IMP: Integrative Multi-species Prediction

Drosophila melanogaster

2 known processes

Hexo1 (Dmel_CG1318)

Hexosaminidase 1

(Aliases: DmHex1,HEXO1,HEX 1,Dmel\CG1318,HEX1,CG1318)

Entrez: 38528
FLYBASE: FBgn0041630
UniProtKB: Q8IRB6
UniProtKB: Q0E8H9

Process Predictions
Disease Predictions

Hexo1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
defense response	GO:0006952	300	0.090
catabolic process	GO:0009056	409	0.088
oxoacid metabolic process	GO:0043436	103	0.085
carboxylic acid metabolic process	GO:0019752	92	0.076
small molecule metabolic process	GO:0044281	305	0.059
organic acid metabolic process	GO:0006082	103	0.055
aging	GO:0007568	143	0.055
cellular protein modification process	GO:0006464	438	0.055	Fly
response to external biotic stimulus	GO:0043207	293	0.054
protein modification process	GO:0036211	438	0.051	Fly
single organism biosynthetic process	GO:0044711	206	0.050
organonitrogen compound metabolic process	GO:1901564	318	0.049
response to other organism	GO:0051707	293	0.048
defense response to bacterium	GO:0042742	178	0.045
response to bacterium	GO:0009617	198	0.045
cellular catabolic process	GO:0044248	372	0.044
organic substance catabolic process	GO:1901575	308	0.044
homeostatic process	GO:0042592	199	0.044
defense response to other organism	GO:0098542	225	0.043
response to abiotic stimulus	GO:0009628	341	0.043
response to organic substance	GO:0010033	284	0.042
determination of adult lifespan	GO:0008340	137	0.041
vesicle mediated transport	GO:0016192	381	0.039
single organism catabolic process	GO:0044712	228	0.039
imaginal disc derived wing morphogenesis	GO:0007476	337	0.038
respiratory system development	GO:0060541	213	0.036
chemical homeostasis	GO:0048878	92	0.035
response to biotic stimulus	GO:0009607	294	0.034
open tracheal system development	GO:0007424	204	0.034
immune system process	GO:0002376	347	0.032
embryonic morphogenesis	GO:0048598	206	0.032
appendage development	GO:0048736	401	0.032
multicellular organismal aging	GO:0010259	140	0.031
wing disc morphogenesis	GO:0007472	344	0.030
endocytosis	GO:0006897	310	0.028
cellular response to chemical stimulus	GO:0070887	199	0.028
carbohydrate derivative metabolic process	GO:1901135	217	0.027	Fly
small molecule biosynthetic process	GO:0044283	37	0.027
organic hydroxy compound metabolic process	GO:1901615	83	0.026
carbohydrate metabolic process	GO:0005975	82	0.025	Fly
response to endogenous stimulus	GO:0009719	119	0.025
organic substance transport	GO:0071702	257	0.025
positive regulation of response to stimulus	GO:0048584	323	0.025
ethanolamine containing compound metabolic process	GO:0042439	4	0.024
developmental pigmentation	GO:0048066	68	0.024
response to nitrogen compound	GO:1901698	90	0.024
phagocytosis	GO:0006909	215	0.024
regulation of localization	GO:0032879	275	0.024
immune response	GO:0006955	246	0.024
regulation of protein metabolic process	GO:0051246	256	0.024
tube development	GO:0035295	244	0.023
multi organism behavior	GO:0051705	175	0.022
response to nutrient levels	GO:0031667	114	0.022
cellular amino acid metabolic process	GO:0006520	61	0.022
single organism carbohydrate metabolic process	GO:0044723	72	0.022	Fly
organonitrogen compound biosynthetic process	GO:1901566	117	0.022
response to oxygen containing compound	GO:1901700	200	0.022
eye pigmentation	GO:0048069	43	0.021
lipid metabolic process	GO:0006629	121	0.021
defense response to gram negative bacterium	GO:0050829	94	0.021
regulation of cellular protein metabolic process	GO:0032268	243	0.020
body morphogenesis	GO:0010171	2	0.020
gland development	GO:0048732	191	0.020
protein complex assembly	GO:0006461	200	0.020
endomembrane system organization	GO:0010256	119	0.020
neuron recognition	GO:0008038	101	0.020
cellular ketone metabolic process	GO:0042180	24	0.020
cellular response to organic substance	GO:0071310	132	0.020
macromolecular complex assembly	GO:0065003	256	0.019
phosphorylation	GO:0016310	294	0.019
response to copper ion	GO:0046688	4	0.019
cellular homeostasis	GO:0019725	80	0.019
hormone catabolic process	GO:0042447	3	0.019
cell proliferation	GO:0008283	299	0.019
chemotaxis	GO:0006935	249	0.019
regulation of intracellular signal transduction	GO:1902531	236	0.019
imaginal disc derived appendage development	GO:0048737	399	0.019
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.019
cell death	GO:0008219	279	0.019
neuron projection guidance	GO:0097485	241	0.019
positive regulation of macromolecule metabolic process	GO:0010604	405	0.018
response to monosaccharide	GO:0034284	4	0.018
regulation of cell cycle	GO:0051726	291	0.018
xenobiotic catabolic process	GO:0042178	1	0.018
cellular amine metabolic process	GO:0044106	12	0.018
lipid localization	GO:0010876	54	0.018
establishment of localization in cell	GO:0051649	402	0.017
response to organophosphorus	GO:0046683	2	0.017
organonitrogen compound catabolic process	GO:1901565	128	0.017
positive regulation of developmental process	GO:0051094	143	0.017
response to extracellular stimulus	GO:0009991	116	0.017
glycoprotein metabolic process	GO:0009100	41	0.017	Fly
anion homeostasis	GO:0055081	3	0.017
regulation of anatomical structure size	GO:0090066	163	0.016
tube morphogenesis	GO:0035239	191	0.016
lateral inhibition	GO:0046331	206	0.016
pigmentation	GO:0043473	75	0.016
developmental growth	GO:0048589	280	0.016
cellular chemical homeostasis	GO:0055082	40	0.016
taxis	GO:0042330	304	0.016
positive regulation of cell communication	GO:0010647	250	0.016
ion transport	GO:0006811	145	0.016
salivary gland morphogenesis	GO:0007435	145	0.016
neurological system process	GO:0050877	358	0.016
response to lipopolysaccharide	GO:0032496	4	0.016
positive regulation of signal transduction	GO:0009967	223	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.015
regionalization	GO:0003002	416	0.015
cell motility	GO:0048870	251	0.015
cellular iron ion homeostasis	GO:0006879	3	0.015
proteolysis	GO:0006508	192	0.015
central nervous system development	GO:0007417	201	0.015	Fly
organophosphate metabolic process	GO:0019637	195	0.015
positive regulation of signaling	GO:0023056	243	0.015
cellular transition metal ion homeostasis	GO:0046916	9	0.015
positive regulation of biosynthetic process	GO:0009891	316	0.015
alditol phosphate metabolic process	GO:0052646	2	0.014
death	GO:0016265	284	0.014
positive regulation of cellular biosynthetic process	GO:0031328	316	0.014
amine metabolic process	GO:0009308	12	0.014
cell adhesion	GO:0007155	136	0.014
regulation of phosphorus metabolic process	GO:0051174	210	0.014
detection of stimulus	GO:0051606	156	0.014
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.014
secondary metabolic process	GO:0019748	75	0.014
lipid storage	GO:0019915	38	0.014
maintenance of location	GO:0051235	73	0.013
regulation of transport	GO:0051049	181	0.013
appendage morphogenesis	GO:0035107	397	0.013
response to inorganic substance	GO:0010035	44	0.013
polyol biosynthetic process	GO:0046173	3	0.013
regulation of multicellular organismal development	GO:2000026	414	0.013
macromolecule catabolic process	GO:0009057	161	0.013
protein complex biogenesis	GO:0070271	201	0.013
regulation of phosphate metabolic process	GO:0019220	210	0.013
kidney development	GO:0001822	3	0.013
regulation of proteolysis	GO:0030162	87	0.013
hindbrain development	GO:0030902	2	0.013
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.013
estrogen metabolic process	GO:0008210	1	0.013
secretion by cell	GO:0032940	101	0.012
regulation of cellular component biogenesis	GO:0044087	201	0.012
response to organonitrogen compound	GO:0010243	75	0.012
aggressive behavior	GO:0002118	63	0.012
nuclear division	GO:0000280	332	0.012
response to light stimulus	GO:0009416	124	0.012
growth	GO:0040007	359	0.012	Fly
exocrine system development	GO:0035272	162	0.012
hormone metabolic process	GO:0042445	33	0.012
epithelial cell differentiation	GO:0030855	322	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
regulation of response to stress	GO:0080134	200	0.012
regulation of apoptotic process	GO:0042981	130	0.012
organelle fission	GO:0048285	340	0.012
camera type eye development	GO:0043010	4	0.012
regulation of tube size	GO:0035150	46	0.012
cell migration	GO:0016477	238	0.012
secretion	GO:0046903	109	0.012
embryonic development via the syncytial blastoderm	GO:0001700	148	0.011
programmed cell death	GO:0012501	257	0.011
response to decreased oxygen levels	GO:0036293	58	0.011
response to starvation	GO:0042594	97	0.011
intracellular signal transduction	GO:0035556	300	0.011
regulation of developmental growth	GO:0048638	174	0.011
positive regulation of cell motility	GO:2000147	3	0.011
salivary gland development	GO:0007431	162	0.011
morphogenesis of an epithelium	GO:0002009	276	0.011
positive regulation of transport	GO:0051050	92	0.011
response to glucose	GO:0009749	2	0.011
cellular response to endogenous stimulus	GO:0071495	80	0.011
positive regulation of cell migration	GO:0030335	2	0.011
response to hexose	GO:0009746	3	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011
post embryonic appendage morphogenesis	GO:0035120	385	0.011
response to radiation	GO:0009314	155	0.011
cellular metal ion homeostasis	GO:0006875	31	0.011
digestive tract morphogenesis	GO:0048546	127	0.011
cellular nitrogen compound catabolic process	GO:0044270	165	0.011
regulation of organelle organization	GO:0033043	196	0.010
fat soluble vitamin metabolic process	GO:0006775	1	0.010
response to oxygen levels	GO:0070482	59	0.010
ubiquitin dependent protein catabolic process	GO:0006511	78	0.010
regulation of lipid transport	GO:0032368	3	0.010
cellular lipid metabolic process	GO:0044255	83	0.010
axon development	GO:0061564	297	0.010
thioester metabolic process	GO:0035383	3	0.010
purine containing compound metabolic process	GO:0072521	155	0.010
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.010
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.010
single organism behavior	GO:0044708	391	0.010
axonogenesis	GO:0007409	290	0.010
positive regulation of molecular function	GO:0044093	136	0.010
regulation of catalytic activity	GO:0050790	185	0.010
mating	GO:0007618	120	0.010
posttranscriptional regulation of gene expression	GO:0010608	145	0.010

Hexo1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.055
disease of metabolism	DOID:0014667	0.022
inherited metabolic disorder	DOID:655	0.014
nervous system disease	DOID:863	0.013
carbohydrate metabolism disease	DOID:0050013	0.012
acquired metabolic disease	DOID:0060158	0.012
cardiovascular system disease	DOID:1287	0.012
type 2 diabetes mellitus	DOID:9352	0.011
diabetes mellitus	DOID:9351	0.011
glucose metabolism disease	DOID:4194	0.011

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