IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Cdlc2 (Dmel_CG5450)

Cytoplasmic dynein light chain 2

(Aliases: dlc,Dmel\CG5450,CG5450,anon-WO0140519.117,Cdcl2)

FLYBASE: FBgn0026141
Entrez: 33319
UniProtKB: M9NDC7
UniProtKB: O96860

Process Predictions
Disease Predictions

Cdlc2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.306	Fly
appendage morphogenesis	GO:0035107	397	0.179	Fly
single organism biosynthetic process	GO:0044711	206	0.153
positive regulation of phosphate metabolic process	GO:0045937	139	0.148
post embryonic appendage morphogenesis	GO:0035120	385	0.145	Fly
wing disc morphogenesis	GO:0007472	344	0.138	Fly
positive regulation of rna biosynthetic process	GO:1902680	266	0.136
positive regulation of cellular biosynthetic process	GO:0031328	316	0.109
catabolic process	GO:0009056	409	0.108	Fly
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.106
imaginal disc derived appendage development	GO:0048737	399	0.092	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.089
innate immune response	GO:0045087	144	0.087
organophosphate metabolic process	GO:0019637	195	0.086
cellular lipid metabolic process	GO:0044255	83	0.084
apoptotic process	GO:0006915	159	0.079
defense response	GO:0006952	300	0.079
regulation of cell cycle	GO:0051726	291	0.075
lipid metabolic process	GO:0006629	121	0.075
death	GO:0016265	284	0.074	Fly
positive regulation of rna metabolic process	GO:0051254	271	0.074
organic hydroxy compound metabolic process	GO:1901615	83	0.073
regulation of molecular function	GO:0065009	217	0.072
organophosphate catabolic process	GO:0046434	112	0.070
response to wounding	GO:0009611	94	0.069
negative regulation of gene expression	GO:0010629	387	0.068
positive regulation of catalytic activity	GO:0043085	118	0.066
regulation of cellular protein metabolic process	GO:0032268	243	0.062
regulation of phosphorus metabolic process	GO:0051174	210	0.060
establishment or maintenance of cell polarity	GO:0007163	167	0.060	Fly
positive regulation of phosphorylation	GO:0042327	87	0.058
positive regulation of phosphorus metabolic process	GO:0010562	139	0.056
positive regulation of transcription dna templated	GO:0045893	266	0.056
melanin metabolic process	GO:0006582	47	0.056
intracellular signal transduction	GO:0035556	300	0.055
regulation of phosphate metabolic process	GO:0019220	210	0.054
positive regulation of cellular protein metabolic process	GO:0032270	118	0.054
small molecule metabolic process	GO:0044281	305	0.052
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.051
positive regulation of macromolecule metabolic process	GO:0010604	405	0.051
positive regulation of molecular function	GO:0044093	136	0.050
regulation of cell proliferation	GO:0042127	163	0.049
positive regulation of cell communication	GO:0010647	250	0.046
organelle assembly	GO:0070925	198	0.046
organic substance catabolic process	GO:1901575	308	0.046
mating	GO:0007618	120	0.044
melanotic encapsulation of foreign target	GO:0035011	30	0.044
programmed cell death	GO:0012501	257	0.044	Fly
lipid biosynthetic process	GO:0008610	46	0.044
response to mercury ion	GO:0046689	3	0.044
positive regulation of gene expression	GO:0010628	290	0.044
melanization defense response	GO:0035006	45	0.044
positive regulation of response to stimulus	GO:0048584	323	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.042
spermatogenesis	GO:0007283	200	0.040	Fly
positive regulation of signaling	GO:0023056	243	0.040
immune effector process	GO:0002252	98	0.040
cell death	GO:0008219	279	0.039	Fly
regulation of phosphorylation	GO:0042325	147	0.039
flight behavior	GO:0007629	26	0.038
body morphogenesis	GO:0010171	2	0.038
imaginal disc derived wing morphogenesis	GO:0007476	337	0.037	Fly
phosphorylation	GO:0016310	294	0.037
cellular protein localization	GO:0034613	160	0.037	Fly
positive regulation of signal transduction	GO:0009967	223	0.037
pigment metabolic process	GO:0042440	84	0.036
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.036
cellular response to chemical stimulus	GO:0070887	199	0.036
negative regulation of protein metabolic process	GO:0051248	85	0.035
negative regulation of biosynthetic process	GO:0009890	277	0.035
organophosphate biosynthetic process	GO:0090407	46	0.035
organic acid metabolic process	GO:0006082	103	0.034
positive regulation of protein kinase activity	GO:0045860	25	0.033
positive regulation of transferase activity	GO:0051347	26	0.033
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.033
cellular ion homeostasis	GO:0006873	39	0.032
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.032
positive regulation of intracellular signal transduction	GO:1902533	116	0.031
negative regulation of response to stimulus	GO:0048585	258	0.031
transcription from rna polymerase ii promoter	GO:0006366	368	0.031
carbohydrate metabolic process	GO:0005975	82	0.031
carbohydrate derivative metabolic process	GO:1901135	217	0.030
lateral inhibition	GO:0046331	206	0.030
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.029
homeostatic process	GO:0042592	199	0.029
encapsulation of foreign target	GO:0035010	38	0.029
small molecule catabolic process	GO:0044282	21	0.029
appendage development	GO:0048736	401	0.029	Fly
protein complex assembly	GO:0006461	200	0.029
response to lipopolysaccharide	GO:0032496	4	0.028
regulation of cellular ketone metabolic process	GO:0010565	3	0.028
multi organism behavior	GO:0051705	175	0.028
multi multicellular organism process	GO:0044706	123	0.028
sensory perception of mechanical stimulus	GO:0050954	72	0.027
spindle assembly	GO:0051225	80	0.027
cell proliferation	GO:0008283	299	0.027
single organism cellular localization	GO:1902580	180	0.027	Fly
positive regulation of biosynthetic process	GO:0009891	316	0.026
regulation of peptidase activity	GO:0052547	39	0.026
regulation of transferase activity	GO:0051338	58	0.026
regulation of protein metabolic process	GO:0051246	256	0.026
regulation of cell differentiation	GO:0045595	302	0.026
nucleotide metabolic process	GO:0009117	161	0.025
cilium morphogenesis	GO:0060271	39	0.025
protein processing	GO:0016485	68	0.024
chemical homeostasis	GO:0048878	92	0.024
cellular protein modification process	GO:0006464	438	0.023
ribonucleotide metabolic process	GO:0009259	145	0.023
neurological system process	GO:0050877	358	0.023
oxoacid metabolic process	GO:0043436	103	0.023
multicellular organismal reproductive behavior	GO:0033057	110	0.023
response to biotic stimulus	GO:0009607	294	0.023
phenol containing compound metabolic process	GO:0018958	57	0.023
single organism carbohydrate metabolic process	GO:0044723	72	0.022
cellular response to organic substance	GO:0071310	132	0.022
chromosome organization	GO:0051276	360	0.021
carbohydrate derivative biosynthetic process	GO:1901137	85	0.021
negative regulation of cellular biosynthetic process	GO:0031327	277	0.021
detection of stimulus	GO:0051606	156	0.021
axon development	GO:0061564	297	0.021
embryo development ending in birth or egg hatching	GO:0009792	152	0.021
response to nitrogen compound	GO:1901698	90	0.020
nucleoside phosphate metabolic process	GO:0006753	162	0.020
chromosome segregation	GO:0007059	157	0.020
cation homeostasis	GO:0055080	51	0.020
positive regulation of protein phosphorylation	GO:0001934	34	0.020
protein maturation	GO:0051604	71	0.020
stem cell differentiation	GO:0048863	117	0.020
carboxylic acid metabolic process	GO:0019752	92	0.020
purine nucleotide metabolic process	GO:0006163	146	0.020
cellular catabolic process	GO:0044248	372	0.020	Fly
forebrain development	GO:0030900	2	0.020
glycerolipid metabolic process	GO:0046486	34	0.020
response to abiotic stimulus	GO:0009628	341	0.020
nucleobase containing small molecule metabolic process	GO:0055086	174	0.019
negative regulation of rna metabolic process	GO:0051253	251	0.019
ribose phosphate metabolic process	GO:0019693	145	0.019
response to organic cyclic compound	GO:0014070	89	0.019
regulation of catalytic activity	GO:0050790	185	0.019
regulation of intracellular signal transduction	GO:1902531	236	0.019
male gamete generation	GO:0048232	201	0.019	Fly
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.019
organonitrogen compound catabolic process	GO:1901565	128	0.019
positive regulation of multi organism process	GO:0043902	40	0.019
regulation of protein phosphorylation	GO:0001932	64	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.019
response to inorganic substance	GO:0010035	44	0.018
chaeta development	GO:0022416	97	0.018	Fly
immune system process	GO:0002376	347	0.018
negative regulation of multicellular organismal process	GO:0051241	142	0.018
response to organic substance	GO:0010033	284	0.018
organic cyclic compound catabolic process	GO:1901361	168	0.018
glycerophospholipid metabolic process	GO:0006650	23	0.018
single organism catabolic process	GO:0044712	228	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
taxis	GO:0042330	304	0.017
response to organophosphorus	GO:0046683	2	0.017
wound healing	GO:0042060	75	0.017
neurotransmitter metabolic process	GO:0042133	2	0.017
regulation of cellular component biogenesis	GO:0044087	201	0.016
locomotory behavior	GO:0007626	176	0.016
spindle organization	GO:0007051	253	0.016
proteolysis	GO:0006508	192	0.016
negative regulation of cellular metabolic process	GO:0031324	382	0.016
protein modification process	GO:0036211	438	0.016
purine nucleotide catabolic process	GO:0006195	109	0.016
regulation of anatomical structure size	GO:0090066	163	0.016
macromolecule catabolic process	GO:0009057	161	0.016
protein localization	GO:0008104	284	0.016	Fly
regulation of kinase activity	GO:0043549	53	0.016
carbohydrate derivative catabolic process	GO:1901136	118	0.016
cellular carbohydrate metabolic process	GO:0044262	22	0.016
endocytosis	GO:0006897	310	0.015
chemotaxis	GO:0006935	249	0.015
glycosyl compound metabolic process	GO:1901657	127	0.015
monocarboxylic acid transport	GO:0015718	3	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
tissue death	GO:0016271	102	0.015	Fly
sensory perception	GO:0007600	196	0.015
alcohol metabolic process	GO:0006066	25	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
response to organonitrogen compound	GO:0010243	75	0.015
positive regulation of kinase activity	GO:0033674	25	0.015
polyol biosynthetic process	GO:0046173	3	0.014
male meiosis	GO:0007140	52	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
cell division	GO:0051301	248	0.014
lipid homeostasis	GO:0055088	33	0.014
cellular macromolecule localization	GO:0070727	220	0.014	Fly
positive regulation of protein binding	GO:0032092	1	0.014
phagocytosis	GO:0006909	215	0.014
vesicle mediated transport	GO:0016192	381	0.014
telencephalon development	GO:0021537	2	0.013
adult locomotory behavior	GO:0008344	76	0.013
circulatory system development	GO:0072359	82	0.013
nitrogen compound transport	GO:0071705	85	0.013
chromatin modification	GO:0016568	147	0.013
positive regulation of defense response	GO:0031349	59	0.013
cellular homeostasis	GO:0019725	80	0.013
mitotic sister chromatid segregation	GO:0000070	87	0.013
neuron projection guidance	GO:0097485	241	0.013
purine containing compound catabolic process	GO:0072523	112	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
regulation of cellular component size	GO:0032535	98	0.013
response to bacterium	GO:0009617	198	0.013
signal transduction by phosphorylation	GO:0023014	107	0.013
response to endogenous stimulus	GO:0009719	119	0.013
regulation of cell death	GO:0010941	173	0.013
axon guidance	GO:0007411	233	0.012
response to oxygen containing compound	GO:1901700	200	0.012
nucleotide catabolic process	GO:0009166	109	0.012
small molecule biosynthetic process	GO:0044283	37	0.012
immune response	GO:0006955	246	0.012
maintenance of location	GO:0051235	73	0.012	Fly
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
nucleosome organization	GO:0034728	59	0.012
salivary gland cell autophagic cell death	GO:0035071	83	0.012	Fly
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.012
rna localization	GO:0006403	115	0.012
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.012
rna processing	GO:0006396	147	0.012
male mating behavior	GO:0060179	70	0.012
regulation of cellular amine metabolic process	GO:0033238	3	0.012
aging	GO:0007568	143	0.012
response to glucose	GO:0009749	2	0.012
autophagic cell death	GO:0048102	83	0.012	Fly
toxin metabolic process	GO:0009404	2	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.012
developmental programmed cell death	GO:0010623	138	0.012	Fly
regulation of purine nucleotide metabolic process	GO:1900542	62	0.012
regulation of protein serine threonine kinase activity	GO:0071900	25	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
ethanolamine containing compound metabolic process	GO:0042439	4	0.012
nucleoside triphosphate catabolic process	GO:0009143	108	0.011
nucleoside phosphate catabolic process	GO:1901292	110	0.011
amine metabolic process	GO:0009308	12	0.011
kidney development	GO:0001822	3	0.011
regulation of nervous system development	GO:0051960	248	0.011
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.011
axonogenesis	GO:0007409	290	0.011
negative regulation of rna biosynthetic process	GO:1902679	240	0.011
nucleobase containing compound transport	GO:0015931	56	0.011
phospholipid metabolic process	GO:0006644	23	0.011
metal ion homeostasis	GO:0055065	44	0.011
spindle elongation	GO:0051231	83	0.011
nucleus organization	GO:0006997	45	0.011	Fly
peripheral nervous system development	GO:0007422	52	0.011
protein polymerization	GO:0051258	42	0.011
protein modification by small protein conjugation	GO:0032446	79	0.011
covalent chromatin modification	GO:0016569	106	0.011
alcohol catabolic process	GO:0046164	4	0.011
microtubule bundle formation	GO:0001578	27	0.011
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.011
aromatic compound catabolic process	GO:0019439	166	0.010
regulation of programmed cell death	GO:0043067	152	0.010
response to oxygen levels	GO:0070482	59	0.010
positive regulation of cell cycle	GO:0045787	43	0.010
regulation of response to external stimulus	GO:0032101	115	0.010
regulation of cellular catabolic process	GO:0031329	157	0.010
response to other organism	GO:0051707	293	0.010
regulation of immune response	GO:0050776	118	0.010
cholesterol homeostasis	GO:0042632	3	0.010
xenobiotic catabolic process	GO:0042178	1	0.010
organonitrogen compound biosynthetic process	GO:1901566	117	0.010
regulation of endopeptidase activity	GO:0052548	36	0.010
rna splicing	GO:0008380	83	0.010
immune response regulating signaling pathway	GO:0002764	2	0.010
regulation of cell substrate adhesion	GO:0010810	2	0.010
transmembrane transport	GO:0055085	139	0.010

Cdlc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.022
disease of metabolism	DOID:0014667	0.016
carbohydrate metabolism disease	DOID:0050013	0.016
acquired metabolic disease	DOID:0060158	0.016
diabetes mellitus	DOID:9351	0.016
glucose metabolism disease	DOID:4194	0.016
connective tissue disease	DOID:65	0.012
musculoskeletal system disease	DOID:17	0.012

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