IMP: Integrative Multi-species Prediction

Drosophila melanogaster

84 known processes

Cby (Dmel_CG13415)

Chibby

(Aliases: Dmel\CG13415,CG13415)

Entrez: 42574
FLYBASE: FBgn0067317
UniProtKB: B9A0M5

Process Predictions
Disease Predictions

Cby biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
courtship behavior	GO:0007619	68	0.878
male mating behavior	GO:0060179	70	0.853
single organism behavior	GO:0044708	391	0.812
spermatogenesis	GO:0007283	200	0.708
sensory perception of mechanical stimulus	GO:0050954	72	0.667
male courtship behavior	GO:0008049	63	0.653
mating behavior	GO:0007617	106	0.609
sensory perception of sound	GO:0007605	56	0.574
sensory perception	GO:0007600	196	0.551
taxis	GO:0042330	304	0.535
gravitaxis	GO:0042332	26	0.534
multicellular organismal reproductive behavior	GO:0033057	110	0.529
cell motility	GO:0048870	251	0.524
response to auditory stimulus	GO:0010996	5	0.513
reproductive behavior	GO:0019098	122	0.493
multi organism behavior	GO:0051705	175	0.492
response to abiotic stimulus	GO:0009628	341	0.446
response to gravity	GO:0009629	26	0.368
rhythmic process	GO:0048511	106	0.358
multi multicellular organism process	GO:0044706	123	0.346
positive regulation of rna metabolic process	GO:0051254	271	0.343
imaginal disc derived appendage development	GO:0048737	399	0.332
renal system development	GO:0072001	72	0.312
mating	GO:0007618	120	0.312
actin filament based process	GO:0030029	220	0.292
spermatid differentiation	GO:0048515	114	0.291
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.286
eye development	GO:0001654	323	0.284
multi organism reproductive behavior	GO:0044705	121	0.278
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.269
urogenital system development	GO:0001655	72	0.268
positive regulation of transcription dna templated	GO:0045893	266	0.246
positive regulation of macromolecule metabolic process	GO:0010604	405	0.240
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.239
appendage development	GO:0048736	401	0.237
positive regulation of gene expression	GO:0010628	290	0.234
auditory behavior	GO:0031223	1	0.220
compound eye development	GO:0048749	307	0.216
epithelial tube morphogenesis	GO:0060562	88	0.187
digestive system development	GO:0055123	149	0.184
transcription from rna polymerase ii promoter	GO:0006366	368	0.180
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.180
response to mechanical stimulus	GO:0009612	28	0.176
tube development	GO:0035295	244	0.162
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.161
localization of cell	GO:0051674	257	0.156
brain development	GO:0007420	120	0.155
circadian rhythm	GO:0007623	105	0.150
positive regulation of cellular biosynthetic process	GO:0031328	316	0.149
central nervous system development	GO:0007417	201	0.145
embryonic morphogenesis	GO:0048598	206	0.145
muscle structure development	GO:0061061	224	0.144
tissue morphogenesis	GO:0048729	297	0.141
wing disc morphogenesis	GO:0007472	344	0.138
regionalization	GO:0003002	416	0.135
organelle assembly	GO:0070925	198	0.134
forebrain development	GO:0030900	2	0.130
appendage morphogenesis	GO:0035107	397	0.128
actomyosin structure organization	GO:0031032	56	0.126
malpighian tubule development	GO:0072002	64	0.125
imaginal disc derived wing morphogenesis	GO:0007476	337	0.125
compound eye morphogenesis	GO:0001745	249	0.122
epithelial cell differentiation	GO:0030855	322	0.121
malpighian tubule morphogenesis	GO:0007443	44	0.120
positive regulation of biosynthetic process	GO:0009891	316	0.117
neurological system process	GO:0050877	358	0.116
centrosome organization	GO:0051297	163	0.115
eye morphogenesis	GO:0048592	260	0.113
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.107
locomotor rhythm	GO:0045475	56	0.105
positive regulation of rna biosynthetic process	GO:1902680	266	0.103
male courtship behavior veined wing extension	GO:0048065	22	0.103
tube morphogenesis	GO:0035239	191	0.102
digestive tract development	GO:0048565	149	0.101
regulation of circadian rhythm	GO:0042752	49	0.095
digestive tract morphogenesis	GO:0048546	127	0.093
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.093
telencephalon development	GO:0021537	2	0.091
positive regulation of cell communication	GO:0010647	250	0.088
morphogenesis of an epithelium	GO:0002009	276	0.082
positive regulation of response to stimulus	GO:0048584	323	0.076
post embryonic appendage morphogenesis	GO:0035120	385	0.076
negative gravitaxis	GO:0048060	7	0.076
kidney development	GO:0001822	3	0.074
epithelial cell development	GO:0002064	274	0.074
single organism intracellular transport	GO:1902582	207	0.069
protein maturation	GO:0051604	71	0.068
dendrite development	GO:0016358	204	0.066
head development	GO:0060322	135	0.065
mechanosensory behavior	GO:0007638	12	0.065
cell junction organization	GO:0034330	57	0.065
embryonic organ development	GO:0048568	50	0.064
compound eye photoreceptor cell differentiation	GO:0001751	140	0.064
male gamete generation	GO:0048232	201	0.063
heart development	GO:0007507	82	0.063
organic substance transport	GO:0071702	257	0.063
regulation of multicellular organismal development	GO:2000026	414	0.062
chemotaxis	GO:0006935	249	0.062
vesicle mediated transport	GO:0016192	381	0.060
positive regulation of signaling	GO:0023056	243	0.058
camera type eye development	GO:0043010	4	0.057
negative regulation of cell communication	GO:0010648	223	0.056
rhythmic behavior	GO:0007622	76	0.055
erbb signaling pathway	GO:0038127	58	0.053
carboxylic acid metabolic process	GO:0019752	92	0.053
axon guidance	GO:0007411	233	0.052
negative regulation of signaling	GO:0023057	219	0.051
positive regulation of cell development	GO:0010720	61	0.050
regulation of cell differentiation	GO:0045595	302	0.050
dorsal ventral pattern formation	GO:0009953	133	0.048
response to oxygen containing compound	GO:1901700	200	0.048
striated muscle cell differentiation	GO:0051146	90	0.048
cellular component assembly involved in morphogenesis	GO:0010927	151	0.047
mitotic spindle organization	GO:0007052	220	0.047
chromosome organization	GO:0051276	360	0.047
positive regulation of signal transduction	GO:0009967	223	0.044
mapk cascade	GO:0000165	107	0.044
hindgut morphogenesis	GO:0007442	58	0.043
negative regulation of cellular metabolic process	GO:0031324	382	0.042	Human
cardiovascular system development	GO:0072358	82	0.041
convergent extension	GO:0060026	2	0.040
gastrulation with mouth forming first	GO:0001703	36	0.040
gland development	GO:0048732	191	0.040
sensory organ morphogenesis	GO:0090596	260	0.039
negative regulation of signal transduction	GO:0009968	206	0.039
locomotory behavior	GO:0007626	176	0.039
renal tubule development	GO:0061326	64	0.038
muscle cell differentiation	GO:0042692	103	0.038
regulation of cell cycle	GO:0051726	291	0.038
protein complex assembly	GO:0006461	200	0.038
eye photoreceptor cell differentiation	GO:0001754	145	0.038
cellular catabolic process	GO:0044248	372	0.037
cilium organization	GO:0044782	41	0.037
determination of bilateral symmetry	GO:0009855	13	0.036
positive regulation of epithelial cell differentiation	GO:0030858	1	0.036
regulation of neurogenesis	GO:0050767	158	0.036
actin cytoskeleton organization	GO:0030036	206	0.036
spermatid development	GO:0007286	98	0.036
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.035
negative regulation of gene expression	GO:0010629	387	0.034	Human
positive regulation of developmental process	GO:0051094	143	0.034
single organism biosynthetic process	GO:0044711	206	0.034
spindle assembly	GO:0051225	80	0.034
gastrulation	GO:0007369	70	0.034
cell death	GO:0008219	279	0.033
photoreceptor cell differentiation	GO:0046530	170	0.033
embryonic heart tube development	GO:0035050	22	0.032
regulation of epithelial cell differentiation	GO:0030856	4	0.032
protein localization	GO:0008104	284	0.032	Human
developmental programmed cell death	GO:0010623	138	0.032
regulation of anatomical structure morphogenesis	GO:0022603	242	0.032
learning or memory	GO:0007611	141	0.031
regulation of nervous system development	GO:0051960	248	0.030
body morphogenesis	GO:0010171	2	0.030
axon development	GO:0061564	297	0.029
circadian behavior	GO:0048512	76	0.029
proteolysis	GO:0006508	192	0.029
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.029	Human
axonogenesis	GO:0007409	290	0.029
mesoderm development	GO:0007498	78	0.029
regulation of programmed cell death	GO:0043067	152	0.029
cellular ketone metabolic process	GO:0042180	24	0.028
dendrite morphogenesis	GO:0048813	199	0.028
salivary gland morphogenesis	GO:0007435	145	0.028
circulatory system development	GO:0072359	82	0.028
microtubule based movement	GO:0007018	51	0.028
intracellular transport	GO:0046907	228	0.028
retina development in camera type eye	GO:0060041	4	0.028
cell migration	GO:0016477	238	0.028
skin development	GO:0043588	65	0.028
very long chain fatty acid metabolic process	GO:0000038	4	0.027
microtubule organizing center organization	GO:0031023	168	0.027
catabolic process	GO:0009056	409	0.026
mitotic cell cycle checkpoint	GO:0007093	88	0.026
male courtship behavior veined wing vibration	GO:0016545	21	0.026
startle response	GO:0001964	16	0.026
protein processing	GO:0016485	68	0.025
regulation of catabolic process	GO:0009894	170	0.025
organelle fission	GO:0048285	340	0.025
camera type eye morphogenesis	GO:0048593	2	0.024
response to organic substance	GO:0010033	284	0.024
organic acid metabolic process	GO:0006082	103	0.024
immune system process	GO:0002376	347	0.024
regulation of response to stress	GO:0080134	200	0.024
organic substance catabolic process	GO:1901575	308	0.024
regulation of endopeptidase activity	GO:0052548	36	0.024
regulation of protein metabolic process	GO:0051246	256	0.024
anterior posterior pattern specification	GO:0009952	136	0.023
neuron projection guidance	GO:0097485	241	0.023
embryonic hindgut morphogenesis	GO:0048619	48	0.023
developmental growth	GO:0048589	280	0.023
mitotic nuclear division	GO:0007067	213	0.022
epidermis development	GO:0008544	65	0.022
small molecule metabolic process	GO:0044281	305	0.022
regulation of mapk cascade	GO:0043408	92	0.021
cellular protein complex assembly	GO:0043623	71	0.021
homeostatic process	GO:0042592	199	0.021
amine metabolic process	GO:0009308	12	0.021
renal tubule morphogenesis	GO:0061333	44	0.021
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.021
memory	GO:0007613	94	0.021
regulation of localization	GO:0032879	275	0.021
adult locomotory behavior	GO:0008344	76	0.021
response to biotic stimulus	GO:0009607	294	0.020
cell fate specification	GO:0001708	71	0.020
regulation of cellular catabolic process	GO:0031329	157	0.020
regulation of autophagy	GO:0010506	62	0.020
phagocytosis	GO:0006909	215	0.020
regulation of intracellular signal transduction	GO:1902531	236	0.020
positive regulation of proteolysis	GO:0045862	52	0.020
phosphorylation	GO:0016310	294	0.020
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.019
death	GO:0016265	284	0.019
neural retina development	GO:0003407	4	0.019
oxoacid metabolic process	GO:0043436	103	0.019
positive regulation of nervous system development	GO:0051962	69	0.019
regulation of cell morphogenesis	GO:0022604	163	0.019
positive regulation of neurogenesis	GO:0050769	41	0.019
regulation of proteolysis	GO:0030162	87	0.019
nephron development	GO:0072006	3	0.019
apoptotic process	GO:0006915	159	0.019
salivary gland development	GO:0007431	162	0.019
protein modification process	GO:0036211	438	0.019
nitrogen compound transport	GO:0071705	85	0.019
regulation of apoptotic process	GO:0042981	130	0.019
endocytosis	GO:0006897	310	0.018
imaginal disc pattern formation	GO:0007447	91	0.018
organonitrogen compound metabolic process	GO:1901564	318	0.018
axis specification	GO:0009798	167	0.018
peripheral nervous system development	GO:0007422	52	0.018
cognition	GO:0050890	141	0.018
cell division	GO:0051301	248	0.018
protein localization to organelle	GO:0033365	82	0.018
wnt signaling pathway	GO:0016055	98	0.018
limb development	GO:0060173	1	0.017
programmed cell death	GO:0012501	257	0.017
regulation of embryonic development	GO:0045995	68	0.017
ribonucleoside metabolic process	GO:0009119	127	0.017
cellular macromolecule localization	GO:0070727	220	0.017
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
antimicrobial humoral response	GO:0019730	99	0.017
nonmotile primary cilium assembly	GO:0035058	8	0.017
biological adhesion	GO:0022610	138	0.017
gland morphogenesis	GO:0022612	145	0.017
regulation of cellular amino acid metabolic process	GO:0006521	0	0.017
negative regulation of cell cycle process	GO:0010948	109	0.017
centrosome duplication	GO:0051298	121	0.017
mitochondrial fusion	GO:0008053	7	0.017
developmental pigmentation	GO:0048066	68	0.016
regulation of cellular ketone metabolic process	GO:0010565	3	0.016
positive regulation of programmed cell death	GO:0043068	62	0.016
cellular response to organic substance	GO:0071310	132	0.016
positive regulation of multicellular organismal process	GO:0051240	143	0.016
regulation of r7 cell differentiation	GO:0045676	15	0.016
carbohydrate derivative metabolic process	GO:1901135	217	0.016
cell cell junction organization	GO:0045216	55	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.016	Human
regulation of neuron differentiation	GO:0045664	103	0.016
pigmentation	GO:0043473	75	0.016
macromolecular complex assembly	GO:0065003	256	0.016
cytokinesis	GO:0000910	90	0.016
cellular protein localization	GO:0034613	160	0.016
positive regulation of peptidase activity	GO:0010952	29	0.016
regulation of smoothened signaling pathway	GO:0008589	28	0.016
regulation of epithelial cell proliferation	GO:0050678	4	0.015
regulation of cellular protein metabolic process	GO:0032268	243	0.015
sperm mitochondrion organization	GO:0030382	7	0.015
gastrulation involving germ band extension	GO:0010004	36	0.015
spindle organization	GO:0007051	253	0.015
regulation of response to extracellular stimulus	GO:0032104	18	0.015
negative regulation of cell death	GO:0060548	81	0.015
centrosome cycle	GO:0007098	137	0.015
innate immune response	GO:0045087	144	0.015
chaeta morphogenesis	GO:0008407	42	0.015
response to lipopolysaccharide	GO:0032496	4	0.015
notch signaling pathway	GO:0007219	120	0.015
establishment of protein localization	GO:0045184	163	0.015
smoothened signaling pathway	GO:0007224	49	0.014
epithelial cell morphogenesis	GO:0003382	25	0.014
autophagy	GO:0006914	108	0.014
regulation of phosphorylation	GO:0042325	147	0.014
establishment of localization in cell	GO:0051649	402	0.014
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.014
limb morphogenesis	GO:0035108	1	0.014
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.014	Human
cellular amino acid metabolic process	GO:0006520	61	0.014
immune effector process	GO:0002252	98	0.014
maintenance of location	GO:0051235	73	0.014
negative regulation of apoptotic process	GO:0043066	63	0.014
hindgut development	GO:0061525	58	0.014
nephron tubule development	GO:0072080	3	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.014
regulation of hydrolase activity	GO:0051336	97	0.014
regulation of cellular response to stress	GO:0080135	89	0.014
protein polymerization	GO:0051258	42	0.014
macromolecule catabolic process	GO:0009057	161	0.013
negative regulation of cellular component organization	GO:0051129	108	0.013
chromosome separation	GO:0051304	42	0.013
organic hydroxy compound metabolic process	GO:1901615	83	0.013
negative regulation of intracellular signal transduction	GO:1902532	57	0.013
flight behavior	GO:0007629	26	0.013
imaginal disc derived leg morphogenesis	GO:0007480	80	0.013
histolysis	GO:0007559	102	0.013
embryonic development via the syncytial blastoderm	GO:0001700	148	0.013
positive regulation of cell differentiation	GO:0045597	64	0.013
leg disc development	GO:0035218	92	0.013
apical constriction	GO:0003383	18	0.013
eye photoreceptor cell fate commitment	GO:0042706	37	0.013
cell junction assembly	GO:0034329	42	0.013
stress activated mapk cascade	GO:0051403	52	0.013
neural precursor cell proliferation	GO:0061351	75	0.013
regulation of catalytic activity	GO:0050790	185	0.013
purine containing compound metabolic process	GO:0072521	155	0.013
protein complex biogenesis	GO:0070271	201	0.013
actin filament organization	GO:0007015	126	0.013
muscle cell development	GO:0055001	50	0.013
posttranscriptional regulation of gene expression	GO:0010608	145	0.013
cellular macromolecular complex assembly	GO:0034622	153	0.013
regulation of cellular amine metabolic process	GO:0033238	3	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
regulation of organ morphogenesis	GO:2000027	78	0.013
positive regulation of endopeptidase activity	GO:0010950	26	0.013
protein dna complex subunit organization	GO:0071824	86	0.012
muscle fiber development	GO:0048747	12	0.012
negative regulation of programmed cell death	GO:0043069	72	0.012
positive regulation of lipid metabolic process	GO:0045834	4	0.012
small molecule biosynthetic process	GO:0044283	37	0.012
heart morphogenesis	GO:0003007	32	0.012
nuclear division	GO:0000280	332	0.012
exocrine system development	GO:0035272	162	0.012
lipid metabolic process	GO:0006629	121	0.012
positive regulation of phosphorus metabolic process	GO:0010562	139	0.012
response to heat	GO:0009408	63	0.012
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.012
male courtship behavior veined wing generated song production	GO:0045433	20	0.012
growth	GO:0040007	359	0.012
regulation of phosphorus metabolic process	GO:0051174	210	0.012
response to other organism	GO:0051707	293	0.012
gliogenesis	GO:0042063	80	0.012
cell projection assembly	GO:0030031	94	0.012
regulation of cell development	GO:0060284	215	0.012
intracellular signal transduction	GO:0035556	300	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
negative regulation of mitotic cell cycle	GO:0045930	109	0.012
positive regulation of i kappab kinase nf kappab signaling	GO:0043123	1	0.012
positive regulation of hydrolase activity	GO:0051345	78	0.012
regulation of mitotic cell cycle	GO:0007346	190	0.012
signal transduction by phosphorylation	GO:0023014	107	0.012
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
ovarian follicle cell development	GO:0030707	248	0.011
modification dependent protein catabolic process	GO:0019941	78	0.011
immune response	GO:0006955	246	0.011
hair cell differentiation	GO:0035315	47	0.011
response to organophosphorus	GO:0046683	2	0.011
developmental maturation	GO:0021700	172	0.011
kidney morphogenesis	GO:0060993	3	0.011
meiotic cell cycle process	GO:1903046	132	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
regulation of notch signaling pathway	GO:0008593	100	0.011
modification dependent macromolecule catabolic process	GO:0043632	79	0.011
negative regulation of cellular response to oxidative stress	GO:1900408	1	0.011
regulation of cell cycle process	GO:0010564	181	0.011
negative regulation of response to oxidative stress	GO:1902883	1	0.011
regulation of cell cycle phase transition	GO:1901987	130	0.011
response to endogenous stimulus	GO:0009719	119	0.011
protein catabolic process	GO:0030163	101	0.011
ubiquitin dependent protein catabolic process	GO:0006511	78	0.011
autophagic cell death	GO:0048102	83	0.011
instar larval development	GO:0002168	55	0.011
cellularization	GO:0007349	90	0.011
compound eye photoreceptor fate commitment	GO:0001752	36	0.011
oxidation reduction process	GO:0055114	123	0.011
molting cycle chitin based cuticle	GO:0007591	56	0.011
respiratory system development	GO:0060541	213	0.011
spinal cord development	GO:0021510	1	0.011
negative regulation of biosynthetic process	GO:0009890	277	0.011	Human
negative regulation of cell cycle	GO:0045786	116	0.011
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.011
defense response to bacterium	GO:0042742	178	0.011
negative regulation of cell cycle phase transition	GO:1901988	103	0.011
humoral immune response	GO:0006959	117	0.011
muscle tissue development	GO:0060537	30	0.011
cell proliferation	GO:0008283	299	0.011
adult behavior	GO:0030534	137	0.011
regulation of phosphate metabolic process	GO:0019220	210	0.010
mitotic cell cycle phase transition	GO:0044772	138	0.010
adherens junction organization	GO:0034332	27	0.010
bolwig s organ morphogenesis	GO:0001746	8	0.010
muscle organ development	GO:0007517	127	0.010
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.010
purine ribonucleoside metabolic process	GO:0046128	127	0.010
purine nucleotide metabolic process	GO:0006163	146	0.010
salivary gland cell autophagic cell death	GO:0035071	83	0.010
nephron tubule morphogenesis	GO:0072078	3	0.010
regulation of protein localization	GO:0032880	76	0.010
cellular macromolecule catabolic process	GO:0044265	136	0.010
cell cell junction assembly	GO:0007043	38	0.010
ion transport	GO:0006811	145	0.010
nucleus organization	GO:0006997	45	0.010
regulation of developmental pigmentation	GO:0048070	24	0.010

Cby disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.014
nervous system disease	DOID:863	0.014
cardiovascular system disease	DOID:1287	0.011

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