IMP: Integrative Multi-species Prediction

Drosophila melanogaster

11 known processes

Mo25 (Dmel_CG4083)

CG4083 gene product from transcript CG4083-RA

(Aliases: l(3)00274,CG4083,dMo25,mo25,Dmo25,Dmel\CG4083)

FLYBASE: FBgn0017572
Entrez: 39858
UniProtKB: M9PI82
UniProtKB: P91891

Process Predictions
Disease Predictions

Mo25 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
wing disc morphogenesis	GO:0007472	344	0.777
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.615
imaginal disc derived appendage development	GO:0048737	399	0.607
eye development	GO:0001654	323	0.534
embryonic morphogenesis	GO:0048598	206	0.494
immune response	GO:0006955	246	0.460
regionalization	GO:0003002	416	0.451
imaginal disc derived wing morphogenesis	GO:0007476	337	0.441
compound eye morphogenesis	GO:0001745	249	0.329
cell migration	GO:0016477	238	0.326
response to biotic stimulus	GO:0009607	294	0.304
cell motility	GO:0048870	251	0.304
sensory organ morphogenesis	GO:0090596	260	0.300
appendage development	GO:0048736	401	0.296
embryo development ending in birth or egg hatching	GO:0009792	152	0.257
compound eye development	GO:0048749	307	0.254
vesicle mediated transport	GO:0016192	381	0.253
morphogenesis of an epithelium	GO:0002009	276	0.235
molting cycle chitin based cuticle	GO:0007591	56	0.226
transcription from rna polymerase ii promoter	GO:0006366	368	0.218
positive regulation of secretion by cell	GO:1903532	20	0.217
axon development	GO:0061564	297	0.216
eye morphogenesis	GO:0048592	260	0.209
compound eye photoreceptor development	GO:0042051	78	0.207
endocytosis	GO:0006897	310	0.203
heparan sulfate proteoglycan biosynthetic process polysaccharide chain biosynthetic process	GO:0015014	5	0.200
neuron projection extension	GO:1990138	32	0.193
response to external biotic stimulus	GO:0043207	293	0.191
cellular polysaccharide biosynthetic process	GO:0033692	7	0.186
organic substance transport	GO:0071702	257	0.177
tissue morphogenesis	GO:0048729	297	0.171
compound eye photoreceptor cell differentiation	GO:0001751	140	0.168
polysaccharide metabolic process	GO:0005976	11	0.165
response to organic substance	GO:0010033	284	0.164
notch signaling pathway	GO:0007219	120	0.160
segmentation	GO:0035282	207	0.152
photoreceptor cell differentiation	GO:0046530	170	0.134
imaginal disc derived wing vein specification	GO:0007474	48	0.133
single organism catabolic process	GO:0044712	228	0.132
growth	GO:0040007	359	0.132	Worm
epithelial cell differentiation	GO:0030855	322	0.128
aminoglycan biosynthetic process	GO:0006023	11	0.128
eye photoreceptor cell differentiation	GO:0001754	145	0.126
adult locomotory behavior	GO:0008344	76	0.124
adult behavior	GO:0030534	137	0.120
body morphogenesis	GO:0010171	2	0.117
regulation of response to stress	GO:0080134	200	0.117
regulation of immune response	GO:0050776	118	0.117
regulation of mitotic cell cycle	GO:0007346	190	0.116
cuticle development	GO:0042335	86	0.115
positive regulation of response to stimulus	GO:0048584	323	0.113
tube morphogenesis	GO:0035239	191	0.109
positive regulation of signaling	GO:0023056	243	0.108
larval development	GO:0002164	104	0.103
tube development	GO:0035295	244	0.102
intracellular transport	GO:0046907	228	0.100
regulation of cell cycle phase transition	GO:1901987	130	0.099
tissue migration	GO:0090130	155	0.097
cellular carbohydrate metabolic process	GO:0044262	22	0.096
ras protein signal transduction	GO:0007265	88	0.095
regulation of anatomical structure morphogenesis	GO:0022603	242	0.093
post embryonic appendage morphogenesis	GO:0035120	385	0.092
regulation of organelle organization	GO:0033043	196	0.090
response to other organism	GO:0051707	293	0.089
phosphorylation	GO:0016310	294	0.086	Human
carbohydrate metabolic process	GO:0005975	82	0.083
defense response	GO:0006952	300	0.083
regulation of protein complex disassembly	GO:0043244	29	0.082
positive regulation of rna biosynthetic process	GO:1902680	266	0.082
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.081
sensory perception of mechanical stimulus	GO:0050954	72	0.078
appendage morphogenesis	GO:0035107	397	0.078
epithelial cell migration	GO:0010631	148	0.076
establishment of localization in cell	GO:0051649	402	0.076
secretion by cell	GO:0032940	101	0.073
regulation of cellular component size	GO:0032535	98	0.072
single organism carbohydrate metabolic process	GO:0044723	72	0.072
regulation of mapk cascade	GO:0043408	92	0.072
regulation of notch signaling pathway	GO:0008593	100	0.072
ameboidal type cell migration	GO:0001667	151	0.071
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.071
cellular amino acid metabolic process	GO:0006520	61	0.069
organic substance catabolic process	GO:1901575	308	0.069
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.068
single organism membrane organization	GO:0044802	93	0.067
ion transport	GO:0006811	145	0.066
chondroitin sulfate proteoglycan biosynthetic process	GO:0050650	3	0.066
catabolic process	GO:0009056	409	0.066
dorsal ventral pattern formation	GO:0009953	133	0.066
regulation of multi organism process	GO:0043900	131	0.066
axon extension	GO:0048675	32	0.065
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.064
macromolecular complex assembly	GO:0065003	256	0.063
organonitrogen compound metabolic process	GO:1901564	318	0.063
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.061
positive regulation of transport	GO:0051050	92	0.060
immune system process	GO:0002376	347	0.060
retina development in camera type eye	GO:0060041	4	0.060
cellular macromolecular complex assembly	GO:0034622	153	0.060
imaginal disc pattern formation	GO:0007447	91	0.060
hindbrain development	GO:0030902	2	0.059
regulation of nervous system development	GO:0051960	248	0.058
lipid storage	GO:0019915	38	0.058
innate immune response	GO:0045087	144	0.058
multi organism behavior	GO:0051705	175	0.057
single organism membrane budding	GO:1902591	2	0.057
mapk cascade	GO:0000165	107	0.057
axonogenesis	GO:0007409	290	0.057
protein complex assembly	GO:0006461	200	0.056
small gtpase mediated signal transduction	GO:0007264	88	0.056
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.055
regulation of defense response	GO:0031347	102	0.055
signal transduction by phosphorylation	GO:0023014	107	0.055	Human
apposition of dorsal and ventral imaginal disc derived wing surfaces	GO:0007475	15	0.055
regulation of intracellular signal transduction	GO:1902531	236	0.054
camera type eye development	GO:0043010	4	0.054
regulation of localization	GO:0032879	275	0.054
endomembrane system organization	GO:0010256	119	0.053
cellular polysaccharide metabolic process	GO:0044264	11	0.053
developmental growth	GO:0048589	280	0.051	Worm
negative regulation of mitotic cell cycle	GO:0045930	109	0.051
cellular response to organic substance	GO:0071310	132	0.051
regulation of secretion	GO:0051046	44	0.051
polysaccharide biosynthetic process	GO:0000271	7	0.050
response to oxygen containing compound	GO:1901700	200	0.049
regulation of ras protein signal transduction	GO:0046578	93	0.049
localization of cell	GO:0051674	257	0.049
regulation of cell size	GO:0008361	63	0.049
response to bacterium	GO:0009617	198	0.049
lipid localization	GO:0010876	54	0.048
regulation of anatomical structure size	GO:0090066	163	0.047
digestive tract morphogenesis	GO:0048546	127	0.046
cell cell junction organization	GO:0045216	55	0.045
sensory perception	GO:0007600	196	0.045
cellular catabolic process	GO:0044248	372	0.044
mitotic nuclear division	GO:0007067	213	0.043
regulation of cell cycle process	GO:0010564	181	0.042
membrane organization	GO:0061024	112	0.042
regulation of phosphate metabolic process	GO:0019220	210	0.042	Human
small molecule metabolic process	GO:0044281	305	0.042
regulation of phosphorylation	GO:0042325	147	0.041	Human
wing disc pattern formation	GO:0035222	66	0.041
cell adhesion	GO:0007155	136	0.041
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.041
chemotaxis	GO:0006935	249	0.041
negative regulation of multicellular organismal process	GO:0051241	142	0.041
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.041
digestive system development	GO:0055123	149	0.040
axon guidance	GO:0007411	233	0.039
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.039
positive regulation of cellular biosynthetic process	GO:0031328	316	0.039
single organism intracellular transport	GO:1902582	207	0.039
neurological system process	GO:0050877	358	0.039
positive regulation of immune response	GO:0050778	63	0.039
photoreceptor cell development	GO:0042461	96	0.038
regulation of cellular amine metabolic process	GO:0033238	3	0.038
rna processing	GO:0006396	147	0.038
renal system development	GO:0072001	72	0.037
embryonic development via the syncytial blastoderm	GO:0001700	148	0.037
organophosphate metabolic process	GO:0019637	195	0.037
positive regulation of protein transport	GO:0051222	37	0.037
positive regulation of signal transduction	GO:0009967	223	0.037
regulation of multicellular organismal development	GO:2000026	414	0.037
positive regulation of mapk cascade	GO:0043410	63	0.037
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.036
mucopolysaccharide metabolic process	GO:1903510	5	0.035
integrin mediated signaling pathway	GO:0007229	3	0.035
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.035
molting cycle	GO:0042303	56	0.035
protein secretion	GO:0009306	45	0.035
cell junction organization	GO:0034330	57	0.035
phagocytosis	GO:0006909	215	0.035
cell division	GO:0051301	248	0.034	Worm
blastoderm segmentation	GO:0007350	159	0.034
ovarian follicle cell migration	GO:0007297	121	0.034
response to endogenous stimulus	GO:0009719	119	0.033
negative regulation of notch signaling pathway	GO:0045746	41	0.033
positive regulation of intracellular signal transduction	GO:1902533	116	0.033
regulation of developmental growth	GO:0048638	174	0.033	Worm
positive regulation of secretion	GO:0051047	22	0.032
proteoglycan biosynthetic process	GO:0030166	10	0.032
chondroitin sulfate proteoglycan metabolic process	GO:0050654	3	0.032
organelle assembly	GO:0070925	198	0.031
intracellular signal transduction	GO:0035556	300	0.031	Human
molting cycle process	GO:0022404	29	0.031
regulation of cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090256	2	0.031
immune response regulating signaling pathway	GO:0002764	2	0.031
positive regulation of cell motility	GO:2000147	3	0.030
single organism cellular localization	GO:1902580	180	0.030
eye photoreceptor cell development	GO:0042462	81	0.030
nuclear division	GO:0000280	332	0.030
response to wounding	GO:0009611	94	0.030
carbohydrate biosynthetic process	GO:0016051	17	0.030
heart development	GO:0007507	82	0.030
cellular amide metabolic process	GO:0043603	80	0.030
embryonic pattern specification	GO:0009880	174	0.029
regulation of cellular component biogenesis	GO:0044087	201	0.029
organic acid metabolic process	GO:0006082	103	0.029
anatomical structure homeostasis	GO:0060249	97	0.029
establishment or maintenance of cell polarity	GO:0007163	167	0.029
negative regulation of developmental process	GO:0051093	201	0.028
single organism behavior	GO:0044708	391	0.028
regulation of reproductive process	GO:2000241	54	0.028
stem cell differentiation	GO:0048863	117	0.028
negative regulation of cell cycle process	GO:0010948	109	0.028
cell proliferation	GO:0008283	299	0.028	Worm
heart process	GO:0003015	37	0.028
death	GO:0016265	284	0.027
regulation of transport	GO:0051049	181	0.027
regulation of blood circulation	GO:1903522	21	0.027
organonitrogen compound biosynthetic process	GO:1901566	117	0.027
chemosensory behavior	GO:0007635	106	0.027
positive regulation of defense response	GO:0031349	59	0.027
immune response activating signal transduction	GO:0002757	2	0.027
secretion	GO:0046903	109	0.026
cellular response to chemical stimulus	GO:0070887	199	0.026
regulation of protein modification process	GO:0031399	112	0.026	Human
carboxylic acid metabolic process	GO:0019752	92	0.026
positive regulation of rna metabolic process	GO:0051254	271	0.025
negative regulation of molecular function	GO:0044092	51	0.025
regulation of secretion by cell	GO:1903530	39	0.025
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.024
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.024
cellular response to endogenous stimulus	GO:0071495	80	0.023
positive regulation of biosynthetic process	GO:0009891	316	0.023
regulation of cell differentiation	GO:0045595	302	0.023
regulation of response to external stimulus	GO:0032101	115	0.023
regulation of immune system process	GO:0002682	176	0.023
developmental growth involved in morphogenesis	GO:0060560	65	0.023
regulation of phosphorus metabolic process	GO:0051174	210	0.022	Human
mrna processing	GO:0006397	104	0.022
circulatory system development	GO:0072359	82	0.022
protein phosphorylation	GO:0006468	169	0.022	Human
regulation of cellular ketone metabolic process	GO:0010565	3	0.022
positive regulation of developmental process	GO:0051094	143	0.022	Worm
spindle organization	GO:0007051	253	0.022
purine nucleotide catabolic process	GO:0006195	109	0.021
epithelial tube morphogenesis	GO:0060562	88	0.021
regulation of cell morphogenesis	GO:0022604	163	0.021
regulation of organ morphogenesis	GO:2000027	78	0.021
negative regulation of cell cycle	GO:0045786	116	0.021
regulation of protein transport	GO:0051223	57	0.021
regulation of cell proliferation	GO:0042127	163	0.021
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.020
multicellular organismal aging	GO:0010259	140	0.020
regulation of cell cycle	GO:0051726	291	0.020
positive regulation of phosphorylation	GO:0042327	87	0.020	Human
actin filament based process	GO:0030029	220	0.020
cell adhesion involved in heart morphogenesis	GO:0061343	12	0.020
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.020
nucleoside triphosphate metabolic process	GO:0009141	120	0.020
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.020
mitotic spindle organization	GO:0007052	220	0.019
positive regulation of cell migration	GO:0030335	2	0.019
smoothened signaling pathway	GO:0007224	49	0.019
maintenance of location	GO:0051235	73	0.019
negative regulation of epithelial cell proliferation	GO:0050680	4	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.019
regulation of molecular function	GO:0065009	217	0.019	Human
biological adhesion	GO:0022610	138	0.019
locomotory behavior	GO:0007626	176	0.019
mitotic cell cycle checkpoint	GO:0007093	88	0.019
mitochondrion morphogenesis	GO:0070584	8	0.019
glycoprotein metabolic process	GO:0009100	41	0.019
cellular response to peptide	GO:1901653	28	0.019
protein transport	GO:0015031	155	0.018
regulation of protein metabolic process	GO:0051246	256	0.018	Human
nucleoside phosphate metabolic process	GO:0006753	162	0.018
peptide metabolic process	GO:0006518	80	0.018
response to temperature stimulus	GO:0009266	106	0.018
imaginal disc derived wing hair organization	GO:0035317	45	0.018
regulation of vesicle mediated transport	GO:0060627	59	0.018
immune effector process	GO:0002252	98	0.018
positive regulation of transcription dna templated	GO:0045893	266	0.018
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.018
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.018
regulation of axon extension	GO:0030516	8	0.017
mitotic cell cycle phase transition	GO:0044772	138	0.017
positive regulation of cell communication	GO:0010647	250	0.017
purine nucleoside catabolic process	GO:0006152	112	0.017
membrane budding	GO:0006900	4	0.017
organonitrogen compound catabolic process	GO:1901565	128	0.017
cellular protein modification process	GO:0006464	438	0.017	Human
organelle fission	GO:0048285	340	0.017
kidney development	GO:0001822	3	0.017
cation transport	GO:0006812	110	0.017
carbohydrate derivative catabolic process	GO:1901136	118	0.017
regulation of metal ion transport	GO:0010959	15	0.017
regulation of system process	GO:0044057	36	0.017
non sensory hair organization	GO:0035316	47	0.016
cell activation	GO:0001775	9	0.016
organic cyclic compound catabolic process	GO:1901361	168	0.016
response to lipopolysaccharide	GO:0032496	4	0.016
periodic partitioning	GO:0007365	29	0.016
regulation of catabolic process	GO:0009894	170	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.016
regulation of dna templated transcription elongation	GO:0032784	17	0.016
regulation of rna splicing	GO:0043484	69	0.016
regulation of cellular protein metabolic process	GO:0032268	243	0.016	Human
negative regulation of response to stimulus	GO:0048585	258	0.016
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.016
reproductive structure development	GO:0048608	74	0.016
positive regulation of neuron apoptotic process	GO:0043525	1	0.016
negative regulation of phosphorylation	GO:0042326	35	0.016
regulation of innate immune response	GO:0045088	71	0.015
learning	GO:0007612	75	0.015
digestive tract development	GO:0048565	149	0.015
single organismal cell cell adhesion	GO:0016337	45	0.015
cellular amine metabolic process	GO:0044106	12	0.015
protein complex biogenesis	GO:0070271	201	0.015
receptor mediated endocytosis	GO:0006898	21	0.015
purine nucleoside metabolic process	GO:0042278	127	0.015
mitotic g2 m transition checkpoint	GO:0044818	70	0.015
establishment of protein localization	GO:0045184	163	0.015
muscle system process	GO:0003012	21	0.015
regulation of actin cytoskeleton organization	GO:0032956	42	0.015
cellular response to mechanical stimulus	GO:0071260	2	0.014
gliogenesis	GO:0042063	80	0.014
response to heat	GO:0009408	63	0.014
sulfur compound biosynthetic process	GO:0044272	16	0.014
homeostatic process	GO:0042592	199	0.014
protein catabolic process	GO:0030163	101	0.014
connective tissue development	GO:0061448	3	0.014
cell proliferation involved in imaginal disc derived wing morphogenesis	GO:0090255	2	0.014
sulfur compound metabolic process	GO:0006790	59	0.014
chromatin organization	GO:0006325	207	0.014
cellular homeostasis	GO:0019725	80	0.014
positive regulation of fibroblast growth factor receptor signaling pathway	GO:0045743	5	0.014
positive regulation of notch signaling pathway	GO:0045747	34	0.014
energy derivation by oxidation of organic compounds	GO:0015980	32	0.013
embryonic axis specification	GO:0000578	107	0.013
nitrogen compound transport	GO:0071705	85	0.013
erk1 and erk2 cascade	GO:0070371	39	0.013
glycosyl compound catabolic process	GO:1901658	112	0.013
head development	GO:0060322	135	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013	Human
instar larval development	GO:0002168	55	0.013
cellular response to biotic stimulus	GO:0071216	4	0.013
heart morphogenesis	GO:0003007	32	0.013
gastrulation	GO:0007369	70	0.013
ribonucleotide catabolic process	GO:0009261	109	0.013
positive regulation of macromolecule metabolic process	GO:0010604	405	0.013	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.012
glycoprotein biosynthetic process	GO:0009101	41	0.012
defense response to other organism	GO:0098542	225	0.012
regulation of protein complex assembly	GO:0043254	42	0.012
regulation of purine nucleotide catabolic process	GO:0033121	48	0.012
lateral inhibition	GO:0046331	206	0.012
epidermal cell differentiation	GO:0009913	51	0.012
mitochondrion organization	GO:0007005	65	0.012
positive regulation of phosphate metabolic process	GO:0045937	139	0.012	Human
kidney morphogenesis	GO:0060993	3	0.012
humoral immune response	GO:0006959	117	0.012
bmp signaling pathway involved in malpighian tubule cell chemotaxis	GO:0061353	3	0.012
wing disc dorsal ventral pattern formation	GO:0048190	47	0.012
endoderm formation	GO:0001706	3	0.012
tricarboxylic acid metabolic process	GO:0072350	1	0.012
leg disc development	GO:0035218	92	0.012
hemocyte differentiation	GO:0042386	38	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.012
developmental cell growth	GO:0048588	52	0.012
nucleoside phosphate catabolic process	GO:1901292	110	0.012
hematopoietic progenitor cell differentiation	GO:0002244	1	0.012
response to alcohol	GO:0097305	95	0.011
amine metabolic process	GO:0009308	12	0.011
glycosyl compound metabolic process	GO:1901657	127	0.011
spermatogenesis	GO:0007283	200	0.011
cholesterol homeostasis	GO:0042632	3	0.011
nucleotide catabolic process	GO:0009166	109	0.011
epithelial structure maintenance	GO:0010669	17	0.011
taxis	GO:0042330	304	0.011
negative regulation of protein complex disassembly	GO:0043242	23	0.011
positive regulation of wnt signaling pathway	GO:0030177	25	0.011
regulation of mitosis	GO:0007088	56	0.011
organ growth	GO:0035265	56	0.011
cellular component disassembly	GO:0022411	46	0.011
positive regulation of cell adhesion	GO:0045785	10	0.011
positive regulation of cell cycle	GO:0045787	43	0.011
blood circulation	GO:0008015	26	0.011
epithelium migration	GO:0090132	148	0.011
regulation of ion transport	GO:0043269	39	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
establishment of synaptic vesicle localization	GO:0097480	50	0.011
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	9	0.011
cell growth	GO:0016049	108	0.011
purine containing compound catabolic process	GO:0072523	112	0.011
response to glucose	GO:0009749	2	0.010
histone modification	GO:0016570	106	0.010
cellular response to dna damage stimulus	GO:0006974	223	0.010
germ cell migration	GO:0008354	43	0.010
positive regulation of ras protein signal transduction	GO:0046579	43	0.010
hematopoietic or lymphoid organ development	GO:0048534	57	0.010
regulation of cell adhesion	GO:0030155	27	0.010
regulation of growth	GO:0040008	233	0.010	Worm
negative regulation of cytoskeleton organization	GO:0051494	30	0.010
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.010

Mo25 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.028
	disease of cellular proliferation	DOID:14566	0	0.012

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