IMP: Integrative Multi-species Prediction

Drosophila melanogaster

185 known processes

Apc (Dmel_CG1451)

APC-like

(Aliases: DAPC,APC1,D-APC,dAPC1,dApc,dAPC,d-APC,D-APC1,CG1451,APC,Apc1,apc,Dmel\CG1451,apc1)

Entrez: 44642
FLYBASE: FBgn0015589
UniProtKB: Q9VAS9

Process Predictions
Disease Predictions

Apc biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell migration	GO:0016477	238	0.911	Human Mouse Worm
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.773	Worm
localization of cell	GO:0051674	257	0.719
photoreceptor cell differentiation	GO:0046530	170	0.647
cell motility	GO:0048870	251	0.628	Human Mouse Worm
epithelial cell migration	GO:0010631	148	0.618
positive regulation of cellular biosynthetic process	GO:0031328	316	0.582	Worm
actin cytoskeleton organization	GO:0030036	206	0.518	Fly
regulation of cell migration	GO:0030334	22	0.474	Human Mouse Worm
ras protein signal transduction	GO:0007265	88	0.454
pigmentation	GO:0043473	75	0.448
glycosyl compound catabolic process	GO:1901658	112	0.438
chemotaxis	GO:0006935	249	0.427
carbohydrate derivative metabolic process	GO:1901135	217	0.424
stem cell differentiation	GO:0048863	117	0.413	Mouse
ameboidal type cell migration	GO:0001667	151	0.412
actomyosin structure organization	GO:0031032	56	0.411
purine nucleotide catabolic process	GO:0006195	109	0.403
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.391
digestive system development	GO:0055123	149	0.371	Worm
eye development	GO:0001654	323	0.366
epithelium migration	GO:0090132	148	0.365
regulation of cell development	GO:0060284	215	0.352
growth	GO:0040007	359	0.350
r7 cell fate commitment	GO:0007465	12	0.350
embryonic morphogenesis	GO:0048598	206	0.344
purine containing compound metabolic process	GO:0072521	155	0.330
meiotic cell cycle	GO:0051321	171	0.322
negative regulation of multicellular organismal process	GO:0051241	142	0.320
regulation of locomotion	GO:0040012	42	0.318	Human Mouse Worm
immune system process	GO:0002376	347	0.318	Mouse
ribonucleotide catabolic process	GO:0009261	109	0.302
single organism behavior	GO:0044708	391	0.295
organophosphate metabolic process	GO:0019637	195	0.289
male gamete generation	GO:0048232	201	0.286
regulation of jnk cascade	GO:0046328	40	0.279
purine nucleoside catabolic process	GO:0006152	112	0.278
axon guidance	GO:0007411	233	0.273
catabolic process	GO:0009056	409	0.272	Human Mouse Fly
positive regulation of cell motility	GO:2000147	3	0.270	Human Mouse
erbb signaling pathway	GO:0038127	58	0.265
purine nucleotide metabolic process	GO:0006163	146	0.264
positive regulation of rna metabolic process	GO:0051254	271	0.264	Worm
regulation of cell motility	GO:2000145	23	0.260	Human Mouse Worm
tube morphogenesis	GO:0035239	191	0.257	Worm
nucleoside catabolic process	GO:0009164	112	0.254
positive regulation of cell migration	GO:0030335	2	0.254	Human Mouse
regulation of cell morphogenesis	GO:0022604	163	0.253	Worm
regulation of cellular component biogenesis	GO:0044087	201	0.252
heterocycle catabolic process	GO:0046700	166	0.251
regulation of intracellular signal transduction	GO:1902531	236	0.251	Mouse
purine nucleoside metabolic process	GO:0042278	127	0.246
negative regulation of phosphorus metabolic process	GO:0010563	45	0.245	Human Mouse
regulation of cellular localization	GO:0060341	136	0.242	Human Mouse
organic substance catabolic process	GO:1901575	308	0.236	Human Mouse Fly
regulation of localization	GO:0032879	275	0.235	Human Mouse Worm
carbohydrate derivative catabolic process	GO:1901136	118	0.232
ovarian follicle cell development	GO:0030707	248	0.225
positive regulation of nucleoside metabolic process	GO:0045979	47	0.218
nucleotide catabolic process	GO:0009166	109	0.214
regulation of developmental growth	GO:0048638	174	0.212
cell proliferation	GO:0008283	299	0.211
small gtpase mediated signal transduction	GO:0007264	88	0.209
oocyte development	GO:0048599	124	0.206
microtubule based movement	GO:0007018	51	0.205
positive regulation of purine nucleotide metabolic process	GO:1900544	55	0.204
digestive tract morphogenesis	GO:0048546	127	0.203	Worm
positive regulation of cell communication	GO:0010647	250	0.199	Worm
response to wounding	GO:0009611	94	0.196
cellular response to chemical stimulus	GO:0070887	199	0.195	Rat
regulation of cell proliferation	GO:0042127	163	0.194	Human Mouse
organic hydroxy compound metabolic process	GO:1901615	83	0.185
ribose phosphate metabolic process	GO:0019693	145	0.180
organic cyclic compound catabolic process	GO:1901361	168	0.177
ovarian follicle cell migration	GO:0007297	121	0.177
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.173	Worm
regulation of ras protein signal transduction	GO:0046578	93	0.172
nucleotide metabolic process	GO:0009117	161	0.171
tissue migration	GO:0090130	155	0.171
nucleoside triphosphate catabolic process	GO:0009143	108	0.171
single organism cellular localization	GO:1902580	180	0.168	Human
developmental pigmentation	GO:0048066	68	0.167
small molecule metabolic process	GO:0044281	305	0.167	Rat
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.165
regulation of cellular component movement	GO:0051270	42	0.165	Human Mouse Worm
regulation of synaptic transmission	GO:0050804	69	0.165
regulation of cellular catabolic process	GO:0031329	157	0.164	Human
response to oxygen containing compound	GO:1901700	200	0.161	Rat
axonogenesis	GO:0007409	290	0.160
negative regulation of developmental process	GO:0051093	201	0.159
cellular catabolic process	GO:0044248	372	0.158	Human Mouse
purine ribonucleoside metabolic process	GO:0046128	127	0.154
regulation of notch signaling pathway	GO:0008593	100	0.154
eye photoreceptor cell differentiation	GO:0001754	145	0.153
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.146
ribonucleoside catabolic process	GO:0042454	112	0.144
nucleobase containing small molecule metabolic process	GO:0055086	174	0.143
regulation of mapk cascade	GO:0043408	92	0.142	Mouse
purine ribonucleotide catabolic process	GO:0009154	109	0.142
nucleobase containing compound catabolic process	GO:0034655	165	0.141
regulation of cell projection organization	GO:0031344	92	0.140	Human
cellular response to organic substance	GO:0071310	132	0.136	Rat
negative regulation of transcription dna templated	GO:0045892	237	0.136
organelle assembly	GO:0070925	198	0.135
nucleoside triphosphate metabolic process	GO:0009141	120	0.132
ribonucleoside metabolic process	GO:0009119	127	0.130
establishment of localization in cell	GO:0051649	402	0.130
regulation of cell shape	GO:0008360	113	0.130	Worm
negative regulation of cellular metabolic process	GO:0031324	382	0.128	Human Mouse
positive regulation of organelle organization	GO:0010638	65	0.127	Mouse
aging	GO:0007568	143	0.125
regulation of ras gtpase activity	GO:0032318	38	0.125
regulation of gtpase activity	GO:0043087	44	0.124
positive regulation of nucleotide metabolic process	GO:0045981	55	0.124
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.122
regulation of organelle organization	GO:0033043	196	0.122	Human Mouse
positive regulation of gene expression	GO:0010628	290	0.122	Worm
spermatogenesis	GO:0007283	200	0.121
cellular macromolecule localization	GO:0070727	220	0.120
programmed cell death	GO:0012501	257	0.119
regulation of actin cytoskeleton organization	GO:0032956	42	0.118
actin filament based process	GO:0030029	220	0.117	Fly
transcription from rna polymerase ii promoter	GO:0006366	368	0.117	Worm
nucleoside phosphate metabolic process	GO:0006753	162	0.117
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.115	Worm
positive regulation of catabolic process	GO:0009896	105	0.114	Human Mouse Fly
negative regulation of phosphorylation	GO:0042326	35	0.113	Human Mouse
organophosphate catabolic process	GO:0046434	112	0.112
rho protein signal transduction	GO:0007266	14	0.112
glycosyl compound metabolic process	GO:1901657	127	0.111
negative regulation of rna metabolic process	GO:0051253	251	0.111
response to endogenous stimulus	GO:0009719	119	0.108	Rat
oocyte differentiation	GO:0009994	145	0.108
single organism catabolic process	GO:0044712	228	0.108	Human Mouse
maintenance of location	GO:0051235	73	0.107	Human Mouse
regulation of phosphorus metabolic process	GO:0051174	210	0.107	Human Mouse
cellular lipid metabolic process	GO:0044255	83	0.106
nucleoside metabolic process	GO:0009116	127	0.105
r7 cell differentiation	GO:0045466	43	0.105
positive regulation of cellular component organization	GO:0051130	156	0.104
organelle fission	GO:0048285	340	0.104	Human Mouse
regulation of protein metabolic process	GO:0051246	256	0.103	Human Mouse Fly
regulation of transferase activity	GO:0051338	58	0.102	Human
purine ribonucleotide metabolic process	GO:0009150	145	0.102
protein localization	GO:0008104	284	0.102
positive regulation of transport	GO:0051050	92	0.101
morphogenesis of an epithelium	GO:0002009	276	0.101
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.100
regulation of neurogenesis	GO:0050767	158	0.100
regulation of purine nucleotide metabolic process	GO:1900542	62	0.099
response to organic substance	GO:0010033	284	0.099	Rat
synaptic growth at neuromuscular junction	GO:0051124	119	0.097
positive regulation of ras gtpase activity	GO:0032320	36	0.097
regulation of response to stress	GO:0080134	200	0.092
endocytosis	GO:0006897	310	0.091	Worm
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.091
negative regulation of response to stimulus	GO:0048585	258	0.090
purine containing compound catabolic process	GO:0072523	112	0.088
eye morphogenesis	GO:0048592	260	0.088
regulation of erbb signaling pathway	GO:1901184	42	0.087
positive regulation of nucleotide catabolic process	GO:0030813	46	0.087
regulation of growth	GO:0040008	233	0.086
regulation of epidermal growth factor receptor signaling pathway	GO:0042058	42	0.085
regulation of phosphorylation	GO:0042325	147	0.084	Human Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.083
macromolecule catabolic process	GO:0009057	161	0.082	Human Mouse Fly
nuclear division	GO:0000280	332	0.082	Human Mouse
gtp metabolic process	GO:0046039	72	0.080
cellular macromolecule catabolic process	GO:0044265	136	0.079	Human Mouse
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.078
compound eye development	GO:0048749	307	0.077
developmental maturation	GO:0021700	172	0.077
regulation of nucleotide metabolic process	GO:0006140	62	0.077
negative regulation of erbb signaling pathway	GO:1901185	29	0.077
negative regulation of rna biosynthetic process	GO:1902679	240	0.076
molting cycle	GO:0042303	56	0.076
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.075
aromatic compound catabolic process	GO:0019439	166	0.075
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.074
negative regulation of intracellular signal transduction	GO:1902532	57	0.073	Mouse
positive regulation of protein metabolic process	GO:0051247	128	0.073	Human Mouse Fly
endomembrane system organization	GO:0010256	119	0.073
purine ribonucleoside catabolic process	GO:0046130	112	0.073
developmental growth	GO:0048589	280	0.072
sensory organ morphogenesis	GO:0090596	260	0.071
regulation of nucleoside metabolic process	GO:0009118	50	0.071
border follicle cell migration	GO:0007298	113	0.070
response to abiotic stimulus	GO:0009628	341	0.070
nucleoside phosphate catabolic process	GO:1901292	110	0.070
organonitrogen compound catabolic process	GO:1901565	128	0.070
organonitrogen compound metabolic process	GO:1901564	318	0.069	Rat
regulation of anatomical structure size	GO:0090066	163	0.069
negative regulation of cell differentiation	GO:0045596	143	0.069
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.068
ribonucleotide metabolic process	GO:0009259	145	0.068
death	GO:0016265	284	0.068
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.067	Worm
meiotic nuclear division	GO:0007126	151	0.067
regulation of gtp catabolic process	GO:0033124	44	0.067
vesicle mediated transport	GO:0016192	381	0.067	Worm
regulation of multicellular organismal development	GO:2000026	414	0.067
positive regulation of cellular catabolic process	GO:0031331	95	0.066
guanosine containing compound catabolic process	GO:1901069	74	0.066
positive regulation of signaling	GO:0023056	243	0.066	Worm
protein catabolic process	GO:0030163	101	0.065	Human Mouse Fly
embryo development ending in birth or egg hatching	GO:0009792	152	0.065
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.064
dna metabolic process	GO:0006259	227	0.064
response to temperature stimulus	GO:0009266	106	0.063
jnk cascade	GO:0007254	50	0.063
positive regulation of hydrolase activity	GO:0051345	78	0.063
axon development	GO:0061564	297	0.062
regulation of cytoskeleton organization	GO:0051493	89	0.062	Human Mouse
digestive tract development	GO:0048565	149	0.060	Worm
tissue morphogenesis	GO:0048729	297	0.060
positive regulation of signal transduction	GO:0009967	223	0.059	Worm
positive regulation of gtp catabolic process	GO:0033126	43	0.059
negative regulation of signal transduction	GO:0009968	206	0.059
epithelial cell differentiation	GO:0030855	322	0.058	Mouse
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.057
cellular nitrogen compound catabolic process	GO:0044270	165	0.057
oocyte construction	GO:0007308	112	0.057
torc1 signaling	GO:0038202	12	0.056
compound eye photoreceptor cell differentiation	GO:0001751	140	0.056
negative regulation of kinase activity	GO:0033673	16	0.055	Human
positive regulation of macromolecule metabolic process	GO:0010604	405	0.054	Human Mouse Worm Fly
phagocytosis	GO:0006909	215	0.054	Worm
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.053
intracellular signal transduction	GO:0035556	300	0.053	Mouse
mapk cascade	GO:0000165	107	0.052	Mouse
negative regulation of cell cycle	GO:0045786	116	0.052	Human
regulation of cellular ketone metabolic process	GO:0010565	3	0.052	Rat
regulation of apoptotic process	GO:0042981	130	0.051	Human Mouse
apoptotic process	GO:0006915	159	0.050	Human Mouse
signal transduction by phosphorylation	GO:0023014	107	0.050	Mouse
guanosine containing compound metabolic process	GO:1901068	74	0.049
regulation of anatomical structure morphogenesis	GO:0022603	242	0.049
positive regulation of gtpase activity	GO:0043547	43	0.049
regulation of catalytic activity	GO:0050790	185	0.049	Human
positive regulation of transcription dna templated	GO:0045893	266	0.048	Worm
negative regulation of cellular biosynthetic process	GO:0031327	277	0.048
positive regulation of protein modification process	GO:0031401	58	0.048
organic substance transport	GO:0071702	257	0.047
regulation of cellular protein metabolic process	GO:0032268	243	0.047	Human
regulation of protein localization	GO:0032880	76	0.047	Human Mouse
positive regulation of molecular function	GO:0044093	136	0.047
positive regulation of biosynthetic process	GO:0009891	316	0.046	Worm
positive regulation of cell differentiation	GO:0045597	64	0.045	Mouse
gastrulation	GO:0007369	70	0.045	Worm
positive regulation of catalytic activity	GO:0043085	118	0.044
regulation of cellular component size	GO:0032535	98	0.043
regulation of cellular amine metabolic process	GO:0033238	3	0.043	Rat
negative regulation of mitotic cell cycle	GO:0045930	109	0.043	Human
regulation of protein phosphorylation	GO:0001932	64	0.043	Human
positive regulation of developmental process	GO:0051094	143	0.043	Mouse
dorsal ventral pattern formation	GO:0009953	133	0.041	Mouse
response to inorganic substance	GO:0010035	44	0.041
female meiotic division	GO:0007143	70	0.041
macromolecular complex assembly	GO:0065003	256	0.041
regulation of purine nucleotide catabolic process	GO:0033121	48	0.041
positive regulation of response to stimulus	GO:0048584	323	0.040	Worm
brain development	GO:0007420	120	0.040
open tracheal system development	GO:0007424	204	0.040
stress activated mapk cascade	GO:0051403	52	0.040
homeostatic process	GO:0042592	199	0.040	Mouse
gene silencing	GO:0016458	138	0.039
negative regulation of cell development	GO:0010721	62	0.039
regulation of protein modification process	GO:0031399	112	0.039	Human
cell growth	GO:0016049	108	0.039
actin filament polymerization	GO:0030041	27	0.038
erk1 and erk2 cascade	GO:0070371	39	0.038
regulation of cell differentiation	GO:0045595	302	0.038
regulation of catabolic process	GO:0009894	170	0.037	Human Mouse Fly
biological adhesion	GO:0022610	138	0.037
regulation of actin filament based process	GO:0032970	42	0.037
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.037
response to organonitrogen compound	GO:0010243	75	0.036
intracellular transport	GO:0046907	228	0.036
regulation of protein kinase activity	GO:0045859	51	0.036	Human
response to external biotic stimulus	GO:0043207	293	0.036
gtp catabolic process	GO:0006184	72	0.035
multicellular organismal aging	GO:0010259	140	0.035
meiotic cell cycle process	GO:1903046	132	0.035
oocyte axis specification	GO:0007309	108	0.035
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.034
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.034
positive regulation of protein kinase activity	GO:0045860	25	0.034
phosphorylation	GO:0016310	294	0.034	Human Mouse
neuromuscular junction development	GO:0007528	149	0.034
positive regulation of purine nucleotide catabolic process	GO:0033123	46	0.033
negative regulation of gene expression	GO:0010629	387	0.033	Human
regulation of photoreceptor cell differentiation	GO:0046532	34	0.033
germ line stem cell maintenance	GO:0030718	50	0.033
columnar cuboidal epithelial cell development	GO:0002066	249	0.033
negative regulation of protein phosphorylation	GO:0001933	17	0.032	Human
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.032
regulation of cellular amino acid metabolic process	GO:0006521	0	0.032	Rat
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.032
cell adhesion	GO:0007155	136	0.032
regulation of nervous system development	GO:0051960	248	0.031
single organism biosynthetic process	GO:0044711	206	0.031
negative regulation of signaling	GO:0023057	219	0.031
regulation of epithelial cell migration	GO:0010632	12	0.031
respiratory system development	GO:0060541	213	0.031
response to organic cyclic compound	GO:0014070	89	0.030
taxis	GO:0042330	304	0.030
protein phosphorylation	GO:0006468	169	0.030	Human
carbohydrate derivative biosynthetic process	GO:1901137	85	0.029
larval development	GO:0002164	104	0.029
positive regulation of cellular protein metabolic process	GO:0032270	118	0.029
secretion by cell	GO:0032940	101	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
body morphogenesis	GO:0010171	2	0.029	Worm
myofibril assembly	GO:0030239	36	0.028
determination of adult lifespan	GO:0008340	137	0.028
regulation of autophagy	GO:0010506	62	0.028
stress activated protein kinase signaling cascade	GO:0031098	55	0.028
cellular response to dna damage stimulus	GO:0006974	223	0.027	Human
cytoskeleton dependent intracellular transport	GO:0030705	44	0.027
regulation of stress activated mapk cascade	GO:0032872	41	0.027
protein complex assembly	GO:0006461	200	0.027
chemosensory behavior	GO:0007635	106	0.026
regulation of cell growth	GO:0001558	43	0.026
axon extension	GO:0048675	32	0.026
positive regulation of jun kinase activity	GO:0043507	4	0.026
negative regulation of nervous system development	GO:0051961	92	0.025
single organism intracellular transport	GO:1902582	207	0.025	Human Worm
positive regulation of phosphorylation	GO:0042327	87	0.025
negative regulation of biosynthetic process	GO:0009890	277	0.025
neuron fate commitment	GO:0048663	50	0.025
tube development	GO:0035295	244	0.025	Worm
neuroblast proliferation	GO:0007405	74	0.025
mitotic nuclear division	GO:0007067	213	0.025	Human Mouse
cell projection assembly	GO:0030031	94	0.025	Human
regulation of neuron differentiation	GO:0045664	103	0.024
positive regulation of transferase activity	GO:0051347	26	0.024
negative regulation of cell communication	GO:0010648	223	0.024
regulation of phosphate metabolic process	GO:0019220	210	0.024	Human Mouse
cell aging	GO:0007569	2	0.024
developmental cell growth	GO:0048588	52	0.024
negative regulation of cell proliferation	GO:0008285	69	0.024	Human Mouse
negative regulation of cell death	GO:0060548	81	0.024
cell cycle phase transition	GO:0044770	140	0.024	Human Mouse
negative regulation of epithelial cell proliferation	GO:0050680	4	0.023	Mouse
regulation of cell death	GO:0010941	173	0.023
endoplasmic reticulum organization	GO:0007029	13	0.023
post embryonic appendage morphogenesis	GO:0035120	385	0.023
response to other organism	GO:0051707	293	0.022
mitotic cell cycle checkpoint	GO:0007093	88	0.022	Human
neurological system process	GO:0050877	358	0.022
regionalization	GO:0003002	416	0.022
regulation of molecular function	GO:0065009	217	0.022	Human
regulation of nucleotide catabolic process	GO:0030811	48	0.022
cellular protein modification process	GO:0006464	438	0.022	Human
ribonucleotide biosynthetic process	GO:0009260	28	0.021
regulation of multicellular organism growth	GO:0040014	40	0.021
positive regulation of rna biosynthetic process	GO:1902680	266	0.021	Worm
regulation of transport	GO:0051049	181	0.021	Human
dephosphorylation	GO:0016311	51	0.021
negative regulation of mapk cascade	GO:0043409	23	0.021	Mouse
negative regulation of organelle organization	GO:0010639	56	0.021	Human Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.021	Worm
response to biotic stimulus	GO:0009607	294	0.020
regulation of kinase activity	GO:0043549	53	0.020	Human
regulation of membrane potential	GO:0042391	35	0.020
glycerolipid metabolic process	GO:0046486	34	0.020
rac protein signal transduction	GO:0016601	3	0.020
cellular response to oxygen containing compound	GO:1901701	79	0.020
regulation of oocyte development	GO:0060281	27	0.020
immune response	GO:0006955	246	0.020
dna integrity checkpoint	GO:0031570	81	0.019
sensory perception	GO:0007600	196	0.019
protein polymerization	GO:0051258	42	0.019	Mouse
endodermal cell differentiation	GO:0035987	3	0.019	Worm
nuclear migration	GO:0007097	20	0.019	Fly
positive regulation of intracellular signal transduction	GO:1902533	116	0.019
learning or memory	GO:0007611	141	0.019
regulation of erk1 and erk2 cascade	GO:0070372	39	0.019
neuron death	GO:0070997	27	0.019
epithelial cell development	GO:0002064	274	0.019
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.019
peptidyl amino acid modification	GO:0018193	105	0.019
immune system development	GO:0002520	57	0.019	Mouse
imaginal disc derived wing morphogenesis	GO:0007476	337	0.018
tripartite regional subdivision	GO:0007351	103	0.018
developmental growth involved in morphogenesis	GO:0060560	65	0.018
regulation of cell cycle process	GO:0010564	181	0.018	Human Mouse
regulation of cyclic nucleotide metabolic process	GO:0030799	13	0.018
cellular component assembly involved in morphogenesis	GO:0010927	151	0.018
chemical homeostasis	GO:0048878	92	0.017
central nervous system development	GO:0007417	201	0.017
regulation of immune system process	GO:0002682	176	0.017	Mouse
regulation of hydrolase activity	GO:0051336	97	0.017
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.017
positive regulation of growth	GO:0045927	75	0.017
response to bacterium	GO:0009617	198	0.017
ubiquitin dependent protein catabolic process	GO:0006511	78	0.017	Human Mouse
oocyte anterior posterior axis specification	GO:0007314	72	0.017
cell death	GO:0008219	279	0.017
cytoplasmic transport	GO:0016482	130	0.017	Human Worm
covalent chromatin modification	GO:0016569	106	0.017
hemopoiesis	GO:0030097	46	0.017	Mouse
fibroblast growth factor receptor signaling pathway	GO:0008543	10	0.017
gland development	GO:0048732	191	0.017	Mouse
establishment of organelle localization	GO:0051656	122	0.016	Fly
cellular protein catabolic process	GO:0044257	83	0.016	Human Mouse
cell fate determination	GO:0001709	91	0.016
modification dependent protein catabolic process	GO:0019941	78	0.016	Human Mouse
positive regulation of programmed cell death	GO:0043068	62	0.016	Human Mouse
negative regulation of neurogenesis	GO:0050768	53	0.016
neuron projection extension	GO:1990138	32	0.015
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.015
somatic stem cell division	GO:0048103	37	0.015
ion homeostasis	GO:0050801	55	0.015
cellular ketone metabolic process	GO:0042180	24	0.015	Rat
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.015
cellular macromolecular complex assembly	GO:0034622	153	0.015	Mouse
cellular response to fibroblast growth factor stimulus	GO:0044344	10	0.015
membrane organization	GO:0061024	112	0.015	Worm
imaginal disc derived appendage development	GO:0048737	399	0.015
axis specification	GO:0009798	167	0.014	Mouse
wound healing	GO:0042060	75	0.014
autophagy	GO:0006914	108	0.014
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.014
regulation of actin polymerization or depolymerization	GO:0008064	27	0.014
mitotic spindle organization	GO:0007052	220	0.014	Worm
negative regulation of cellular component organization	GO:0051129	108	0.014	Human Mouse
positive regulation of protein phosphorylation	GO:0001934	34	0.014
regulation of protein serine threonine kinase activity	GO:0071900	25	0.013	Human
regulation of establishment of protein localization	GO:0070201	61	0.013	Human
actin cytoskeleton reorganization	GO:0031532	22	0.013
regulation of protein polymerization	GO:0032271	28	0.013	Mouse
positive regulation of cell death	GO:0010942	69	0.013	Human Mouse
hindbrain development	GO:0030902	2	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.013	Human
regulation of hemocyte proliferation	GO:0035206	37	0.013
inositol lipid mediated signaling	GO:0048017	4	0.013
appendage development	GO:0048736	401	0.013
camera type eye development	GO:0043010	4	0.013	Mouse
anterior posterior axis specification	GO:0009948	109	0.013
lipid metabolic process	GO:0006629	121	0.013
positive regulation of mapk cascade	GO:0043410	63	0.013
positive regulation of locomotion	GO:0040017	8	0.012	Human Mouse
stem cell division	GO:0017145	69	0.012
cell cycle g1 s phase transition	GO:0044843	31	0.012
epithelial cell proliferation involved in renal tubule morphogenesis	GO:2001013	11	0.012
molting cycle chitin based cuticle	GO:0007591	56	0.012
nuclear transport	GO:0051169	72	0.012	Human Worm
sensory perception of chemical stimulus	GO:0007606	116	0.012
regulation of secretion by cell	GO:1903530	39	0.012
stem cell development	GO:0048864	79	0.012	Mouse
striated muscle cell development	GO:0055002	50	0.012
regulation of cell cycle	GO:0051726	291	0.011	Human Mouse
regulation of actin filament polymerization	GO:0030833	25	0.011
morphogenesis of follicular epithelium	GO:0016333	36	0.011
protein modification process	GO:0036211	438	0.011	Human
secretion	GO:0046903	109	0.011
negative regulation of cell cycle process	GO:0010948	109	0.011	Human
compound eye morphogenesis	GO:0001745	249	0.011
positive regulation of immune system process	GO:0002684	68	0.011
regulation of cellular response to insulin stimulus	GO:1900076	17	0.011
response to growth factor	GO:0070848	31	0.011	Rat
modification dependent macromolecule catabolic process	GO:0043632	79	0.011	Human Mouse
spindle organization	GO:0007051	253	0.011	Worm
negative regulation of growth	GO:0045926	84	0.011
regulation of immune response	GO:0050776	118	0.011
phospholipid metabolic process	GO:0006644	23	0.011
response to radiation	GO:0009314	155	0.011
peptidyl threonine phosphorylation	GO:0018107	2	0.010
establishment of nucleus localization	GO:0040023	26	0.010	Fly
cellular response to peptide	GO:1901653	28	0.010
phosphatidylinositol mediated signaling	GO:0048015	4	0.010
regulation of dna templated transcription elongation	GO:0032784	17	0.010
olfactory behavior	GO:0042048	97	0.010
neuron projection guidance	GO:0097485	241	0.010
actin polymerization or depolymerization	GO:0008154	31	0.010

Apc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.168
nervous system disease	DOID:863	0.046
central nervous system disease	DOID:331	0.046
neurodegenerative disease	DOID:1289	0.046
disease of cellular proliferation	DOID:14566	0.020	Human
cancer	DOID:162	0.017	Human
organ system cancer	DOID:0050686	0.017	Human

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