IMP: Integrative Multi-species Prediction

Drosophila melanogaster

24 known processes

mats (Dmel_CG13852)

mob as tumor suppressor

(Aliases: dmob1,DMob1,Dmob1,anon-WO0118547.303,Dmel\CG13852,CG13852,Mats)

Entrez: 42634
FLYBASE: FBgn0038965
UniProtKB: Q95RA8

Process Predictions
Disease Predictions

mats biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
epithelial cell differentiation	GO:0030855	322	0.672
chromosome organization	GO:0051276	360	0.662
protein modification process	GO:0036211	438	0.543
regulation of anatomical structure morphogenesis	GO:0022603	242	0.487
protein ubiquitination	GO:0016567	70	0.389
regulation of cell development	GO:0060284	215	0.360
regulation of neurogenesis	GO:0050767	158	0.358
regulation of multicellular organismal development	GO:2000026	414	0.345
protein modification by small protein conjugation or removal	GO:0070647	106	0.344
central nervous system development	GO:0007417	201	0.308
head development	GO:0060322	135	0.303
regulation of cell differentiation	GO:0045595	302	0.296
vesicle mediated transport	GO:0016192	381	0.272
synapse organization	GO:0050808	196	0.260
cell proliferation	GO:0008283	299	0.252
cytokinesis	GO:0000910	90	0.251
reproductive behavior	GO:0019098	122	0.249
proteolysis	GO:0006508	192	0.248
growth	GO:0040007	359	0.245
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.239
protein modification by small protein conjugation	GO:0032446	79	0.238
multicellular organismal aging	GO:0010259	140	0.231
cellular protein modification process	GO:0006464	438	0.221
negative regulation of developmental process	GO:0051093	201	0.201
columnar cuboidal epithelial cell development	GO:0002066	249	0.201
macromolecule catabolic process	GO:0009057	161	0.183
mitotic cell cycle checkpoint	GO:0007093	88	0.173
nuclear division	GO:0000280	332	0.170
cellular protein complex assembly	GO:0043623	71	0.168
actin cytoskeleton organization	GO:0030036	206	0.161
histone modification	GO:0016570	106	0.160
larval development	GO:0002164	104	0.155
multi organism behavior	GO:0051705	175	0.150
stem cell differentiation	GO:0048863	117	0.147
negative regulation of response to stimulus	GO:0048585	258	0.145
body morphogenesis	GO:0010171	2	0.145
regulation of nervous system development	GO:0051960	248	0.140
regulation of protein metabolic process	GO:0051246	256	0.137
cellular catabolic process	GO:0044248	372	0.130
cell maturation	GO:0048469	144	0.119
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.117
catabolic process	GO:0009056	409	0.117
wing disc morphogenesis	GO:0007472	344	0.117
multicellular organismal reproductive behavior	GO:0033057	110	0.114
modification dependent protein catabolic process	GO:0019941	78	0.111
modification dependent macromolecule catabolic process	GO:0043632	79	0.109
negative regulation of cell differentiation	GO:0045596	143	0.108
ovarian follicle cell development	GO:0030707	248	0.105
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.105
eye development	GO:0001654	323	0.103
determination of adult lifespan	GO:0008340	137	0.102
multi organism reproductive behavior	GO:0044705	121	0.102
axon development	GO:0061564	297	0.101
organelle fission	GO:0048285	340	0.099
chemotaxis	GO:0006935	249	0.098
ovarian follicle cell migration	GO:0007297	121	0.097
rna catabolic process	GO:0006401	37	0.096
regulation of canonical wnt signaling pathway	GO:0060828	15	0.095
regulation of cellular protein metabolic process	GO:0032268	243	0.094
sensory organ morphogenesis	GO:0090596	260	0.094
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.090
chromatin modification	GO:0016568	147	0.090
peptidyl lysine modification	GO:0018205	57	0.090
negative regulation of cell communication	GO:0010648	223	0.088
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.083
organic substance catabolic process	GO:1901575	308	0.082
epithelial cell development	GO:0002064	274	0.081
germarium derived egg chamber formation	GO:0007293	101	0.080
dendrite development	GO:0016358	204	0.080
cilium morphogenesis	GO:0060271	39	0.078
response to abiotic stimulus	GO:0009628	341	0.078
imaginal disc derived wing morphogenesis	GO:0007476	337	0.078
neuron projection guidance	GO:0097485	241	0.078
protein catabolic process	GO:0030163	101	0.076
negative regulation of cellular metabolic process	GO:0031324	382	0.076
death	GO:0016265	284	0.074
cellular protein localization	GO:0034613	160	0.074
multi multicellular organism process	GO:0044706	123	0.073
axonogenesis	GO:0007409	290	0.072
regulation of growth	GO:0040008	233	0.071
axon guidance	GO:0007411	233	0.071
canonical wnt signaling pathway	GO:0060070	21	0.071
morphogenesis of an epithelium	GO:0002009	276	0.071
mrna catabolic process	GO:0006402	33	0.070
negative regulation of signal transduction	GO:0009968	206	0.070
appendage morphogenesis	GO:0035107	397	0.068
regulation of intracellular signal transduction	GO:1902531	236	0.068
endocytosis	GO:0006897	310	0.068
gene silencing by rna	GO:0031047	57	0.067
positive regulation of catabolic process	GO:0009896	105	0.067
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.067
aging	GO:0007568	143	0.066
brain development	GO:0007420	120	0.066
regulation of cell morphogenesis	GO:0022604	163	0.065
establishment or maintenance of cell polarity	GO:0007163	167	0.064
negative regulation of cellular biosynthetic process	GO:0031327	277	0.064
dendrite morphogenesis	GO:0048813	199	0.062
proteasomal protein catabolic process	GO:0010498	59	0.062
eye morphogenesis	GO:0048592	260	0.062
cellular protein catabolic process	GO:0044257	83	0.061
protein depolymerization	GO:0051261	31	0.061
developmental growth	GO:0048589	280	0.061
ubiquitin dependent protein catabolic process	GO:0006511	78	0.060
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.060
mitotic nuclear division	GO:0007067	213	0.059
embryo development ending in birth or egg hatching	GO:0009792	152	0.059
programmed cell death	GO:0012501	257	0.058
posttranscriptional gene silencing by rna	GO:0035194	45	0.058
eye photoreceptor cell differentiation	GO:0001754	145	0.056
establishment of localization in cell	GO:0051649	402	0.056
dendrite self avoidance	GO:0070593	8	0.054
endocytic recycling	GO:0032456	13	0.054
cellular macromolecular complex assembly	GO:0034622	153	0.053
response to organic substance	GO:0010033	284	0.053
autophagy	GO:0006914	108	0.053
segmentation	GO:0035282	207	0.053
chromosome segregation	GO:0007059	157	0.052
regulation of protein depolymerization	GO:1901879	27	0.052
response to oxygen containing compound	GO:1901700	200	0.052
regulation of cell death	GO:0010941	173	0.052
cellular macromolecule localization	GO:0070727	220	0.050
organelle assembly	GO:0070925	198	0.050
ameboidal type cell migration	GO:0001667	151	0.050
regulation of developmental growth	GO:0048638	174	0.050
oocyte construction	GO:0007308	112	0.048
covalent chromatin modification	GO:0016569	106	0.047
positive regulation of mrna catabolic process	GO:0061014	5	0.046
negative regulation of cell cycle	GO:0045786	116	0.046
cell cell adhesion	GO:0098609	26	0.046
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.046
protein complex biogenesis	GO:0070271	201	0.046
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.045
regulation of cell proliferation	GO:0042127	163	0.045
compound eye morphogenesis	GO:0001745	249	0.044
positive regulation of macromolecule metabolic process	GO:0010604	405	0.044
rna localization	GO:0006403	115	0.044
oocyte differentiation	GO:0009994	145	0.042
positive regulation of rna metabolic process	GO:0051254	271	0.042
compound eye photoreceptor cell differentiation	GO:0001751	140	0.042
cellular component assembly involved in morphogenesis	GO:0010927	151	0.041
regulation of localization	GO:0032879	275	0.041
compound eye development	GO:0048749	307	0.040
wnt signaling pathway	GO:0016055	98	0.040
lamellipodium assembly	GO:0030032	21	0.040
endomembrane system organization	GO:0010256	119	0.039
macromolecular complex assembly	GO:0065003	256	0.039
appendage development	GO:0048736	401	0.039
negative regulation of signaling	GO:0023057	219	0.039
taxis	GO:0042330	304	0.039
oviposition	GO:0018991	19	0.038
tissue morphogenesis	GO:0048729	297	0.038
response to radiation	GO:0009314	155	0.038
imaginal disc derived appendage development	GO:0048737	399	0.037
cellular protein complex disassembly	GO:0043624	35	0.036
spermatid development	GO:0007286	98	0.035
positive regulation of signal transduction	GO:0009967	223	0.035
ubiquitin homeostasis	GO:0010992	1	0.035
regulation of epithelial cell proliferation	GO:0050678	4	0.035
stem cell development	GO:0048864	79	0.035
membrane organization	GO:0061024	112	0.034
oocyte development	GO:0048599	124	0.034
regionalization	GO:0003002	416	0.034
wound healing	GO:0042060	75	0.034
regulation of cellular localization	GO:0060341	136	0.033
regulation of actin polymerization or depolymerization	GO:0008064	27	0.033
regulation of mitosis	GO:0007088	56	0.033
protein acylation	GO:0043543	42	0.033
intracellular signal transduction	GO:0035556	300	0.033
regulation of catalytic activity	GO:0050790	185	0.033
transcription from rna polymerase ii promoter	GO:0006366	368	0.032
peptidyl amino acid modification	GO:0018193	105	0.032
synaptic growth at neuromuscular junction	GO:0051124	119	0.032
sister chromatid segregation	GO:0000819	92	0.032
cellularization	GO:0007349	90	0.032
cell cycle checkpoint	GO:0000075	95	0.031
negative regulation of cell cycle phase transition	GO:1901988	103	0.031
positive regulation of protein catabolic process	GO:0045732	34	0.030
regulation of protein modification process	GO:0031399	112	0.030
negative regulation of gene expression	GO:0010629	387	0.030
regulation of catabolic process	GO:0009894	170	0.030
posttranscriptional regulation of gene expression	GO:0010608	145	0.030
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.029
protein modification by small protein removal	GO:0070646	28	0.029
negative regulation of mitotic cell cycle	GO:0045930	109	0.029
regulation of cell shape	GO:0008360	113	0.029
negative regulation of transcription dna templated	GO:0045892	237	0.028
instar larval development	GO:0002168	55	0.028
positive regulation of multicellular organismal process	GO:0051240	143	0.028
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.027
regulation of vesicle mediated transport	GO:0060627	59	0.027
pole plasm assembly	GO:0007315	61	0.027
negative regulation of multicellular organismal process	GO:0051241	142	0.027
cuticle development	GO:0042335	86	0.026
regulation of mitotic cell cycle	GO:0007346	190	0.026
regulation of protein catabolic process	GO:0042176	55	0.026
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	24	0.026
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.025
negative regulation of cell cycle process	GO:0010948	109	0.025
negative regulation of intracellular signal transduction	GO:1902532	57	0.025
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.025
phagocytosis	GO:0006909	215	0.025
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.025
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.025
protein localization	GO:0008104	284	0.025
regulation of synapse structure and activity	GO:0050803	128	0.024
protein acetylation	GO:0006473	39	0.024
cell projection assembly	GO:0030031	94	0.024
histone ubiquitination	GO:0016574	4	0.024
gliogenesis	GO:0042063	80	0.024
oocyte axis specification	GO:0007309	108	0.024
mushroom body development	GO:0016319	70	0.023
imaginal disc derived leg morphogenesis	GO:0007480	80	0.023
ribonucleoprotein complex biogenesis	GO:0022613	31	0.023
positive regulation of cellular component organization	GO:0051130	156	0.023
single organism membrane organization	GO:0044802	93	0.023
dorsal appendage formation	GO:0046843	47	0.023
neuromuscular junction development	GO:0007528	149	0.023
protein localization to plasma membrane	GO:0072659	13	0.023
response to other organism	GO:0051707	293	0.022
regulation of protein complex assembly	GO:0043254	42	0.022
regulation of cell cycle phase transition	GO:1901987	130	0.022
mitotic cell cycle phase transition	GO:0044772	138	0.022
gland development	GO:0048732	191	0.022
post embryonic appendage morphogenesis	GO:0035120	385	0.021
regulation of apoptotic process	GO:0042981	130	0.021
pole plasm oskar mrna localization	GO:0045451	46	0.021
cellular macromolecule catabolic process	GO:0044265	136	0.021
regulation of membrane potential	GO:0042391	35	0.021
tissue death	GO:0016271	102	0.021
regulation of actin filament length	GO:0030832	27	0.020
positive regulation of cellular component biogenesis	GO:0044089	80	0.020
regulation of response to stress	GO:0080134	200	0.020
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.020
border follicle cell migration	GO:0007298	113	0.020
dna integrity checkpoint	GO:0031570	81	0.020
pronuclear migration	GO:0035046	4	0.020
protein deubiquitination	GO:0016579	17	0.020
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.019
ras protein signal transduction	GO:0007265	88	0.019
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.019
morphogenesis of follicular epithelium	GO:0016333	36	0.019
positive regulation of response to stimulus	GO:0048584	323	0.019
epithelial cell migration	GO:0010631	148	0.019
mitotic dna damage checkpoint	GO:0044773	74	0.019
synapse assembly	GO:0007416	143	0.018
regulation of transport	GO:0051049	181	0.018
regulation of wnt signaling pathway	GO:0030111	68	0.018
positive regulation of cell proliferation	GO:0008284	47	0.018
neurological system process	GO:0050877	358	0.018
positive regulation of cellular catabolic process	GO:0031331	95	0.018
positive regulation of proteolysis	GO:0045862	52	0.017
regulation of molecular function	GO:0065009	217	0.017
sensory perception	GO:0007600	196	0.017
negative regulation of canonical wnt signaling pathway	GO:0090090	6	0.017
regulation of cellular catabolic process	GO:0031329	157	0.017
single organism intracellular transport	GO:1902582	207	0.017
positive regulation of protein metabolic process	GO:0051247	128	0.017
positive regulation of nervous system development	GO:0051962	69	0.017
developmental pigmentation	GO:0048066	68	0.017
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	19	0.017
establishment or maintenance of bipolar cell polarity	GO:0061245	34	0.017
positive regulation of developmental process	GO:0051094	143	0.017
positive regulation of rna biosynthetic process	GO:1902680	266	0.017
amine metabolic process	GO:0009308	12	0.016
regulation of cell cycle	GO:0051726	291	0.016
blastoderm segmentation	GO:0007350	159	0.016
chromatin organization	GO:0006325	207	0.016
regulation of actin cytoskeleton organization	GO:0032956	42	0.016
regulation of dendrite morphogenesis	GO:0048814	28	0.016
intracellular mrna localization involved in anterior posterior axis specification	GO:0060811	53	0.016
immune response	GO:0006955	246	0.016
negative regulation of protein metabolic process	GO:0051248	85	0.016
post golgi vesicle mediated transport	GO:0006892	11	0.015
g2 dna damage checkpoint	GO:0031572	69	0.015
synaptic transmission	GO:0007268	288	0.015
defense response	GO:0006952	300	0.015
response to wounding	GO:0009611	94	0.015
mating	GO:0007618	120	0.015
retina development in camera type eye	GO:0060041	4	0.015
mitotic sister chromatid segregation	GO:0000070	87	0.015
regulation of multi organism process	GO:0043900	131	0.015
positive regulation of transcription dna templated	GO:0045893	266	0.015
regulation of gene expression epigenetic	GO:0040029	128	0.015
maintenance of location	GO:0051235	73	0.015
camera type eye development	GO:0043010	4	0.014
chaeta development	GO:0022416	97	0.014
establishment of nucleus localization	GO:0040023	26	0.014
protein complex assembly	GO:0006461	200	0.014
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.014
phosphorylation	GO:0016310	294	0.014
meiotic nuclear division	GO:0007126	151	0.014
endosome to lysosome transport	GO:0008333	7	0.014
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.014
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.014
small gtpase mediated signal transduction	GO:0007264	88	0.014
regulation of mapk cascade	GO:0043408	92	0.013
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.013
positive regulation of gene expression	GO:0010628	290	0.013
meiotic cell cycle	GO:0051321	171	0.013
endosomal vesicle fusion	GO:0034058	4	0.013
regulation of endocytosis	GO:0030100	37	0.013
positive regulation of cellular protein metabolic process	GO:0032270	118	0.013
rrna processing	GO:0006364	3	0.013
muscle cell development	GO:0055001	50	0.013
mating behavior	GO:0007617	106	0.013
negative regulation of phosphorylation	GO:0042326	35	0.013
receptor mediated endocytosis	GO:0006898	21	0.013
negative regulation of cell death	GO:0060548	81	0.013
establishment of rna localization	GO:0051236	47	0.013
regulation of cytoskeleton organization	GO:0051493	89	0.013
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay	GO:1900153	4	0.013
regulation of mrna metabolic process	GO:1903311	72	0.013
translation	GO:0006412	69	0.013
regulation of cell projection organization	GO:0031344	92	0.013
positive regulation of intracellular protein transport	GO:0090316	30	0.012
endoplasmic reticulum organization	GO:0007029	13	0.012
proteasome assembly	GO:0043248	2	0.012
protein transport	GO:0015031	155	0.012
localization of cell	GO:0051674	257	0.012
neuron remodeling	GO:0016322	29	0.012
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.012
regulation of neuron differentiation	GO:0045664	103	0.012
nitrogen compound transport	GO:0071705	85	0.012
purine containing compound catabolic process	GO:0072523	112	0.012
striated muscle cell development	GO:0055002	50	0.012
rhabdomere development	GO:0042052	38	0.012
lipid localization	GO:0010876	54	0.012
regulation of protein modification by small protein conjugation or removal	GO:1903320	25	0.012
pole plasm rna localization	GO:0007316	52	0.012
dendrite guidance	GO:0070983	21	0.012
regulation of behavior	GO:0050795	75	0.012
plasma membrane organization	GO:0007009	26	0.012
eggshell chorion assembly	GO:0007306	66	0.012
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.012
homeostatic process	GO:0042592	199	0.012
notch receptor processing	GO:0007220	13	0.011
regulation of cell cycle process	GO:0010564	181	0.011
regulation of phosphorus metabolic process	GO:0051174	210	0.011
striated muscle cell differentiation	GO:0051146	90	0.011
regulation of programmed cell death	GO:0043067	152	0.011
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.011
anterior posterior pattern specification	GO:0009952	136	0.011
spindle organization	GO:0007051	253	0.011
germ line cyst encapsulation	GO:0048138	8	0.011
skin development	GO:0043588	65	0.011
reproductive structure development	GO:0048608	74	0.011
establishment of protein localization	GO:0045184	163	0.011
regulation of anatomical structure size	GO:0090066	163	0.011
cell migration	GO:0016477	238	0.011
cellular response to dna damage stimulus	GO:0006974	223	0.011
glycosyl compound catabolic process	GO:1901658	112	0.011
germ line cyst formation	GO:0048134	44	0.011
regulation of phosphorylation	GO:0042325	147	0.011
aromatic compound catabolic process	GO:0019439	166	0.011
meiosis i	GO:0007127	59	0.011
hindbrain development	GO:0030902	2	0.011
camera type eye morphogenesis	GO:0048593	2	0.011
regulation of protein complex disassembly	GO:0043244	29	0.011
regulation of synapse assembly	GO:0051963	94	0.011
cell death	GO:0008219	279	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011
pole plasm mrna localization	GO:0019094	49	0.010
cytoplasmic transport	GO:0016482	130	0.010
exocrine system development	GO:0035272	162	0.010
single organism cellular localization	GO:1902580	180	0.010
regulation of synapse organization	GO:0050807	110	0.010
response to lipid	GO:0033993	38	0.010
secondary metabolic process	GO:0019748	75	0.010
eggshell formation	GO:0030703	105	0.010
positive regulation of cellular protein catabolic process	GO:1903364	24	0.010
single organism biosynthetic process	GO:0044711	206	0.010
dna damage checkpoint	GO:0000077	78	0.010
organonitrogen compound biosynthetic process	GO:1901566	117	0.010
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.010
regulation of response to gamma radiation	GO:2001228	4	0.010

mats disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.010
	nervous system disease	DOID:863	0	0.010

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