Drosophila melanogaster

53 known processes

Trh (Dmel_CG9122)

Tryptophan hydroxylase

(Aliases: Dmel\CG9122,CG9122,DTRH,TRH,CT9937)

Trh biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
single organism behaviorGO:00447083910.998
male courtship behaviorGO:0008049630.944
Fly
g protein coupled receptor signaling pathwayGO:00071861360.890
response to ethanolGO:0045471590.865
sensory perceptionGO:00076001960.814
regulation of reproductive processGO:2000241540.736
Worm
olfactory behaviorGO:0042048970.736
multi multicellular organism processGO:00447061230.680
Worm Fly
tube morphogenesisGO:00352391910.661
chemosensory behaviorGO:00076351060.616
positive regulation of behaviorGO:0048520190.594
gliogenesisGO:0042063800.592
embryonic morphogenesisGO:00485982060.557
response to organic substanceGO:00100332840.553
Worm
rhythmic processGO:00485111060.543
open tracheal system developmentGO:00074242040.521
Fly
negative regulation of cell communicationGO:00106482230.493
multi organism reproductive behaviorGO:00447051210.472
Worm Fly
multi organism behaviorGO:00517051750.463
Worm Fly
circadian rhythmGO:00076231050.449
feeding behaviorGO:0007631500.436
Worm
negative regulation of signal transductionGO:00099682060.397
male mating behaviorGO:0060179700.356
Fly
head developmentGO:00603221350.351
immune responseGO:00069552460.347
axis specificationGO:00097981670.335
central nervous system developmentGO:00074172010.334
negative regulation of signalingGO:00230572190.334
behavioral response to ethanolGO:0048149490.322
positive regulation of signal transductionGO:00099672230.288
Worm
secretion by cellGO:00329401010.271
tissue migrationGO:00901301550.266
Fly
embryonic development via the syncytial blastodermGO:00017001480.261
adult behaviorGO:00305341370.257
Fly
regulation of tube architecture open tracheal systemGO:0035152680.257
brain developmentGO:00074201200.252
response to endogenous stimulusGO:00097191190.248
Worm
negative regulation of nucleic acid templated transcriptionGO:19035072400.247
positive regulation of nucleic acid templated transcriptionGO:19035082660.238
malpighian tubule morphogenesisGO:0007443440.234
dendrite morphogenesisGO:00488131990.224
negative regulation of rna metabolic processGO:00512532510.222
enzyme linked receptor protein signaling pathwayGO:00071671790.220
Worm
regulation of tube sizeGO:0035150460.216
regulation of cellular protein metabolic processGO:00322682430.213
defense responseGO:00069523000.212
cell motilityGO:00488702510.210
Fly
hindgut morphogenesisGO:0007442580.203
negative regulation of gene expressionGO:00106293870.201
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.200
phenol containing compound metabolic processGO:0018958570.198
negative regulation of nitrogen compound metabolic processGO:00511722650.198
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.190
cell migrationGO:00164772380.187
Fly
positive regulation of biosynthetic processGO:00098913160.187
positive regulation of rna metabolic processGO:00512542710.183
negative regulation of nucleobase containing compound metabolic processGO:00459342610.182
respiratory system developmentGO:00605412130.177
Fly
wnt signaling pathwayGO:0016055980.171
response to alcoholGO:0097305950.169
regulation of tube length open tracheal systemGO:0035159240.166
regulation of phosphorus metabolic processGO:00511742100.162
phosphorylationGO:00163102940.154
negative regulation of transcription dna templatedGO:00458922370.154
regulation of epithelial cell proliferationGO:005067840.153
regulation of protein metabolic processGO:00512462560.153
regulation of muscle organ developmentGO:0048634130.148
regulation of response to nutrient levelsGO:0032107180.141
negative regulation of cell proliferationGO:0008285690.141
regulation of transcription from rna polymerase ii promoterGO:00063573780.135
sensory perception of chemical stimulusGO:00076061160.131
regulation of behaviorGO:0050795750.131
positive regulation of response to stimulusGO:00485843230.128
Worm
positive regulation of rna biosynthetic processGO:19026802660.124
regulation of cell developmentGO:00602842150.122
sensory perception of smellGO:0007608800.120
negative regulation of response to stimulusGO:00485852580.119
organophosphate metabolic processGO:00196371950.115
larval feeding behaviorGO:0030536150.115
regulation of canonical wnt signaling pathwayGO:0060828150.114
peptidyl amino acid modificationGO:00181931050.113
positive regulation of macromolecule biosynthetic processGO:00105572830.112
regionalizationGO:00030024160.112
multicellular organismal agingGO:00102591400.111
Worm
regulation of phosphate metabolic processGO:00192202100.110
developmental maturationGO:00217001720.109
Fly
regulation of cellular amine metabolic processGO:003323830.107
single organismal cell cell adhesionGO:0016337450.107
response to organonitrogen compoundGO:0010243750.105
cellular amino acid metabolic processGO:0006520610.104
Worm
regulation of immune system processGO:00026821760.102
response to other organismGO:00517072930.102
cell junction assemblyGO:0034329420.102
positive regulation of macromolecule metabolic processGO:00106044050.101
mesodermal cell fate specificationGO:000750120.100
cellular response to organic substanceGO:00713101320.100
Worm
anterior posterior pattern specificationGO:00099521360.100
cellular amine metabolic processGO:0044106120.097
Worm
embryonic hindgut morphogenesisGO:0048619480.095
negative regulation of fibroblast growth factor receptor signaling pathwayGO:004003720.095
regulation of cell deathGO:00109411730.094
embryo development ending in birth or egg hatchingGO:00097921520.094
Worm
regulation of anatomical structure sizeGO:00900661630.091
canonical wnt signaling pathwayGO:0060070210.089
cellular protein modification processGO:00064644380.088
embryonic axis specificationGO:00005781070.087
localization of cellGO:00516742570.086
Fly
digestive system developmentGO:00551231490.086
negative regulation of macromolecule biosynthetic processGO:00105582700.085
digestive tract morphogenesisGO:00485461270.085
dorsal trunk growth open tracheal systemGO:003500170.085
protein modification processGO:00362114380.084
molting cycle chitin based cuticleGO:0007591560.084
Fly
regulation of protein kinase activityGO:0045859510.083
regulation of cellular component movementGO:0051270420.082
Fly
urogenital system developmentGO:0001655720.082
regulation of immune responseGO:00507761180.080
regulation of locomotionGO:0040012420.079
Fly
regulation of cell cell adhesionGO:0022407210.079
regulation of localizationGO:00328792750.078
Fly
intracellular signal transductionGO:00355563000.077
morphogenesis of an epitheliumGO:00020092760.077
regulation of defense responseGO:00313471020.074
negative regulation of epithelial cell proliferationGO:005068040.074
formation of primary germ layerGO:0001704240.073
regulation of cell morphogenesis involved in differentiationGO:0010769610.073
positive regulation of cell communicationGO:00106472500.073
Worm
single organism intracellular transportGO:19025822070.073
intracellular receptor signaling pathwayGO:0030522190.073
negative regulation of cellular metabolic processGO:00313243820.073
regulation of organelle organizationGO:00330431960.070
regulation of innate immune responseGO:0045088710.070
protein transportGO:00150311550.066
innate immune responseGO:00450871440.066
epithelium migrationGO:00901321480.066
Fly
positive regulation of protein metabolic processGO:00512471280.066
cell deathGO:00082192790.066
positive regulation of cellular biosynthetic processGO:00313283160.065
regulation of tube diameter open tracheal systemGO:0035158110.064
positive regulation of gene expressionGO:00106282900.064
deathGO:00162652840.064
forebrain developmentGO:003090020.063
regulation of cellular localizationGO:00603411360.062
protein catabolic processGO:00301631010.062
regulation of multicellular organismal developmentGO:20000264140.062
Fly
proteolysisGO:00065081920.062
response to abiotic stimulusGO:00096283410.061
Fly
positive regulation of cell proliferationGO:0008284470.061
cellular response to chemical stimulusGO:00708871990.061
Worm
establishment of localization in cellGO:00516494020.061
segmentationGO:00352822070.060
regulation of wnt signaling pathwayGO:0030111680.060
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.059
carbohydrate derivative biosynthetic processGO:1901137850.058
positive regulation of multicellular organismal processGO:00512401430.058
matingGO:00076181200.058
Fly
regulation of cell proliferationGO:00421271630.057
regulation of molecular functionGO:00650092170.057
extracellular matrix disassemblyGO:002261740.057
negative regulation of phosphorus metabolic processGO:0010563450.056
response to external biotic stimulusGO:00432072930.056
cell maturationGO:00484691440.055
tracheal outgrowth open tracheal systemGO:0007426180.055
taxisGO:00423303040.055
Fly
spermatogenesisGO:00072832000.053
male gamete generationGO:00482322010.053
response to organic cyclic compoundGO:0014070890.052
larval behaviorGO:0030537420.052
negative regulation of cellular biosynthetic processGO:00313272770.052
amine metabolic processGO:0009308120.050
Worm
growthGO:00400073590.050
response to oxygen containing compoundGO:19017002000.050
digestive tract developmentGO:00485651490.049
positive regulation of signalingGO:00230562430.049
Worm
organic substance catabolic processGO:19015753080.049
regulation of intracellular signal transductionGO:19025312360.049
embryonic pattern specificationGO:00098801740.048
macromolecule catabolic processGO:00090571610.048
positive regulation of nucleobase containing compound metabolic processGO:00459353320.048
transcription from rna polymerase ii promoterGO:00063663680.047
cell fate commitment involved in formation of primary germ layerGO:0060795100.046
organic acid metabolic processGO:00060821030.046
Worm
protein phosphorylationGO:00064681690.046
response to lipidGO:0033993380.046
locomotory behaviorGO:00076261760.045
Fly
cellular response to endogenous stimulusGO:0071495800.045
Worm
regulation of phosphorylationGO:00423251470.045
extracellular structure organizationGO:0043062460.044
neuroblast proliferationGO:0007405740.044
positive regulation of growthGO:0045927750.044
epithelial cell migrationGO:00106311480.042
Fly
developmental growth involved in morphogenesisGO:0060560650.042
anterior posterior axis specification embryoGO:00085951030.042
positive regulation of cell motilityGO:200014730.042
regulation of response to external stimulusGO:00321011150.041
renal tubule morphogenesisGO:0061333440.041
organic substance transportGO:00717022570.041
neurological system processGO:00508773580.041
oxoacid metabolic processGO:00434361030.041
Worm
appendage morphogenesisGO:00351073970.040
regulation of epithelial cell migration open tracheal systemGO:2000274110.040
Fly
mesoderm morphogenesisGO:0048332220.040
mesoderm formationGO:0001707210.039
positive regulation of developmental growthGO:0048639620.039
imaginal disc derived appendage developmentGO:00487373990.039
glial cell differentiationGO:0010001350.038
regulation of cell differentiationGO:00455953020.038
Mouse
synapse assemblyGO:00074161430.038
single organism cell adhesionGO:0098602470.037
tripartite regional subdivisionGO:00073511030.037
regulation of tube size open tracheal systemGO:0035151430.037
negative regulation of apoptotic processGO:0043066630.037
post embryonic appendage morphogenesisGO:00351203850.036
establishment or maintenance of cell polarityGO:00071631670.036
negative regulation of multicellular organismal processGO:00512411420.036
positive regulation of phosphorus metabolic processGO:00105621390.036
epithelial cell migration open tracheal systemGO:0007427320.036
Fly
regulation of organ morphogenesisGO:2000027780.036
cell cell junction assemblyGO:0007043380.035
regulation of growthGO:00400082330.034
multicellular organismal reproductive behaviorGO:00330571100.034
Worm Fly
morphogenesis of embryonic epitheliumGO:0016331940.034
regulation of transferase activityGO:0051338580.034
extrinsic apoptotic signaling pathwayGO:009719110.034
response to biotic stimulusGO:00096072940.034
regulation of cellular component biogenesisGO:00440872010.033
response to woundingGO:0009611940.033
Fly
regulation of response to stressGO:00801342000.032
glandular epithelial cell differentiationGO:000206710.032
multicellular organism growthGO:0035264460.032
positive regulation of developmental processGO:00510941430.032
Mouse
muscle organ developmentGO:00075171270.032
imaginal disc derived appendage morphogenesisGO:00351143950.032
regulation of protein modification processGO:00313991120.032
cell migration involved in gastrulationGO:004207490.031
regulation of response to extracellular stimulusGO:0032104180.031
cell cell junction organizationGO:0045216550.031
immune response regulating signaling pathwayGO:000276420.031
catabolic processGO:00090564090.031
response to drugGO:0042493170.031
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.031
intracellular transportGO:00469072280.030
cellular ketone metabolic processGO:0042180240.030
positive regulation of immune responseGO:0050778630.030
branching involved in open tracheal system developmentGO:0060446450.030
positive regulation of immune system processGO:0002684680.030
cell proliferationGO:00082832990.029
regulation of tube diameterGO:0035296140.029
branching morphogenesis of an epithelial tubeGO:0048754450.028
neuroblast divisionGO:0055057350.028
regulation of nucleocytoplasmic transportGO:0046822350.028
negative regulation of cell deathGO:0060548810.027
organ growthGO:0035265560.027
response to nitrogen compoundGO:1901698900.027
cell junction organizationGO:0034330570.027
regulation of catalytic activityGO:00507901850.027
regulation of cellular amino acid metabolic processGO:000652100.026
cell fate specificationGO:0001708710.026
cytoplasmic transportGO:00164821300.026
programmed cell deathGO:00125012570.025
developmental growthGO:00485892800.025
salivary gland developmentGO:00074311620.025
regulation of programmed cell deathGO:00430671520.025
r7 cell differentiationGO:0045466430.025
mitotic nuclear divisionGO:00070672130.024
tube developmentGO:00352952440.024
regulation of cell morphogenesisGO:00226041630.024
positive regulation of defense responseGO:0031349590.024
telencephalon developmentGO:002153720.024
ribosomal large subunit biogenesisGO:004227310.024
blastoderm segmentationGO:00073501590.023
adult locomotory behaviorGO:0008344760.023
Fly
negative regulation of protein metabolic processGO:0051248850.023
regulation of protein transportGO:0051223570.023
single organism carbohydrate metabolic processGO:0044723720.023
establishment of protein localizationGO:00451841630.023
nucleocytoplasmic transportGO:0006913720.023
wing disc morphogenesisGO:00074723440.023
negative regulation of molecular functionGO:0044092510.022
foregut morphogenesisGO:0007440100.022
positive regulation of nitrogen compound metabolic processGO:00511733540.022
intercellular transportGO:001049620.021
regulation of nervous system developmentGO:00519602480.021
negative regulation of phosphate metabolic processGO:0045936450.021
organic hydroxy compound biosynthetic processGO:1901617210.021
negative regulation of cellular protein metabolic processGO:0032269850.021
imaginal disc derived wing morphogenesisGO:00074763370.021
regulation of protein localizationGO:0032880760.021
neuromuscular junction developmentGO:00075281490.020
protein localizationGO:00081042840.020
cell divisionGO:00513012480.020
sex differentiationGO:0007548810.020
regulation of multi organism processGO:00439001310.020
Worm
stem cell developmentGO:0048864790.020
endoderm formationGO:000170630.020
regulation of synaptic growth at neuromuscular junctionGO:0008582890.020
regulation of phosphatase activityGO:001092130.020
regulation of cellular ketone metabolic processGO:001056530.020
single organism biosynthetic processGO:00447112060.020
Worm
lateral inhibitionGO:00463312060.020
secondary branching open tracheal systemGO:000742920.020
cranial nerve developmentGO:002154510.020
appendage developmentGO:00487364010.020
regulation of embryonic developmentGO:0045995680.019
regulation of cell cycle processGO:00105641810.019
nucleotide metabolic processGO:00091171610.019
compound eye morphogenesisGO:00017452490.019
rhythmic behaviorGO:0007622760.019
negative regulation of rna biosynthetic processGO:19026792400.019
negative regulation of intracellular signal transductionGO:1902532570.019
stem cell maintenanceGO:0019827670.018
gland developmentGO:00487321910.018
Mouse
positive regulation of phosphorylationGO:0042327870.018
dendrite developmentGO:00163582040.018
positive regulation of nervous system developmentGO:0051962690.018
primary branching open tracheal systemGO:000742860.018
neuromuscular processGO:0050905210.018
detection of stimulus involved in sensory perceptionGO:0050906920.018
anterior posterior axis specificationGO:00099481090.018
cellular macromolecule catabolic processGO:00442651360.018
endocytosisGO:00068973100.017
mesoderm developmentGO:0007498780.017
negative regulation of cyclic nucleotide metabolic processGO:003080030.017
regulation of kinase activityGO:0043549530.017
cellular response to hormone stimulusGO:0032870440.017
regulation of hydrolase activityGO:0051336970.017
tissue morphogenesisGO:00487292970.017
defense response to bacteriumGO:00427421780.017
nuclear transportGO:0051169720.017
renal tubule developmentGO:0061326640.017
carbohydrate metabolic processGO:0005975820.017
response to extracellular stimulusGO:00099911160.017
negative regulation of cell cell adhesionGO:002240880.017
regulation of cell migrationGO:0030334220.017
Fly
maintenance of locationGO:0051235730.016
Worm
oocyte developmentGO:00485991240.016
carbohydrate derivative metabolic processGO:19011352170.016
nitrogen compound transportGO:0071705850.016
positive regulation of feeding behaviorGO:200025380.016
protein modification by small protein conjugation or removalGO:00706471060.016
response to nutrient levelsGO:00316671140.016
regulation of proteolysisGO:0030162870.016
regulation of establishment of protein localizationGO:0070201610.016
regulation of cell adhesionGO:0030155270.016
internal peptidyl lysine acetylationGO:0018393380.016
positive regulation of canonical wnt signaling pathwayGO:009026370.016
mesenchymal cell differentiationGO:004876210.016
negative regulation of developmental processGO:00510932010.016
apoptotic processGO:00069151590.016
secretionGO:00469031090.016
regulation of organ growthGO:0046620420.015
single organism nuclear importGO:1902593510.015
courtship behaviorGO:0007619680.015
Fly
glial cell migrationGO:0008347310.015
renal system developmentGO:0072001720.015
imaginal disc growthGO:0007446370.015
chromosome organizationGO:00512763600.015
positive regulation of cellular component biogenesisGO:0044089800.015
mapk cascadeGO:00001651070.015
salivary gland cell autophagic cell deathGO:0035071830.015
cellular response to oxygen containing compoundGO:1901701790.015
muscle system processGO:0003012210.014
immune system processGO:00023763470.014
hindgut developmentGO:0061525580.014
mushroom body developmentGO:0016319700.014
sensory organ morphogenesisGO:00905962600.014
protein ubiquitinationGO:0016567700.014
phagocytosisGO:00069092150.014
nucleoside phosphate metabolic processGO:00067531620.014
body morphogenesisGO:001017120.013
salivary gland histolysisGO:0035070880.013
muscle structure developmentGO:00610612240.013
positive regulation of multicellular organism growthGO:0040018210.013
regulation of membrane depolarizationGO:000325410.013
negative regulation of proteolysisGO:0045861310.013
cellular response to decreased oxygen levelsGO:0036294300.013
branch fusion open tracheal systemGO:0035147170.013
positive regulation of intracellular signal transductionGO:19025331160.013
nucleobase containing small molecule metabolic processGO:00550861740.013
cellular catabolic processGO:00442483720.013
response to axon injuryGO:0048678120.013
camera type eye developmentGO:004301040.013
regulation of camp biosynthetic processGO:0030817120.012
chitin based cuticle developmentGO:0040003490.012
regulation of cell cycleGO:00517262910.012
organonitrogen compound biosynthetic processGO:19015661170.012
positive regulation of molecular functionGO:00440931360.012
positive regulation of transportGO:0051050920.012
posttranscriptional regulation of gene expressionGO:00106081450.012
gland morphogenesisGO:00226121450.012
smoothened signaling pathwayGO:0007224490.012
regulation of apoptotic processGO:00429811300.012
stem cell divisionGO:0017145690.012
reproductive system developmentGO:0061458740.012
regulation of i kappab kinase nf kappab signalingGO:004312220.012
regulation of malpighian tubule diameterGO:003529730.012
circadian behaviorGO:0048512760.012
head involutionGO:0008258350.012
regulation of compound eye cone cell fate specificationGO:004268240.012
memoryGO:0007613940.011
response to bacteriumGO:00096171980.011
epithelial cell proliferationGO:0050673150.011
cellular protein catabolic processGO:0044257830.011
cellular response to organic cyclic compoundGO:0071407320.011
positive regulation of protein modification processGO:0031401580.011
endodermal cell differentiationGO:003598730.011
regulation of neuron deathGO:1901214260.011
reproductive behaviorGO:00190981220.011
Worm Fly
positive regulation of transcription dna templatedGO:00458932660.011
extracellular matrix organizationGO:0030198320.011
regulation of protein phosphorylationGO:0001932640.011
hindbrain developmentGO:003090220.011
negative regulation of catalytic activityGO:0043086420.011
instar larval developmentGO:0002168550.011
regulation of transportGO:00510491810.011
positive regulation of neurotransmitter transportGO:005159020.011
morphogenesis of follicular epitheliumGO:0016333360.011
regulation of developmental growthGO:00486381740.011
morphogenesis of a branching epitheliumGO:0061138450.010
long term memoryGO:0007616620.010
protein secretionGO:0009306450.010
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.010
dorsal ventral pattern formationGO:00099531330.010
defense response to gram negative bacteriumGO:0050829940.010
cellular macromolecule localizationGO:00707272200.010

Trh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.030
cancerDOID:16200.030
organ system cancerDOID:005068600.030
bone development diseaseDOID:008000600.029
disease of anatomical entityDOID:700.029
connective tissue diseaseDOID:6500.029
bone diseaseDOID:008000100.029
musculoskeletal system diseaseDOID:1700.029