IMP: Integrative Multi-species Prediction

Drosophila melanogaster

44 known processes

salr (Dmel_CG4881)

spalt-related

(Aliases: 32F,sal,spalt,CG4881,Dmel\CG4881,Sal-r,Spalt,sal-r,salR,Cf3)

Entrez: 34568
FLYBASE: FBgn0000287
UniProtKB: Q9VKH3

Process Predictions
Disease Predictions

salr biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
appendage development	GO:0048736	401	0.392
morphogenesis of an epithelium	GO:0002009	276	0.273	Human Mouse
appendage morphogenesis	GO:0035107	397	0.264
positive regulation of rna metabolic process	GO:0051254	271	0.256	Human Mouse
dendrite development	GO:0016358	204	0.255
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.173	Human Mouse
negative regulation of cellular biosynthetic process	GO:0031327	277	0.161	Human Mouse
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.134	Human Mouse
compound eye development	GO:0048749	307	0.131
embryonic development via the syncytial blastoderm	GO:0001700	148	0.128
negative regulation of gene expression	GO:0010629	387	0.126	Human Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.122	Human Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.120	Human Mouse
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.117	Human Mouse
positive regulation of transcription dna templated	GO:0045893	266	0.113	Human Mouse
dendrite morphogenesis	GO:0048813	199	0.112
negative regulation of rna biosynthetic process	GO:1902679	240	0.106	Human Mouse
taxis	GO:0042330	304	0.103
gland development	GO:0048732	191	0.099	Human
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.099	Human Mouse
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.095	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.095	Human Mouse
regionalization	GO:0003002	416	0.094
muscle structure development	GO:0061061	224	0.093
wing disc morphogenesis	GO:0007472	344	0.091
forebrain development	GO:0030900	2	0.087	Human Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.087	Human Mouse
eye morphogenesis	GO:0048592	260	0.083
cell fate specification	GO:0001708	71	0.080
photoreceptor cell fate commitment	GO:0046552	41	0.080
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.079	Human Mouse
respiratory system development	GO:0060541	213	0.079
positive regulation of macromolecule metabolic process	GO:0010604	405	0.077	Human Mouse
phagocytosis	GO:0006909	215	0.077
tissue morphogenesis	GO:0048729	297	0.075	Human Mouse
multi organism behavior	GO:0051705	175	0.075
positive regulation of rna biosynthetic process	GO:1902680	266	0.069	Human Mouse
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.068
tube morphogenesis	GO:0035239	191	0.068	Mouse
negative regulation of cellular metabolic process	GO:0031324	382	0.067	Human Mouse
regulation of neurogenesis	GO:0050767	158	0.066	Mouse
negative regulation of cell differentiation	GO:0045596	143	0.065	Mouse
multi organism reproductive behavior	GO:0044705	121	0.064
vesicle mediated transport	GO:0016192	381	0.064
imaginal disc derived wing morphogenesis	GO:0007476	337	0.062
eye photoreceptor cell differentiation	GO:0001754	145	0.061
neuron recognition	GO:0008038	101	0.060
positive regulation of biosynthetic process	GO:0009891	316	0.060	Human Mouse
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.060	Human Mouse
brain development	GO:0007420	120	0.059	Human Mouse
negative regulation of transcription dna templated	GO:0045892	237	0.057	Human Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.057	Human Mouse
cell death	GO:0008219	279	0.057
response to alcohol	GO:0097305	95	0.056
compound eye photoreceptor cell differentiation	GO:0001751	140	0.056
compound eye morphogenesis	GO:0001745	249	0.056
neuron projection guidance	GO:0097485	241	0.054
axis specification	GO:0009798	167	0.053
imaginal disc derived wing vein specification	GO:0007474	48	0.053
response to organic substance	GO:0010033	284	0.053	Zebrafish
programmed cell death	GO:0012501	257	0.053
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.052	Human Mouse
camera type eye development	GO:0043010	4	0.051
neural precursor cell proliferation	GO:0061351	75	0.049	Mouse
positive regulation of gene expression	GO:0010628	290	0.048	Human Mouse
reproductive behavior	GO:0019098	122	0.048
endocytosis	GO:0006897	310	0.047
central nervous system development	GO:0007417	201	0.047	Human Mouse
sensory organ morphogenesis	GO:0090596	260	0.044	Human
response to oxygen containing compound	GO:1901700	200	0.044
catabolic process	GO:0009056	409	0.042
negative regulation of biosynthetic process	GO:0009890	277	0.042	Human Mouse
post embryonic appendage morphogenesis	GO:0035120	385	0.041
cellular catabolic process	GO:0044248	372	0.041
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.040	Human Mouse
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.040	Human Mouse
neurological system process	GO:0050877	358	0.039
regulation of cell cycle	GO:0051726	291	0.038
eye antennal disc development	GO:0035214	60	0.038
regulation of cellular amine metabolic process	GO:0033238	3	0.038
epithelial tube morphogenesis	GO:0060562	88	0.038	Mouse
establishment of ommatidial planar polarity	GO:0042067	49	0.037
regulation of cell death	GO:0010941	173	0.037
chaeta development	GO:0022416	97	0.037
regulation of nervous system development	GO:0051960	248	0.037	Mouse
regulation of organelle organization	GO:0033043	196	0.037
muscle cell differentiation	GO:0042692	103	0.036
aggressive behavior	GO:0002118	63	0.036
inter male aggressive behavior	GO:0002121	60	0.035
embryo development ending in birth or egg hatching	GO:0009792	152	0.035	Mouse
blastoderm segmentation	GO:0007350	159	0.035
stem cell maintenance	GO:0019827	67	0.035	Mouse
photoreceptor cell differentiation	GO:0046530	170	0.035
body morphogenesis	GO:0010171	2	0.035
axon development	GO:0061564	297	0.034
open tracheal system development	GO:0007424	204	0.034
amine metabolic process	GO:0009308	12	0.033
retina development in camera type eye	GO:0060041	4	0.033
head development	GO:0060322	135	0.033	Human Mouse
carboxylic acid metabolic process	GO:0019752	92	0.033
striated muscle cell differentiation	GO:0051146	90	0.033
stem cell differentiation	GO:0048863	117	0.033	Mouse
malpighian tubule development	GO:0072002	64	0.033
regulation of multicellular organismal development	GO:2000026	414	0.032	Mouse
muscle cell development	GO:0055001	50	0.032
eye development	GO:0001654	323	0.032
lateral inhibition	GO:0046331	206	0.031
cellular amine metabolic process	GO:0044106	12	0.031
multicellular organismal reproductive behavior	GO:0033057	110	0.031
compound eye photoreceptor fate commitment	GO:0001752	36	0.030
organic acid metabolic process	GO:0006082	103	0.030
regulation of cell development	GO:0060284	215	0.030	Mouse
leg disc development	GO:0035218	92	0.030
neural retina development	GO:0003407	4	0.030
negative regulation of developmental process	GO:0051093	201	0.029	Mouse
regulation of epidermal growth factor activated receptor activity	GO:0007176	4	0.029
regulation of cellular protein metabolic process	GO:0032268	243	0.029
organonitrogen compound metabolic process	GO:1901564	318	0.028
death	GO:0016265	284	0.028
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.028
salivary gland development	GO:0007431	162	0.028
intracellular transport	GO:0046907	228	0.028
regulation of cellular ketone metabolic process	GO:0010565	3	0.028
anterior posterior axis specification	GO:0009948	109	0.028
negative regulation of signaling	GO:0023057	219	0.027	Mouse
establishment of planar polarity	GO:0001736	87	0.027
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.027	Zebrafish
developmental maturation	GO:0021700	172	0.027
negative regulation of nervous system development	GO:0051961	92	0.027
chaeta morphogenesis	GO:0008407	42	0.026
regulation of cellular amino acid metabolic process	GO:0006521	0	0.026
apoptotic process	GO:0006915	159	0.026
positive regulation of cell development	GO:0010720	61	0.025	Mouse
mushroom body development	GO:0016319	70	0.025
establishment of localization in cell	GO:0051649	402	0.025
embryonic heart tube development	GO:0035050	22	0.025
imaginal disc derived appendage development	GO:0048737	399	0.025
oxoacid metabolic process	GO:0043436	103	0.025
positive regulation of signal transduction	GO:0009967	223	0.025	Human Zebrafish
transcription from rna polymerase ii promoter	GO:0006366	368	0.024	Human Mouse
male gamete generation	GO:0048232	201	0.024
camera type eye morphogenesis	GO:0048593	2	0.024
male courtship behavior veined wing generated song production	GO:0045433	20	0.024
sterol homeostasis	GO:0055092	4	0.023
retina morphogenesis in camera type eye	GO:0060042	2	0.023
cellular macromolecule localization	GO:0070727	220	0.023
segmentation	GO:0035282	207	0.023
axonogenesis	GO:0007409	290	0.022
chorion containing eggshell formation	GO:0007304	105	0.022
regulation of erbb signaling pathway	GO:1901184	42	0.022
antimicrobial peptide production	GO:0002775	46	0.022
regulation of histone deacetylation	GO:0031063	2	0.022
eggshell formation	GO:0030703	105	0.022
establishment of vesicle localization	GO:0051650	51	0.022
cellular response to chemical stimulus	GO:0070887	199	0.021	Zebrafish
morphogenesis of a branching epithelium	GO:0061138	45	0.021	Mouse
negative regulation of neurogenesis	GO:0050768	53	0.021
positive regulation of histone deacetylation	GO:0031065	2	0.021
small molecule metabolic process	GO:0044281	305	0.020
neuron fate commitment	GO:0048663	50	0.020
muscle organ development	GO:0007517	127	0.020
regulation of cell cycle process	GO:0010564	181	0.020
cell division	GO:0051301	248	0.020
male courtship behavior veined wing extension	GO:0048065	22	0.019
hindbrain development	GO:0030902	2	0.019
organonitrogen compound biosynthetic process	GO:1901566	117	0.019
cellular component assembly involved in morphogenesis	GO:0010927	151	0.019
spermatogenesis	GO:0007283	200	0.019
olfactory behavior	GO:0042048	97	0.019
regulation of neuron differentiation	GO:0045664	103	0.018	Mouse
eye photoreceptor cell fate commitment	GO:0042706	37	0.018
cell recognition	GO:0008037	102	0.018
epithelial cell development	GO:0002064	274	0.018	Human Mouse
response to organic cyclic compound	GO:0014070	89	0.018
dorsal appendage formation	GO:0046843	47	0.018
imaginal disc derived leg morphogenesis	GO:0007480	80	0.018
growth	GO:0040007	359	0.018	Mouse
negative regulation of response to stimulus	GO:0048585	258	0.018	Mouse
regulation of mitotic cell cycle	GO:0007346	190	0.018
positive regulation of protein deacetylation	GO:0090312	2	0.018
mitotic nuclear division	GO:0007067	213	0.018
protein localization	GO:0008104	284	0.017
cellular ketone metabolic process	GO:0042180	24	0.017
regulation of cell differentiation	GO:0045595	302	0.017	Mouse
negative regulation of growth	GO:0045926	84	0.017
positive regulation of response to stimulus	GO:0048584	323	0.017	Human Zebrafish
positive regulation of cell differentiation	GO:0045597	64	0.017	Mouse
establishment of synaptic vesicle localization	GO:0097480	50	0.017
axon guidance	GO:0007411	233	0.017
regulation of localization	GO:0032879	275	0.016
negative regulation of multicellular organismal process	GO:0051241	142	0.016	Mouse
intracellular signal transduction	GO:0035556	300	0.016
cellular response to organic substance	GO:0071310	132	0.016	Zebrafish
antennal development	GO:0007469	25	0.016
rna localization	GO:0006403	115	0.016
synapse organization	GO:0050808	196	0.016
positive regulation of cell communication	GO:0010647	250	0.016	Human Zebrafish
multi multicellular organism process	GO:0044706	123	0.016
morphogenesis of a polarized epithelium	GO:0001738	93	0.016
protein modification by small protein conjugation	GO:0032446	79	0.016
phospholipid homeostasis	GO:0055091	1	0.016
actin filament organization	GO:0007015	126	0.015
cilium organization	GO:0044782	41	0.015
mating behavior	GO:0007617	106	0.015
immune response	GO:0006955	246	0.015
single organism cellular localization	GO:1902580	180	0.015
telencephalon development	GO:0021537	2	0.015	Human Mouse
regulation of dendrite development	GO:0050773	37	0.015
sensory perception of sound	GO:0007605	56	0.015
compound eye photoreceptor development	GO:0042051	78	0.015
regulation of molecular function	GO:0065009	217	0.015
cellular protein modification process	GO:0006464	438	0.015	Mouse
branching morphogenesis of an epithelial tube	GO:0048754	45	0.015	Mouse
renal system development	GO:0072001	72	0.015	Human Mouse
sensory perception	GO:0007600	196	0.015
leg disc morphogenesis	GO:0007478	80	0.015
regulation of protein metabolic process	GO:0051246	256	0.014
eye photoreceptor cell development	GO:0042462	81	0.014
cellular protein localization	GO:0034613	160	0.014
positive regulation of catabolic process	GO:0009896	105	0.014
bmp signaling pathway	GO:0030509	27	0.014
single organism intracellular transport	GO:1902582	207	0.014
regulation of cell cycle phase transition	GO:1901987	130	0.014
notum cell fate specification	GO:0035310	5	0.014
exocrine system development	GO:0035272	162	0.014
negative regulation of cellular component organization	GO:0051129	108	0.014	Mouse
regulation of protein deacetylation	GO:0090311	2	0.014
nuclear import	GO:0051170	51	0.013
embryonic morphogenesis	GO:0048598	206	0.013	Human Zebrafish Mouse
establishment of organelle localization	GO:0051656	122	0.013
cell cycle phase transition	GO:0044770	140	0.013
ovarian follicle cell development	GO:0030707	248	0.013
cholesterol homeostasis	GO:0042632	3	0.013
mitotic spindle organization	GO:0007052	220	0.013
chemotaxis	GO:0006935	249	0.013
peripheral nervous system development	GO:0007422	52	0.013
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.013	Zebrafish
negative regulation of cell cycle	GO:0045786	116	0.013
notch signaling pathway	GO:0007219	120	0.013
organic substance catabolic process	GO:1901575	308	0.013
anterior posterior pattern specification	GO:0009952	136	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
positive regulation of developmental process	GO:0051094	143	0.013	Mouse
germ line stem cell maintenance	GO:0030718	50	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.013
regulation of antimicrobial peptide production	GO:0002784	44	0.013
intracellular protein transport	GO:0006886	104	0.013
erbb signaling pathway	GO:0038127	58	0.013
regulation of cellular catabolic process	GO:0031329	157	0.012
protein modification process	GO:0036211	438	0.012	Mouse
locomotory behavior	GO:0007626	176	0.012
single organism behavior	GO:0044708	391	0.012
endodermal cell fate commitment	GO:0001711	3	0.012
ommatidial rotation	GO:0016318	20	0.012
synaptic growth at neuromuscular junction	GO:0051124	119	0.012
extrinsic apoptotic signaling pathway	GO:0097191	1	0.012
immune system process	GO:0002376	347	0.012
single organism catabolic process	GO:0044712	228	0.012
negative regulation of signal transduction	GO:0009968	206	0.012	Mouse
organelle assembly	GO:0070925	198	0.012
branching involved in open tracheal system development	GO:0060446	45	0.012
phosphorylation	GO:0016310	294	0.012
nuclear division	GO:0000280	332	0.012
protein localization to organelle	GO:0033365	82	0.012
regulation of proteolysis	GO:0030162	87	0.012
regulation of catabolic process	GO:0009894	170	0.012
protein processing	GO:0016485	68	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
establishment of protein localization	GO:0045184	163	0.012
carbohydrate metabolic process	GO:0005975	82	0.012
negative regulation of cellular protein metabolic process	GO:0032269	85	0.012
kidney development	GO:0001822	3	0.012	Human Mouse
regulation of intracellular signal transduction	GO:1902531	236	0.012
positive regulation of cellular catabolic process	GO:0031331	95	0.012
single organism membrane organization	GO:0044802	93	0.012
humoral immune response	GO:0006959	117	0.012
regulation of mitosis	GO:0007088	56	0.012
cellular amino acid metabolic process	GO:0006520	61	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
organelle fission	GO:0048285	340	0.011
negative regulation of erbb signaling pathway	GO:1901185	29	0.011
endomembrane system organization	GO:0010256	119	0.011
chemosensory behavior	GO:0007635	106	0.011
negative regulation of organelle organization	GO:0010639	56	0.011
organ formation	GO:0048645	39	0.011
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.011
regulation of anatomical structure morphogenesis	GO:0022603	242	0.011	Mouse
cell fate determination	GO:0001709	91	0.011
gland morphogenesis	GO:0022612	145	0.011
synaptic target recognition	GO:0008039	45	0.011
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.011
embryonic axis specification	GO:0000578	107	0.011
heterocycle catabolic process	GO:0046700	166	0.011
tube development	GO:0035295	244	0.011	Human Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.011
response to biotic stimulus	GO:0009607	294	0.011
response to extracellular stimulus	GO:0009991	116	0.010
convergent extension	GO:0060026	2	0.010
anterior posterior axis specification embryo	GO:0008595	103	0.010
regulation of catalytic activity	GO:0050790	185	0.010
positive regulation of notch signaling pathway	GO:0045747	34	0.010
circulatory system development	GO:0072359	82	0.010	Human Mouse
carbohydrate derivative biosynthetic process	GO:1901137	85	0.010
glandular epithelial cell differentiation	GO:0002067	1	0.010
posttranscriptional regulation of gene expression	GO:0010608	145	0.010
nucleoside phosphate catabolic process	GO:1901292	110	0.010
regulation of sterol transport	GO:0032371	1	0.010
protein import	GO:0017038	55	0.010
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.010
adult behavior	GO:0030534	137	0.010
negative regulation of apoptotic process	GO:0043066	63	0.010
eggshell chorion assembly	GO:0007306	66	0.010
connective tissue development	GO:0061448	3	0.010
muscle tissue development	GO:0060537	30	0.010

salr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.061
disease of metabolism	DOID:0014667	0.024
carbohydrate metabolism disease	DOID:0050013	0.024
acquired metabolic disease	DOID:0060158	0.024
cardiovascular system disease	DOID:1287	0.022
diabetes mellitus	DOID:9351	0.022
glucose metabolism disease	DOID:4194	0.022
type 2 diabetes mellitus	DOID:9352	0.022
inherited metabolic disorder	DOID:655	0.020
nervous system disease	DOID:863	0.015

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