Drosophila melanogaster

131 known processes

lack (Dmel_CG4943)

lethal with a checkpoint kinase

(Aliases: CG4943,d-smurf,dSmurf,dSmurf1,Lack,D-smurf,DSmurf,Dsmurf,Smurf,Smurf ubiquitin ligase,Dmel\CG4943)

lack biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
positive regulation of cellular biosynthetic processGO:00313283160.192
Yeast
organelle fissionGO:00482853400.166
single organism biosynthetic processGO:00447112060.140
Yeast
response to abiotic stimulusGO:00096283410.123
Yeast
post embryonic appendage morphogenesisGO:00351203850.117
Fly
imaginal disc derived wing morphogenesisGO:00074763370.108
Fly
cell migrationGO:00164772380.102
localization of cellGO:00516742570.097
regulation of cell differentiationGO:00455953020.093
organic substance transportGO:00717022570.087
Human Yeast
chromosome organizationGO:00512763600.087
Yeast
wing disc morphogenesisGO:00074723440.082
Fly
positive regulation of macromolecule biosynthetic processGO:00105572830.076
Yeast
mitotic nuclear divisionGO:00070672130.075
nuclear divisionGO:00002803320.074
ovarian follicle cell developmentGO:00307072480.071
appendage morphogenesisGO:00351073970.071
Fly
cell motilityGO:00488702510.069
positive regulation of nucleobase containing compound metabolic processGO:00459353320.069
Yeast
cell deathGO:00082192790.066
organic acid metabolic processGO:00060821030.064
Yeast
response to organic substanceGO:00100332840.063
deathGO:00162652840.063
organelle localizationGO:00516401480.061
Yeast
regulation of organelle organizationGO:00330431960.058
Yeast
imaginal disc derived appendage morphogenesisGO:00351143950.058
Fly
organonitrogen compound biosynthetic processGO:19015661170.058
positive regulation of biosynthetic processGO:00098913160.056
Yeast
notch signaling pathwayGO:00072191200.055
Fly
regulation of mrna processingGO:0050684710.055
nucleocytoplasmic transportGO:0006913720.055
Human Yeast
carboxylic acid metabolic processGO:0019752920.054
Yeast
mitotic spindle organizationGO:00070522200.054
synapse organizationGO:00508081960.054
establishment of tissue polarityGO:0007164870.051
cellular macromolecule localizationGO:00707272200.051
Human
taxisGO:00423303040.050
epithelial cell migrationGO:00106311480.049
epithelium migrationGO:00901321480.047
immune system processGO:00023763470.045
protein modification by small protein conjugation or removalGO:00706471060.044
epithelial cell developmentGO:00020642740.044
appendage developmentGO:00487364010.044
Fly
organelle assemblyGO:00709251980.044
chromatin organizationGO:00063252070.043
Yeast
exocrine system developmentGO:00352721620.042
homeostatic processGO:00425921990.041
positive regulation of nitrogen compound metabolic processGO:00511733540.041
Yeast
nucleobase containing small molecule metabolic processGO:00550861740.040
regulation of notch signaling pathwayGO:00085931000.040
Fly
spermatid developmentGO:0007286980.039
cellular macromolecular complex assemblyGO:00346221530.039
negative regulation of signal transductionGO:00099682060.039
spermatid differentiationGO:00485151140.038
cellular response to chemical stimulusGO:00708871990.038
positive regulation of cell deathGO:0010942690.038
apoptotic processGO:00069151590.038
cellular protein modification processGO:00064644380.038
regulation of cellular component biogenesisGO:00440872010.038
Yeast
hematopoietic or lymphoid organ developmentGO:0048534570.038
spindle organizationGO:00070512530.037
organonitrogen compound metabolic processGO:19015643180.036
imaginal disc derived appendage developmentGO:00487373990.036
Fly
covalent chromatin modificationGO:00165691060.036
eye developmentGO:00016543230.035
rna processingGO:00063961470.034
Yeast
response to biotic stimulusGO:00096072940.033
establishment of protein localization to organelleGO:0072594620.033
tissue morphogenesisGO:00487292970.033
regulation of multicellular organismal developmentGO:20000264140.033
response to oxygen containing compoundGO:19017002000.033
cellular amino acid metabolic processGO:0006520610.033
programmed cell deathGO:00125012570.032
response to radiationGO:00093141550.032
Yeast
response to other organismGO:00517072930.032
organic substance catabolic processGO:19015753080.032
negative regulation of multicellular organismal processGO:00512411420.031
Mouse
vesicle mediated transportGO:00161923810.030
Yeast Fly
cell divisionGO:00513012480.030
single organism cellular localizationGO:19025801800.030
macromolecular complex assemblyGO:00650032560.030
lateral inhibitionGO:00463312060.030
regulation of cell developmentGO:00602842150.029
oxoacid metabolic processGO:00434361030.029
Yeast
growthGO:00400073590.028
imaginal disc fusionGO:0046528190.028
regulation of developmental growthGO:00486381740.028
negative regulation of developmental processGO:00510932010.028
cell proliferationGO:00082832990.028
rna splicing via transesterification reactionsGO:0000375730.028
establishment of localization in cellGO:00516494020.027
Human Yeast
regulation of cell proliferationGO:00421271630.027
regulation of meiosisGO:004002030.027
cellular nitrogen compound catabolic processGO:00442701650.027
ribonucleoprotein complex subunit organizationGO:0071826280.027
regulation of molecular functionGO:00650092170.027
aromatic compound catabolic processGO:00194391660.027
morphogenesis of an epitheliumGO:00020092760.027
columnar cuboidal epithelial cell differentiationGO:00020652560.027
columnar cuboidal epithelial cell developmentGO:00020662490.026
small molecule metabolic processGO:00442813050.026
Yeast
regulation of neurogenesisGO:00507671580.026
cytoplasmic transportGO:00164821300.025
Human Yeast
negative regulation of cell communicationGO:00106482230.025
nitrogen compound transportGO:0071705850.025
Yeast
compound eye developmentGO:00487493070.025
response to temperature stimulusGO:00092661060.025
intracellular protein transportGO:00068861040.024
Human
defense responseGO:00069523000.024
positive regulation of signalingGO:00230562430.024
cellular protein localizationGO:00346131600.024
Human
nucleoside phosphate metabolic processGO:00067531620.024
cellular amine metabolic processGO:0044106120.024
dna metabolic processGO:00062592270.023
centrosome organizationGO:00512971630.023
sex differentiationGO:0007548810.023
positive regulation of gene expressionGO:00106282900.023
Yeast
regulation of cell deathGO:00109411730.023
mrna metabolic processGO:00160711240.023
reproductive system developmentGO:0061458740.023
positive regulation of programmed cell deathGO:0043068620.023
gonad developmentGO:0008406500.023
positive regulation of rna metabolic processGO:00512542710.023
Yeast
negative regulation of growthGO:0045926840.022
eye morphogenesisGO:00485922600.022
protein targeting to nucleusGO:0044744510.022
body morphogenesisGO:001017120.022
establishment or maintenance of cell polarityGO:00071631670.022
protein targetingGO:0006605640.022
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.021
Yeast
salivary gland developmentGO:00074311620.021
ameboidal type cell migrationGO:00016671510.021
establishment of organelle localizationGO:00516561220.021
Yeast
positive regulation of transcription dna templatedGO:00458932660.020
Yeast
muscle structure developmentGO:00610612240.020
tissue migrationGO:00901301550.020
nucleobase containing compound catabolic processGO:00346551650.020
establishment of protein localizationGO:00451841630.020
Human Yeast
amine metabolic processGO:0009308120.020
cellularizationGO:0007349900.020
response to external biotic stimulusGO:00432072930.020
protein transportGO:00150311550.020
Human Yeast
regulation of transportGO:00510491810.020
Yeast
cellular response to oxygen containing compoundGO:1901701790.019
axon guidanceGO:00074112330.019
embryonic morphogenesisGO:00485982060.019
carbohydrate derivative metabolic processGO:19011352170.019
regulation of cell cycleGO:00517262910.019
meiotic cell cycleGO:00513211710.019
ovarian follicle cell migrationGO:00072971210.019
mrna splicing via spliceosomeGO:0000398730.019
cellular response to organic substanceGO:00713101320.019
regulation of vesicle mediated transportGO:0060627590.019
Yeast
stem cell differentiationGO:00488631170.019
spermatogenesisGO:00072832000.018
histone modificationGO:00165701060.018
negative regulation of response to stimulusGO:00485852580.018
response to extracellular stimulusGO:00099911160.018
positive regulation of signal transductionGO:00099672230.018
compound eye morphogenesisGO:00017452490.018
embryo development ending in birth or egg hatchingGO:00097921520.018
neuron projection guidanceGO:00974852410.018
transcription from rna polymerase ii promoterGO:00063663680.018
Human Yeast
actin filament based processGO:00300292200.018
Yeast
regulation of apoptotic processGO:00429811300.018
mrna processingGO:00063971040.017
immune effector processGO:0002252980.017
endocytosisGO:00068973100.017
Yeast Fly
ribonucleoprotein complex biogenesisGO:0022613310.017
Yeast
regulation of mrna metabolic processGO:1903311720.017
protein localization to nucleusGO:0034504550.017
cell cell signaling involved in cell fate commitmentGO:00451682100.017
positive regulation of catalytic activityGO:00430851180.017
phagocytosisGO:00069092150.016
nuclear importGO:0051170510.016
chromatin modificationGO:00165681470.016
regulation of cell morphogenesisGO:00226041630.016
Yeast
cellular response to biotic stimulusGO:007121640.016
purine containing compound metabolic processGO:00725211550.016
ribonucleotide metabolic processGO:00092591450.016
regulation of localizationGO:00328792750.016
Yeast Fly
developmental growthGO:00485892800.016
tube morphogenesisGO:00352391910.016
response to lipopolysaccharideGO:003249640.016
regulation of growthGO:00400082330.016
determination of adult lifespanGO:00083401370.015
positive regulation of rna biosynthetic processGO:19026802660.015
Yeast
regulation of nervous system developmentGO:00519602480.015
intracellular signal transductionGO:00355563000.015
morphogenesis of embryonic epitheliumGO:0016331940.015
immune system developmentGO:0002520570.015
positive regulation of proteolysisGO:0045862520.015
Yeast
single organism catabolic processGO:00447122280.015
regulation of cellular localizationGO:00603411360.015
Yeast
positive regulation of cell communicationGO:00106472500.014
protein import into nucleusGO:0006606510.014
response to nutrient levelsGO:00316671140.014
regulation of programmed cell deathGO:00430671520.014
positive regulation of macromolecule metabolic processGO:00106044050.014
Yeast
heterocycle catabolic processGO:00467001660.014
positive regulation of apoptotic processGO:0043065470.014
protein localizationGO:00081042840.014
Human Yeast Fly
multicellular organismal agingGO:00102591400.014
salivary gland morphogenesisGO:00074351450.014
axon developmentGO:00615642970.014
regulation of nuclear divisionGO:0051783580.014
pigment metabolic process involved in pigmentationGO:0043474330.014
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377730.014
protein modification by small protein conjugationGO:0032446790.014
agingGO:00075681430.014
regulation of intracellular signal transductionGO:19025312360.014
organonitrogen compound catabolic processGO:19015651280.013
connective tissue developmentGO:006144830.013
tetraterpenoid metabolic processGO:001610810.013
dendrite morphogenesisGO:00488131990.013
cellular ketone metabolic processGO:0042180240.013
Yeast
establishment of rna localizationGO:0051236470.013
Yeast
single organism intracellular transportGO:19025822070.013
Human Yeast
epithelial cell differentiationGO:00308553220.013
protein ubiquitinationGO:0016567700.013
blastoderm segmentationGO:00073501590.013
compound eye photoreceptor cell differentiationGO:00017511400.013
nucleobase containing compound transportGO:0015931560.013
Yeast
macromolecule catabolic processGO:00090571610.013
protein maturationGO:0051604710.013
regulation of anatomical structure sizeGO:00900661630.013
Yeast
developmental growth involved in morphogenesisGO:0060560650.012
purine containing compound catabolic processGO:00725231120.012
single organism behaviorGO:00447083910.012
mesenchymal cell differentiationGO:004876210.012
germline ring canal formationGO:0030725130.012
regionalizationGO:00030024160.012
Fly
phosphorylationGO:00163102940.012
positive regulation of peptidase activityGO:0010952290.012
developmental programmed cell deathGO:00106231380.012
positive regulation of nucleic acid templated transcriptionGO:19035082660.012
Yeast
regulation of cellular amine metabolic processGO:003323830.012
cellular response to uvGO:0034644120.012
Yeast
morphogenesis of a polarized epitheliumGO:0001738930.012
protein localization to organelleGO:0033365820.012
positive regulation of cellular component organizationGO:00511301560.012
Yeast
positive regulation of cysteine type endopeptidase activityGO:2001056240.011
ribonucleoprotein complex assemblyGO:0022618230.011
regulation of immune effector processGO:0002697520.011
positive regulation of cellular protein metabolic processGO:00322701180.011
Yeast
negative regulation of cell differentiationGO:00455961430.011
regulation of neuron differentiationGO:00456641030.011
purine nucleotide metabolic processGO:00061631460.011
nuclear transportGO:0051169720.011
Human Yeast
regulation of transcription from rna polymerase ii promoterGO:00063573780.011
regulation of cell cycle processGO:00105641810.011
neurological system processGO:00508773580.011
cellular response to molecule of bacterial originGO:007121930.011
cellular response to lipopolysaccharideGO:007122230.011
positive regulation of cellular amine metabolic processGO:003324000.011
positive regulation of hydrolase activityGO:0051345780.011
cellular protein complex assemblyGO:0043623710.011
histone ubiquitinationGO:001657440.011
regulation of intracellular transportGO:0032386640.010
Yeast
regulation of peptidase activityGO:0052547390.010
cellular modified amino acid metabolic processGO:0006575450.010
regulation of mitotic cell cycle phase transitionGO:19019901300.010
reproductive structure developmentGO:0048608740.010
tube developmentGO:00352952440.010
regulation of rna splicingGO:0043484690.010
chemotaxisGO:00069352490.010
skin developmentGO:0043588650.010
organophosphate metabolic processGO:00196371950.010
negative regulation of nitrogen compound metabolic processGO:00511722650.010
purine nucleoside metabolic processGO:00422781270.010
intracellular transportGO:00469072280.010
Human Yeast
peptidyl amino acid modificationGO:00181931050.010
negative regulation of notch signaling pathwayGO:0045746410.010
Fly
reproductive behaviorGO:00190981220.010
synapse assemblyGO:00074161430.010

lack disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.015
organ system cancerDOID:005068600.015
cancerDOID:16200.015