IMP: Integrative Multi-species Prediction

Drosophila melanogaster

50 known processes

YL-1 (Dmel_CG4621)

CG4621 gene product from transcript CG4621-RA

(Aliases: dYL-1,Dmel\CG4621,CG4621)

Entrez: 34516
FLYBASE: FBgn0032321
UniProtKB: X2JA36
UniProtKB: Q9VKM6

Process Predictions
Disease Predictions

YL-1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
cellular response to dna damage stimulus	GO:0006974	223	0.192
chromatin organization	GO:0006325	207	0.167
cellular protein modification process	GO:0006464	438	0.132
nuclear division	GO:0000280	332	0.118
organelle fission	GO:0048285	340	0.117
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.108
neurological system process	GO:0050877	358	0.101
multi organism reproductive behavior	GO:0044705	121	0.099
chromatin modification	GO:0016568	147	0.093
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.090
negative regulation of gene expression	GO:0010629	387	0.087
regulation of cell cycle	GO:0051726	291	0.086
localization of cell	GO:0051674	257	0.083
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.083
positive regulation of response to stimulus	GO:0048584	323	0.079
establishment of localization in cell	GO:0051649	402	0.079
meiotic cell cycle	GO:0051321	171	0.078
endocytosis	GO:0006897	310	0.071
meiotic cell cycle process	GO:1903046	132	0.071
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.070
terminal button organization	GO:0072553	19	0.066
body morphogenesis	GO:0010171	2	0.065
covalent chromatin modification	GO:0016569	106	0.062
negative regulation of signaling	GO:0023057	219	0.062
regionalization	GO:0003002	416	0.061
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.059
response to temperature stimulus	GO:0009266	106	0.059
negative regulation of cellular metabolic process	GO:0031324	382	0.059
positive regulation of cellular biosynthetic process	GO:0031328	316	0.058
protein modification process	GO:0036211	438	0.056
chromosome organization	GO:0051276	360	0.055
negative regulation of cell communication	GO:0010648	223	0.050
chromatin remodeling	GO:0006338	72	0.050
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.047
response to abiotic stimulus	GO:0009628	341	0.046
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.046
histone acetylation	GO:0016573	38	0.045
synaptic transmission	GO:0007268	288	0.044
mrna metabolic process	GO:0016071	124	0.043
positive regulation of signaling	GO:0023056	243	0.042
positive regulation of signal transduction	GO:0009967	223	0.041
reproductive behavior	GO:0019098	122	0.041
positive regulation of rna metabolic process	GO:0051254	271	0.041
cellular macromolecule localization	GO:0070727	220	0.041
regulation of cell cycle process	GO:0010564	181	0.040
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.039
organelle assembly	GO:0070925	198	0.038
cell motility	GO:0048870	251	0.037
positive regulation of macromolecule metabolic process	GO:0010604	405	0.037
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.036
positive regulation of rna biosynthetic process	GO:1902680	266	0.035
positive regulation of cell communication	GO:0010647	250	0.035
regulation of mitotic cell cycle	GO:0007346	190	0.034
histone modification	GO:0016570	106	0.034
negative regulation of cell cycle process	GO:0010948	109	0.032
positive regulation of transcription dna templated	GO:0045893	266	0.032
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.031
multi multicellular organism process	GO:0044706	123	0.029
negative regulation of signal transduction	GO:0009968	206	0.028
positive regulation of biosynthetic process	GO:0009891	316	0.028
spermatogenesis	GO:0007283	200	0.028
macromolecular complex assembly	GO:0065003	256	0.028
dna metabolic process	GO:0006259	227	0.028
negative regulation of transcription dna templated	GO:0045892	237	0.027
cellular macromolecular complex assembly	GO:0034622	153	0.027
forebrain development	GO:0030900	2	0.026
negative regulation of erk1 and erk2 cascade	GO:0070373	3	0.026
embryo development ending in birth or egg hatching	GO:0009792	152	0.026
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.026
negative regulation of rna biosynthetic process	GO:1902679	240	0.026
phosphorylation	GO:0016310	294	0.026
cell cycle phase transition	GO:0044770	140	0.025
ras protein signal transduction	GO:0007265	88	0.025
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.025
multicellular organismal reproductive behavior	GO:0033057	110	0.025
meiotic dna double strand break formation involved in reciprocal meiotic recombination	GO:0010780	1	0.025
transcription from rna polymerase ii promoter	GO:0006366	368	0.025
cellular amino acid metabolic process	GO:0006520	61	0.024
single organism cellular localization	GO:1902580	180	0.024
regulation of programmed cell death	GO:0043067	152	0.024
regulation of localization	GO:0032879	275	0.024
vesicle mediated transport	GO:0016192	381	0.024
dna damage checkpoint	GO:0000077	78	0.023
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.023
spindle assembly involved in mitosis	GO:0090307	50	0.023
central nervous system development	GO:0007417	201	0.022
protein acetylation	GO:0006473	39	0.022
mitotic g2 m transition checkpoint	GO:0044818	70	0.022
regulation of cellular localization	GO:0060341	136	0.021
cell migration	GO:0016477	238	0.021
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.021
protein dna complex subunit organization	GO:0071824	86	0.021
regulation of growth	GO:0040008	233	0.021
intracellular transport	GO:0046907	228	0.021
cognition	GO:0050890	141	0.021
amine metabolic process	GO:0009308	12	0.021
negative regulation of rna metabolic process	GO:0051253	251	0.020
internal peptidyl lysine acetylation	GO:0018393	38	0.020
cell proliferation	GO:0008283	299	0.020
peptidyl amino acid modification	GO:0018193	105	0.020
cellular protein localization	GO:0034613	160	0.020
organic substance catabolic process	GO:1901575	308	0.020
negative regulation of cellular biosynthetic process	GO:0031327	277	0.020
maintenance of protein location	GO:0045185	28	0.020
regulation of immune system process	GO:0002682	176	0.020
organic substance transport	GO:0071702	257	0.020
regulation of multi organism process	GO:0043900	131	0.019
meiotic dna double strand break formation	GO:0042138	1	0.019
response to heat	GO:0009408	63	0.019
mitotic g2 dna damage checkpoint	GO:0007095	69	0.019
multi organism behavior	GO:0051705	175	0.019
histone h3 k4 methylation	GO:0051568	16	0.019
synapse assembly	GO:0007416	143	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
cellular amine metabolic process	GO:0044106	12	0.018
negative regulation of biosynthetic process	GO:0009890	277	0.018
negative regulation of response to stimulus	GO:0048585	258	0.018
positive regulation of gene expression	GO:0010628	290	0.018
regulation of response to stress	GO:0080134	200	0.018
phagocytosis	GO:0006909	215	0.018
regulation of anatomical structure morphogenesis	GO:0022603	242	0.018
appendage morphogenesis	GO:0035107	397	0.017
protein complex biogenesis	GO:0070271	201	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.017
heterocycle catabolic process	GO:0046700	166	0.017
appendage development	GO:0048736	401	0.017
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.017
cell growth	GO:0016049	108	0.017
head development	GO:0060322	135	0.016
regulation of protein metabolic process	GO:0051246	256	0.016
dendrite morphogenesis	GO:0048813	199	0.016
chromosome localization	GO:0050000	20	0.016
oocyte differentiation	GO:0009994	145	0.016
rna processing	GO:0006396	147	0.016
regulation of cell cycle phase transition	GO:1901987	130	0.016
regulation of intracellular signal transduction	GO:1902531	236	0.016
synapse organization	GO:0050808	196	0.016
mitotic cell cycle checkpoint	GO:0007093	88	0.016
methylation	GO:0032259	47	0.016
oocyte development	GO:0048599	124	0.016
death	GO:0016265	284	0.016
cellular response to organic substance	GO:0071310	132	0.015
meiosis i	GO:0007127	59	0.015
actin cytoskeleton organization	GO:0030036	206	0.015
peptidyl lysine methylation	GO:0018022	16	0.015
peptidyl lysine modification	GO:0018205	57	0.015
homeostatic process	GO:0042592	199	0.015
mitotic nuclear division	GO:0007067	213	0.015
dna integrity checkpoint	GO:0031570	81	0.015
spindle assembly	GO:0051225	80	0.015
regulation of neuron projection development	GO:0010975	69	0.015
histone exchange	GO:0043486	21	0.015
cellular response to organic cyclic compound	GO:0071407	32	0.014
response to oxygen containing compound	GO:1901700	200	0.014
cellular nitrogen compound catabolic process	GO:0044270	165	0.014
cell cycle checkpoint	GO:0000075	95	0.014
dna templated transcription elongation	GO:0006354	18	0.014
regulation of mapk cascade	GO:0043408	92	0.014
negative regulation of cell cycle phase transition	GO:1901988	103	0.014
protein localization	GO:0008104	284	0.014
response to organic substance	GO:0010033	284	0.014
male gamete generation	GO:0048232	201	0.013
gliogenesis	GO:0042063	80	0.013
positive regulation of protein metabolic process	GO:0051247	128	0.013
response to radiation	GO:0009314	155	0.013
maintenance of protein location in cell	GO:0032507	26	0.013
regulation of cell death	GO:0010941	173	0.013
aromatic compound catabolic process	GO:0019439	166	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.013
cellularization	GO:0007349	90	0.013
post embryonic appendage morphogenesis	GO:0035120	385	0.013
brain development	GO:0007420	120	0.013
small molecule metabolic process	GO:0044281	305	0.013
ncrna processing	GO:0034470	30	0.013
intracellular signal transduction	GO:0035556	300	0.013
dephosphorylation	GO:0016311	51	0.013
positive regulation of cell motility	GO:2000147	3	0.013
protein dephosphorylation	GO:0006470	27	0.013
nucleobase containing small molecule metabolic process	GO:0055086	174	0.013
organonitrogen compound metabolic process	GO:1901564	318	0.013
telencephalon development	GO:0021537	2	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
cellular macromolecule catabolic process	GO:0044265	136	0.012
regulation of erk1 and erk2 cascade	GO:0070372	39	0.012
imaginal disc derived appendage development	GO:0048737	399	0.012
determination of adult lifespan	GO:0008340	137	0.012
cellular response to chemical stimulus	GO:0070887	199	0.012
wing disc morphogenesis	GO:0007472	344	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
dorsal ventral pattern formation	GO:0009953	133	0.012
rho protein signal transduction	GO:0007266	14	0.012
maintenance of location in cell	GO:0051651	28	0.012
stem cell proliferation	GO:0072089	88	0.012
negative regulation of programmed cell death	GO:0043069	72	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
negative regulation of cell death	GO:0060548	81	0.012
stem cell differentiation	GO:0048863	117	0.012
mrna catabolic process	GO:0006402	33	0.012
ncrna metabolic process	GO:0034660	43	0.012
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.012
positive regulation of cellular component biogenesis	GO:0044089	80	0.011
positive regulation of immune response	GO:0050778	63	0.011
microtubule based transport	GO:0010970	42	0.011
positive regulation of lipid metabolic process	GO:0045834	4	0.011
developmental maturation	GO:0021700	172	0.011
positive regulation of cellular component organization	GO:0051130	156	0.011
negative regulation of intracellular signal transduction	GO:1902532	57	0.011
establishment of protein localization	GO:0045184	163	0.011
regulation of cellular ketone metabolic process	GO:0010565	3	0.011
regulation of erbb signaling pathway	GO:1901184	42	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
protein localization to organelle	GO:0033365	82	0.011
regulation of intracellular transport	GO:0032386	64	0.011
nuclear transport	GO:0051169	72	0.011
membrane depolarization	GO:0051899	4	0.011
regulation of cytoplasmic transport	GO:1903649	47	0.011
axonogenesis	GO:0007409	290	0.011
regulation of cell differentiation	GO:0045595	302	0.011
small gtpase mediated signal transduction	GO:0007264	88	0.011
epithelial cell development	GO:0002064	274	0.011
regulation of cell morphogenesis	GO:0022604	163	0.011
macromolecule catabolic process	GO:0009057	161	0.011
regulation of synapse structure and activity	GO:0050803	128	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
positive regulation of transport	GO:0051050	92	0.011
nucleoside phosphate metabolic process	GO:0006753	162	0.011
spindle organization	GO:0007051	253	0.011
histone methylation	GO:0016571	40	0.010
positive regulation of phosphorus metabolic process	GO:0010562	139	0.010
regulation of transport	GO:0051049	181	0.010
meiotic nuclear division	GO:0007126	151	0.010
positive regulation of intracellular transport	GO:0032388	42	0.010
dna methylation or demethylation	GO:0044728	4	0.010
anatomical structure homeostasis	GO:0060249	97	0.010
catabolic process	GO:0009056	409	0.010
erbb signaling pathway	GO:0038127	58	0.010
embryonic axis specification	GO:0000578	107	0.010

YL-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.017
	nervous system disease	DOID:863	0	0.015

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