IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

CG5335 (Dmel_CG5335)

CG5335 gene product from transcript CG5335-RA

(Aliases: Dmel\CG5335)

Entrez: 37140
FLYBASE: FBgn0034365
UniProtKB: A1ZBB1

Process Predictions
Disease Predictions

CG5335 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
steroid catabolic process	GO:0006706	1	0.197
response to organic substance	GO:0010033	284	0.180
response to abiotic stimulus	GO:0009628	341	0.150
single organism biosynthetic process	GO:0044711	206	0.126
oxoacid metabolic process	GO:0043436	103	0.086
small molecule metabolic process	GO:0044281	305	0.085
vitamin metabolic process	GO:0006766	2	0.084
carboxylic acid metabolic process	GO:0019752	92	0.080
organonitrogen compound metabolic process	GO:1901564	318	0.080
kidney development	GO:0001822	3	0.076
cellular catabolic process	GO:0044248	372	0.071
protein complex assembly	GO:0006461	200	0.071
negative regulation of cellular metabolic process	GO:0031324	382	0.070
growth	GO:0040007	359	0.065
anion homeostasis	GO:0055081	3	0.062
lipid biosynthetic process	GO:0008610	46	0.061
secondary metabolite catabolic process	GO:0090487	1	0.060
organic hydroxy compound metabolic process	GO:1901615	83	0.060
tube development	GO:0035295	244	0.059
cellular ketone metabolic process	GO:0042180	24	0.054
embryonic morphogenesis	GO:0048598	206	0.053
regulation of developmental growth	GO:0048638	174	0.052
embryonic development via the syncytial blastoderm	GO:0001700	148	0.050
ketone biosynthetic process	GO:0042181	16	0.050
protein complex biogenesis	GO:0070271	201	0.049
positive regulation of lipid storage	GO:0010884	4	0.047
vitamin biosynthetic process	GO:0009110	1	0.046
positive regulation of gene expression	GO:0010628	290	0.045
immune response	GO:0006955	246	0.042	Human
regulation of cell death	GO:0010941	173	0.041
sulfur compound metabolic process	GO:0006790	59	0.040
response to nutrient levels	GO:0031667	114	0.040
response to mercury ion	GO:0046689	3	0.040
phosphatidic acid metabolic process	GO:0046473	1	0.039
negative regulation of response to stimulus	GO:0048585	258	0.038
forebrain development	GO:0030900	2	0.038
toxin metabolic process	GO:0009404	2	0.038
negative regulation of cell communication	GO:0010648	223	0.037
cellular amide metabolic process	GO:0043603	80	0.037
organic substance transport	GO:0071702	257	0.036
response to extracellular stimulus	GO:0009991	116	0.035
developmental growth	GO:0048589	280	0.035
cellular modified amino acid metabolic process	GO:0006575	45	0.034
fat soluble vitamin biosynthetic process	GO:0042362	1	0.033
negative regulation of signal transduction	GO:0009968	206	0.033
positive regulation of cell communication	GO:0010647	250	0.032
phospholipid homeostasis	GO:0055091	1	0.032
response to organic cyclic compound	GO:0014070	89	0.032
epithelial cell differentiation	GO:0030855	322	0.032
digestive system development	GO:0055123	149	0.032
tissue morphogenesis	GO:0048729	297	0.031
toxin catabolic process	GO:0009407	1	0.031
protein modification process	GO:0036211	438	0.031
cell proliferation	GO:0008283	299	0.031	Human
response to organophosphorus	GO:0046683	2	0.030
protein import into nucleus	GO:0006606	51	0.030
positive regulation of signaling	GO:0023056	243	0.030
oxidation reduction process	GO:0055114	123	0.030
cellular lipid metabolic process	GO:0044255	83	0.030
insecticide metabolic process	GO:0017143	2	0.030
positive regulation of macromolecule metabolic process	GO:0010604	405	0.030
programmed cell death	GO:0012501	257	0.030	Human
morphogenesis of embryonic epithelium	GO:0016331	94	0.029
secondary metabolic process	GO:0019748	75	0.029
vesicle mediated transport	GO:0016192	381	0.029
morphogenesis of an epithelium	GO:0002009	276	0.029
carbohydrate derivative biosynthetic process	GO:1901137	85	0.029
wing disc morphogenesis	GO:0007472	344	0.029
positive regulation of cell migration	GO:0030335	2	0.029
defense response	GO:0006952	300	0.029
cellular amino acid metabolic process	GO:0006520	61	0.028
regulation of localization	GO:0032879	275	0.028
telencephalon development	GO:0021537	2	0.028
glutathione metabolic process	GO:0006749	37	0.028
nephron development	GO:0072006	3	0.028
nephron epithelium development	GO:0072009	3	0.028
response to temperature stimulus	GO:0009266	106	0.028
catabolic process	GO:0009056	409	0.028
post embryonic appendage morphogenesis	GO:0035120	385	0.028
response to biotic stimulus	GO:0009607	294	0.027
small molecule biosynthetic process	GO:0044283	37	0.027
macromolecular complex assembly	GO:0065003	256	0.027
protein transport	GO:0015031	155	0.027
response to other organism	GO:0051707	293	0.027
positive regulation of multicellular organismal process	GO:0051240	143	0.027
digestive tract development	GO:0048565	149	0.026
fat soluble vitamin metabolic process	GO:0006775	1	0.026
negative regulation of biosynthetic process	GO:0009890	277	0.026
response to lipopolysaccharide	GO:0032496	4	0.026
imaginal disc derived wing morphogenesis	GO:0007476	337	0.025
immune response regulating signaling pathway	GO:0002764	2	0.025
brain development	GO:0007420	120	0.025
response to inorganic substance	GO:0010035	44	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.025
regulation of rna splicing	GO:0043484	69	0.025
kidney epithelium development	GO:0072073	3	0.025
body morphogenesis	GO:0010171	2	0.025
immune system process	GO:0002376	347	0.025	Human
carbohydrate derivative metabolic process	GO:1901135	217	0.024
rna splicing via transesterification reactions	GO:0000375	73	0.024
response to oxygen containing compound	GO:1901700	200	0.024
regulation of programmed cell death	GO:0043067	152	0.024
negative regulation of rna metabolic process	GO:0051253	251	0.024
regulation of hormone levels	GO:0010817	40	0.024
response to starvation	GO:0042594	97	0.024
organic acid metabolic process	GO:0006082	103	0.024
immune response activating signal transduction	GO:0002757	2	0.024
head development	GO:0060322	135	0.024
intracellular protein transport	GO:0006886	104	0.024
negative regulation of signaling	GO:0023057	219	0.023
regulation of multi organism process	GO:0043900	131	0.023
sterol homeostasis	GO:0055092	4	0.023
central nervous system development	GO:0007417	201	0.023
intracellular signal transduction	GO:0035556	300	0.023
regulation of response to stress	GO:0080134	200	0.022
medium chain fatty acid metabolic process	GO:0051791	1	0.022
imaginal disc derived appendage development	GO:0048737	399	0.022
peptide metabolic process	GO:0006518	80	0.022
nucleocytoplasmic transport	GO:0006913	72	0.022
negative regulation of gene expression	GO:0010629	387	0.022
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.022
positive regulation of signal transduction	GO:0009967	223	0.022
single organism nuclear import	GO:1902593	51	0.022
acylglycerol catabolic process	GO:0046464	3	0.022
negative regulation of cellular biosynthetic process	GO:0031327	277	0.021
regulation of cell cycle	GO:0051726	291	0.021
sensory perception of smell	GO:0007608	80	0.021
ethanolamine containing compound metabolic process	GO:0042439	4	0.021
positive regulation of cell proliferation	GO:0008284	47	0.021
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.021
regulation of protein metabolic process	GO:0051246	256	0.021
organic substance catabolic process	GO:1901575	308	0.020
regulation of intracellular signal transduction	GO:1902531	236	0.020
regulation of immune system process	GO:0002682	176	0.020	Human
ameboidal type cell migration	GO:0001667	151	0.020
nuclear transport	GO:0051169	72	0.020
establishment of localization in cell	GO:0051649	402	0.020
proteolysis	GO:0006508	192	0.020	Human
lipid metabolic process	GO:0006629	121	0.020
positive regulation of cell motility	GO:2000147	3	0.019
regulation of immune response	GO:0050776	118	0.019	Human
dorsal closure	GO:0007391	79	0.019
neurological system process	GO:0050877	358	0.019
endocytosis	GO:0006897	310	0.019
cell migration	GO:0016477	238	0.019
regulation of multicellular organismal development	GO:2000026	414	0.019	Human
embryo development ending in birth or egg hatching	GO:0009792	152	0.019
cellular amine metabolic process	GO:0044106	12	0.019
positive regulation of response to stimulus	GO:0048584	323	0.018
phosphorylation	GO:0016310	294	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.018
response to external biotic stimulus	GO:0043207	293	0.018
chaeta development	GO:0022416	97	0.018
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.018
organic hydroxy compound biosynthetic process	GO:1901617	21	0.017
neutral lipid catabolic process	GO:0046461	3	0.017
defense response to gram negative bacterium	GO:0050829	94	0.017
single organism catabolic process	GO:0044712	228	0.017
amine metabolic process	GO:0009308	12	0.017
cellular macromolecule localization	GO:0070727	220	0.017
single organism intracellular transport	GO:1902582	207	0.017
rna processing	GO:0006396	147	0.017
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
cuticle development	GO:0042335	86	0.017
digestive tract morphogenesis	GO:0048546	127	0.017
gland development	GO:0048732	191	0.017
cellular protein modification process	GO:0006464	438	0.017
steroid biosynthetic process	GO:0006694	16	0.017
renal system development	GO:0072001	72	0.016
mrna processing	GO:0006397	104	0.016
death	GO:0016265	284	0.016	Human
response to light stimulus	GO:0009416	124	0.016
triglyceride catabolic process	GO:0019433	3	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016
establishment of protein localization	GO:0045184	163	0.016
regulation of catalytic activity	GO:0050790	185	0.016
regulation of defense response	GO:0031347	102	0.016
proteoglycan metabolic process	GO:0006029	10	0.016
regulation of molecular function	GO:0065009	217	0.016
gonad development	GO:0008406	50	0.016
innate immune response	GO:0045087	144	0.016
response to hexose	GO:0009746	3	0.015
mrna metabolic process	GO:0016071	124	0.015
response to glucose	GO:0009749	2	0.015
xenobiotic catabolic process	GO:0042178	1	0.015
alcohol biosynthetic process	GO:0046165	14	0.015
appendage development	GO:0048736	401	0.015
maintenance of location	GO:0051235	73	0.015
positive regulation of cellular biosynthetic process	GO:0031328	316	0.015
cellular response to extracellular stimulus	GO:0031668	64	0.015
response to radiation	GO:0009314	155	0.015
acylglycerol biosynthetic process	GO:0046463	2	0.014
cellular response to organic substance	GO:0071310	132	0.014
aging	GO:0007568	143	0.014
hormone metabolic process	GO:0042445	33	0.014
cholesterol homeostasis	GO:0042632	3	0.014
localization of cell	GO:0051674	257	0.014
regulation of response to external stimulus	GO:0032101	115	0.014
regulation of cell differentiation	GO:0045595	302	0.014
polyol biosynthetic process	GO:0046173	3	0.014
pattern recognition receptor signaling pathway	GO:0002221	2	0.014
antimicrobial humoral response	GO:0019730	99	0.014
signal transduction by phosphorylation	GO:0023014	107	0.014
protein targeting to nucleus	GO:0044744	51	0.014
regulation of immune effector process	GO:0002697	52	0.013	Human
innate immune response activating signal transduction	GO:0002758	2	0.013
response to copper ion	GO:0046688	4	0.013
androgen metabolic process	GO:0008209	1	0.013
regulation of growth	GO:0040008	233	0.013
protein localization to nucleus	GO:0034504	55	0.013
steroid metabolic process	GO:0008202	20	0.013
regulation of transport	GO:0051049	181	0.013
neuron recognition	GO:0008038	101	0.013	Fly
activation of innate immune response	GO:0002218	4	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013
cellular response to chemical stimulus	GO:0070887	199	0.013
chromosome segregation	GO:0007059	157	0.013
response to drug	GO:0042493	17	0.013
homeostatic process	GO:0042592	199	0.013
phagocytosis	GO:0006909	215	0.013
tergite morphogenesis	GO:0007490	1	0.013
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.013
sensory perception of chemical stimulus	GO:0007606	116	0.013
tube morphogenesis	GO:0035239	191	0.013
positive regulation of programmed cell death	GO:0043068	62	0.013
organonitrogen compound catabolic process	GO:1901565	128	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.013
regulation of cellular ketone metabolic process	GO:0010565	3	0.013
cellular response to starvation	GO:0009267	61	0.013
columnar cuboidal epithelial cell development	GO:0002066	249	0.013
spindle organization	GO:0007051	253	0.013
cellular aldehyde metabolic process	GO:0006081	10	0.013
regulation of apoptotic process	GO:0042981	130	0.013
nuclear import	GO:0051170	51	0.013
nephron tubule development	GO:0072080	3	0.013
regulation of catabolic process	GO:0009894	170	0.013
response to oxidative stress	GO:0006979	86	0.013
insecticide catabolic process	GO:0046701	1	0.013
organic cyclic compound catabolic process	GO:1901361	168	0.013
reproductive structure development	GO:0048608	74	0.013
regulation of cellular localization	GO:0060341	136	0.012
single organism behavior	GO:0044708	391	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.012
protein oligomerization	GO:0051259	16	0.012
cell death	GO:0008219	279	0.012	Human
positive regulation of cell death	GO:0010942	69	0.012
axon guidance	GO:0007411	233	0.012
chemical homeostasis	GO:0048878	92	0.012
protein localization	GO:0008104	284	0.012
response to bacterium	GO:0009617	198	0.012
cellular protein localization	GO:0034613	160	0.012
positive regulation of biosynthetic process	GO:0009891	316	0.012
response to toxic substance	GO:0009636	22	0.012
sex differentiation	GO:0007548	81	0.012
connective tissue development	GO:0061448	3	0.012
negative regulation of protein metabolic process	GO:0051248	85	0.012
positive regulation of phosphorylation	GO:0042327	87	0.012
ovarian follicle cell development	GO:0030707	248	0.012
histoblast morphogenesis	GO:0007488	9	0.012
developmental maturation	GO:0021700	172	0.012
positive regulation of developmental process	GO:0051094	143	0.012
aromatic compound catabolic process	GO:0019439	166	0.012
regulation of cell proliferation	GO:0042127	163	0.012	Human
immune effector process	GO:0002252	98	0.012	Human
positive regulation of transcription dna templated	GO:0045893	266	0.012
alditol phosphate metabolic process	GO:0052646	2	0.012
negative regulation of rna biosynthetic process	GO:1902679	240	0.012
positive regulation of rna metabolic process	GO:0051254	271	0.012
epidermis development	GO:0008544	65	0.012
apoptotic process	GO:0006915	159	0.012	Human
appendage morphogenesis	GO:0035107	397	0.012
reproductive system development	GO:0061458	74	0.012
nucleoside phosphate metabolic process	GO:0006753	162	0.012
heterocycle catabolic process	GO:0046700	166	0.012
cell projection assembly	GO:0030031	94	0.012
cellular response to cadmium ion	GO:0071276	6	0.011
regulation of response to biotic stimulus	GO:0002831	63	0.011
cell aging	GO:0007569	2	0.011
urogenital system development	GO:0001655	72	0.011
sterol metabolic process	GO:0016125	12	0.011
ion transport	GO:0006811	145	0.011
jnk cascade	GO:0007254	50	0.011
positive regulation of transport	GO:0051050	92	0.011
negative regulation of defense response	GO:0031348	35	0.011
regulation of phosphorylation	GO:0042325	147	0.011
ecdysteroid metabolic process	GO:0045455	19	0.011
regulation of phosphorus metabolic process	GO:0051174	210	0.011
positive regulation of cellular component organization	GO:0051130	156	0.011
lateral inhibition	GO:0046331	206	0.011
olfactory learning	GO:0008355	56	0.011
chitin based cuticle development	GO:0040003	49	0.011
organic hydroxy compound catabolic process	GO:1901616	4	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.011
xenobiotic metabolic process	GO:0006805	5	0.011
cytoplasmic transport	GO:0016482	130	0.011
response to organonitrogen compound	GO:0010243	75	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
response to hormone	GO:0009725	45	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
response to endogenous stimulus	GO:0009719	119	0.011
regulation of phosphate metabolic process	GO:0019220	210	0.011
response to nitrogen compound	GO:1901698	90	0.011
regulation of mapk cascade	GO:0043408	92	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
cellular response to external stimulus	GO:0071496	66	0.011
epithelial cell development	GO:0002064	274	0.010
camera type eye development	GO:0043010	4	0.010
cell motility	GO:0048870	251	0.010
lauric acid metabolic process	GO:0048252	1	0.010
protein kinase b signaling	GO:0043491	1	0.010
protein import	GO:0017038	55	0.010
defense response to other organism	GO:0098542	225	0.010
response to calcium ion	GO:0051592	1	0.010
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.010

CG5335 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.055
disease of metabolism	DOID:0014667	0.038
lipid metabolism disorder	DOID:3146	0.036
inherited metabolic disorder	DOID:655	0.036
diabetes mellitus	DOID:9351	0.025
glucose metabolism disease	DOID:4194	0.025
acquired metabolic disease	DOID:0060158	0.025
carbohydrate metabolism disease	DOID:0050013	0.025
type 2 diabetes mellitus	DOID:9352	0.025
cardiovascular system disease	DOID:1287	0.014
nervous system disease	DOID:863	0.012
integumentary system disease	DOID:16	0.011
hypotrichosis	DOID:4535	0.011
hair disease	DOID:421	0.011
vascular disease	DOID:178	0.011

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