Drosophila melanogaster

46 known processes

eIF-4B (Dmel_CG10837)

Eukaryotic initiation factor 4B

(Aliases: eIF-4B-S,eIf4b,eIF-4b,EIF-4B,Dm-eIF4B,CG10837,Dmel\CG10837,eIF4B,eIF-4B-L,Eif4B)

eIF-4B biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
growthGO:00400073590.241
positive regulation of nitrogen compound metabolic processGO:00511733540.178
negative regulation of macromolecule biosynthetic processGO:00105582700.164
defense response to bacteriumGO:00427421780.155
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.139
catabolic processGO:00090564090.119
regulation of cell differentiationGO:00455953020.119
cellular catabolic processGO:00442483720.112
chromatin organizationGO:00063252070.111
negative regulation of gene expressionGO:00106293870.106
cytoplasmic transportGO:00164821300.104
regulation of intracellular signal transductionGO:19025312360.100
positive regulation of response to stimulusGO:00485843230.090
response to bacteriumGO:00096171980.089
vesicle mediated transportGO:00161923810.085
autophagyGO:00069141080.084
organic substance transportGO:00717022570.084
response to biotic stimulusGO:00096072940.078
positive regulation of macromolecule metabolic processGO:00106044050.078
establishment of localization in cellGO:00516494020.077
establishment of protein localizationGO:00451841630.075
protein complex assemblyGO:00064612000.071
protein localizationGO:00081042840.070
intracellular protein transportGO:00068861040.069
appendage developmentGO:00487364010.069
ion transportGO:00068111450.069
chemotaxisGO:00069352490.068
segmentationGO:00352822070.067
phagocytosisGO:00069092150.067
cellular macromolecule localizationGO:00707272200.066
response to external biotic stimulusGO:00432072930.065
phosphorylationGO:00163102940.064
protein importGO:0017038550.063
response to organic substanceGO:00100332840.063
negative regulation of cellular biosynthetic processGO:00313272770.062
positive regulation of rna biosynthetic processGO:19026802660.062
intracellular transportGO:00469072280.060
single organism intracellular transportGO:19025822070.060
negative regulation of cellular metabolic processGO:00313243820.058
regulation of cellular catabolic processGO:00313291570.058
macromolecular complex assemblyGO:00650032560.058
organonitrogen compound biosynthetic processGO:19015661170.057
dna metabolic processGO:00062592270.057
protein phosphorylationGO:00064681690.056
regulation of autophagyGO:0010506620.056
regulation of growthGO:00400082330.055
negative regulation of cell cycle phase transitionGO:19019881030.054
cellular protein localizationGO:00346131600.053
microtubule organizing center organizationGO:00310231680.052
single organism nuclear importGO:1902593510.051
protein targeting to nucleusGO:0044744510.051
regulation of cell proliferationGO:00421271630.050
positive regulation of nucleobase containing compound metabolic processGO:00459353320.049
appendage morphogenesisGO:00351073970.049
positive regulation of catalytic activityGO:00430851180.049
regulation of protein metabolic processGO:00512462560.048
enzyme linked receptor protein signaling pathwayGO:00071671790.047
negative regulation of biosynthetic processGO:00098902770.047
positive regulation of signal transductionGO:00099672230.047
developmental growthGO:00485892800.046
cell deathGO:00082192790.046
regulation of catabolic processGO:00098941700.046
establishment of protein localization to organelleGO:0072594620.045
positive regulation of biosynthetic processGO:00098913160.045
protein localization to nucleusGO:0034504550.044
protein import into nucleusGO:0006606510.044
regulation of programmed cell deathGO:00430671520.044
macromolecule catabolic processGO:00090571610.044
regulation of multicellular organismal developmentGO:20000264140.044
organic substance catabolic processGO:19015753080.043
cellular protein complex assemblyGO:0043623710.043
tube developmentGO:00352952440.043
regulation of cellular protein metabolic processGO:00322682430.042
regulation of cellular component biogenesisGO:00440872010.041
centrosome cycleGO:00070981370.041
response to other organismGO:00517072930.040
organic hydroxy compound metabolic processGO:1901615830.040
protein modification processGO:00362114380.040
positive regulation of phosphate metabolic processGO:00459371390.039
nucleocytoplasmic transportGO:0006913720.039
positive regulation of cellular component organizationGO:00511301560.039
single organism cellular localizationGO:19025801800.038
regulation of immune system processGO:00026821760.037
transcription from rna polymerase ii promoterGO:00063663680.037
endocytosisGO:00068973100.037
imaginal disc derived appendage developmentGO:00487373990.036
positive regulation of intracellular signal transductionGO:19025331160.036
cellular protein modification processGO:00064644380.036
cell growthGO:00160491080.035
positive regulation of signalingGO:00230562430.035
deathGO:00162652840.034
single organism membrane organizationGO:0044802930.034
eye developmentGO:00016543230.033
regulation of transcription from rna polymerase ii promoterGO:00063573780.033
positive regulation of catabolic processGO:00098961050.033
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178650.033
positive regulation of protein metabolic processGO:00512471280.033
regulation of apoptotic processGO:00429811300.033
embryonic axis specificationGO:00005781070.033
regulation of mitotic cell cycle phase transitionGO:19019901300.033
intracellular signal transductionGO:00355563000.032
regulation of localizationGO:00328792750.032
immune responseGO:00069552460.032
protein localization to organelleGO:0033365820.031
anterior posterior pattern specificationGO:00099521360.031
protein catabolic processGO:00301631010.031
positive regulation of nucleic acid templated transcriptionGO:19035082660.030
nuclear importGO:0051170510.030
negative regulation of neurogenesisGO:0050768530.030
negative regulation of cellular catabolic processGO:0031330340.029
organonitrogen compound metabolic processGO:19015643180.029
response to endogenous stimulusGO:00097191190.029
negative regulation of mitotic cell cycle phase transitionGO:19019911030.029
regulation of nervous system developmentGO:00519602480.029
innate immune responseGO:00450871440.029
regulation of phosphorylationGO:00423251470.029
negative regulation of catabolic processGO:0009895360.028
centrosome organizationGO:00512971630.028
taxisGO:00423303040.028
protein targetingGO:0006605640.028
regulation of phosphorus metabolic processGO:00511742100.028
response to abiotic stimulusGO:00096283410.028
anterior posterior axis specification embryoGO:00085951030.028
negative regulation of growthGO:0045926840.027
apoptotic processGO:00069151590.027
sensory organ morphogenesisGO:00905962600.027
lipid metabolic processGO:00066291210.027
imaginal disc derived appendage morphogenesisGO:00351143950.027
negative regulation of cell proliferationGO:0008285690.026
negative regulation of developmental processGO:00510932010.026
agingGO:00075681430.026
imaginal disc derived wing morphogenesisGO:00074763370.026
salivary gland morphogenesisGO:00074351450.026
protein complex biogenesisGO:00702712010.026
positive regulation of gene expressionGO:00106282900.026
endomembrane system organizationGO:00102561190.026
negative regulation of nucleic acid templated transcriptionGO:19035072400.026
phenol containing compound metabolic processGO:0018958570.026
regulation of catalytic activityGO:00507901850.025
ubiquitin dependent protein catabolic processGO:0006511780.025
response to oxygen containing compoundGO:19017002000.024
carbohydrate derivative metabolic processGO:19011352170.024
chromatin modificationGO:00165681470.024
stem cell divisionGO:0017145690.024
single organism carbohydrate metabolic processGO:0044723720.023
gland morphogenesisGO:00226121450.023
negative regulation of cellular component organizationGO:00511291080.023
positive regulation of rna metabolic processGO:00512542710.023
organic acid metabolic processGO:00060821030.023
positive regulation of cellular biosynthetic processGO:00313283160.023
cellular amino acid metabolic processGO:0006520610.023
compound eye morphogenesisGO:00017452490.023
imaginal disc derived leg morphogenesisGO:0007480800.023
regulation of chromatin modificationGO:1903308280.023
cellular response to organic substanceGO:00713101320.023
proteolysisGO:00065081920.023
negative regulation of cell differentiationGO:00455961430.023
kidney developmentGO:000182230.022
protein transportGO:00150311550.022
regulation of synapse organizationGO:00508071100.022
transforming growth factor beta receptor signaling pathwayGO:0007179160.022
axon guidanceGO:00074112330.022
organic hydroxy compound biosynthetic processGO:1901617210.022
organelle fissionGO:00482853400.022
positive regulation of cell communicationGO:00106472500.021
regionalizationGO:00030024160.021
regulation of protein modification processGO:00313991120.021
extrinsic apoptotic signaling pathwayGO:009719110.021
nucleus organizationGO:0006997450.021
negative regulation of nervous system developmentGO:0051961920.021
regulation of mitotic cell cycleGO:00073461900.021
negative regulation of transcription dna templatedGO:00458922370.020
aminoglycan biosynthetic processGO:0006023110.020
purine ribonucleotide metabolic processGO:00091501450.020
regulation of immune responseGO:00507761180.020
regulation of transportGO:00510491810.020
response to lipopolysaccharideGO:003249640.020
ras protein signal transductionGO:0007265880.020
cellular lipid metabolic processGO:0044255830.020
negative regulation of nitrogen compound metabolic processGO:00511722650.020
regulation of small gtpase mediated signal transductionGO:0051056930.020
cellular response to dna damage stimulusGO:00069742230.020
embryonic pattern specificationGO:00098801740.019
sterol homeostasisGO:005509240.019
regulation of molecular functionGO:00650092170.019
meiotic nuclear divisionGO:00071261510.019
nuclear transportGO:0051169720.019
translationGO:0006412690.019
neuromuscular junction developmentGO:00075281490.019
positive regulation of cellular protein metabolic processGO:00322701180.019
regulation of neurogenesisGO:00507671580.019
regulation of cell deathGO:00109411730.019
membrane organizationGO:00610241120.019
small gtpase mediated signal transductionGO:0007264880.018
peptidyl threonine phosphorylationGO:001810720.018
cellular macromolecular complex assemblyGO:00346221530.018
response to extracellular stimulusGO:00099911160.018
regulation of cell growthGO:0001558430.018
negative regulation of apoptotic processGO:0043066630.018
programmed cell deathGO:00125012570.018
cellular protein catabolic processGO:0044257830.018
cellular carbohydrate metabolic processGO:0044262220.018
defense responseGO:00069523000.018
cellular nitrogen compound catabolic processGO:00442701650.018
connective tissue developmentGO:006144830.018
neuron projection guidanceGO:00974852410.018
nitrogen compound transportGO:0071705850.018
regulation of cellular amine metabolic processGO:003323830.018
wing disc morphogenesisGO:00074723440.018
response to alcoholGO:0097305950.017
negative regulation of cell developmentGO:0010721620.017
immune system processGO:00023763470.017
regulation of cell developmentGO:00602842150.017
compound eye developmentGO:00487493070.017
protein modification by small protein conjugationGO:0032446790.017
small molecule metabolic processGO:00442813050.017
blastoderm segmentationGO:00073501590.017
carboxylic acid metabolic processGO:0019752920.017
modification dependent macromolecule catabolic processGO:0043632790.017
proteolysis involved in cellular protein catabolic processGO:0051603830.017
body morphogenesisGO:001017120.017
axon developmentGO:00615642970.017
homeostatic processGO:00425921990.017
salivary gland histolysisGO:0035070880.017
positive regulation of molecular functionGO:00440931360.016
estrogen metabolic processGO:000821010.016
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.016
cell cell signaling involved in cell fate commitmentGO:00451682100.016
olfactory behaviorGO:0042048970.016
response to monosaccharideGO:003428440.016
eye morphogenesisGO:00485922600.016
regulation of response to stressGO:00801342000.016
extracellular structure organizationGO:0043062460.016
positive regulation of phosphorylationGO:0042327870.016
localization of cellGO:00516742570.016
positive regulation of transcription dna templatedGO:00458932660.016
epithelial tube morphogenesisGO:0060562880.016
response to glucoseGO:000974920.016
nuclear divisionGO:00002803320.016
negative regulation of protein metabolic processGO:0051248850.016
leg disc morphogenesisGO:0007478800.016
response to drugGO:0042493170.016
cellular response to external stimulusGO:0071496660.016
negative regulation of cellular protein metabolic processGO:0032269850.015
single organism biosynthetic processGO:00447112060.015
mitotic cell cycle checkpointGO:0007093880.015
regulation of protein localizationGO:0032880760.015
regulation of cytoplasmic transportGO:1903649470.015
regulation of establishment of protein localizationGO:0070201610.015
cell cycle checkpointGO:0000075950.015
cell migrationGO:00164772380.015
regulation of cellular localizationGO:00603411360.015
negative regulation of rna biosynthetic processGO:19026792400.015
regulation of proteolysisGO:0030162870.015
positive regulation of apoptotic signaling pathwayGO:200123540.015
regulation of neuron differentiationGO:00456641030.015
camera type eye developmentGO:004301040.015
negative regulation of response to stimulusGO:00485852580.015
multicellular organismal agingGO:00102591400.015
cytoplasm organizationGO:0007028640.014
purine ribonucleoside triphosphate metabolic processGO:00092051190.014
single organism catabolic processGO:00447122280.014
rrna processingGO:000636430.014
organic cyclic compound catabolic processGO:19013611680.014
protein modification by small protein conjugation or removalGO:00706471060.014
tissue deathGO:00162711020.014
positive regulation of macromolecule biosynthetic processGO:00105572830.014
mapk cascadeGO:00001651070.014
ribonucleotide metabolic processGO:00092591450.014
positive regulation of cell motilityGO:200014730.014
positive regulation of phosphorus metabolic processGO:00105621390.014
regulation of mapk cascadeGO:0043408920.014
digestive tract developmentGO:00485651490.014
cellular response to chemical stimulusGO:00708871990.014
regulation of apoptotic signaling pathwayGO:2001233100.014
cellular response to endogenous stimulusGO:0071495800.014
catechol containing compound metabolic processGO:0009712100.013
response to nutrient levelsGO:00316671140.013
purine nucleoside monophosphate metabolic processGO:0009126500.013
tripartite regional subdivisionGO:00073511030.013
regulation of hydrolase activityGO:0051336970.013
regulation of cell cycle phase transitionGO:19019871300.013
exocrine system developmentGO:00352721620.013
negative regulation of programmed cell deathGO:0043069720.013
cell proliferationGO:00082832990.013
organophosphate metabolic processGO:00196371950.013
carbohydrate derivative catabolic processGO:19011361180.013
hormone catabolic processGO:004244730.013
synapse organizationGO:00508081960.013
protein ubiquitinationGO:0016567700.013
regulation of intracellular protein transportGO:0033157460.013
mitochondrion organizationGO:0007005650.013
regulation of protein complex assemblyGO:0043254420.013
regulation of cellular ketone metabolic processGO:001056530.013
autophagic cell deathGO:0048102830.013
positive regulation of protein modification processGO:0031401580.013
negative regulation of signal transductionGO:00099682060.013
purine nucleoside triphosphate catabolic processGO:00091461080.013
cellular macromolecule catabolic processGO:00442651360.013
morphogenesis of an epitheliumGO:00020092760.012
cholesterol homeostasisGO:004263230.012
purine containing compound metabolic processGO:00725211550.012
chemosensory behaviorGO:00076351060.012
telencephalon developmentGO:002153720.012
purine nucleotide metabolic processGO:00061631460.012
regulation of alternative mrna splicing via spliceosomeGO:0000381600.012
maintenance of locationGO:0051235730.012
response to nitrogen compoundGO:1901698900.012
cellular amine metabolic processGO:0044106120.012
nucleoside catabolic processGO:00091641120.012
peptidyl threonine modificationGO:001821030.012
positive regulation of hydrolase activityGO:0051345780.012
nucleoside metabolic processGO:00091161270.012
carbohydrate metabolic processGO:0005975820.012
positive regulation of developmental growthGO:0048639620.012
cellular response to nutrient levelsGO:0031669620.012
cellular response to extracellular stimulusGO:0031668640.012
nucleoside phosphate metabolic processGO:00067531620.012
regulation of synapse structure and activityGO:00508031280.012
chorion containing eggshell formationGO:00073041050.012
salivary gland developmentGO:00074311620.012
mitotic spindle organizationGO:00070522200.012
anterior posterior axis specificationGO:00099481090.012
smad protein import into nucleusGO:0007184110.012
histolysisGO:00075591020.012
axis specificationGO:00097981670.011
developmental programmed cell deathGO:00106231380.011
mitotic cell cycle phase transitionGO:00447721380.011
meiotic cell cycleGO:00513211710.011
guanosine containing compound metabolic processGO:1901068740.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092380.011
aminoglycan metabolic processGO:0006022180.011
positive regulation of organelle organizationGO:0010638650.011
actin filament based movementGO:0030048260.011
cellular ketone metabolic processGO:0042180240.011
defense response to gram negative bacteriumGO:0050829940.011
regulation of synapse assemblyGO:0051963940.011
oxoacid metabolic processGO:00434361030.011
positive regulation of cellular catabolic processGO:0031331950.011
regulation of phosphate metabolic processGO:00192202100.011
ribonucleoside metabolic processGO:00091191270.011
ribose phosphate metabolic processGO:00196931450.011
positive regulation of cell migrationGO:003033520.011
dna replicationGO:0006260480.011
establishment of rna localizationGO:0051236470.011
heterocycle catabolic processGO:00467001660.011
carbohydrate derivative biosynthetic processGO:1901137850.011
positive regulation of mapk cascadeGO:0043410630.011
cellular response to lipopolysaccharideGO:007122230.011
negative regulation of translationGO:0017148280.011
signal transduction by phosphorylationGO:00230141070.011
nucleobase containing compound catabolic processGO:00346551650.011
regulation of chromosome organizationGO:0033044640.011
regulation of intracellular transportGO:0032386640.011
negative regulation of cell cycle processGO:00109481090.011
negative regulation of cell communicationGO:00106482230.011
positive regulation of i kappab kinase nf kappab signalingGO:004312310.010
nucleoside triphosphate metabolic processGO:00091411200.010
salivary gland cell autophagic cell deathGO:0035071830.010
digestive system developmentGO:00551231490.010
proteasomal protein catabolic processGO:0010498590.010
mesenchymal cell developmentGO:001403110.010
ribonucleotide catabolic processGO:00092611090.010
positive regulation of growthGO:0045927750.010
regulation of protein localization to nucleusGO:1900180290.010
response to transforming growth factor betaGO:0071559180.010
positive regulation of nucleotide metabolic processGO:0045981550.010
cellular modified amino acid metabolic processGO:0006575450.010
cellular response to biotic stimulusGO:007121640.010
dopamine biosynthetic processGO:004241630.010
positive regulation of multicellular organismal processGO:00512401430.010

eIF-4B disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.047
nervous system diseaseDOID:86300.020
musculoskeletal system diseaseDOID:1700.020
disease of metabolismDOID:001466700.019
central nervous system diseaseDOID:33100.015
neurodegenerative diseaseDOID:128900.013
connective tissue diseaseDOID:6500.012
bone diseaseDOID:008000100.012