IMP: Integrative Multi-species Prediction

Drosophila melanogaster

22 known processes

MP1 (Dmel_CG1102)

Melanization Protease 1

(Aliases: proPO-AE,SP25,BEST:GH02921,CG1102,Dmel\CG1102)

Entrez: 40541
FLYBASE: FBgn0027930
UniProtKB: Q9Y157
UniProtKB: B7Z0T0

Process Predictions
Disease Predictions

MP1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
melanization defense response	GO:0035006	45	0.685
response to fungus	GO:0009620	50	0.564	Fly
peptide metabolic process	GO:0006518	80	0.538	Fly
melanin metabolic process	GO:0006582	47	0.364
defense response	GO:0006952	300	0.361
immune system process	GO:0002376	347	0.350
secondary metabolic process	GO:0019748	75	0.251
pigment metabolic process	GO:0042440	84	0.245
regulation of neuron differentiation	GO:0045664	103	0.234
regulation of immune system process	GO:0002682	176	0.212	Fly
response to external biotic stimulus	GO:0043207	293	0.204	Fly
response to wounding	GO:0009611	94	0.197
positive regulation of biosynthetic process	GO:0009891	316	0.191	Fly
post embryonic appendage morphogenesis	GO:0035120	385	0.185
regulation of multi organism process	GO:0043900	131	0.165	Fly
vesicle mediated transport	GO:0016192	381	0.161	Fly
positive regulation of response to external stimulus	GO:0032103	44	0.157	Fly
negative regulation of developmental process	GO:0051093	201	0.152
response to other organism	GO:0051707	293	0.151	Fly
defense response to fungus	GO:0050832	48	0.146	Fly
regulation of secondary metabolic process	GO:0043455	7	0.143	Fly
response to bacterium	GO:0009617	198	0.137	Fly
regulation of response to stress	GO:0080134	200	0.128	Fly
regulation of cellular component size	GO:0032535	98	0.126
positive regulation of immune system process	GO:0002684	68	0.124	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.122	Fly
appendage morphogenesis	GO:0035107	397	0.119
phenol containing compound metabolic process	GO:0018958	57	0.118
defense response to gram negative bacterium	GO:0050829	94	0.117	Fly
regulation of cell differentiation	GO:0045595	302	0.112
gland development	GO:0048732	191	0.111
regulation of production of molecular mediator of immune response	GO:0002700	44	0.111	Fly
proteolysis	GO:0006508	192	0.106	Fly
dorsal ventral pattern formation	GO:0009953	133	0.099	Fly
endocytosis	GO:0006897	310	0.092	Fly
regulation of cellular amide metabolic process	GO:0034248	39	0.088	Fly
phagocytosis	GO:0006909	215	0.087	Fly
protein processing	GO:0016485	68	0.087	Fly
immune response	GO:0006955	246	0.086
positive regulation of defense response	GO:0031349	59	0.085	Fly
axis specification	GO:0009798	167	0.082	Fly
innate immune response	GO:0045087	144	0.082
positive regulation of immune effector process	GO:0002699	28	0.081	Fly
negative regulation of cellular component organization	GO:0051129	108	0.081
positive regulation of signal transduction	GO:0009967	223	0.080	Fly
protein maturation	GO:0051604	71	0.080	Fly
dna metabolic process	GO:0006259	227	0.079
negative regulation of cellular metabolic process	GO:0031324	382	0.078
imaginal disc derived appendage development	GO:0048737	399	0.078
negative regulation of signaling	GO:0023057	219	0.077
regulation of cell morphogenesis	GO:0022604	163	0.077
negative regulation of gene expression	GO:0010629	387	0.076
positive regulation of cell communication	GO:0010647	250	0.075	Fly
wing disc morphogenesis	GO:0007472	344	0.074
positive regulation of signaling	GO:0023056	243	0.074	Fly
regulation of protein kinase activity	GO:0045859	51	0.074
response to abiotic stimulus	GO:0009628	341	0.073
organic hydroxy compound metabolic process	GO:1901615	83	0.070
response to biotic stimulus	GO:0009607	294	0.069	Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.067
regulation of molecular function	GO:0065009	217	0.066
regulation of kinase activity	GO:0043549	53	0.065
regulation of nervous system development	GO:0051960	248	0.061
regulation of response to wounding	GO:1903034	19	0.060
hormone catabolic process	GO:0042447	3	0.060
regulation of neurogenesis	GO:0050767	158	0.059
regulation of multicellular organismal development	GO:2000026	414	0.059
positive regulation of defense response to bacterium	GO:1900426	23	0.059	Fly
regulation of anatomical structure morphogenesis	GO:0022603	242	0.058
gastrulation	GO:0007369	70	0.057
regulation of cell development	GO:0060284	215	0.056
homeostatic process	GO:0042592	199	0.055
humoral immune response	GO:0006959	117	0.054	Fly
melanotic encapsulation of foreign target	GO:0035011	30	0.053
lipid metabolic process	GO:0006629	121	0.052
single organism behavior	GO:0044708	391	0.051
regulation of protein modification process	GO:0031399	112	0.051
regulation of defense response	GO:0031347	102	0.050	Fly
cellular response to organic substance	GO:0071310	132	0.047
establishment of localization in cell	GO:0051649	402	0.047
wound healing	GO:0042060	75	0.047
regulation of catalytic activity	GO:0050790	185	0.047
growth	GO:0040007	359	0.046
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.045
regulation of cellular protein metabolic process	GO:0032268	243	0.045
negative regulation of protein metabolic process	GO:0051248	85	0.044
positive regulation of response to stimulus	GO:0048584	323	0.043	Fly
cellular amide metabolic process	GO:0043603	80	0.042	Fly
negative regulation of cellular protein metabolic process	GO:0032269	85	0.041
appendage development	GO:0048736	401	0.041
salivary gland histolysis	GO:0035070	88	0.040
cellular response to cadmium ion	GO:0071276	6	0.040
regulation of protein serine threonine kinase activity	GO:0071900	25	0.040
developmental programmed cell death	GO:0010623	138	0.039
neurological system process	GO:0050877	358	0.037
cellular protein modification process	GO:0006464	438	0.036
gliogenesis	GO:0042063	80	0.035
cellular response to lipid	GO:0071396	20	0.034
response to lipopolysaccharide	GO:0032496	4	0.033
regulation of immune response	GO:0050776	118	0.033	Fly
aging	GO:0007568	143	0.033
nurse cell apoptotic process	GO:0045476	17	0.032
regulation of cell size	GO:0008361	63	0.032
actin filament organization	GO:0007015	126	0.031
chemosensory behavior	GO:0007635	106	0.031
regulation of response to external stimulus	GO:0032101	115	0.031	Fly
cellular response to chemical stimulus	GO:0070887	199	0.031
antimicrobial peptide production	GO:0002775	46	0.031	Fly
negative regulation of growth	GO:0045926	84	0.030
small molecule metabolic process	GO:0044281	305	0.030
defense response to gram positive bacterium	GO:0050830	41	0.030	Fly
defense response to bacterium	GO:0042742	178	0.029	Fly
regulation of transferase activity	GO:0051338	58	0.029
organophosphate metabolic process	GO:0019637	195	0.029
dorsal ventral axis specification	GO:0009950	66	0.029	Fly
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.029
negative regulation of multicellular organismal process	GO:0051241	142	0.029
negative regulation of cell development	GO:0010721	62	0.029
pigment biosynthetic process	GO:0046148	36	0.028
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.028
regulation of intracellular signal transduction	GO:1902531	236	0.028
cellular response to abiotic stimulus	GO:0071214	58	0.028
positive regulation of cellular biosynthetic process	GO:0031328	316	0.028	Fly
retina development in camera type eye	GO:0060041	4	0.028
negative regulation of cell communication	GO:0010648	223	0.028
organic substance transport	GO:0071702	257	0.027
activation of mapk activity	GO:0000187	9	0.027
compound eye development	GO:0048749	307	0.027
rhythmic process	GO:0048511	106	0.027
regulation of response to biotic stimulus	GO:0002831	63	0.027	Fly
regulation of growth	GO:0040008	233	0.027
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.027
carbohydrate metabolic process	GO:0005975	82	0.026
reproductive structure development	GO:0048608	74	0.026
organonitrogen compound metabolic process	GO:1901564	318	0.026	Fly
positive regulation of catalytic activity	GO:0043085	118	0.026
embryonic development via the syncytial blastoderm	GO:0001700	148	0.026
positive regulation of immune response	GO:0050778	63	0.026	Fly
regulation of innate immune response	GO:0045088	71	0.025	Fly
regulation of peptidoglycan recognition protein signaling pathway	GO:0061058	4	0.025
regionalization	GO:0003002	416	0.025	Fly
regulation of phosphorus metabolic process	GO:0051174	210	0.024
gene silencing	GO:0016458	138	0.024
regulation of phosphorylation	GO:0042325	147	0.024
cell growth	GO:0016049	108	0.024
response to sterol	GO:0036314	34	0.024
protein modification process	GO:0036211	438	0.023
dorsal appendage formation	GO:0046843	47	0.023
antimicrobial humoral response	GO:0019730	99	0.023	Fly
immune system development	GO:0002520	57	0.023
cellular response to arsenic containing substance	GO:0071243	6	0.022
mating behavior	GO:0007617	106	0.022
cell cell junction assembly	GO:0007043	38	0.022
programmed cell death	GO:0012501	257	0.022
cellular response to lipopolysaccharide	GO:0071222	3	0.022
defense response to other organism	GO:0098542	225	0.021	Fly
cell motility	GO:0048870	251	0.021
negative regulation of protein processing	GO:0010955	31	0.021
negative regulation of response to stimulus	GO:0048585	258	0.021
organelle fission	GO:0048285	340	0.021
glycerolipid metabolic process	GO:0046486	34	0.021
pattern recognition receptor signaling pathway	GO:0002221	2	0.021
cuticle pigmentation	GO:0048067	22	0.021
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
compound eye morphogenesis	GO:0001745	249	0.020
regulation of proteolysis	GO:0030162	87	0.020
regulation of melanization defense response	GO:0035007	6	0.020	Fly
acid secretion	GO:0046717	1	0.020
response to oxygen containing compound	GO:1901700	200	0.020
transcription from rna polymerase ii promoter	GO:0006366	368	0.020
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.020
developmental growth involved in morphogenesis	GO:0060560	65	0.019
regulation of neuron projection development	GO:0010975	69	0.019
peptidoglycan metabolic process	GO:0000270	3	0.019
positive regulation of molecular function	GO:0044093	136	0.019
response to alcohol	GO:0097305	95	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
cell death	GO:0008219	279	0.019
camera type eye development	GO:0043010	4	0.019
regulation of localization	GO:0032879	275	0.019
positive regulation of intracellular signal transduction	GO:1902533	116	0.019
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.019
regulation of protein metabolic process	GO:0051246	256	0.019
androgen metabolic process	GO:0008209	1	0.018
muscle cell differentiation	GO:0042692	103	0.018
secretion	GO:0046903	109	0.018
death	GO:0016265	284	0.018
positive regulation of macromolecule metabolic process	GO:0010604	405	0.018
determination of dorsal ventral asymmetry	GO:0048262	3	0.018
negative regulation of neurogenesis	GO:0050768	53	0.018
small gtpase mediated signal transduction	GO:0007264	88	0.018
regulation of apoptotic process	GO:0042981	130	0.018
regulation of anatomical structure size	GO:0090066	163	0.018
neutral lipid metabolic process	GO:0006638	12	0.018
salivary gland development	GO:0007431	162	0.018
cellular response to endogenous stimulus	GO:0071495	80	0.018
antibacterial humoral response	GO:0019731	44	0.018	Fly
cell projection assembly	GO:0030031	94	0.018
cholesterol transport	GO:0030301	2	0.018
negative regulation of proteolysis	GO:0045861	31	0.018
neurotransmitter catabolic process	GO:0042135	1	0.017
extracellular matrix organization	GO:0030198	32	0.017
forebrain development	GO:0030900	2	0.017
negative regulation of biosynthetic process	GO:0009890	277	0.017
response to organic substance	GO:0010033	284	0.017
cellular response to nitrogen compound	GO:1901699	51	0.017
central nervous system development	GO:0007417	201	0.017
thermotaxis	GO:0043052	16	0.017
response to uv	GO:0009411	24	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
zygotic determination of anterior posterior axis embryo	GO:0007354	27	0.017
protein phosphorylation	GO:0006468	169	0.017
extracellular structure organization	GO:0043062	46	0.017
ras protein signal transduction	GO:0007265	88	0.017
hemolymph coagulation	GO:0042381	10	0.017
histolysis	GO:0007559	102	0.016
positive regulation of antimicrobial humoral response	GO:0002760	28	0.016	Fly
negative regulation of rna biosynthetic process	GO:1902679	240	0.016
regulation of transport	GO:0051049	181	0.016
connective tissue development	GO:0061448	3	0.016
benzene containing compound metabolic process	GO:0042537	3	0.016
regulation of protein processing	GO:0070613	32	0.016
regeneration	GO:0031099	16	0.016
anatomical structure homeostasis	GO:0060249	97	0.016
regulation of protein phosphorylation	GO:0001932	64	0.016
ovarian follicle cell development	GO:0030707	248	0.016
salivary gland morphogenesis	GO:0007435	145	0.016
blastoderm segmentation	GO:0007350	159	0.016
positive regulation of production of molecular mediator of immune response	GO:0002702	28	0.016	Fly
regulation of antimicrobial peptide production	GO:0002784	44	0.016	Fly
extracellular matrix disassembly	GO:0022617	4	0.015
tissue morphogenesis	GO:0048729	297	0.015
positive regulation of multi organism process	GO:0043902	40	0.015	Fly
positive regulation of transcription dna templated	GO:0045893	266	0.015
regulation of cell cycle process	GO:0010564	181	0.015
amide biosynthetic process	GO:0043604	42	0.015	Fly
single organism carbohydrate metabolic process	GO:0044723	72	0.015
ovarian follicle cell migration	GO:0007297	121	0.015
chitin based cuticle sclerotization	GO:0007593	19	0.015
endomembrane system organization	GO:0010256	119	0.015
organonitrogen compound biosynthetic process	GO:1901566	117	0.015	Fly
regulation of cell cycle	GO:0051726	291	0.015
cellular amine metabolic process	GO:0044106	12	0.015
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.015	Fly
ion transport	GO:0006811	145	0.015
eggshell formation	GO:0030703	105	0.015
regulation of gene expression epigenetic	GO:0040029	128	0.015
regulation of mitotic cell cycle	GO:0007346	190	0.015
intracellular signal transduction	GO:0035556	300	0.014
negative regulation of transcription dna templated	GO:0045892	237	0.014
negative regulation of defense response	GO:0031348	35	0.014
positive regulation of response to biotic stimulus	GO:0002833	31	0.014	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.014
positive regulation of protein kinase activity	GO:0045860	25	0.014
regulation of cellular ketone metabolic process	GO:0010565	3	0.014
positive regulation of antifungal peptide biosynthetic process	GO:0006967	5	0.014
regulation of cell substrate adhesion	GO:0010810	2	0.014
regulation of mapk cascade	GO:0043408	92	0.014
signal transduction by phosphorylation	GO:0023014	107	0.013
regulation of nuclear division	GO:0051783	58	0.013
immune response regulating signaling pathway	GO:0002764	2	0.013
cellular response to peptide hormone stimulus	GO:0071375	28	0.013
fatty acid homeostasis	GO:0055089	2	0.013
epiboly involved in wound healing	GO:0090505	2	0.013
apoptotic process	GO:0006915	159	0.013
regulation of cellular component biogenesis	GO:0044087	201	0.013
regulation of insulin receptor signaling pathway	GO:0046626	17	0.013
mesoderm development	GO:0007498	78	0.013
cellular amino acid metabolic process	GO:0006520	61	0.013
amine metabolic process	GO:0009308	12	0.013
jak stat cascade	GO:0007259	49	0.013
response to temperature stimulus	GO:0009266	106	0.013
eye development	GO:0001654	323	0.013
imaginal disc derived wing vein morphogenesis	GO:0008586	44	0.013
mitotic spindle organization	GO:0007052	220	0.013
exocrine system development	GO:0035272	162	0.013
epithelial cell development	GO:0002064	274	0.013
catabolic process	GO:0009056	409	0.013
cellular response to oxygen containing compound	GO:1901701	79	0.013
nuclear dna replication	GO:0033260	1	0.013
cellular response to biotic stimulus	GO:0071216	4	0.013
organelle localization	GO:0051640	148	0.013
cellular lipid metabolic process	GO:0044255	83	0.013
regulation of secretion	GO:0051046	44	0.013
negative regulation of cellular biosynthetic process	GO:0031327	277	0.013
neural retina development	GO:0003407	4	0.012
dendrite development	GO:0016358	204	0.012
organic acid metabolic process	GO:0006082	103	0.012
regulation of phosphate metabolic process	GO:0019220	210	0.012
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	20	0.012	Fly
regulation of notch signaling pathway	GO:0008593	100	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
localization of cell	GO:0051674	257	0.012
spindle organization	GO:0007051	253	0.012
negative regulation of chromosome organization	GO:2001251	19	0.012
rrna processing	GO:0006364	3	0.012
compound eye photoreceptor cell differentiation	GO:0001751	140	0.012
hematopoietic or lymphoid organ development	GO:0048534	57	0.012
negative regulation of protein maturation	GO:1903318	31	0.012
biological adhesion	GO:0022610	138	0.012
regulation of cell proliferation	GO:0042127	163	0.012
regulation of humoral immune response	GO:0002920	51	0.011	Fly
regulation of developmental growth	GO:0048638	174	0.011
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002813	14	0.011	Fly
basement membrane organization	GO:0071711	10	0.011
cation transport	GO:0006812	110	0.011
cell migration	GO:0016477	238	0.011
regulation of cell division	GO:0051302	72	0.011
positive regulation of protein metabolic process	GO:0051247	128	0.011
epiboly	GO:0090504	2	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011
metal ion transport	GO:0030001	74	0.011
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.011
regulation of cell projection organization	GO:0031344	92	0.011
positive regulation of rna biosynthetic process	GO:1902680	266	0.011
cellular response to molecule of bacterial origin	GO:0071219	3	0.011
olfactory behavior	GO:0042048	97	0.011
regulation of immune effector process	GO:0002697	52	0.011	Fly
cell adhesion	GO:0007155	136	0.011
regulation of cellular amine metabolic process	GO:0033238	3	0.011
posttranscriptional regulation of gene expression	GO:0010608	145	0.011
body morphogenesis	GO:0010171	2	0.011
golgi organization	GO:0007030	66	0.011
negative regulation of nervous system development	GO:0051961	92	0.011
development of primary sexual characteristics	GO:0045137	50	0.011
immune effector process	GO:0002252	98	0.011	Fly
taxis	GO:0042330	304	0.011
triglyceride biosynthetic process	GO:0019432	2	0.011
regulation of map kinase activity	GO:0043405	17	0.011
regulation of bmp signaling pathway	GO:0030510	23	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
chorion containing eggshell formation	GO:0007304	105	0.011
lipid modification	GO:0030258	24	0.011
carbohydrate derivative metabolic process	GO:1901135	217	0.011
positive regulation of innate immune response	GO:0045089	38	0.010	Fly
mesodermal cell differentiation	GO:0048333	7	0.010
chromosome segregation	GO:0007059	157	0.010
actin filament based process	GO:0030029	220	0.010
trachea development	GO:0060438	29	0.010

MP1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.020
cardiovascular system disease	DOID:1287	0.016
congenital heart disease	DOID:1682	0.016
heart disease	DOID:114	0.016

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