IMP: Integrative Multi-species Prediction

Drosophila melanogaster

31 known processes

rod (Dmel_CG1569)

rough deal

(Aliases: EP3408,Rod,ROD,CG1569,Dmel\CG1569,pNB20A)

Entrez: 43719
FLYBASE: FBgn0003268
UniProtKB: Q9V9W7

Process Predictions
Disease Predictions

rod biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organelle fission	GO:0048285	340	0.947
spindle assembly involved in mitosis	GO:0090307	50	0.825
centrosome organization	GO:0051297	163	0.654
centrosome cycle	GO:0007098	137	0.488
mitotic sister chromatid segregation	GO:0000070	87	0.460
organelle assembly	GO:0070925	198	0.379
negative regulation of cellular biosynthetic process	GO:0031327	277	0.350
neural precursor cell proliferation	GO:0061351	75	0.318
mitotic nuclear division	GO:0007067	213	0.318
chromosome organization	GO:0051276	360	0.312
asymmetric neuroblast division	GO:0055059	33	0.287
regulation of neuron differentiation	GO:0045664	103	0.284
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.276
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.268
negative regulation of cellular metabolic process	GO:0031324	382	0.260
negative regulation of cell cycle process	GO:0010948	109	0.239	Human
lateral inhibition	GO:0046331	206	0.238
microtubule organizing center organization	GO:0031023	168	0.238
negative regulation of gene expression	GO:0010629	387	0.222
dna replication	GO:0006260	48	0.218
nuclear dna replication	GO:0033260	1	0.210
mitotic spindle organization	GO:0007052	220	0.208
sister chromatid segregation	GO:0000819	92	0.206
regulation of mitotic cell cycle	GO:0007346	190	0.203	Human Worm
dna packaging	GO:0006323	91	0.200
negative regulation of cell cycle	GO:0045786	116	0.193	Human
nuclear division	GO:0000280	332	0.185
cell proliferation	GO:0008283	299	0.183
centriole replication	GO:0007099	24	0.176
protein complex biogenesis	GO:0070271	201	0.155
dna endoreduplication	GO:0042023	22	0.154
cellular protein modification process	GO:0006464	438	0.151
regulation of localization	GO:0032879	275	0.150	Worm
cellular macromolecular complex assembly	GO:0034622	153	0.147
chromosome segregation	GO:0007059	157	0.146
regulation of cell development	GO:0060284	215	0.142
protein phosphorylation	GO:0006468	169	0.129
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.124	Human
centrosome separation	GO:0051299	20	0.122
cell cycle phase transition	GO:0044770	140	0.121	Human
negative regulation of biosynthetic process	GO:0009890	277	0.121
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.120
ras protein signal transduction	GO:0007265	88	0.119
regulation of chromatin silencing	GO:0031935	36	0.117
protein complex assembly	GO:0006461	200	0.116
negative regulation of mitotic cell cycle	GO:0045930	109	0.109	Human
macromolecular complex assembly	GO:0065003	256	0.108
regulation of phosphate metabolic process	GO:0019220	210	0.106
protein dna complex assembly	GO:0065004	63	0.103
negative regulation of rna metabolic process	GO:0051253	251	0.097
regulation of molecular function	GO:0065009	217	0.095
negative regulation of transcription dna templated	GO:0045892	237	0.095
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.091	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.091
negative regulation of signal transduction	GO:0009968	206	0.089
cell maturation	GO:0048469	144	0.087
chromosome condensation	GO:0030261	41	0.086
negative regulation of rna biosynthetic process	GO:1902679	240	0.084
cellular macromolecule localization	GO:0070727	220	0.084
regulation of nervous system development	GO:0051960	248	0.080
regulation of neuron projection development	GO:0010975	69	0.077
photoreceptor cell differentiation	GO:0046530	170	0.076
phosphorylation	GO:0016310	294	0.076
heterocycle catabolic process	GO:0046700	166	0.073
dna conformation change	GO:0071103	105	0.073
intracellular signal transduction	GO:0035556	300	0.071
meiotic nuclear division	GO:0007126	151	0.070
regulation of cell differentiation	GO:0045595	302	0.067
germ line cyst formation	GO:0048134	44	0.067
regulation of anatomical structure morphogenesis	GO:0022603	242	0.067
negative regulation of cellular component organization	GO:0051129	108	0.067
spindle organization	GO:0007051	253	0.066
negative regulation of cellular protein metabolic process	GO:0032269	85	0.061
response to abiotic stimulus	GO:0009628	341	0.059
regulation of catalytic activity	GO:0050790	185	0.057
metaphase anaphase transition of cell cycle	GO:0044784	28	0.057
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.055	Worm
regulation of cellular ketone metabolic process	GO:0010565	3	0.055
mitotic spindle stabilization	GO:0043148	6	0.055
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.054
axonogenesis	GO:0007409	290	0.051
mitotic sister chromatid separation	GO:0051306	30	0.051
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.051
negative regulation of small gtpase mediated signal transduction	GO:0051058	13	0.051
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.048	Worm
response to organic substance	GO:0010033	284	0.048
axon development	GO:0061564	297	0.046
cell division	GO:0051301	248	0.046	Worm
small molecule metabolic process	GO:0044281	305	0.045
regulation of ras protein signal transduction	GO:0046578	93	0.045
regulation of chromosome segregation	GO:0051983	32	0.044	Worm
mitotic chromosome condensation	GO:0007076	22	0.044
regulation of neurogenesis	GO:0050767	158	0.044
cell projection assembly	GO:0030031	94	0.043
protein polymerization	GO:0051258	42	0.043
purine ribonucleotide catabolic process	GO:0009154	109	0.042
regulation of hydrolase activity	GO:0051336	97	0.042
neuroblast proliferation	GO:0007405	74	0.042
cellular catabolic process	GO:0044248	372	0.041
centriole assembly	GO:0098534	24	0.041
centriole centriole cohesion	GO:0010457	5	0.041
dna amplification	GO:0006277	11	0.041
eye photoreceptor cell differentiation	GO:0001754	145	0.041
rho protein signal transduction	GO:0007266	14	0.040
small gtpase mediated signal transduction	GO:0007264	88	0.039
regulation of organelle organization	GO:0033043	196	0.039	Worm
mitotic spindle elongation	GO:0000022	81	0.039
endocytosis	GO:0006897	310	0.039
regulation of mitotic spindle organization	GO:0060236	9	0.039
regulation of cellular protein metabolic process	GO:0032268	243	0.038
regulation of cell size	GO:0008361	63	0.038
regulation of phosphorus metabolic process	GO:0051174	210	0.038
actin filament organization	GO:0007015	126	0.038
oxoacid metabolic process	GO:0043436	103	0.038
cellular protein complex assembly	GO:0043623	71	0.038
dna metabolic process	GO:0006259	227	0.037
negative regulation of molecular function	GO:0044092	51	0.037
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.036
amine metabolic process	GO:0009308	12	0.036
carbohydrate derivative metabolic process	GO:1901135	217	0.036
regulation of cellular component size	GO:0032535	98	0.036
mitotic sister chromatid cohesion	GO:0007064	6	0.035
oocyte maturation	GO:0001556	3	0.035
single organism biosynthetic process	GO:0044711	206	0.034
single organism cellular localization	GO:1902580	180	0.034
axon guidance	GO:0007411	233	0.034
organophosphate metabolic process	GO:0019637	195	0.033
transcription from rna polymerase ii promoter	GO:0006366	368	0.033
negative regulation of organelle organization	GO:0010639	56	0.033
regulation of cell morphogenesis	GO:0022604	163	0.032
mitotic centrosome separation	GO:0007100	8	0.031
regulation of cell cycle phase transition	GO:1901987	130	0.031	Human
organic substance transport	GO:0071702	257	0.031
response to ionizing radiation	GO:0010212	32	0.031
muscle structure development	GO:0061061	224	0.031
somatic stem cell division	GO:0048103	37	0.031
purine nucleotide metabolic process	GO:0006163	146	0.030
protein transport	GO:0015031	155	0.030
organic substance catabolic process	GO:1901575	308	0.030
negative regulation of gene expression epigenetic	GO:0045814	77	0.030
eye morphogenesis	GO:0048592	260	0.030
actin cytoskeleton organization	GO:0030036	206	0.030
eye photoreceptor cell development	GO:0042462	81	0.029
death	GO:0016265	284	0.029
protein dna complex subunit organization	GO:0071824	86	0.029
asymmetric stem cell division	GO:0098722	49	0.029
regulation of cell projection organization	GO:0031344	92	0.028
dna dependent dna replication	GO:0006261	17	0.028
compound eye photoreceptor cell differentiation	GO:0001751	140	0.028
regulation of developmental growth	GO:0048638	174	0.028
negative regulation of ras protein signal transduction	GO:0046580	13	0.027
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.027
vesicle mediated transport	GO:0016192	381	0.027
cell cycle g1 s phase transition	GO:0044843	31	0.027
male meiosis cytokinesis	GO:0007112	26	0.026
negative regulation of catalytic activity	GO:0043086	42	0.026
carboxylic acid metabolic process	GO:0019752	92	0.026
dna geometric change	GO:0032392	16	0.026
cellular amine metabolic process	GO:0044106	12	0.025
cellular protein localization	GO:0034613	160	0.025
organonitrogen compound metabolic process	GO:1901564	318	0.025
spindle assembly	GO:0051225	80	0.025
nucleotide metabolic process	GO:0009117	161	0.024
purine ribonucleoside catabolic process	GO:0046130	112	0.024
regulation of proteolysis	GO:0030162	87	0.024
organic acid metabolic process	GO:0006082	103	0.024
negative regulation of microtubule depolymerization	GO:0007026	21	0.024
negative regulation of cell communication	GO:0010648	223	0.024
regulation of meiosis	GO:0040020	3	0.024
positive regulation of nervous system development	GO:0051962	69	0.023
developmental maturation	GO:0021700	172	0.023
negative regulation of phosphate metabolic process	GO:0045936	45	0.023
spindle assembly involved in meiosis	GO:0090306	20	0.022
regulation of cellular catabolic process	GO:0031329	157	0.022
regulation of gene expression epigenetic	GO:0040029	128	0.022
negative regulation of response to stimulus	GO:0048585	258	0.022
germarium derived female germ line cyst formation	GO:0030727	42	0.022
cell adhesion	GO:0007155	136	0.022
mitotic cell cycle embryonic	GO:0045448	38	0.021
muscle cell differentiation	GO:0042692	103	0.021
regulation of mitosis	GO:0007088	56	0.021	Worm
growth	GO:0040007	359	0.021
regulation of cytoskeleton organization	GO:0051493	89	0.021	Worm
establishment of localization in cell	GO:0051649	402	0.021
response to other organism	GO:0051707	293	0.021
protein modification process	GO:0036211	438	0.020
cellular ketone metabolic process	GO:0042180	24	0.020
regulation of catabolic process	GO:0009894	170	0.020
dorsal ventral pattern formation	GO:0009953	133	0.020
maintenance of protein location in cell	GO:0032507	26	0.020	Worm
centrosome duplication	GO:0051298	121	0.020
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.019
cellular macromolecule catabolic process	GO:0044265	136	0.019
regulation of organ morphogenesis	GO:2000027	78	0.019
sensory organ morphogenesis	GO:0090596	260	0.019
nucleoside triphosphate catabolic process	GO:0009143	108	0.019
regulation of microtubule cytoskeleton organization	GO:0070507	41	0.019	Worm
positive regulation of r7 cell differentiation	GO:0045678	7	0.018
stem cell division	GO:0017145	69	0.018
positive regulation of catalytic activity	GO:0043085	118	0.018
dna replication initiation	GO:0006270	6	0.018
nucleoside catabolic process	GO:0009164	112	0.018
mitotic cell cycle phase transition	GO:0044772	138	0.018	Human
single organism catabolic process	GO:0044712	228	0.018
regulation of cell cycle process	GO:0010564	181	0.018	Human Worm
peptidyl amino acid modification	GO:0018193	105	0.018
mitotic spindle midzone assembly	GO:0051256	1	0.018
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.018
cell death	GO:0008219	279	0.018
response to heat	GO:0009408	63	0.018
dna duplex unwinding	GO:0032508	16	0.017
negative regulation of cell cycle phase transition	GO:1901988	103	0.017	Human
cellular response to lipopolysaccharide	GO:0071222	3	0.017
regulation of protein metabolic process	GO:0051246	256	0.017
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.017
photoreceptor cell development	GO:0042461	96	0.017
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.017
neuroblast division	GO:0055057	35	0.017
positive regulation of phosphorus metabolic process	GO:0010562	139	0.017
ribonucleotide catabolic process	GO:0009261	109	0.017
ribose phosphate metabolic process	GO:0019693	145	0.017
positive regulation of response to stimulus	GO:0048584	323	0.016
ribonucleoside metabolic process	GO:0009119	127	0.016
chemotaxis	GO:0006935	249	0.016
regulation of dna metabolic process	GO:0051052	34	0.016
regulation of mitotic sister chromatid separation	GO:0010965	28	0.016
secretion	GO:0046903	109	0.016
sister chromatid cohesion	GO:0007062	18	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
regulation of cellular localization	GO:0060341	136	0.016	Worm
cell cycle dna replication	GO:0044786	23	0.016
negative regulation of phosphorus metabolic process	GO:0010563	45	0.016
regulation of cell shape	GO:0008360	113	0.016
salivary gland development	GO:0007431	162	0.015
cellular nitrogen compound catabolic process	GO:0044270	165	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
regulation of mitotic spindle elongation	GO:0032888	1	0.015
epithelial tube morphogenesis	GO:0060562	88	0.015
posttranscriptional gene silencing by rna	GO:0035194	45	0.015
posttranscriptional regulation of gene expression	GO:0010608	145	0.015
chromatin silencing	GO:0006342	76	0.015
cardiovascular system development	GO:0072358	82	0.015
aromatic compound catabolic process	GO:0019439	166	0.015
programmed cell death	GO:0012501	257	0.015
regulation of protein transport	GO:0051223	57	0.015
establishment of protein localization	GO:0045184	163	0.015
cellular response to dna damage stimulus	GO:0006974	223	0.015
meiotic cytokinesis	GO:0033206	33	0.014
wound healing	GO:0042060	75	0.014
regulation of actin filament based process	GO:0032970	42	0.014
response to organophosphorus	GO:0046683	2	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.014
regulation of protein localization	GO:0032880	76	0.014	Worm
regulation of microtubule depolymerization	GO:0031114	24	0.014
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.014
compound eye morphogenesis	GO:0001745	249	0.014
regulation of dna replication	GO:0006275	13	0.013
protein localization	GO:0008104	284	0.013
dephosphorylation	GO:0016311	51	0.013
negative regulation of chromosome segregation	GO:0051985	14	0.013
positive regulation of cellular amine metabolic process	GO:0033240	0	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
regulation of transcription by chromatin organization	GO:0034401	3	0.013
cilium organization	GO:0044782	41	0.013
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.013
neuron projection guidance	GO:0097485	241	0.013
negative regulation of signaling	GO:0023057	219	0.012
female meiotic division	GO:0007143	70	0.012
endomembrane system organization	GO:0010256	119	0.012
positive regulation of cell cycle process	GO:0090068	28	0.012
camera type eye development	GO:0043010	4	0.012
actin filament based process	GO:0030029	220	0.012
mitochondrion organization	GO:0007005	65	0.012
microtubule anchoring	GO:0034453	11	0.012	Worm
regulation of intracellular signal transduction	GO:1902531	236	0.012
phagocytosis	GO:0006909	215	0.012
regulation of nucleoside metabolic process	GO:0009118	50	0.012
purine ribonucleotide metabolic process	GO:0009150	145	0.012
protein localization to organelle	GO:0033365	82	0.012
negative regulation of protein depolymerization	GO:1901880	23	0.012
immune system process	GO:0002376	347	0.012
atp metabolic process	GO:0046034	49	0.011
regulation of cellular component biogenesis	GO:0044087	201	0.011
regulation of phosphorylation	GO:0042325	147	0.011
positive regulation of programmed cell death	GO:0043068	62	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
biological adhesion	GO:0022610	138	0.011
neuronal stem cell division	GO:0036445	35	0.011
developmental growth	GO:0048589	280	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
mitotic cell cycle checkpoint	GO:0007093	88	0.011	Human
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.011
positive regulation of neurogenesis	GO:0050769	41	0.011
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.011
regulation of behavior	GO:0050795	75	0.011
defense response	GO:0006952	300	0.011
regulation of protein phosphorylation	GO:0001932	64	0.011
protein processing	GO:0016485	68	0.011
positive regulation of cell development	GO:0010720	61	0.011
embryonic pattern specification	GO:0009880	174	0.011
wnt signaling pathway	GO:0016055	98	0.010
histone lysine methylation	GO:0034968	32	0.010
regionalization	GO:0003002	416	0.010
chromatin organization	GO:0006325	207	0.010
regulation of purine nucleotide metabolic process	GO:1900542	62	0.010
organic cyclic compound catabolic process	GO:1901361	168	0.010
body morphogenesis	GO:0010171	2	0.010
nucleoside metabolic process	GO:0009116	127	0.010
meiotic g2 mi transition	GO:0008315	3	0.010
regulation of cellular protein catabolic process	GO:1903362	44	0.010
negative regulation of protein maturation	GO:1903318	31	0.010

rod disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.018
organ system cancer	DOID:0050686	0.018
cancer	DOID:162	0.018

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