IMP: Integrative Multi-species Prediction

Drosophila melanogaster

60 known processes

ppk (Dmel_CG3478)

pickpocket

(Aliases: CG3478,BG:DS06238.1,pkt,Dmel\CG3478,PPK,mdNaC1,dmdNaC1,dmdNaCl,PPK1,ppk1)

Entrez: 34843
FLYBASE: FBgn0020258
UniProtKB: Q7KT94

Process Predictions
Disease Predictions

ppk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
larval behavior	GO:0030537	42	0.951
single organism behavior	GO:0044708	391	0.786
circadian behavior	GO:0048512	76	0.697
regulation of behavior	GO:0050795	75	0.608
multi organism reproductive behavior	GO:0044705	121	0.598	Fly
aggressive behavior	GO:0002118	63	0.521	Fly
circadian rhythm	GO:0007623	105	0.501
mating	GO:0007618	120	0.481	Fly
rhythmic process	GO:0048511	106	0.475
response to temperature stimulus	GO:0009266	106	0.451
response to abiotic stimulus	GO:0009628	341	0.438
locomotory behavior	GO:0007626	176	0.401
sensory perception of mechanical stimulus	GO:0050954	72	0.369
detection of mechanical stimulus involved in sensory perception of pain	GO:0050966	2	0.359
feeding behavior	GO:0007631	50	0.349
response to radiation	GO:0009314	155	0.329
response to light stimulus	GO:0009416	124	0.311
larval locomotory behavior	GO:0008345	27	0.308
synaptic transmission	GO:0007268	288	0.296	Fly
mating behavior	GO:0007617	106	0.251	Fly
multi organism behavior	GO:0051705	175	0.237	Fly
multicellular organismal reproductive behavior	GO:0033057	110	0.219	Fly
negative regulation of response to stimulus	GO:0048585	258	0.197
inter male aggressive behavior	GO:0002121	60	0.167	Fly
response to organic substance	GO:0010033	284	0.166	Fly
cellular response to abiotic stimulus	GO:0071214	58	0.161	Fly
larval feeding behavior	GO:0030536	15	0.155
courtship behavior	GO:0007619	68	0.147	Fly
male courtship behavior	GO:0008049	63	0.139	Fly
rhythmic behavior	GO:0007622	76	0.133
cell migration	GO:0016477	238	0.131	Rat
cellular response to organonitrogen compound	GO:0071417	36	0.130
regulation of anatomical structure size	GO:0090066	163	0.114
glycerolipid catabolic process	GO:0046503	3	0.112
positive regulation of cell communication	GO:0010647	250	0.111
cellular response to insulin stimulus	GO:0032869	28	0.110
multi multicellular organism process	GO:0044706	123	0.108	Fly
cell motility	GO:0048870	251	0.101	Rat
localization of cell	GO:0051674	257	0.100	Rat
aging	GO:0007568	143	0.100
positive regulation of response to stimulus	GO:0048584	323	0.098
male mating behavior	GO:0060179	70	0.097	Fly
reproductive behavior	GO:0019098	122	0.095	Fly
negative regulation of developmental process	GO:0051093	201	0.093
sensory perception of salty taste	GO:0050914	3	0.090	Fly
response to insulin	GO:0032868	29	0.089
taxis	GO:0042330	304	0.089
determination of adult lifespan	GO:0008340	137	0.089
mechanosensory behavior	GO:0007638	12	0.087
detection of stimulus involved in sensory perception	GO:0050906	92	0.085
positive regulation of multicellular organismal process	GO:0051240	143	0.080
growth	GO:0040007	359	0.079
chemical homeostasis	GO:0048878	92	0.076	Human
developmental growth	GO:0048589	280	0.076
cellular response to organic substance	GO:0071310	132	0.075
embryonic morphogenesis	GO:0048598	206	0.074
intracellular signal transduction	GO:0035556	300	0.074
negative regulation of behavior	GO:0048521	8	0.070
cellular response to nitrogen compound	GO:1901699	51	0.070
response to mechanical stimulus	GO:0009612	28	0.069
response to oxygen containing compound	GO:1901700	200	0.069	Fly
multicellular organismal aging	GO:0010259	140	0.066
sensory perception of pain	GO:0019233	4	0.066
response to food	GO:0032094	3	0.062
locomotor rhythm	GO:0045475	56	0.061
positive regulation of signaling	GO:0023056	243	0.060
intraspecies interaction between organisms	GO:0051703	4	0.059
negative regulation of signaling	GO:0023057	219	0.058
regulation of growth	GO:0040008	233	0.056
homeostatic process	GO:0042592	199	0.055	Human
response to pain	GO:0048265	3	0.055
cellular response to peptide hormone stimulus	GO:0071375	28	0.054
positive regulation of growth	GO:0045927	75	0.053
single organism catabolic process	GO:0044712	228	0.053
organic substance catabolic process	GO:1901575	308	0.052
regulation of developmental growth	GO:0048638	174	0.052
response to wounding	GO:0009611	94	0.051	Rat
response to peptide hormone	GO:0043434	29	0.051
small molecule metabolic process	GO:0044281	305	0.051
cellular response to oxygen containing compound	GO:1901701	79	0.050	Fly
cellular response to endogenous stimulus	GO:0071495	80	0.049
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	17	0.048
social behavior	GO:0035176	4	0.048
regulation of synapse structure and activity	GO:0050803	128	0.048	Fly
response to nitrogen compound	GO:1901698	90	0.047
organonitrogen compound metabolic process	GO:1901564	318	0.046
detection of stimulus	GO:0051606	156	0.045
regulation of localization	GO:0032879	275	0.045	Rat
kidney development	GO:0001822	3	0.044
regulation of circadian rhythm	GO:0042752	49	0.044
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.044
wound healing	GO:0042060	75	0.043	Rat
regulation of cell development	GO:0060284	215	0.042
cellular response to peptide	GO:1901653	28	0.041
cilium morphogenesis	GO:0060271	39	0.041
cell proliferation	GO:0008283	299	0.041
neurological system process	GO:0050877	358	0.040
cellular protein modification process	GO:0006464	438	0.039
positive regulation of developmental growth	GO:0048639	62	0.039
telencephalon development	GO:0021537	2	0.039
regulation of cell morphogenesis	GO:0022604	163	0.038
g protein coupled receptor signaling pathway	GO:0007186	136	0.038
response to nutrient levels	GO:0031667	114	0.038
cation homeostasis	GO:0055080	51	0.038	Human
female mating behavior	GO:0060180	30	0.037
regulation of tube size	GO:0035150	46	0.037
regulation of dendrite development	GO:0050773	37	0.037
negative regulation of cellular component organization	GO:0051129	108	0.036
response to endogenous stimulus	GO:0009719	119	0.036
tissue morphogenesis	GO:0048729	297	0.036	Rat
digestive tract development	GO:0048565	149	0.036
organic acid metabolic process	GO:0006082	103	0.036
response to inorganic substance	GO:0010035	44	0.035	Fly
morphogenesis of an epithelium	GO:0002009	276	0.035	Rat
protein modification process	GO:0036211	438	0.035
detection of abiotic stimulus	GO:0009582	66	0.034
regulation of camp biosynthetic process	GO:0030817	12	0.034
protein phosphorylation	GO:0006468	169	0.034
epiboly	GO:0090504	2	0.033	Rat
response to acid chemical	GO:0001101	25	0.033	Fly
negative regulation of nervous system development	GO:0051961	92	0.033
negative regulation of developmental growth	GO:0048640	64	0.033
regionalization	GO:0003002	416	0.032
olfactory learning	GO:0008355	56	0.032
forebrain development	GO:0030900	2	0.032
spermatogenesis	GO:0007283	200	0.032
oxoacid metabolic process	GO:0043436	103	0.031
water homeostasis	GO:0030104	3	0.031	Human
epiboly involved in wound healing	GO:0090505	2	0.031	Rat
negative regulation of cell communication	GO:0010648	223	0.030
response to extracellular stimulus	GO:0009991	116	0.030
chemosensory behavior	GO:0007635	106	0.030
cognition	GO:0050890	141	0.029
regulation of multicellular organismal development	GO:2000026	414	0.029
regulation of synaptic transmission	GO:0050804	69	0.029	Fly
positive regulation of phosphate metabolic process	GO:0045937	139	0.029
olfactory behavior	GO:0042048	97	0.028
regulation of cell size	GO:0008361	63	0.028
regulation of nervous system development	GO:0051960	248	0.028
thermotaxis	GO:0043052	16	0.028
cuticle development	GO:0042335	86	0.028
convergent extension	GO:0060026	2	0.027
circulatory system process	GO:0003013	37	0.027
sensory perception	GO:0007600	196	0.027
anatomical structure homeostasis	GO:0060249	97	0.027
cellular response to chemical stimulus	GO:0070887	199	0.027	Fly
camera type eye development	GO:0043010	4	0.026
developmental maturation	GO:0021700	172	0.026
salt aversion	GO:0035199	3	0.025	Fly
actin filament based process	GO:0030029	220	0.025
epithelial cell differentiation	GO:0030855	322	0.025
columnar cuboidal epithelial cell development	GO:0002066	249	0.025
regulation of dendrite morphogenesis	GO:0048814	28	0.025
negative regulation of multicellular organismal process	GO:0051241	142	0.024
regulation of cellular protein metabolic process	GO:0032268	243	0.024
ovarian follicle cell development	GO:0030707	248	0.024
mitotic nuclear division	GO:0007067	213	0.024
sleep	GO:0030431	49	0.024
positive regulation of biosynthetic process	GO:0009891	316	0.023
positive regulation of cellular biosynthetic process	GO:0031328	316	0.023
spinal cord development	GO:0021510	1	0.023
regulation of locomotion	GO:0040012	42	0.023
stem cell differentiation	GO:0048863	117	0.023
cellular amino acid metabolic process	GO:0006520	61	0.023
sensory organ morphogenesis	GO:0090596	260	0.022
monovalent inorganic cation transport	GO:0015672	40	0.022
regulation of feeding behavior	GO:0060259	16	0.022
regulation of anatomical structure morphogenesis	GO:0022603	242	0.021
negative regulation of growth	GO:0045926	84	0.021
regulation of membrane potential	GO:0042391	35	0.021
cellular response to hormone stimulus	GO:0032870	44	0.021
appendage development	GO:0048736	401	0.021
positive regulation of developmental process	GO:0051094	143	0.021
post embryonic appendage morphogenesis	GO:0035120	385	0.020
negative regulation of signal transduction	GO:0009968	206	0.020
catabolic process	GO:0009056	409	0.020
cell projection assembly	GO:0030031	94	0.020
carboxylic acid metabolic process	GO:0019752	92	0.020
digestive tract morphogenesis	GO:0048546	127	0.020
phototaxis	GO:0042331	21	0.020
sodium ion transport	GO:0006814	22	0.019
regulation of system process	GO:0044057	36	0.019
respiratory system development	GO:0060541	213	0.019	Fly
central nervous system development	GO:0007417	201	0.019
gastrulation	GO:0007369	70	0.019
actin cytoskeleton organization	GO:0030036	206	0.019
epithelial cell development	GO:0002064	274	0.019
cell recognition	GO:0008037	102	0.019
cellular lipid catabolic process	GO:0044242	16	0.019
learning	GO:0007612	75	0.019
phosphorylation	GO:0016310	294	0.019
cellular amine metabolic process	GO:0044106	12	0.019
biological adhesion	GO:0022610	138	0.018
positive regulation of signal transduction	GO:0009967	223	0.018
eye development	GO:0001654	323	0.018
chaeta development	GO:0022416	97	0.018
negative regulation of cellular metabolic process	GO:0031324	382	0.018
regulation of phosphorylation	GO:0042325	147	0.018
regulation of protein metabolic process	GO:0051246	256	0.018
sensory perception of sound	GO:0007605	56	0.018
positive regulation of intracellular signal transduction	GO:1902533	116	0.017
detection of mechanical stimulus	GO:0050982	6	0.017
dendrite development	GO:0016358	204	0.017
nucleoside phosphate metabolic process	GO:0006753	162	0.017
epithelial tube morphogenesis	GO:0060562	88	0.017
regulation of protein modification process	GO:0031399	112	0.017
vesicle mediated transport	GO:0016192	381	0.017
regulation of programmed cell death	GO:0043067	152	0.017
appendage morphogenesis	GO:0035107	397	0.017
camera type eye morphogenesis	GO:0048593	2	0.017
photoreceptor cell axon guidance	GO:0072499	23	0.017
regulation of cell cycle	GO:0051726	291	0.017
regulation of cellular component size	GO:0032535	98	0.016
neuropeptide signaling pathway	GO:0007218	45	0.016
response to ethanol	GO:0045471	59	0.016
regulation of intracellular signal transduction	GO:1902531	236	0.016
response to oxygen levels	GO:0070482	59	0.016	Rat
regulation of blood circulation	GO:1903522	21	0.016
response to organophosphorus	GO:0046683	2	0.016
notch signaling pathway	GO:0007219	120	0.016
memory	GO:0007613	94	0.016
cyclic purine nucleotide metabolic process	GO:0052652	25	0.016
ion transmembrane transport	GO:0034220	122	0.016
response to alcohol	GO:0097305	95	0.015
ras protein signal transduction	GO:0007265	88	0.015
nuclear division	GO:0000280	332	0.015
metal ion transport	GO:0030001	74	0.015
urogenital system development	GO:0001655	72	0.015
negative regulation of phosphorylation	GO:0042326	35	0.015
digestive system development	GO:0055123	149	0.015
steroid catabolic process	GO:0006706	1	0.015
positive regulation of phosphorus metabolic process	GO:0010562	139	0.015
insulin receptor signaling pathway	GO:0008286	25	0.015
negative regulation of cellular protein metabolic process	GO:0032269	85	0.015
cellular response to carbohydrate stimulus	GO:0071322	4	0.015
behavioral response to pain	GO:0048266	3	0.014
antennal morphogenesis	GO:0048800	14	0.014
sensory perception of touch	GO:0050975	11	0.014	Fly
response to alkaloid	GO:0043279	26	0.014
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.014
apoptotic process	GO:0006915	159	0.014
compound eye photoreceptor cell differentiation	GO:0001751	140	0.014
dendrite morphogenesis	GO:0048813	199	0.014
nucleobase containing small molecule metabolic process	GO:0055086	174	0.014
adult locomotory behavior	GO:0008344	76	0.014
stem cell proliferation	GO:0072089	88	0.014
negative regulation of cell differentiation	GO:0045596	143	0.014
organelle fission	GO:0048285	340	0.014
purine ribonucleotide metabolic process	GO:0009150	145	0.014
purine containing compound metabolic process	GO:0072521	155	0.014
protein localization	GO:0008104	284	0.014
regulation of camp metabolic process	GO:0030814	12	0.013
imaginal disc derived appendage development	GO:0048737	399	0.013
protein processing	GO:0016485	68	0.013
organelle assembly	GO:0070925	198	0.013
tube morphogenesis	GO:0035239	191	0.013
associative learning	GO:0008306	65	0.013
chitin based cuticle development	GO:0040003	49	0.013
regulation of response to extracellular stimulus	GO:0032104	18	0.013
neuromuscular junction development	GO:0007528	149	0.013
cellular protein localization	GO:0034613	160	0.013
eggshell formation	GO:0030703	105	0.013
cellular ketone metabolic process	GO:0042180	24	0.013
response to organonitrogen compound	GO:0010243	75	0.013
regulation of notch signaling pathway	GO:0008593	100	0.013
response to heat	GO:0009408	63	0.013
programmed cell death	GO:0012501	257	0.013
organophosphate catabolic process	GO:0046434	112	0.013
actin filament based movement	GO:0030048	26	0.012
phagocytosis	GO:0006909	215	0.012
response to hypoxia	GO:0001666	53	0.012	Rat
purine nucleotide metabolic process	GO:0006163	146	0.012
single organism biosynthetic process	GO:0044711	206	0.012
cilium assembly	GO:0042384	38	0.012
photoreceptor cell differentiation	GO:0046530	170	0.012
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.012
response to decreased oxygen levels	GO:0036293	58	0.012	Rat
regulation of phosphorus metabolic process	GO:0051174	210	0.012
regulation of transport	GO:0051049	181	0.012	Rat
organic substance transport	GO:0071702	257	0.012
visual learning	GO:0008542	4	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
transmembrane transport	GO:0055085	139	0.012
response to other organism	GO:0051707	293	0.012
organic cyclic compound catabolic process	GO:1901361	168	0.012
lipid catabolic process	GO:0016042	21	0.012
regulation of cell differentiation	GO:0045595	302	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
compound eye morphogenesis	GO:0001745	249	0.012
hindbrain development	GO:0030902	2	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
blood circulation	GO:0008015	26	0.012
protein maturation	GO:0051604	71	0.012
regulation of cellular component movement	GO:0051270	42	0.012
regulation of neuron projection development	GO:0010975	69	0.012
mesenchymal cell development	GO:0014031	1	0.012
axon development	GO:0061564	297	0.012
regulation of cell substrate adhesion	GO:0010810	2	0.011
salivary gland morphogenesis	GO:0007435	145	0.011
lipid homeostasis	GO:0055088	33	0.011
regulation of protein phosphorylation	GO:0001932	64	0.011
positive regulation of behavior	GO:0048520	19	0.011
adult behavior	GO:0030534	137	0.011
macromolecular complex assembly	GO:0065003	256	0.011
metal ion homeostasis	GO:0055065	44	0.011	Human
purine nucleotide biosynthetic process	GO:0006164	29	0.011
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.011
regulation of response to nutrient levels	GO:0032107	18	0.011
tube development	GO:0035295	244	0.011
dendrite self avoidance	GO:0070593	8	0.011
carbohydrate metabolic process	GO:0005975	82	0.011
response to peptide	GO:1901652	29	0.011
response to salt stress	GO:0009651	11	0.011	Fly
renal system development	GO:0072001	72	0.011
nucleotide metabolic process	GO:0009117	161	0.011
endocytosis	GO:0006897	310	0.011
cell maturation	GO:0048469	144	0.011
regulation of cell shape	GO:0008360	113	0.011
chemotaxis	GO:0006935	249	0.011
chaeta morphogenesis	GO:0008407	42	0.010
retina development in camera type eye	GO:0060041	4	0.010
formation of anatomical boundary	GO:0048859	37	0.010
compound eye development	GO:0048749	307	0.010
negative regulation of protein metabolic process	GO:0051248	85	0.010
synapse organization	GO:0050808	196	0.010
regulation of apoptotic process	GO:0042981	130	0.010
mapk cascade	GO:0000165	107	0.010
circadian sleep wake cycle sleep	GO:0050802	23	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010
response to drug	GO:0042493	17	0.010
male courtship behavior veined wing generated song production	GO:0045433	20	0.010
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.010

ppk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability	Func Analog Org
renal tubular transport disease	DOID:447	0.358	Human
liddle syndrome	DOID:0050477	0.358	Human
kidney disease	DOID:557	0.358	Human
disease of anatomical entity	DOID:7	0.358	Human
urinary system disease	DOID:18	0.358	Human
respiratory system disease	DOID:1579	0.307	Human
lower respiratory tract disease	DOID:0050161	0.307	Human
bronchial disease	DOID:1176	0.275	Human
nervous system disease	DOID:863	0.038
central nervous system disease	DOID:331	0.019
bronchiectasis	DOID:9563	0.013	Human
sensory system disease	DOID:0050155	0.010

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