GO:0040029	128	0.053
regulation of cell cycle process	GO:0010564	181	0.053
positive regulation of cell communication	GO:0010647	250	0.052	Mouse
intracellular transport	GO:0046907	228	0.052	Fly
cellular response to dna damage stimulus	GO:0006974	223	0.052
protein complex assembly	GO:0006461	200	0.052
regulation of nucleocytoplasmic transport	GO:0046822	35	0.052
mucosal immune response	GO:0002385	10	0.052
nucleocytoplasmic transport	GO:0006913	72	0.051
macromolecular complex assembly	GO:0065003	256	0.051
positive regulation of protein transport	GO:0051222	37	0.050
negative regulation of response to stimulus	GO:0048585	258	0.050	Zebrafish
regulation of cellular response to stress	GO:0080135	89	0.050
organic substance transport	GO:0071702	257	0.049
salivary gland morphogenesis	GO:0007435	145	0.049
regulation of mitotic cell cycle	GO:0007346	190	0.049
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.049
cellular response to lipopolysaccharide	GO:0071222	3	0.049
posttranscriptional gene silencing by rna	GO:0035194	45	0.049
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.048
cellular response to starvation	GO:0009267	61	0.048
microtubule organizing center organization	GO:0031023	168	0.048
response to wounding	GO:0009611	94	0.048
dna damage checkpoint	GO:0000077	78	0.047
positive regulation of proteolysis	GO:0045862	52	0.047	Fly
cellular response to abiotic stimulus	GO:0071214	58	0.047
positive regulation of macromolecule metabolic process	GO:0010604	405	0.047	Human Fly
g2 dna damage checkpoint	GO:0031572	69	0.047
gastrulation involving germ band extension	GO:0010004	36	0.047
melanin metabolic process	GO:0006582	47	0.046
developmental programmed cell death	GO:0010623	138	0.046
regulation of autophagy	GO:0010506	62	0.045
head involution	GO:0008258	35	0.045
response to organonitrogen compound	GO:0010243	75	0.045
regulation of establishment of protein localization	GO:0070201	61	0.045
positive regulation of signaling	GO:0023056	243	0.043	Mouse
organic substance catabolic process	GO:1901575	308	0.043
histolysis	GO:0007559	102	0.043
response to organic cyclic compound	GO:0014070	89	0.042
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.042
apoptotic signaling pathway	GO:0097190	27	0.042
tissue death	GO:0016271	102	0.042
chitin based cuticle sclerotization	GO:0007593	19	0.041
response to organic substance	GO:0010033	284	0.041	Human Rat
regulation of intracellular transport	GO:0032386	64	0.041
regulation of multicellular organismal development	GO:2000026	414	0.040
jnk cascade	GO:0007254	50	0.040
positive regulation of cellular component organization	GO:0051130	156	0.040
positive regulation of molecular function	GO:0044093	136	0.040	Human Mouse Rat Fly
nf kappab import into nucleus	GO:0042348	1	0.040
extrinsic apoptotic signaling pathway	GO:0097191	1	0.040
organelle fission	GO:0048285	340	0.040
positive regulation of gene expression	GO:0010628	290	0.039	Human
regulation of catalytic activity	GO:0050790	185	0.039	Fly
cellular response to molecule of bacterial origin	GO:0071219	3	0.038
protein modification process	GO:0036211	438	0.038
single organism cellular localization	GO:1902580	180	0.038
salivary gland cell autophagic cell death	GO:0035071	83	0.038
posttranscriptional gene silencing	GO:0016441	46	0.037
regulation of cytoplasmic transport	GO:1903649	47	0.037
negative regulation of rna biosynthetic process	GO:1902679	240	0.037
phagocytosis	GO:0006909	215	0.037
salivary gland histolysis	GO:0035070	88	0.037
defense response to fungus	GO:0050832	48	0.037
regulation of intracellular protein transport	GO:0033157	46	0.037
apoptotic process	GO:0006915	159	0.036	Zebrafish Fly
regulation of cell cycle phase transition	GO:1901987	130	0.036
positive regulation of cellular catabolic process	GO:0031331	95	0.036
cellular response to biotic stimulus	GO:0071216	4	0.036
response to temperature stimulus	GO:0009266	106	0.036
cell proliferation	GO:0008283	299	0.036	Mouse Rat
negative regulation of cell cycle process	GO:0010948	109	0.036
gland morphogenesis	GO:0022612	145	0.036
cellular response to organic substance	GO:0071310	132	0.036	Human
regulation of gene silencing	GO:0060968	63	0.036
post embryonic appendage morphogenesis	GO:0035120	385	0.035
courtship behavior	GO:0007619	68	0.035
cellular response to oxygen containing compound	GO:1901701	79	0.034
macromolecule catabolic process	GO:0009057	161	0.034
response to fungus	GO:0009620	50	0.034
cellular response to dsrna	GO:0071359	15	0.034
regulation of cellular localization	GO:0060341	136	0.034
heterocycle catabolic process	GO:0046700	166	0.034
mitotic cell cycle phase transition	GO:0044772	138	0.034
compound eye morphogenesis	GO:0001745	249	0.034
regulation of protein import into nucleus	GO:0042306	28	0.033
neuron remodeling	GO:0016322	29	0.033	Fly
protein complex biogenesis	GO:0070271	201	0.033
production of small rna involved in gene silencing by rna	GO:0070918	15	0.033
single organism behavior	GO:0044708	391	0.033
imaginal disc derived wing morphogenesis	GO:0007476	337	0.033
protein targeting to nucleus	GO:0044744	51	0.033
regulation of nf kappab import into nucleus	GO:0042345	1	0.033
response to radiation	GO:0009314	155	0.033
negative regulation of rna metabolic process	GO:0051253	251	0.033
regulation of molecular function	GO:0065009	217	0.033	Human Mouse Rat Fly
regulation of catabolic process	GO:0009894	170	0.032
proteolysis	GO:0006508	192	0.032	Fly
membrane organization	GO:0061024	112	0.032
regulation of transport	GO:0051049	181	0.032	Mouse
neurological system process	GO:0050877	358	0.032
regulation of cellular component biogenesis	GO:0044087	201	0.032
memory	GO:0007613	94	0.032
negative regulation of response to external stimulus	GO:0032102	22	0.031
protein localization to organelle	GO:0033365	82	0.031
regulation of cellular catabolic process	GO:0031329	157	0.031
negative regulation of cellular biosynthetic process	GO:0031327	277	0.031
male mating behavior	GO:0060179	70	0.030
salivary gland development	GO:0007431	162	0.030
regulation of response to wounding	GO:1903034	19	0.030
nuclear division	GO:0000280	332	0.030
negative regulation of signal transduction	GO:0009968	206	0.030	Zebrafish
positive regulation of cell cycle process	GO:0090068	28	0.030
retinal cell programmed cell death	GO:0046666	25	0.029
wing disc morphogenesis	GO:0007472	344	0.029
response to nitrogen compound	GO:1901698	90	0.029
organ or tissue specific immune response	GO:0002251	10	0.029
autophagy	GO:0006914	108	0.029
single organism nuclear import	GO:1902593	51	0.029
protein targeting	GO:0006605	64	0.029
cell cycle phase transition	GO:0044770	140	0.029
negative regulation of cell cycle	GO:0045786	116	0.029
positive regulation of transport	GO:0051050	92	0.028	Mouse
regulation of jnk cascade	GO:0046328	40	0.028
central nervous system development	GO:0007417	201	0.028	Zebrafish
developmental pigmentation	GO:0048066	68	0.028
regulation of localization	GO:0032879	275	0.028	Mouse
endocytosis	GO:0006897	310	0.028
lysosomal transport	GO:0007041	13	0.028
response to alkaloid	GO:0043279	26	0.028
positive regulation of protein import into nucleus	GO:0042307	21	0.028
response to unfolded protein	GO:0006986	9	0.028
mitotic dna damage checkpoint	GO:0044773	74	0.028
chromosome segregation	GO:0007059	157	0.027
stem cell proliferation	GO:0072089	88	0.027
protein maturation	GO:0051604	71	0.027
dsrna fragmentation	GO:0031050	15	0.027
dorsal closure	GO:0007391	79	0.027
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.027
positive regulation of peptidase activity	GO:0010952	29	0.027	Fly
response to dsrna	GO:0043331	15	0.026
cellular response to organic cyclic compound	GO:0071407	32	0.026
nitrogen compound transport	GO:0071705	85	0.026
digestive tract development	GO:0048565	149	0.026	Zebrafish
autophagic cell death	GO:0048102	83	0.026
apoptotic process involved in development	GO:1902742	20	0.026
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.026	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.026	Human
neuromuscular synaptic transmission	GO:0007274	67	0.026
peptidyl amino acid modification	GO:0018193	105	0.026
nuclear import	GO:0051170	51	0.026
histone acetylation	GO:0016573	38	0.026
embryonic development via the syncytial blastoderm	GO:0001700	148	0.025
cuticle development	GO:0042335	86	0.025
intracellular protein transport	GO:0006886	104	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.025
cell division	GO:0051301	248	0.025	Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.025	Human
protein acylation	GO:0043543	42	0.025
rna processing	GO:0006396	147	0.025
sperm individualization	GO:0007291	48	0.025
regulation of protein localization	GO:0032880	76	0.025
chromatin silencing	GO:0006342	76	0.024
organic hydroxy compound metabolic process	GO:1901615	83	0.024
regulation of hydrolase activity	GO:0051336	97	0.024	Fly
pigment biosynthetic process	GO:0046148	36	0.024
mitotic g2 m transition checkpoint	GO:0044818	70	0.024
fat soluble vitamin biosynthetic process	GO:0042362	1	0.024
negative regulation of transcription dna templated	GO:0045892	237	0.024
negative regulation of biosynthetic process	GO:0009890	277	0.024
spindle organization	GO:0007051	253	0.024
aging	GO:0007568	143	0.024
regulation of wnt signaling pathway	GO:0030111	68	0.024
pole cell development	GO:0007277	26	0.024
cellular macromolecule catabolic process	GO:0044265	136	0.024
gastrulation with mouth forming first	GO:0001703	36	0.023
negative regulation of protein metabolic process	GO:0051248	85	0.023
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.023
mitotic cell cycle checkpoint	GO:0007093	88	0.023
regulation of developmental growth	GO:0048638	174	0.023
neural retina development	GO:0003407	4	0.023
protein import	GO:0017038	55	0.023
stress activated mapk cascade	GO:0051403	52	0.023
regulation of phosphorylation	GO:0042325	147	0.023
chromatin modification	GO:0016568	147	0.023
protein modification by small protein conjugation or removal	GO:0070647	106	0.023
peripheral nervous system development	GO:0007422	52	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023	Human
gland development	GO:0048732	191	0.023	Mouse
negative regulation of immune response	GO:0050777	39	0.022
regulation of synapse organization	GO:0050807	110	0.022
telencephalon development	GO:0021537	2	0.022
detection of light stimulus	GO:0009583	58	0.022
positive regulation of innate immune response	GO:0045089	38	0.022
digestive system development	GO:0055123	149	0.022	Zebrafish
oocyte dorsal ventral axis specification	GO:0007310	34	0.022
positive regulation of catabolic process	GO:0009896	105	0.022
cellular response to chemical stimulus	GO:0070887	199	0.022	Human
macroautophagy	GO:0016236	42	0.022
regionalization	GO:0003002	416	0.022	Zebrafish
peptidyl lysine modification	GO:0018205	57	0.022
positive regulation of cellular protein metabolic process	GO:0032270	118	0.021	Fly
regulation of growth	GO:0040008	233	0.021
response to endogenous stimulus	GO:0009719	119	0.021
positive regulation of rna biosynthetic process	GO:1902680	266	0.021	Human
segment polarity determination	GO:0007367	25	0.021
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.020
protein import into nucleus	GO:0006606	51	0.020
positive regulation of intracellular signal transduction	GO:1902533	116	0.020	Mouse
synaptic growth at neuromuscular junction	GO:0051124	119	0.020
positive regulation of catalytic activity	GO:0043085	118	0.020	Fly
spindle assembly	GO:0051225	80	0.020
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.020
organic cyclic compound catabolic process	GO:1901361	168	0.020
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.020
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.020
ectopic germ cell programmed cell death	GO:0035234	8	0.020
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.020
connective tissue development	GO:0061448	3	0.020
response to oxidative stress	GO:0006979	86	0.020
male gamete generation	GO:0048232	201	0.020
dorsal ventral axis specification	GO:0009950	66	0.020
respiratory system development	GO:0060541	213	0.020	Fly
positive regulation of rna metabolic process	GO:0051254	271	0.019	Human
appendage development	GO:0048736	401	0.019
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.019	Mouse
embryonic morphogenesis	GO:0048598	206	0.019	Zebrafish
regulation of nuclear division	GO:0051783	58	0.019
response to lipid	GO:0033993	38	0.019	Rat
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.019
negative regulation of cellular component organization	GO:0051129	108	0.019
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.019	Human
interspecies interaction between organisms	GO:0044419	16	0.019
forebrain development	GO:0030900	2	0.019
positive regulation of apoptotic process	GO:0043065	47	0.019	Fly
positive regulation of growth	GO:0045927	75	0.019
positive regulation of hydrolase activity	GO:0051345	78	0.019	Fly
embryonic pattern specification	GO:0009880	174	0.019	Zebrafish
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.019
sensory organ morphogenesis	GO:0090596	260	0.019
detection of abiotic stimulus	GO:0009582	66	0.019
compound eye retinal cell programmed cell death	GO:0046667	23	0.019
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.019
cellular response to sterol depletion	GO:0071501	3	0.019
establishment of tissue polarity	GO:0007164	87	0.018
regulation of proteolysis	GO:0030162	87	0.018	Fly
positive regulation of cell cycle	GO:0045787	43	0.018
regulation of mapk cascade	GO:0043408	92	0.018
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.018
apoptotic cell clearance	GO:0043277	14	0.018
alternative mrna splicing via spliceosome	GO:0000380	60	0.018
neuron maturation	GO:0042551	31	0.018	Fly
vesicle mediated transport	GO:0016192	381	0.018	Fly
myotube cell development	GO:0014904	3	0.018
spermatid development	GO:0007286	98	0.018
mitotic nuclear division	GO:0007067	213	0.017
cellular response to nutrient levels	GO:0031669	62	0.017
locomotory behavior	GO:0007626	176	0.017
regulation of apoptotic process	GO:0042981	130	0.017	Zebrafish Fly
cellular amino acid metabolic process	GO:0006520	61	0.017
positive regulation of intracellular transport	GO:0032388	42	0.017
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.017
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.017
cellular nitrogen compound catabolic process	GO:0044270	165	0.017
ncrna metabolic process	GO:0034660	43	0.017
mating behavior	GO:0007617	106	0.017
embryo development ending in birth or egg hatching	GO:0009792	152	0.017	Zebrafish
mrna metabolic process	GO:0016071	124	0.017
exocrine system development	GO:0035272	162	0.017
cellular response to nitrogen compound	GO:1901699	51	0.017
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.017	Human
protein processing	GO:0016485	68	0.017
germ line stem cell maintenance	GO:0030718	50	0.016
nucleobase containing compound transport	GO:0015931	56	0.016
regulation of epithelial cell differentiation	GO:0030856	4	0.016
peptidyl lysine acetylation	GO:0018394	39	0.016
response to copper ion	GO:0046688	4	0.016
imaginal disc fusion	GO:0046528	19	0.016
regulation of protein transport	GO:0051223	57	0.016
limb development	GO:0060173	1	0.016
cation transport	GO:0006812	110	0.016	Mouse
spermatogenesis	GO:0007283	200	0.016
positive regulation of developmental growth	GO:0048639	62	0.016
positive regulation of developmental process	GO:0051094	143	0.016
camera type eye development	GO:0043010	4	0.016
cell cycle arrest	GO:0007050	4	0.016
centrosome duplication	GO:0051298	121	0.016
negative regulation of innate immune response	GO:0045824	30	0.016
covalent chromatin modification	GO:0016569	106	0.016
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.015
regulation of ras gtpase activity	GO:0032318	38	0.015
positive regulation of cell migration	GO:0030335	2	0.015
regulation of response to extracellular stimulus	GO:0032104	18	0.015
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.015
cellular response to ethanol	GO:0071361	4	0.015
regulation of anatomical structure morphogenesis	GO:0022603	242	0.015
vitamin metabolic process	GO:0006766	2	0.015
positive regulation of phosphate metabolic process	GO:0045937	139	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
endomembrane system organization	GO:0010256	119	0.015
appendage morphogenesis	GO:0035107	397	0.015
retina development in camera type eye	GO:0060041	4	0.015
molting cycle chitin based cuticle	GO:0007591	56	0.015
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.015
membrane depolarization	GO:0051899	4	0.015
response to ethanol	GO:0045471	59	0.015
morphogenesis of an epithelium	GO:0002009	276	0.015	Zebrafish Mouse
negative regulation of growth	GO:0045926	84	0.015
negative regulation of cell differentiation	GO:0045596	143	0.015
negative regulation of cell death	GO:0060548	81	0.015	Zebrafish
regulation of synapse structure and activity	GO:0050803	128	0.015
muscle cell differentiation	GO:0042692	103	0.015

ird5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.077
cancer	DOID:162	0.018
disease of cellular proliferation	DOID:14566	0.018
organ system cancer	DOID:0050686	0.016

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