IMP: Integrative Multi-species Prediction

Drosophila melanogaster

195 known processes

Ced-12 (Dmel_CG5336)

CG5336 gene product from transcript CG5336-RA

(Aliases: dced-12,Dced-12,Ced12,Elmo,ELMO,elmo,ced-12,CG5336,Dmel\CG5336)

FLYBASE: FBgn0032409
Entrez: 34633
UniProtKB: Q9VKB2

Process Predictions
Disease Predictions

Ced-12 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell migration	GO:0016477	238	1.000
border follicle cell migration	GO:0007298	113	1.000
cell motility	GO:0048870	251	0.999
ovarian follicle cell migration	GO:0007297	121	0.999
epithelial cell differentiation	GO:0030855	322	0.999
ameboidal type cell migration	GO:0001667	151	0.998
localization of cell	GO:0051674	257	0.997
ovarian follicle cell development	GO:0030707	248	0.997
tissue migration	GO:0090130	155	0.996
epithelium migration	GO:0090132	148	0.979
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.973
columnar cuboidal epithelial cell development	GO:0002066	249	0.973
epithelial cell migration	GO:0010631	148	0.967
axonogenesis	GO:0007409	290	0.937
epithelial cell development	GO:0002064	274	0.889
small molecule metabolic process	GO:0044281	305	0.857
central nervous system development	GO:0007417	201	0.844
axon development	GO:0061564	297	0.816
positive regulation of developmental process	GO:0051094	143	0.771	Zebrafish
actin cytoskeleton organization	GO:0030036	206	0.771
embryonic morphogenesis	GO:0048598	206	0.756
chemotaxis	GO:0006935	249	0.749
open tracheal system development	GO:0007424	204	0.741
purine nucleoside metabolic process	GO:0042278	127	0.718
organonitrogen compound metabolic process	GO:1901564	318	0.717
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.689
growth	GO:0040007	359	0.687
regulation of cellular catabolic process	GO:0031329	157	0.675
tube development	GO:0035295	244	0.664
purine ribonucleotide catabolic process	GO:0009154	109	0.656
developmental growth	GO:0048589	280	0.624
neuron projection guidance	GO:0097485	241	0.611
purine ribonucleoside metabolic process	GO:0046128	127	0.608
response to alcohol	GO:0097305	95	0.603
g protein coupled receptor signaling pathway	GO:0007186	136	0.585
activation of rac gtpase activity	GO:0032863	3	0.564
purine containing compound metabolic process	GO:0072521	155	0.545
single organism intracellular transport	GO:1902582	207	0.525
positive regulation of response to stimulus	GO:0048584	323	0.518
nucleoside triphosphate metabolic process	GO:0009141	120	0.509
negative regulation of cellular metabolic process	GO:0031324	382	0.501
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.490
gtp metabolic process	GO:0046039	72	0.486
regulation of immune system process	GO:0002682	176	0.481
negative regulation of rna biosynthetic process	GO:1902679	240	0.477
endocytosis	GO:0006897	310	0.475	Human Worm
eye development	GO:0001654	323	0.458
intracellular signal transduction	GO:0035556	300	0.449	Human
positive regulation of signal transduction	GO:0009967	223	0.442
nucleoside catabolic process	GO:0009164	112	0.441
cell projection assembly	GO:0030031	94	0.438
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.428
carbohydrate derivative catabolic process	GO:1901136	118	0.419
nucleotide catabolic process	GO:0009166	109	0.396
eye morphogenesis	GO:0048592	260	0.391
gtp catabolic process	GO:0006184	72	0.377
positive regulation of phosphate metabolic process	GO:0045937	139	0.358
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.357
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.349
regulation of cell differentiation	GO:0045595	302	0.345
muscle structure development	GO:0061061	224	0.345
regulation of multicellular organismal development	GO:2000026	414	0.339	Zebrafish
glycosyl compound catabolic process	GO:1901658	112	0.333
cellular ketone metabolic process	GO:0042180	24	0.330
nucleoside metabolic process	GO:0009116	127	0.330
positive regulation of cell communication	GO:0010647	250	0.324
axon guidance	GO:0007411	233	0.320
actin filament based process	GO:0030029	220	0.318
muscle attachment	GO:0016203	36	0.317
positive regulation of hydrolase activity	GO:0051345	78	0.315
cell proliferation	GO:0008283	299	0.313
positive regulation of signaling	GO:0023056	243	0.307
negative regulation of biosynthetic process	GO:0009890	277	0.304
carbohydrate derivative metabolic process	GO:1901135	217	0.300
establishment of organelle localization	GO:0051656	122	0.298
regulation of cell projection organization	GO:0031344	92	0.297
regulation of organelle organization	GO:0033043	196	0.292
positive regulation of cell differentiation	GO:0045597	64	0.290
purine nucleoside catabolic process	GO:0006152	112	0.288
nucleoside triphosphate catabolic process	GO:0009143	108	0.283
cell growth	GO:0016049	108	0.280
catabolic process	GO:0009056	409	0.279
immune system process	GO:0002376	347	0.279
homeostatic process	GO:0042592	199	0.271
regulation of endocytosis	GO:0030100	37	0.269
establishment or maintenance of cell polarity	GO:0007163	167	0.269
camera type eye development	GO:0043010	4	0.267
purine nucleotide catabolic process	GO:0006195	109	0.266
regulation of cell proliferation	GO:0042127	163	0.264
mapk cascade	GO:0000165	107	0.263
vesicle mediated transport	GO:0016192	381	0.258	Human Worm
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.253
ribonucleoside metabolic process	GO:0009119	127	0.249
regulation of gtpase activity	GO:0043087	44	0.245
regulation of cell development	GO:0060284	215	0.243
divalent inorganic cation transport	GO:0072511	30	0.240
ribonucleoside catabolic process	GO:0042454	112	0.238
negative regulation of cellular biosynthetic process	GO:0031327	277	0.235
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.231
positive regulation of macromolecule metabolic process	GO:0010604	405	0.230
digestive tract morphogenesis	GO:0048546	127	0.223
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.223
regulation of nervous system development	GO:0051960	248	0.222
nucleoside phosphate metabolic process	GO:0006753	162	0.219
biological adhesion	GO:0022610	138	0.215
establishment of localization in cell	GO:0051649	402	0.214
regulation of cellular component biogenesis	GO:0044087	201	0.213
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.212
sensory organ morphogenesis	GO:0090596	260	0.212
regulation of actin cytoskeleton organization	GO:0032956	42	0.211
oxoacid metabolic process	GO:0043436	103	0.211
positive regulation of cellular component organization	GO:0051130	156	0.209
ribonucleotide metabolic process	GO:0009259	145	0.204
organic acid metabolic process	GO:0006082	103	0.203
digestive tract development	GO:0048565	149	0.200
response to organic substance	GO:0010033	284	0.199
digestive system development	GO:0055123	149	0.197
regionalization	GO:0003002	416	0.197
carboxylic acid metabolic process	GO:0019752	92	0.195
head development	GO:0060322	135	0.195
organonitrogen compound catabolic process	GO:1901565	128	0.186
gliogenesis	GO:0042063	80	0.183
cellular catabolic process	GO:0044248	372	0.181
epidermis development	GO:0008544	65	0.178
positive regulation of transcription dna templated	GO:0045893	266	0.175
regulation of response to stress	GO:0080134	200	0.175
cellular macromolecule localization	GO:0070727	220	0.174
regulation of cell morphogenesis	GO:0022604	163	0.171
positive regulation of cellular catabolic process	GO:0031331	95	0.168
negative regulation of transcription dna templated	GO:0045892	237	0.168
response to fibroblast growth factor	GO:0071774	10	0.165
rho protein signal transduction	GO:0007266	14	0.162
actin filament organization	GO:0007015	126	0.162
purine containing compound catabolic process	GO:0072523	112	0.161
regulation of system process	GO:0044057	36	0.160
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.158
single organism cellular localization	GO:1902580	180	0.156
positive regulation of phosphorus metabolic process	GO:0010562	139	0.154
regulation of phosphate metabolic process	GO:0019220	210	0.154
single organism catabolic process	GO:0044712	228	0.146
multi organism behavior	GO:0051705	175	0.141
neurological system process	GO:0050877	358	0.135
small gtpase mediated signal transduction	GO:0007264	88	0.134	Human
glycosyl compound metabolic process	GO:1901657	127	0.133
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.132
organophosphate metabolic process	GO:0019637	195	0.129
regulation of catabolic process	GO:0009894	170	0.129
skin development	GO:0043588	65	0.128
regulation of vesicle mediated transport	GO:0060627	59	0.128
embryo development ending in birth or egg hatching	GO:0009792	152	0.128
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.123
organophosphate catabolic process	GO:0046434	112	0.117
heart development	GO:0007507	82	0.115
regulation of developmental growth	GO:0048638	174	0.114
positive regulation of cellular component biogenesis	GO:0044089	80	0.114
regulation of hydrolase activity	GO:0051336	97	0.114
membrane organization	GO:0061024	112	0.112	Human Worm
positive regulation of gene expression	GO:0010628	290	0.112
positive regulation of nucleoside metabolic process	GO:0045979	47	0.112
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.111
cell death	GO:0008219	279	0.110
neuroblast division	GO:0055057	35	0.110
regulation of growth	GO:0040008	233	0.110
regulation of localization	GO:0032879	275	0.109	Worm
regulation of epithelial cell migration	GO:0010632	12	0.109
nucleobase containing compound catabolic process	GO:0034655	165	0.108
cellular amine metabolic process	GO:0044106	12	0.108
embryonic pattern specification	GO:0009880	174	0.108
immune effector process	GO:0002252	98	0.108
nucleoside phosphate catabolic process	GO:1901292	110	0.107
regulation of intracellular signal transduction	GO:1902531	236	0.106
regulation of transport	GO:0051049	181	0.106
negative regulation of rna metabolic process	GO:0051253	251	0.103
secretion	GO:0046903	109	0.103
positive regulation of phagocytosis	GO:0050766	3	0.102
regulation of cellular localization	GO:0060341	136	0.102
response to external biotic stimulus	GO:0043207	293	0.101
tissue homeostasis	GO:0001894	36	0.100
striated muscle cell differentiation	GO:0051146	90	0.100
regulation of cellular amine metabolic process	GO:0033238	3	0.099
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.099
positive regulation of cell motility	GO:2000147	3	0.099
skeletal muscle organ development	GO:0060538	48	0.098
positive regulation of rna metabolic process	GO:0051254	271	0.097
adult behavior	GO:0030534	137	0.097
tissue morphogenesis	GO:0048729	297	0.097
cognition	GO:0050890	141	0.096
regulation of mapk cascade	GO:0043408	92	0.096
regulation of actin filament length	GO:0030832	27	0.095
guanosine containing compound metabolic process	GO:1901068	74	0.095
macromolecular complex assembly	GO:0065003	256	0.095
regulation of ras gtpase activity	GO:0032318	38	0.094
cellular homeostasis	GO:0019725	80	0.094
positive regulation of molecular function	GO:0044093	136	0.093
actin filament bundle organization	GO:0061572	28	0.092
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.091
positive regulation of multicellular organismal process	GO:0051240	143	0.091	Zebrafish
intracellular transport	GO:0046907	228	0.090
positive regulation of lipid metabolic process	GO:0045834	4	0.088
regulation of neurogenesis	GO:0050767	158	0.087
regulation of proteolysis	GO:0030162	87	0.087
glial cell differentiation	GO:0010001	35	0.087
negative regulation of response to stimulus	GO:0048585	258	0.087
chaeta development	GO:0022416	97	0.086
activation of ras gtpase activity	GO:0032856	6	0.086
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.085
cellular component assembly involved in morphogenesis	GO:0010927	151	0.084
hindbrain development	GO:0030902	2	0.083
endomembrane system organization	GO:0010256	119	0.082
notch signaling pathway	GO:0007219	120	0.082
multi multicellular organism process	GO:0044706	123	0.080
retina morphogenesis in camera type eye	GO:0060042	2	0.080
regulation of axonogenesis	GO:0050770	32	0.080
purine nucleotide metabolic process	GO:0006163	146	0.078
respiratory system development	GO:0060541	213	0.077
guanosine containing compound catabolic process	GO:1901069	74	0.076
positive regulation of catabolic process	GO:0009896	105	0.076
peptidyl tyrosine modification	GO:0018212	24	0.075
regulation of cell migration	GO:0030334	22	0.075	Worm
negative regulation of neuron apoptotic process	GO:0043524	14	0.072
protein complex assembly	GO:0006461	200	0.072
cell division	GO:0051301	248	0.072
positive regulation of cell development	GO:0010720	61	0.071
regulation of cellular amino acid metabolic process	GO:0006521	0	0.070
retina development in camera type eye	GO:0060041	4	0.070
ribose phosphate metabolic process	GO:0019693	145	0.070
positive regulation of cell migration	GO:0030335	2	0.069
nucleobase containing small molecule metabolic process	GO:0055086	174	0.069
wnt signaling pathway	GO:0016055	98	0.068
positive regulation of response to external stimulus	GO:0032103	44	0.068
single organismal cell cell adhesion	GO:0016337	45	0.068
cell recognition	GO:0008037	102	0.067
negative regulation of cell communication	GO:0010648	223	0.067
stress activated protein kinase signaling cascade	GO:0031098	55	0.067
immune response	GO:0006955	246	0.066
regulation of neuron differentiation	GO:0045664	103	0.066
negative regulation of signaling	GO:0023057	219	0.066
positive regulation of rna biosynthetic process	GO:1902680	266	0.066
heterocycle catabolic process	GO:0046700	166	0.065
neural precursor cell proliferation	GO:0061351	75	0.065
anatomical structure homeostasis	GO:0060249	97	0.065
proteolysis	GO:0006508	192	0.065
actin filament bundle assembly	GO:0051017	26	0.064
regulation of cell shape	GO:0008360	113	0.064
protein localization	GO:0008104	284	0.063
brain development	GO:0007420	120	0.063
cellular protein complex assembly	GO:0043623	71	0.062
regulation of nucleotide catabolic process	GO:0030811	48	0.061
neuron maturation	GO:0042551	31	0.059
cytoplasmic transport	GO:0016482	130	0.059
positive regulation of receptor mediated endocytosis	GO:0048260	7	0.058
regulation of anatomical structure morphogenesis	GO:0022603	242	0.057	Zebrafish
regulation of wnt signaling pathway	GO:0030111	68	0.057
phagocytosis	GO:0006909	215	0.056	Human Worm
cellular protein localization	GO:0034613	160	0.056
apoptotic process	GO:0006915	159	0.056
regulation of cell death	GO:0010941	173	0.055
organelle localization	GO:0051640	148	0.055
regulation of programmed cell death	GO:0043067	152	0.055
positive regulation of transport	GO:0051050	92	0.054
mitotic spindle organization	GO:0007052	220	0.053
regulation of secretion	GO:0051046	44	0.053
regulation of apoptotic process	GO:0042981	130	0.053
programmed cell death	GO:0012501	257	0.053
regulation of rho protein signal transduction	GO:0035023	20	0.053
regulation of nucleoside metabolic process	GO:0009118	50	0.052
neuron recognition	GO:0008038	101	0.052
secretion by cell	GO:0032940	101	0.052
death	GO:0016265	284	0.052
positive regulation of cell proliferation	GO:0008284	47	0.051
oviposition	GO:0018991	19	0.051
glial cell migration	GO:0008347	31	0.051
nucleotide metabolic process	GO:0009117	161	0.049
ras protein signal transduction	GO:0007265	88	0.049	Human
cellular response to chemical stimulus	GO:0070887	199	0.049
pigmentation	GO:0043473	75	0.049
developmental maturation	GO:0021700	172	0.049
telencephalon development	GO:0021537	2	0.048
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.048
regulation of actin filament based process	GO:0032970	42	0.048
organic cyclic compound catabolic process	GO:1901361	168	0.048
cellular macromolecular complex assembly	GO:0034622	153	0.048
response to biotic stimulus	GO:0009607	294	0.048
memory	GO:0007613	94	0.047
positive regulation of nervous system development	GO:0051962	69	0.047
reproductive system development	GO:0061458	74	0.046	Worm
purine ribonucleoside catabolic process	GO:0046130	112	0.046
camera type eye morphogenesis	GO:0048593	2	0.046
chromosome organization	GO:0051276	360	0.046
positive regulation of cytoskeleton organization	GO:0051495	21	0.046
purine ribonucleotide metabolic process	GO:0009150	145	0.045
axis specification	GO:0009798	167	0.045
cell adhesion	GO:0007155	136	0.044
regulation of gtp catabolic process	GO:0033124	44	0.044
somatic stem cell division	GO:0048103	37	0.044
cellular lipid metabolic process	GO:0044255	83	0.044
positive regulation of nucleotide metabolic process	GO:0045981	55	0.044
anterior posterior pattern specification	GO:0009952	136	0.044
transcription from rna polymerase ii promoter	GO:0006366	368	0.044
muscle organ development	GO:0007517	127	0.044
chemical homeostasis	GO:0048878	92	0.043
response to other organism	GO:0051707	293	0.042
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.042
muscle system process	GO:0003012	21	0.042
positive regulation of gtpase activity	GO:0043547	43	0.042
regulation of molecular function	GO:0065009	217	0.042
negative regulation of cellular component organization	GO:0051129	108	0.041
establishment of cell polarity	GO:0030010	40	0.041
regulation of cellular ketone metabolic process	GO:0010565	3	0.041
regulation of actin polymerization or depolymerization	GO:0008064	27	0.041
actomyosin structure organization	GO:0031032	56	0.040
stem cell differentiation	GO:0048863	117	0.039
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.039
single organism membrane organization	GO:0044802	93	0.039
regulation of neuron death	GO:1901214	26	0.039
gene silencing	GO:0016458	138	0.038
gastrulation	GO:0007369	70	0.038
regulation of endopeptidase activity	GO:0052548	36	0.038
multicellular organismal homeostasis	GO:0048871	41	0.038
defense response to bacterium	GO:0042742	178	0.038
regulation of nucleotide metabolic process	GO:0006140	62	0.038
somatic muscle development	GO:0007525	66	0.038
cell activation	GO:0001775	9	0.038
positive regulation of apoptotic process	GO:0043065	47	0.038
regulation of cell motility	GO:2000145	23	0.038	Worm
positive regulation of exocytosis	GO:0045921	4	0.038
regulation of cytoskeleton organization	GO:0051493	89	0.038
regulation of protein metabolic process	GO:0051246	256	0.037
metal ion homeostasis	GO:0055065	44	0.037
positive regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043280	23	0.037
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.036
positive regulation of nucleotide catabolic process	GO:0030813	46	0.036
cellular nitrogen compound catabolic process	GO:0044270	165	0.036
terminal button organization	GO:0072553	19	0.036
positive regulation of cell adhesion	GO:0045785	10	0.036
lysosomal transport	GO:0007041	13	0.035
defense response	GO:0006952	300	0.035
positive regulation of cellular biosynthetic process	GO:0031328	316	0.034
mitotic nuclear division	GO:0007067	213	0.034
larval development	GO:0002164	104	0.034
lipid metabolic process	GO:0006629	121	0.034
compound eye morphogenesis	GO:0001745	249	0.033
leg disc development	GO:0035218	92	0.033
negative regulation of neuron death	GO:1901215	18	0.033
tube morphogenesis	GO:0035239	191	0.032
microtubule anchoring	GO:0034453	11	0.032
positive regulation of immune system process	GO:0002684	68	0.032
morphogenesis of an epithelium	GO:0002009	276	0.032
signal transduction by phosphorylation	GO:0023014	107	0.032
regulation of lipid metabolic process	GO:0019216	15	0.031
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.031
cortical actin cytoskeleton organization	GO:0030866	24	0.031
negative regulation of growth	GO:0045926	84	0.031
taxis	GO:0042330	304	0.030
positive regulation of neurogenesis	GO:0050769	41	0.030
regulation of anatomical structure size	GO:0090066	163	0.030
response to nutrient levels	GO:0031667	114	0.030
myoblast fusion	GO:0007520	43	0.029
positive regulation of organelle organization	GO:0010638	65	0.029
aromatic compound catabolic process	GO:0019439	166	0.029
regulation of cell cycle	GO:0051726	291	0.028
positive regulation of ras gtpase activity	GO:0032320	36	0.028
cellular amino acid metabolic process	GO:0006520	61	0.028
jak stat cascade	GO:0007259	49	0.028
signal release	GO:0023061	49	0.028
metal ion transport	GO:0030001	74	0.027
erk1 and erk2 cascade	GO:0070371	39	0.027
ribonucleotide catabolic process	GO:0009261	109	0.027
regulation of response to external stimulus	GO:0032101	115	0.027
renal system development	GO:0072001	72	0.026
germ cell migration	GO:0008354	43	0.026
regulation of phosphorus metabolic process	GO:0051174	210	0.026
cell maturation	GO:0048469	144	0.026
organic substance transport	GO:0071702	257	0.026
regulation of response to wounding	GO:1903034	19	0.026
morphogenesis of embryonic epithelium	GO:0016331	94	0.026
compound eye development	GO:0048749	307	0.025
cardiovascular system development	GO:0072358	82	0.025	Zebrafish
organic substance catabolic process	GO:1901575	308	0.025
phenol containing compound metabolic process	GO:0018958	57	0.025
regulation of cellular component movement	GO:0051270	42	0.024	Worm
positive regulation of peptidase activity	GO:0010952	29	0.024
positive regulation of endocytosis	GO:0045807	22	0.024
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.024
response to organic cyclic compound	GO:0014070	89	0.024
blastoderm segmentation	GO:0007350	159	0.024
regulation of purine nucleotide catabolic process	GO:0033121	48	0.024
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.024
mesoderm development	GO:0007498	78	0.024
response to ethanol	GO:0045471	59	0.024
forebrain development	GO:0030900	2	0.023
positive regulation of cellular amine metabolic process	GO:0033240	0	0.023
response to bacterium	GO:0009617	198	0.023
positive regulation of catalytic activity	GO:0043085	118	0.023
regulation of catalytic activity	GO:0050790	185	0.023
single organism cell adhesion	GO:0098602	47	0.022
negative regulation of gene expression	GO:0010629	387	0.022
developmental cell growth	GO:0048588	52	0.022
gland development	GO:0048732	191	0.022
steroid metabolic process	GO:0008202	20	0.022
actin filament polymerization	GO:0030041	27	0.022
regulation of notch signaling pathway	GO:0008593	100	0.021
regulation of gliogenesis	GO:0014013	11	0.021
negative regulation of signal transduction	GO:0009968	206	0.021
segmentation	GO:0035282	207	0.021
positive regulation of proteolysis	GO:0045862	52	0.021
protein complex biogenesis	GO:0070271	201	0.021
positive regulation of protein metabolic process	GO:0051247	128	0.021
regulation of protein polymerization	GO:0032271	28	0.021
protein polymerization	GO:0051258	42	0.020
substrate dependent cell migration	GO:0006929	3	0.020
regulation of canonical wnt signaling pathway	GO:0060828	15	0.020
inositol lipid mediated signaling	GO:0048017	4	0.020
actin polymerization or depolymerization	GO:0008154	31	0.020
regulation of cell junction assembly	GO:1901888	2	0.020
response to ionizing radiation	GO:0010212	32	0.020
negative regulation of developmental process	GO:0051093	201	0.020
neuron apoptotic process	GO:0051402	17	0.020
positive regulation of mapk cascade	GO:0043410	63	0.019
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.019
cellular response to oxygen containing compound	GO:1901701	79	0.019
wound healing	GO:0042060	75	0.019
cellular response to peptide hormone stimulus	GO:0071375	28	0.019
regulation of erbb signaling pathway	GO:1901184	42	0.018
muscle cell differentiation	GO:0042692	103	0.018
reproductive behavior	GO:0019098	122	0.018
regulation of synapse organization	GO:0050807	110	0.018
regulation of cell adhesion	GO:0030155	27	0.018
cellular component disassembly	GO:0022411	46	0.018
regulation of actin filament polymerization	GO:0030833	25	0.018
positive regulation of intracellular signal transduction	GO:1902533	116	0.018
regulation of neuron apoptotic process	GO:0043523	16	0.017
positive regulation of gtp catabolic process	GO:0033126	43	0.017
regulation of purine nucleotide metabolic process	GO:1900542	62	0.017
regulation of cell cycle process	GO:0010564	181	0.017
regulation of receptor mediated endocytosis	GO:0048259	9	0.017
exocrine system development	GO:0035272	162	0.017
positive regulation of neural precursor cell proliferation	GO:2000179	8	0.017
body morphogenesis	GO:0010171	2	0.017
regulation of chromosome organization	GO:0033044	64	0.017
response to oxygen containing compound	GO:1901700	200	0.017
positive regulation of rho gtpase activity	GO:0032321	19	0.017
positive regulation of immune response	GO:0050778	63	0.017
cellular response to peptide	GO:1901653	28	0.016
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.016
dorsal closure	GO:0007391	79	0.016
development of primary sexual characteristics	GO:0045137	50	0.016	Worm
nitrogen compound transport	GO:0071705	85	0.016
regulation of stress activated mapk cascade	GO:0032872	41	0.016
leg disc morphogenesis	GO:0007478	80	0.016
regulation of embryonic development	GO:0045995	68	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
cation transport	GO:0006812	110	0.016
cellularization	GO:0007349	90	0.016
establishment of protein localization to organelle	GO:0072594	62	0.016
regulation of autophagy	GO:0010506	62	0.015
circulatory system development	GO:0072359	82	0.015	Zebrafish
stress activated mapk cascade	GO:0051403	52	0.015
negative regulation of phosphorylation	GO:0042326	35	0.015
regulation of mitotic cell cycle	GO:0007346	190	0.015
single organism carbohydrate metabolic process	GO:0044723	72	0.015
meiotic cell cycle	GO:0051321	171	0.015
cytoskeleton dependent cytokinesis	GO:0061640	81	0.015
receptor mediated endocytosis	GO:0006898	21	0.015
myofibril assembly	GO:0030239	36	0.015
response to wounding	GO:0009611	94	0.015
negative regulation of neurotransmitter secretion	GO:0046929	2	0.015
histone modification	GO:0016570	106	0.014
response to heat	GO:0009408	63	0.014
atp metabolic process	GO:0046034	49	0.014
defense response to other organism	GO:0098542	225	0.014
single organism behavior	GO:0044708	391	0.014
positive regulation of mitotic cell cycle	GO:0045931	34	0.014
negative regulation of nervous system development	GO:0051961	92	0.014
divalent metal ion transport	GO:0070838	26	0.014
oocyte differentiation	GO:0009994	145	0.014
maintenance of protein location	GO:0045185	28	0.014
response to extracellular stimulus	GO:0009991	116	0.014
hematopoietic progenitor cell differentiation	GO:0002244	1	0.014
eggshell formation	GO:0030703	105	0.014
sensory perception	GO:0007600	196	0.014
organic hydroxy compound metabolic process	GO:1901615	83	0.013
cellular response to growth factor stimulus	GO:0071363	30	0.013
protein transport	GO:0015031	155	0.013
regulation of immune response	GO:0050776	118	0.013
axon extension	GO:0048675	32	0.013
mesenchymal cell development	GO:0014031	1	0.013
muscle cell migration	GO:0014812	3	0.013
anterior malpighian tubule development	GO:0061327	12	0.013
neuron remodeling	GO:0016322	29	0.013
regulation of lipid kinase activity	GO:0043550	2	0.013
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.013
amine metabolic process	GO:0009308	12	0.013
cellular chemical homeostasis	GO:0055082	40	0.013

Ced-12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.165
nervous system disease	DOID:863	0.029
musculoskeletal system disease	DOID:17	0.024

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