IMP: Integrative Multi-species Prediction

Drosophila melanogaster

150 known processes

chico (Dmel_CG5686)

CG5686 gene product from transcript CG5686-RB

(Aliases: Dmel\CG5686,dIRS,fs(2)4,anon-WO0078940.4,IRS/chico,fs(2)ry4,BcDNA.GH11263,IRS,BcDNA:GH11263,CHICO,chic,CG5686,Chico,anon-WO0078940.1)

FLYBASE: FBgn0024248
Entrez: 64880
UniProtKB: M9PCQ8
UniProtKB: Q9XTN2

Process Predictions
Disease Predictions

chico biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
nuclear division	GO:0000280	332	0.995
multicellular organismal aging	GO:0010259	140	0.995
regulation of growth	GO:0040008	233	0.994
growth	GO:0040007	359	0.979
negative regulation of signaling	GO:0023057	219	0.969	Human Rat
organelle fission	GO:0048285	340	0.940
regulation of developmental growth	GO:0048638	174	0.938
negative regulation of cell communication	GO:0010648	223	0.934	Human Rat
aging	GO:0007568	143	0.931
determination of adult lifespan	GO:0008340	137	0.931
regulation of protein phosphorylation	GO:0001932	64	0.925
lipid metabolic process	GO:0006629	121	0.908
regulation of multicellular organism growth	GO:0040014	40	0.885
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.881
response to organic substance	GO:0010033	284	0.874
regulation of cell growth	GO:0001558	43	0.859
embryo development ending in birth or egg hatching	GO:0009792	152	0.851
positive regulation of macromolecule metabolic process	GO:0010604	405	0.839	Human
positive regulation of growth	GO:0045927	75	0.833
dna metabolic process	GO:0006259	227	0.830
protein phosphorylation	GO:0006468	169	0.827
germarium derived egg chamber formation	GO:0007293	101	0.817
regulation of cell death	GO:0010941	173	0.774	Mouse
molting cycle	GO:0042303	56	0.773
negative regulation of kinase activity	GO:0033673	16	0.767	Mouse
brain development	GO:0007420	120	0.757	Mouse
cell motility	GO:0048870	251	0.752	Mouse
regulation of cell size	GO:0008361	63	0.749
negative regulation of response to stimulus	GO:0048585	258	0.748	Rat
regulation of autophagy	GO:0010506	62	0.731
response to nitrogen compound	GO:1901698	90	0.721
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.702
epithelial cell development	GO:0002064	274	0.701
phosphorylation	GO:0016310	294	0.691	Mouse Rat
negative regulation of cellular metabolic process	GO:0031324	382	0.683	Mouse
negative regulation of nervous system development	GO:0051961	92	0.675
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.668
regulation of multicellular organismal development	GO:2000026	414	0.665
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.647	Human
regulation of cellular protein metabolic process	GO:0032268	243	0.641
associative learning	GO:0008306	65	0.641
ovarian follicle cell development	GO:0030707	248	0.627
autophagy	GO:0006914	108	0.621
response to oxidative stress	GO:0006979	86	0.607
regulation of cell differentiation	GO:0045595	302	0.601
positive regulation of cell growth	GO:0030307	19	0.588
regulation of protein kinase activity	GO:0045859	51	0.586
regulation of phosphorus metabolic process	GO:0051174	210	0.585	Mouse Rat
regulation of nervous system development	GO:0051960	248	0.583
regulation of cellular component size	GO:0032535	98	0.582
protein complex biogenesis	GO:0070271	201	0.530	Rat
cellular response to chemical stimulus	GO:0070887	199	0.523
regulation of protein metabolic process	GO:0051246	256	0.519
compound eye morphogenesis	GO:0001745	249	0.516
chromosome organization	GO:0051276	360	0.505
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.501
regulation of mapk cascade	GO:0043408	92	0.484
cellular protein modification process	GO:0006464	438	0.474
synaptic growth at neuromuscular junction	GO:0051124	119	0.470
axon development	GO:0061564	297	0.468
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.465
mitotic nuclear division	GO:0007067	213	0.462
developmental growth	GO:0048589	280	0.459
positive regulation of multicellular organism growth	GO:0040018	21	0.459
transcription from rna polymerase ii promoter	GO:0006366	368	0.455
cellular response to organonitrogen compound	GO:0071417	36	0.452
positive regulation of cellular response to insulin stimulus	GO:1900078	4	0.446	Human Rat
positive regulation of cellular component organization	GO:0051130	156	0.444
cell growth	GO:0016049	108	0.441
regulation of cellular ketone metabolic process	GO:0010565	3	0.421	Human
cellular carbohydrate metabolic process	GO:0044262	22	0.420	Human
positive regulation of phosphate metabolic process	GO:0045937	139	0.419	Mouse Rat
positive regulation of cellular biosynthetic process	GO:0031328	316	0.415	Human
regulation of phosphatidylinositol 3 kinase activity	GO:0043551	2	0.414	Mouse Rat
negative regulation of cell differentiation	GO:0045596	143	0.402
positive regulation of developmental process	GO:0051094	143	0.393
regulation of insulin receptor signaling pathway	GO:0046626	17	0.390	Rat
response to bacterium	GO:0009617	198	0.387
mitotic cell cycle checkpoint	GO:0007093	88	0.385
regulation of kinase activity	GO:0043549	53	0.384	Mouse Rat
positive regulation of protein metabolic process	GO:0051247	128	0.381
catabolic process	GO:0009056	409	0.369	Human Mouse
cellular response to dna damage stimulus	GO:0006974	223	0.359
response to organonitrogen compound	GO:0010243	75	0.357
neurological system process	GO:0050877	358	0.351
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.351
positive regulation of transcription dna templated	GO:0045893	266	0.344
positive regulation of multicellular organismal process	GO:0051240	143	0.337
collateral sprouting	GO:0048668	3	0.335
regulation of phosphorylation	GO:0042325	147	0.335	Mouse Rat
cellular response to endogenous stimulus	GO:0071495	80	0.330
columnar cuboidal epithelial cell development	GO:0002066	249	0.330
positive regulation of rna metabolic process	GO:0051254	271	0.327
chromatin organization	GO:0006325	207	0.325
regulation of cellular component biogenesis	GO:0044087	201	0.324
macromolecular complex assembly	GO:0065003	256	0.324	Rat
multicellular organism growth	GO:0035264	46	0.317
cellular response to oxygen containing compound	GO:1901701	79	0.315
protein catabolic process	GO:0030163	101	0.313
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.312
positive regulation of biosynthetic process	GO:0009891	316	0.304	Human
mushroom body development	GO:0016319	70	0.304
regulation of neuron differentiation	GO:0045664	103	0.303
negative regulation of signal transduction	GO:0009968	206	0.299	Rat
stress activated mapk cascade	GO:0051403	52	0.299
epithelium migration	GO:0090132	148	0.297
regulation of immune system process	GO:0002682	176	0.294
embryonic development via the syncytial blastoderm	GO:0001700	148	0.293
regulation of catabolic process	GO:0009894	170	0.289	Human
learning	GO:0007612	75	0.286
single organism cellular localization	GO:1902580	180	0.285
positive regulation of gene expression	GO:0010628	290	0.276
signal transduction by phosphorylation	GO:0023014	107	0.275
tor signaling	GO:0031929	32	0.274
positive regulation of rna biosynthetic process	GO:1902680	266	0.274
regulation of protein modification process	GO:0031399	112	0.274
response to reactive oxygen species	GO:0000302	24	0.272
imaginal disc growth	GO:0007446	37	0.269
regulation of anatomical structure size	GO:0090066	163	0.263
mapk cascade	GO:0000165	107	0.261
actin cytoskeleton organization	GO:0030036	206	0.261
regulation of cellular amino acid metabolic process	GO:0006521	0	0.261
metal ion transport	GO:0030001	74	0.260
positive regulation of developmental growth	GO:0048639	62	0.260
response to starvation	GO:0042594	97	0.256
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.254
cellular response to organic substance	GO:0071310	132	0.250
multicellular organismal reproductive behavior	GO:0033057	110	0.248
negative regulation of phosphate metabolic process	GO:0045936	45	0.242	Mouse
positive regulation of cell size	GO:0045793	21	0.241
protein modification process	GO:0036211	438	0.241
regulation of response to oxidative stress	GO:1902882	4	0.237
neuron death	GO:0070997	27	0.237
positive regulation of phosphorus metabolic process	GO:0010562	139	0.237	Mouse Rat
regulation of apoptotic process	GO:0042981	130	0.235	Mouse
negative regulation of intracellular signal transduction	GO:1902532	57	0.231
central nervous system development	GO:0007417	201	0.226	Mouse
purine containing compound metabolic process	GO:0072521	155	0.225
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.221
activation of protein kinase activity	GO:0032147	12	0.221
inositol lipid mediated signaling	GO:0048017	4	0.221	Human
homeostatic process	GO:0042592	199	0.218
neuron projection guidance	GO:0097485	241	0.214
cellular response to hormone stimulus	GO:0032870	44	0.214
regulation of proteolysis	GO:0030162	87	0.210
regulation of organelle organization	GO:0033043	196	0.201
cation transport	GO:0006812	110	0.201
positive regulation of autophagy	GO:0010508	21	0.201
negative regulation of growth	GO:0045926	84	0.200
regulation of lipid metabolic process	GO:0019216	15	0.198	Human Mouse Rat
gene silencing	GO:0016458	138	0.198
positive regulation of phosphorylation	GO:0042327	87	0.193	Mouse Rat
cellular ketone metabolic process	GO:0042180	24	0.193	Human
positive regulation of signal transduction	GO:0009967	223	0.193	Rat
imaginal disc derived wing morphogenesis	GO:0007476	337	0.192
chemical homeostasis	GO:0048878	92	0.192
cellular response to insulin stimulus	GO:0032869	28	0.188
response to nutrient levels	GO:0031667	114	0.188
regulation of cellular response to insulin stimulus	GO:1900076	17	0.187	Human Rat
negative regulation of phosphorylation	GO:0042326	35	0.186	Mouse
localization of cell	GO:0051674	257	0.184	Mouse
molting cycle chitin based cuticle	GO:0007591	56	0.182
golgi organization	GO:0007030	66	0.181
positive regulation of cell migration	GO:0030335	2	0.180	Mouse
proteolysis	GO:0006508	192	0.176
regulation of jnk cascade	GO:0046328	40	0.174
regionalization	GO:0003002	416	0.172
rhythmic process	GO:0048511	106	0.169
epithelial cell migration	GO:0010631	148	0.167
regulation of stress activated mapk cascade	GO:0032872	41	0.166
peptidyl amino acid modification	GO:0018193	105	0.165
stress activated protein kinase signaling cascade	GO:0031098	55	0.163
protein complex assembly	GO:0006461	200	0.161	Rat
germarium derived female germ line cyst formation	GO:0030727	42	0.161
cellular response to reactive oxygen species	GO:0034614	14	0.160
regulation of macroautophagy	GO:0016241	15	0.159
negative regulation of protein metabolic process	GO:0051248	85	0.158
response to heat	GO:0009408	63	0.156
positive regulation of signaling	GO:0023056	243	0.155	Mouse Rat
regulation of cytoplasmic transport	GO:1903649	47	0.155
regulation of response to stress	GO:0080134	200	0.155
regulation of imaginal disc growth	GO:0045570	26	0.155
activation of mapk activity	GO:0000187	9	0.152
nucleotide metabolic process	GO:0009117	161	0.151
cellular response to external stimulus	GO:0071496	66	0.149
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.149
dna packaging	GO:0006323	91	0.149
regulation of programmed cell death	GO:0043067	152	0.148	Mouse
mitotic dna damage checkpoint	GO:0044773	74	0.147
negative regulation of developmental process	GO:0051093	201	0.147
negative regulation of developmental growth	GO:0048640	64	0.146
response to temperature stimulus	GO:0009266	106	0.146
developmental maturation	GO:0021700	172	0.144
ameboidal type cell migration	GO:0001667	151	0.142
cellular protein catabolic process	GO:0044257	83	0.141
intracellular signal transduction	GO:0035556	300	0.141	Human Mouse
positive regulation of protein phosphorylation	GO:0001934	34	0.141
jak stat cascade	GO:0007259	49	0.140
oxoacid metabolic process	GO:0043436	103	0.140	Human
regulation of intracellular signal transduction	GO:1902531	236	0.140
cation homeostasis	GO:0055080	51	0.139
macromolecule catabolic process	GO:0009057	161	0.139
response to endogenous stimulus	GO:0009719	119	0.137
response to hydrogen peroxide	GO:0042542	11	0.137
negative regulation of autophagy	GO:0010507	16	0.135
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.134
imaginal disc derived appendage development	GO:0048737	399	0.133
cell death	GO:0008219	279	0.132	Mouse
forebrain development	GO:0030900	2	0.130
organ growth	GO:0035265	56	0.129
immune system process	GO:0002376	347	0.128
regulation of g1 s transition of mitotic cell cycle	GO:2000045	23	0.128
meiotic nuclear division	GO:0007126	151	0.128
negative regulation of insulin receptor signaling pathway	GO:0046627	11	0.127	Rat
jnk cascade	GO:0007254	50	0.126
regulation of transferase activity	GO:0051338	58	0.126	Mouse Rat
cellular amine metabolic process	GO:0044106	12	0.125
purine ribonucleoside metabolic process	GO:0046128	127	0.125
asymmetric protein localization	GO:0008105	33	0.123
negative regulation of phosphorus metabolic process	GO:0010563	45	0.123	Mouse
positive regulation of protein kinase activity	GO:0045860	25	0.123
positive regulation of lipid metabolic process	GO:0045834	4	0.122	Human Mouse Rat
maintenance of location in cell	GO:0051651	28	0.122
phosphatidylinositol 3 kinase signaling	GO:0014065	4	0.120	Human
negative regulation of programmed cell death	GO:0043069	72	0.119	Mouse
metal ion homeostasis	GO:0055065	44	0.119
epithelial cell differentiation	GO:0030855	322	0.119
entry into diapause	GO:0055115	1	0.118
neuromuscular junction development	GO:0007528	149	0.118
meiotic chromosome segregation	GO:0045132	59	0.118
regulation of epithelial cell proliferation	GO:0050678	4	0.117
female germ line cyst formation	GO:0048135	42	0.117
regulation of cell cycle	GO:0051726	291	0.116
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.116
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.116
post embryonic appendage morphogenesis	GO:0035120	385	0.116
response to oxygen containing compound	GO:1901700	200	0.116
extrinsic apoptotic signaling pathway	GO:0097191	1	0.114
positive regulation of mapk cascade	GO:0043410	63	0.114
positive regulation of insulin receptor signaling pathway	GO:0046628	3	0.114	Rat
regulation of synapse organization	GO:0050807	110	0.113
chorion containing eggshell formation	GO:0007304	105	0.112
wing disc morphogenesis	GO:0007472	344	0.112
reproductive behavior	GO:0019098	122	0.112
negative regulation of transcription dna templated	GO:0045892	237	0.111
multi organism reproductive behavior	GO:0044705	121	0.110
regulation of cell cycle process	GO:0010564	181	0.110
negative regulation of multicellular organismal process	GO:0051241	142	0.110
cellular response to oxidative stress	GO:0034599	28	0.109
negative regulation of gene expression	GO:0010629	387	0.106
protein localization to organelle	GO:0033365	82	0.106	Mouse
cell cycle dna replication	GO:0044786	23	0.105
cellular macromolecule localization	GO:0070727	220	0.104	Mouse
positive regulation of protein modification process	GO:0031401	58	0.103
regulation of reactive oxygen species metabolic process	GO:2000377	8	0.102
endocytosis	GO:0006897	310	0.101
heterochromatin organization	GO:0070828	25	0.101
regulation of organ growth	GO:0046620	42	0.101
spindle organization	GO:0007051	253	0.101
positive regulation of cellular protein metabolic process	GO:0032270	118	0.101
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.101
neural precursor cell proliferation	GO:0061351	75	0.099
cell proliferation	GO:0008283	299	0.099	Mouse
regulation of cell migration	GO:0030334	22	0.098	Mouse
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.097
small gtpase mediated signal transduction	GO:0007264	88	0.094
compound eye development	GO:0048749	307	0.092
response to ethanol	GO:0045471	59	0.092
circadian rhythm	GO:0007623	105	0.091
regulation of cell development	GO:0060284	215	0.091
regulation of immune response	GO:0050776	118	0.090
chromatin modification	GO:0016568	147	0.090
developmental cell growth	GO:0048588	52	0.089
organophosphate metabolic process	GO:0019637	195	0.089	Mouse Rat
regulation of cellular response to oxidative stress	GO:1900407	4	0.087
larval development	GO:0002164	104	0.084
head development	GO:0060322	135	0.084	Mouse
negative regulation of neurogenesis	GO:0050768	53	0.083
chromatin silencing	GO:0006342	76	0.083
positive regulation of cell motility	GO:2000147	3	0.082	Mouse
negative regulation of protein phosphorylation	GO:0001933	17	0.082
maintenance of protein location in cell	GO:0032507	26	0.082
regulation of cysteine type endopeptidase activity involved in apoptotic process	GO:0043281	25	0.081
positive regulation of protein serine threonine kinase activity	GO:0071902	15	0.081
cell competition in a multicellular organism	GO:0035212	10	0.081
divalent inorganic cation homeostasis	GO:0072507	29	0.080
positive regulation of cell differentiation	GO:0045597	64	0.079
negative regulation of cellular component organization	GO:0051129	108	0.079
chromosome segregation	GO:0007059	157	0.078
nucleoside catabolic process	GO:0009164	112	0.078
dna endoreduplication	GO:0042023	22	0.078
actin filament based process	GO:0030029	220	0.077
single organism biosynthetic process	GO:0044711	206	0.077	Human
autophagic vacuole assembly	GO:0000045	2	0.076
small molecule metabolic process	GO:0044281	305	0.076	Human
germarium derived oocyte differentiation	GO:0030706	29	0.076
mitotic cell cycle phase transition	GO:0044772	138	0.076
cellular protein localization	GO:0034613	160	0.075	Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.075
cellular lipid metabolic process	GO:0044255	83	0.075	Human Mouse Rat
oocyte development	GO:0048599	124	0.074
taxis	GO:0042330	304	0.073
regulation of neural precursor cell proliferation	GO:2000177	35	0.072
carbohydrate metabolic process	GO:0005975	82	0.072	Human
cellular response to nitrogen compound	GO:1901699	51	0.072
negative regulation of cellular biosynthetic process	GO:0031327	277	0.072
organic acid metabolic process	GO:0006082	103	0.071	Human
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.071
regulation of synapse structure and activity	GO:0050803	128	0.071
maintenance of location	GO:0051235	73	0.070
glycerolipid metabolic process	GO:0046486	34	0.070	Mouse Rat
regulation of mitotic cell cycle	GO:0007346	190	0.069
regulation of neurogenesis	GO:0050767	158	0.069
cell junction organization	GO:0034330	57	0.068
translation	GO:0006412	69	0.068
hindbrain development	GO:0030902	2	0.068
negative regulation of phosphatidylinositol 3 kinase signaling	GO:0014067	4	0.068
nucleobase containing small molecule metabolic process	GO:0055086	174	0.068
positive regulation of nitric oxide biosynthetic process	GO:0045429	1	0.068
regulation of response to nutrient levels	GO:0032107	18	0.067
long term memory	GO:0007616	62	0.067
regulation of phosphate metabolic process	GO:0019220	210	0.067	Mouse Rat
regulation of cell motility	GO:2000145	23	0.066	Mouse
regulation of localization	GO:0032879	275	0.065	Human Mouse Rat
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.065
response to biotic stimulus	GO:0009607	294	0.064
negative regulation of cell development	GO:0010721	62	0.064
death	GO:0016265	284	0.064	Mouse
paracrine signaling	GO:0038001	7	0.063
positive regulation of nervous system development	GO:0051962	69	0.063
regulation of catalytic activity	GO:0050790	185	0.063	Mouse Rat
mating behavior	GO:0007617	106	0.062
locomotor rhythm	GO:0045475	56	0.062
regulation of epithelial cell migration	GO:0010632	12	0.061
cellular amino acid metabolic process	GO:0006520	61	0.061
protein localization	GO:0008104	284	0.061	Mouse
cellular response to heat	GO:0034605	24	0.061
oocyte axis specification	GO:0007309	108	0.060
innate immune response	GO:0045087	144	0.060
establishment of protein localization to organelle	GO:0072594	62	0.060
ribonucleoside catabolic process	GO:0042454	112	0.060
histone modification	GO:0016570	106	0.059
regulation of stem cell proliferation	GO:0072091	40	0.059	Mouse
germarium derived oocyte fate determination	GO:0007294	26	0.059
regulation of defense response	GO:0031347	102	0.059
dna conformation change	GO:0071103	105	0.058
positive regulation of neurogenesis	GO:0050769	41	0.057
regulation of cell projection organization	GO:0031344	92	0.057
oocyte maturation	GO:0001556	3	0.057
digestive system development	GO:0055123	149	0.056
regulation of cell substrate adhesion	GO:0010810	2	0.056
carboxylic acid metabolic process	GO:0019752	92	0.056	Human
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.055
organonitrogen compound metabolic process	GO:1901564	318	0.055
negative regulation of transferase activity	GO:0051348	18	0.055	Mouse
response to monosaccharide	GO:0034284	4	0.054	Mouse
peptidyl tyrosine phosphorylation	GO:0018108	24	0.053
negative regulation of apoptotic process	GO:0043066	63	0.053	Mouse
regulation of photoreceptor cell differentiation	GO:0046532	34	0.053
positive regulation of proteolysis	GO:0045862	52	0.053
ovarian follicle cell migration	GO:0007297	121	0.053
negative regulation of immune response	GO:0050777	39	0.053
positive regulation of nurse cell apoptotic process	GO:0045850	5	0.053
response to organic cyclic compound	GO:0014070	89	0.052	Rat
regulation of nurse cell apoptotic process	GO:0045477	9	0.052
negative regulation of synaptic growth at neuromuscular junction	GO:0045886	39	0.050
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	11	0.050
positive regulation of cell development	GO:0010720	61	0.050
eye morphogenesis	GO:0048592	260	0.050
apoptotic process	GO:0006915	159	0.050	Mouse
purine ribonucleotide metabolic process	GO:0009150	145	0.050
cellular response to nutrient levels	GO:0031669	62	0.050
cell cycle phase transition	GO:0044770	140	0.049
cellular response to organic cyclic compound	GO:0071407	32	0.049
telencephalon development	GO:0021537	2	0.049
olfactory behavior	GO:0042048	97	0.049
membrane organization	GO:0061024	112	0.048
positive regulation of g2 m transition of mitotic cell cycle	GO:0010971	2	0.047
regulation of phosphatase activity	GO:0010921	3	0.047
purine containing compound catabolic process	GO:0072523	112	0.047
positive regulation of cell communication	GO:0010647	250	0.046	Mouse Rat
oocyte differentiation	GO:0009994	145	0.046
defense response to bacterium	GO:0042742	178	0.046
cell type specific apoptotic process	GO:0097285	38	0.046	Mouse
endomembrane system organization	GO:0010256	119	0.045
positive regulation of neuron apoptotic process	GO:0043525	1	0.045
apoptotic signaling pathway	GO:0097190	27	0.045
negative regulation of epithelial cell proliferation	GO:0050680	4	0.045
positive regulation of cell adhesion	GO:0045785	10	0.045
behavioral response to ethanol	GO:0048149	49	0.044
programmed cell death	GO:0012501	257	0.044	Mouse
immune response	GO:0006955	246	0.044
reactive oxygen species metabolic process	GO:0072593	22	0.044
aromatic compound catabolic process	GO:0019439	166	0.044
regulation of wnt signaling pathway	GO:0030111	68	0.044
purine ribonucleotide catabolic process	GO:0009154	109	0.044
response to hormone	GO:0009725	45	0.044
positive regulation of tor signaling	GO:0032008	13	0.044
positive regulation of neuron differentiation	GO:0045666	26	0.044
circadian behavior	GO:0048512	76	0.043
mitochondrial fission	GO:0000266	8	0.043
positive regulation of response to stimulus	GO:0048584	323	0.043
regulation of intracellular protein transport	GO:0033157	46	0.043
heterocycle catabolic process	GO:0046700	166	0.042
cell migration	GO:0016477	238	0.042	Mouse
regulation of cell junction assembly	GO:1901888	2	0.042
carbohydrate derivative metabolic process	GO:1901135	217	0.042
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.042
negative regulation of catalytic activity	GO:0043086	42	0.042	Mouse
regulation of cellular component movement	GO:0051270	42	0.042	Mouse
regulation of protein complex assembly	GO:0043254	42	0.041
regulation of map kinase activity	GO:0043405	17	0.041
axon guidance	GO:0007411	233	0.041
camera type eye morphogenesis	GO:0048593	2	0.041
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.040
regulation of lipid kinase activity	GO:0043550	2	0.040	Mouse Rat
regulation of cell matrix adhesion	GO:0001952	1	0.040
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	29	0.040
ribose phosphate metabolic process	GO:0019693	145	0.040
adult behavior	GO:0030534	137	0.040
regulation of gliogenesis	GO:0014013	11	0.040
carbohydrate derivative catabolic process	GO:1901136	118	0.040
regulation of cellular response to stress	GO:0080135	89	0.040
regulation of cellular localization	GO:0060341	136	0.039	Human Mouse Rat
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.039
negative regulation of cellular protein metabolic process	GO:0032269	85	0.039
regulation of system process	GO:0044057	36	0.038
response to insulin	GO:0032868	29	0.038
mitotic spindle organization	GO:0007052	220	0.038
meiotic cell cycle	GO:0051321	171	0.038
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.038
negative regulation of photoreceptor cell differentiation	GO:0046533	8	0.038
learning or memory	GO:0007611	141	0.038
modification dependent protein catabolic process	GO:0019941	78	0.037
negative regulation of protein modification process	GO:0031400	29	0.037
cognition	GO:0050890	141	0.036
hematopoietic or lymphoid organ development	GO:0048534	57	0.036
cellular response to starvation	GO:0009267	61	0.036
protein import into nucleus	GO:0006606	51	0.035
positive regulation of organelle organization	GO:0010638	65	0.035
positive regulation of kinase activity	GO:0033674	25	0.035	Mouse Rat
peptidyl tyrosine modification	GO:0018212	24	0.035
regeneration	GO:0031099	16	0.035
regulation of molecular function	GO:0065009	217	0.035	Mouse Rat
purine nucleotide catabolic process	GO:0006195	109	0.034
negative regulation of neuron death	GO:1901215	18	0.034
calcium ion homeostasis	GO:0055074	23	0.034
positive regulation of catalytic activity	GO:0043085	118	0.034	Mouse Rat
tube development	GO:0035295	244	0.034
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.033
protein autophosphorylation	GO:0046777	15	0.033
organic substance transport	GO:0071702	257	0.033	Human Mouse Rat
cell maturation	GO:0048469	144	0.033
response to axon injury	GO:0048678	12	0.033
germ band shortening	GO:0007390	19	0.033
organic substance catabolic process	GO:1901575	308	0.033	Human Mouse
ion homeostasis	GO:0050801	55	0.033
regulation of carbohydrate metabolic process	GO:0006109	10	0.033	Human
glycosyl compound catabolic process	GO:1901658	112	0.032
cellular response to peptide	GO:1901653	28	0.032
regulation of meiosis	GO:0040020	3	0.032
macroautophagy	GO:0016236	42	0.032
response to extracellular stimulus	GO:0009991	116	0.032
ras protein signal transduction	GO:0007265	88	0.032
cellular response to ionizing radiation	GO:0071479	15	0.032
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	38	0.032
regulation of phosphatidylinositol 3 kinase signaling	GO:0014066	4	0.031
chemotaxis	GO:0006935	249	0.031
regulation of axon regeneration	GO:0048679	4	0.031
posttranscriptional regulation of gene expression	GO:0010608	145	0.031
wnt signaling pathway	GO:0016055	98	0.031
regulation of nitric oxide biosynthetic process	GO:0045428	1	0.031
nucleus localization	GO:0051647	34	0.031
nucleoside metabolic process	GO:0009116	127	0.031
amine metabolic process	GO:0009308	12	0.031
cellular response to extracellular stimulus	GO:0031668	64	0.030
response to oxygen levels	GO:0070482	59	0.030
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.030
cellular homeostasis	GO:0019725	80	0.030
negative regulation of gene expression epigenetic	GO:0045814	77	0.030
cellular macromolecule catabolic process	GO:0044265	136	0.030
negative regulation of cell cycle	GO:0045786	116	0.030
regulation of actin filament polymerization	GO:0030833	25	0.029
regulation of translation	GO:0006417	56	0.029
regulation of nucleocytoplasmic transport	GO:0046822	35	0.029
cellular catabolic process	GO:0044248	372	0.029	Human
regulation of protein transport	GO:0051223	57	0.029
regulation of nuclear division	GO:0051783	58	0.029
negative regulation of mitotic cell cycle	GO:0045930	109	0.029
microtubule bundle formation	GO:0001578	27	0.028
positive regulation of cell death	GO:0010942	69	0.028
establishment of protein localization	GO:0045184	163	0.028
response to wounding	GO:0009611	94	0.028
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.028
regulation of gene expression epigenetic	GO:0040029	128	0.027
positive regulation of jun kinase activity	GO:0043507	4	0.027

chico disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
cancer	DOID:162	0.035
disease of cellular proliferation	DOID:14566	0.035
organ system cancer	DOID:0050686	0.035

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