IMP: Integrative Multi-species Prediction

Drosophila melanogaster

117 known processes

spn-A (Dmel_CG7948)

spindle A

(Aliases: Dm Rad51,Dmrad51,CG7948,RA51,DMR1,Dmel\CG7948,RA51_DROME,dmRAD51,rad51,DMR,RAD51,D37788,Spn-A,Rad51,spnA,DmRad51,DMR/DroRAD51,Rad51dm,DmRAD51)

FLYBASE: FBgn0003479
Entrez: 43577
UniProtKB: Q27297
UniProtKB: C6SV45

Process Predictions
Disease Predictions

spn-A biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
reciprocal meiotic recombination	GO:0007131	19	1.000	Yeast
meiotic nuclear division	GO:0007126	151	0.999
dna recombination	GO:0006310	32	0.991
reciprocal dna recombination	GO:0035825	19	0.990	Yeast
meiotic cell cycle process	GO:1903046	132	0.986	Yeast Worm
organelle fission	GO:0048285	340	0.965
dna metabolic process	GO:0006259	227	0.959
female meiotic division	GO:0007143	70	0.955
chorion containing eggshell formation	GO:0007304	105	0.948
meiotic cell cycle	GO:0051321	171	0.948
meiosis i	GO:0007127	59	0.946	Yeast
double strand break repair	GO:0006302	26	0.938
germarium derived oocyte fate determination	GO:0007294	26	0.921
transcription from rna polymerase ii promoter	GO:0006366	368	0.913
germarium derived egg chamber formation	GO:0007293	101	0.908
nuclear division	GO:0000280	332	0.901
double strand break repair via nonhomologous end joining	GO:0006303	5	0.895
chromosome segregation	GO:0007059	157	0.886	Worm
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.873
karyosome formation	GO:0030717	22	0.811
nucleotide excision repair	GO:0006289	8	0.799
oocyte differentiation	GO:0009994	145	0.791
meiotic chromosome segregation	GO:0045132	59	0.762	Worm
nucleobase containing compound catabolic process	GO:0034655	165	0.709	Human Yeast Worm
negative regulation of cellular biosynthetic process	GO:0031327	277	0.682
non recombinational repair	GO:0000726	7	0.651
double strand break repair via homologous recombination	GO:0000724	13	0.632
oocyte development	GO:0048599	124	0.617
columnar cuboidal epithelial cell development	GO:0002066	249	0.612
chromosome organization	GO:0051276	360	0.495
negative regulation of rna metabolic process	GO:0051253	251	0.492
recombinational repair	GO:0000725	13	0.473
cellular nitrogen compound catabolic process	GO:0044270	165	0.432	Human Yeast Worm
mitotic dna damage checkpoint	GO:0044773	74	0.429
embryo development ending in birth or egg hatching	GO:0009792	152	0.419	Worm
ovarian follicle cell development	GO:0030707	248	0.407
regulation of phosphorylation	GO:0042325	147	0.399
oocyte anterior posterior axis specification	GO:0007314	72	0.382
negative regulation of biosynthetic process	GO:0009890	277	0.366
aromatic compound catabolic process	GO:0019439	166	0.361	Human Yeast Worm
response to uv	GO:0009411	24	0.360
dna synthesis involved in dna repair	GO:0000731	5	0.359
anterior posterior axis specification	GO:0009948	109	0.353
organelle fusion	GO:0048284	46	0.343
oocyte fate determination	GO:0030716	27	0.332
negative regulation of rna biosynthetic process	GO:1902679	240	0.307
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.291
axis specification	GO:0009798	167	0.291
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.280
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.278
embryonic pattern specification	GO:0009880	174	0.274
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.272
negative regulation of cellular metabolic process	GO:0031324	382	0.269
rna localization	GO:0006403	115	0.266
cellular response to dna damage stimulus	GO:0006974	223	0.264
germarium derived oocyte differentiation	GO:0030706	29	0.260
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.256
macromolecule catabolic process	GO:0009057	161	0.254
dna geometric change	GO:0032392	16	0.241	Human
organic substance catabolic process	GO:1901575	308	0.229	Human Yeast Worm
developmental maturation	GO:0021700	172	0.226
response to ionizing radiation	GO:0010212	32	0.225	Human
polarity specification of dorsal ventral axis	GO:0009951	6	0.222
segmentation	GO:0035282	207	0.218
oocyte axis specification	GO:0007309	108	0.218
protein modification process	GO:0036211	438	0.216
chromatin organization	GO:0006325	207	0.213
anterior posterior pattern specification	GO:0009952	136	0.211
phosphorylation	GO:0016310	294	0.209
cell death	GO:0008219	279	0.206	Worm
response to organonitrogen compound	GO:0010243	75	0.199
intracellular mrna localization	GO:0008298	66	0.197
dna double strand break processing	GO:0000729	3	0.195
cellular macromolecule localization	GO:0070727	220	0.181
negative regulation of gene expression	GO:0010629	387	0.180
purine ribonucleoside metabolic process	GO:0046128	127	0.176	Human Yeast Worm
specification of axis polarity	GO:0065001	6	0.170
glycosyl compound catabolic process	GO:1901658	112	0.167	Human Yeast Worm
regionalization	GO:0003002	416	0.164
positive regulation of intracellular signal transduction	GO:1902533	116	0.162
epithelial cell differentiation	GO:0030855	322	0.159
double strand break repair via synthesis dependent strand annealing	GO:0045003	6	0.156
eggshell chorion assembly	GO:0007306	66	0.155
negative regulation of transcription dna templated	GO:0045892	237	0.154
cell division	GO:0051301	248	0.153
regulation of cell cycle process	GO:0010564	181	0.153
organic cyclic compound catabolic process	GO:1901361	168	0.153	Human Yeast Worm
positive regulation of gene expression	GO:0010628	290	0.149
eggshell formation	GO:0030703	105	0.149
positive regulation of cell communication	GO:0010647	250	0.148
carbohydrate derivative catabolic process	GO:1901136	118	0.148	Human Yeast Worm
dna replication	GO:0006260	48	0.148	Human
oocyte dorsal ventral axis specification	GO:0007310	34	0.146
embryonic axis specification	GO:0000578	107	0.145
pole plasm rna localization	GO:0007316	52	0.144
cell cycle checkpoint	GO:0000075	95	0.141
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.141	Human Yeast Worm
cellular protein modification process	GO:0006464	438	0.136
regulation of cell cycle	GO:0051726	291	0.136
oocyte construction	GO:0007308	112	0.135
response to light stimulus	GO:0009416	124	0.134
mrna metabolic process	GO:0016071	124	0.130
regulation of mrna splicing via spliceosome	GO:0048024	64	0.129
tripartite regional subdivision	GO:0007351	103	0.127
negative regulation of cell cycle	GO:0045786	116	0.125
cellular catabolic process	GO:0044248	372	0.125	Human Yeast Worm
dna repair	GO:0006281	54	0.123
regulation of mitotic cell cycle	GO:0007346	190	0.120
regulation of cellular response to stress	GO:0080135	89	0.114
purine containing compound metabolic process	GO:0072521	155	0.113	Human Yeast Worm
regulation of cell cycle phase transition	GO:1901987	130	0.111
regulation of phosphate metabolic process	GO:0019220	210	0.110
cellular component assembly involved in morphogenesis	GO:0010927	151	0.104
oocyte localization involved in germarium derived egg chamber formation	GO:0030720	12	0.102
pole plasm assembly	GO:0007315	61	0.099
positive regulation of response to stimulus	GO:0048584	323	0.098
aging	GO:0007568	143	0.097
regulation of intracellular signal transduction	GO:1902531	236	0.097
growth	GO:0040007	359	0.096
apoptotic signaling pathway	GO:0097190	27	0.095	Worm
catabolic process	GO:0009056	409	0.095	Human Yeast Worm
single organism membrane organization	GO:0044802	93	0.093
single organism cellular localization	GO:1902580	180	0.092
regulation of developmental growth	GO:0048638	174	0.091
positive regulation of signaling	GO:0023056	243	0.089
organophosphate metabolic process	GO:0019637	195	0.088	Human Yeast Worm
mitotic dna integrity checkpoint	GO:0044774	75	0.086
regulation of mapk cascade	GO:0043408	92	0.086
alternative mrna splicing via spliceosome	GO:0000380	60	0.082
negative regulation of developmental process	GO:0051093	201	0.082
ribose phosphate metabolic process	GO:0019693	145	0.081	Human Yeast Worm
reproductive system development	GO:0061458	74	0.079
development of primary sexual characteristics	GO:0045137	50	0.079
positive regulation of programmed cell death	GO:0043068	62	0.079
pole plasm oskar mrna localization	GO:0045451	46	0.078
regulation of cell proliferation	GO:0042127	163	0.077
regulation of catalytic activity	GO:0050790	185	0.076
body morphogenesis	GO:0010171	2	0.075
regulation of cellular protein metabolic process	GO:0032268	243	0.075
intracellular signal transduction	GO:0035556	300	0.075	Worm
regulation of organelle organization	GO:0033043	196	0.075
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.075	Human Yeast Worm
regulation of protein metabolic process	GO:0051246	256	0.074
dna damage checkpoint	GO:0000077	78	0.074
pole plasm mrna localization	GO:0019094	49	0.073
regulation of phosphorus metabolic process	GO:0051174	210	0.073
ribonucleoside catabolic process	GO:0042454	112	0.071	Human Yeast Worm
purine ribonucleotide metabolic process	GO:0009150	145	0.071	Human Yeast Worm
g2 m transition of mitotic cell cycle	GO:0000086	19	0.070
cellular macromolecule catabolic process	GO:0044265	136	0.068
translesion synthesis	GO:0019985	2	0.068
oocyte nucleus localization involved in oocyte dorsal ventral axis specification	GO:0051663	12	0.065
multicellular organismal aging	GO:0010259	140	0.064
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.063
purine nucleoside metabolic process	GO:0042278	127	0.062	Human Yeast Worm
female meiosis chromosome segregation	GO:0016321	33	0.062
regulation of mrna metabolic process	GO:1903311	72	0.061
response to abiotic stimulus	GO:0009628	341	0.059	Human
epithelial cell development	GO:0002064	274	0.059
death	GO:0016265	284	0.059	Worm
nucleoside catabolic process	GO:0009164	112	0.059	Human Yeast Worm
positive regulation of cellular protein metabolic process	GO:0032270	118	0.058
response to radiation	GO:0009314	155	0.057	Human
immune system development	GO:0002520	57	0.056
dorsal appendage formation	GO:0046843	47	0.055
mrna processing	GO:0006397	104	0.054
anterior posterior axis specification embryo	GO:0008595	103	0.054
dna conformation change	GO:0071103	105	0.054	Human Worm
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.053
positive regulation of cellular component organization	GO:0051130	156	0.052
purine ribonucleoside catabolic process	GO:0046130	112	0.051	Human Yeast Worm
gene silencing	GO:0016458	138	0.049
vesicle mediated transport	GO:0016192	381	0.049
positive regulation of phosphorylation	GO:0042327	87	0.048
regulation of response to stress	GO:0080134	200	0.047
gene silencing by rna	GO:0031047	57	0.047
maternal determination of anterior posterior axis embryo	GO:0008358	74	0.047
regulation of nervous system development	GO:0051960	248	0.046
blastoderm segmentation	GO:0007350	159	0.046
establishment or maintenance of cell polarity	GO:0007163	167	0.045
larval development	GO:0002164	104	0.044
nucleotide metabolic process	GO:0009117	161	0.043	Human Yeast Worm
protein phosphorylation	GO:0006468	169	0.043
negative regulation of protein metabolic process	GO:0051248	85	0.042
purine nucleoside catabolic process	GO:0006152	112	0.042	Human Yeast Worm
positive regulation of macromolecule metabolic process	GO:0010604	405	0.041	Human
positive regulation of signal transduction	GO:0009967	223	0.041
eggshell chorion gene amplification	GO:0007307	9	0.041
sex differentiation	GO:0007548	81	0.041
mitotic cell cycle phase transition	GO:0044772	138	0.041
male gamete generation	GO:0048232	201	0.040
single organism behavior	GO:0044708	391	0.040
response to nitrogen compound	GO:1901698	90	0.040
establishment of localization in cell	GO:0051649	402	0.039
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.038	Human Yeast Worm
telomere maintenance via recombination	GO:0000722	1	0.038	Yeast
regulation of gene expression epigenetic	GO:0040029	128	0.038
positive regulation of phosphorus metabolic process	GO:0010562	139	0.038
cellular protein localization	GO:0034613	160	0.038
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.038	Human Yeast Worm
positive regulation of cellular biosynthetic process	GO:0031328	316	0.037
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.037	Human Yeast Worm
negative regulation of cellular component organization	GO:0051129	108	0.037
regulation of meiosis	GO:0040020	3	0.037
rna processing	GO:0006396	147	0.036
meiotic chromosome separation	GO:0051307	8	0.036
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.036
cognition	GO:0050890	141	0.035
apoptotic process	GO:0006915	159	0.035	Worm
dna biosynthetic process	GO:0071897	24	0.035
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.034
chromatin modification	GO:0016568	147	0.033
positive regulation of phosphate metabolic process	GO:0045937	139	0.033
nuclear dna replication	GO:0033260	1	0.033
regulation of meiotic cell cycle	GO:0051445	9	0.032
telomere maintenance	GO:0000723	21	0.032	Yeast
spindle assembly involved in female meiosis	GO:0007056	14	0.031
negative regulation of mitotic cell cycle	GO:0045930	109	0.031
positive regulation of cellular catabolic process	GO:0031331	95	0.031
ribonucleotide metabolic process	GO:0009259	145	0.031	Human Yeast Worm
endocytosis	GO:0006897	310	0.031
purine nucleotide catabolic process	GO:0006195	109	0.030	Human Yeast Worm
heterocycle catabolic process	GO:0046700	166	0.030	Human Yeast Worm
positive regulation of protein metabolic process	GO:0051247	128	0.030
polarity specification of anterior posterior axis	GO:0009949	5	0.030
purine nucleotide metabolic process	GO:0006163	146	0.030	Human Yeast Worm
negative regulation of cell communication	GO:0010648	223	0.030
protein complex biogenesis	GO:0070271	201	0.030	Human
nucleotide catabolic process	GO:0009166	109	0.030	Human Yeast Worm
small molecule metabolic process	GO:0044281	305	0.030	Human Yeast Worm
dna integrity checkpoint	GO:0031570	81	0.029
regulation of rna splicing	GO:0043484	69	0.029
cell cycle arrest	GO:0007050	4	0.029
negative regulation of gene expression epigenetic	GO:0045814	77	0.029
imaginal disc derived appendage development	GO:0048737	399	0.028
nucleoside metabolic process	GO:0009116	127	0.028	Human Yeast Worm
positive regulation of organelle organization	GO:0010638	65	0.027
regulation of cell death	GO:0010941	173	0.027	Worm
morphogenesis of follicular epithelium	GO:0016333	36	0.027
negative regulation of signal transduction	GO:0009968	206	0.027
mapk cascade	GO:0000165	107	0.027
cell proliferation	GO:0008283	299	0.026
mitotic g2 dna damage checkpoint	GO:0007095	69	0.026
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.026
positive regulation of apoptotic process	GO:0043065	47	0.025
positive regulation of mapk cascade	GO:0043410	63	0.025
negative regulation of cell proliferation	GO:0008285	69	0.025
negative regulation of cell cycle g1 s phase transition	GO:1902807	13	0.025
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.025
negative regulation of programmed cell death	GO:0043069	72	0.025	Worm
response to endogenous stimulus	GO:0009719	119	0.024
negative regulation of multicellular organismal process	GO:0051241	142	0.024
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.024
rna interference	GO:0016246	27	0.024
locomotory behavior	GO:0007626	176	0.024
response to organic substance	GO:0010033	284	0.024
positive regulation of biosynthetic process	GO:0009891	316	0.024
regulation of programmed cell death	GO:0043067	152	0.024	Worm
regulation of catabolic process	GO:0009894	170	0.023
protein complex assembly	GO:0006461	200	0.023	Human
ovarian fusome organization	GO:0030723	11	0.023
organonitrogen compound catabolic process	GO:1901565	128	0.023	Human Yeast Worm
dna packaging	GO:0006323	91	0.023	Worm
spindle organization	GO:0007051	253	0.023
signal transduction by phosphorylation	GO:0023014	107	0.022
negative regulation of signaling	GO:0023057	219	0.022
regulation of cellular component biogenesis	GO:0044087	201	0.022
organonitrogen compound metabolic process	GO:1901564	318	0.022	Human Yeast Worm
mitotic g2 m transition checkpoint	GO:0044818	70	0.022
dna dependent dna replication	GO:0006261	17	0.022	Human
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.021	Worm
glycosyl compound metabolic process	GO:1901657	127	0.021	Human Yeast Worm
postreplication repair	GO:0006301	2	0.021
dna catabolic process	GO:0006308	16	0.021
jak stat cascade	GO:0007259	49	0.021
purine containing compound catabolic process	GO:0072523	112	0.020	Human Yeast Worm
mitotic cell cycle checkpoint	GO:0007093	88	0.020
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020	Human
protein localization	GO:0008104	284	0.020
establishment of organelle localization	GO:0051656	122	0.020
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.020
positive regulation of cell death	GO:0010942	69	0.019
organelle assembly	GO:0070925	198	0.019
chromatin silencing	GO:0006342	76	0.019
response to alkaloid	GO:0043279	26	0.019
nucleobase containing small molecule metabolic process	GO:0055086	174	0.019	Human Yeast Worm
purine ribonucleotide catabolic process	GO:0009154	109	0.019	Human Yeast Worm
nucleoside phosphate metabolic process	GO:0006753	162	0.018	Human Yeast Worm
positive regulation of catalytic activity	GO:0043085	118	0.018
negative regulation of cell differentiation	GO:0045596	143	0.018
regulation of mrna processing	GO:0050684	71	0.017
negative regulation of cell cycle process	GO:0010948	109	0.017
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.017
wing disc morphogenesis	GO:0007472	344	0.017
learning or memory	GO:0007611	141	0.017
positive regulation of protein modification process	GO:0031401	58	0.016
intrinsic apoptotic signaling pathway	GO:0097193	16	0.016	Worm
reproductive structure development	GO:0048608	74	0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.016
rna splicing	GO:0008380	83	0.016
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.015
regulation of growth	GO:0040008	233	0.015
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.015	Human Yeast Worm
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.015	Human Yeast Worm
regulation of phosphatase activity	GO:0010921	3	0.015
intracellular mrna localization involved in pattern specification process	GO:0060810	56	0.015
cellular response to growth factor stimulus	GO:0071363	30	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.015	Human
mitotic recombination	GO:0006312	2	0.015	Yeast
dorsal ventral pattern formation	GO:0009953	133	0.015
nucleoside phosphate catabolic process	GO:1901292	110	0.015	Human Yeast Worm
genitalia development	GO:0048806	26	0.014
meiotic spindle organization	GO:0000212	36	0.014
immune system process	GO:0002376	347	0.014
nucleoside triphosphate catabolic process	GO:0009143	108	0.014	Human Yeast Worm
mrna splicing via spliceosome	GO:0000398	73	0.014
ubiquitin dependent protein catabolic process	GO:0006511	78	0.014
spindle assembly involved in meiosis	GO:0090306	20	0.014
forebrain development	GO:0030900	2	0.014
cell maturation	GO:0048469	144	0.014
ribonucleoside metabolic process	GO:0009119	127	0.013	Human Yeast Worm
atp metabolic process	GO:0046034	49	0.013	Human Yeast Worm
glandular epithelial cell differentiation	GO:0002067	1	0.013
protein maturation	GO:0051604	71	0.013
dorsal ventral axis specification ovarian follicular epithelium	GO:0008069	13	0.013
telomere organization	GO:0032200	21	0.013	Yeast
g2 dna damage checkpoint	GO:0031572	69	0.013
proteolysis	GO:0006508	192	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
negative regulation of phosphate metabolic process	GO:0045936	45	0.012
regulation of pole plasm oskar mrna localization	GO:0007317	27	0.012
mrna catabolic process	GO:0006402	33	0.012
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.012
organophosphate catabolic process	GO:0046434	112	0.012	Human Yeast Worm
regulation of double strand break repair	GO:2000779	3	0.012
appendage morphogenesis	GO:0035107	397	0.012
gonad development	GO:0008406	50	0.012
nuclear transcribed mrna catabolic process	GO:0000956	24	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.011
defense response to bacterium	GO:0042742	178	0.011
positive regulation of rna metabolic process	GO:0051254	271	0.011
cell cycle dna replication	GO:0044786	23	0.011
connective tissue development	GO:0061448	3	0.011
cell cycle phase transition	GO:0044770	140	0.011
positive regulation of cell proliferation	GO:0008284	47	0.011
sister chromatid cohesion	GO:0007062	18	0.011
jnk cascade	GO:0007254	50	0.011
dna replication initiation	GO:0006270	6	0.011
nuclear transcribed mrna catabolic process nonsense mediated decay	GO:0000184	8	0.011
ribonucleotide catabolic process	GO:0009261	109	0.011	Human Yeast Worm
hematopoietic or lymphoid organ development	GO:0048534	57	0.011
posttranscriptional gene silencing by rna	GO:0035194	45	0.011
glycerolipid catabolic process	GO:0046503	3	0.010
peptidyl amino acid modification	GO:0018193	105	0.010
positive regulation of developmental process	GO:0051094	143	0.010
membrane fusion	GO:0061025	42	0.010
positive regulation of transcription dna templated	GO:0045893	266	0.010
cellular response to radiation	GO:0071478	52	0.010	Human
defense response to gram negative bacterium	GO:0050829	94	0.010
regulation of protein modification process	GO:0031399	112	0.010
macromolecular complex assembly	GO:0065003	256	0.010	Human
modification dependent protein catabolic process	GO:0019941	78	0.010
negative regulation of dna metabolic process	GO:0051053	12	0.010
regulation of multi organism process	GO:0043900	131	0.010
spermatogenesis	GO:0007283	200	0.010

spn-A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of cellular proliferation	DOID:14566	0.077	Human
cancer	DOID:162	0.077	Human
organ system cancer	DOID:0050686	0.032	Human
thoracic cancer	DOID:5093	0.013	Human
disease of metabolism	DOID:0014667	0.011

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