IMP: Integrative Multi-species Prediction

Drosophila melanogaster

82 known processes

snRNP-U1-70K (Dmel_CG8749)

small ribonucleoprotein particle U1 subunit 70K

(Aliases: U170K,snRNP70K,U1 70K snRNP,U1snRNP-70K,U1 70k,Dm70K,U1 snRNP,U1 70K,U1-70K,snRNP27D,dU1-70K,l(2)02107,70K,snRNP,CG8749,U1-70k,Dmel\CG8749)

Entrez: 33982
FLYBASE: FBgn0016978
UniProtKB: M9PC89
UniProtKB: P17133

Process Predictions
Disease Predictions

snRNP-U1-70K biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mrna processing	GO:0006397	104	0.581
rna splicing via transesterification reactions with bulged adenosine as nucleophile	GO:0000377	73	0.432
rna splicing via transesterification reactions	GO:0000375	73	0.390
regulation of meiosis	GO:0040020	3	0.382
rna splicing	GO:0008380	83	0.361
larval development	GO:0002164	104	0.339	Worm
regulation of mrna splicing via spliceosome	GO:0048024	64	0.241
developmental growth	GO:0048589	280	0.231
rna processing	GO:0006396	147	0.197
localization of cell	GO:0051674	257	0.191
embryo development ending in birth or egg hatching	GO:0009792	152	0.191	Worm
cytoskeleton dependent cytokinesis	GO:0061640	81	0.176
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.153
regulation of growth	GO:0040008	233	0.152
intracellular signal transduction	GO:0035556	300	0.146
regulation of cellular component biogenesis	GO:0044087	201	0.145
positive regulation of gene expression	GO:0010628	290	0.144	Mouse
positive regulation of signaling	GO:0023056	243	0.143
regulation of cell cycle process	GO:0010564	181	0.137
mrna splicing via spliceosome	GO:0000398	73	0.125
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.124
body morphogenesis	GO:0010171	2	0.117
negative regulation of cellular metabolic process	GO:0031324	382	0.114
multicellular organism growth	GO:0035264	46	0.112
cell death	GO:0008219	279	0.110
protein localization	GO:0008104	284	0.109
nuclear division	GO:0000280	332	0.107
positive regulation of response to stimulus	GO:0048584	323	0.106
negative regulation of rna metabolic process	GO:0051253	251	0.105
regulation of developmental growth	GO:0048638	174	0.105
organelle fission	GO:0048285	340	0.099
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.095
mitotic g2 m transition checkpoint	GO:0044818	70	0.094
regulation of rna splicing	GO:0043484	69	0.093
photoreceptor cell differentiation	GO:0046530	170	0.093
reproductive system development	GO:0061458	74	0.091	Worm
positive regulation of cell communication	GO:0010647	250	0.087
endocytosis	GO:0006897	310	0.086
protein complex biogenesis	GO:0070271	201	0.085
mitotic nuclear division	GO:0007067	213	0.084
development of primary sexual characteristics	GO:0045137	50	0.082	Worm
cell division	GO:0051301	248	0.081
determination of adult lifespan	GO:0008340	137	0.081
alternative mrna splicing via spliceosome	GO:0000380	60	0.079
cell migration	GO:0016477	238	0.077
mitotic cell cycle phase transition	GO:0044772	138	0.077
growth	GO:0040007	359	0.077
positive regulation of rna metabolic process	GO:0051254	271	0.075	Mouse
dephosphorylation	GO:0016311	51	0.073
regulation of phosphate metabolic process	GO:0019220	210	0.071
positive regulation of signal transduction	GO:0009967	223	0.067
regulation of intracellular signal transduction	GO:1902531	236	0.065
immune system process	GO:0002376	347	0.064
death	GO:0016265	284	0.062
aging	GO:0007568	143	0.061
mrna metabolic process	GO:0016071	124	0.061
positive regulation of intracellular signal transduction	GO:1902533	116	0.060
mitotic cytokinesis	GO:0000281	50	0.060
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.060
regulation of mrna processing	GO:0050684	71	0.058
regulation of protein complex disassembly	GO:0043244	29	0.056
protein modification process	GO:0036211	438	0.054
phosphorylation	GO:0016310	294	0.053
mitotic spindle organization	GO:0007052	220	0.053
regulation of phosphorus metabolic process	GO:0051174	210	0.053
posttranscriptional regulation of gene expression	GO:0010608	145	0.053
actin filament based process	GO:0030029	220	0.052
negative regulation of cellular component organization	GO:0051129	108	0.052
regulation of phosphorylation	GO:0042325	147	0.048
histone h2a acetylation	GO:0043968	1	0.048
regulation of cell cycle	GO:0051726	291	0.047
regulation of mrna metabolic process	GO:1903311	72	0.047
embryonic morphogenesis	GO:0048598	206	0.047
regulation of multicellular organismal development	GO:2000026	414	0.047
negative regulation of developmental process	GO:0051093	201	0.046
imaginal disc derived wing morphogenesis	GO:0007476	337	0.046
cellular response to dna damage stimulus	GO:0006974	223	0.046
cell cycle g1 s phase transition	GO:0044843	31	0.045
positive regulation of transcription dna templated	GO:0045893	266	0.045
sex differentiation	GO:0007548	81	0.044	Worm
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.044
establishment of organelle localization	GO:0051656	122	0.044
modification dependent macromolecule catabolic process	GO:0043632	79	0.042
cell cycle phase transition	GO:0044770	140	0.042
macromolecule catabolic process	GO:0009057	161	0.041
vesicle mediated transport	GO:0016192	381	0.041
dna templated transcription elongation	GO:0006354	18	0.041
regulation of cell division	GO:0051302	72	0.040
molting cycle	GO:0042303	56	0.040
positive regulation of rna biosynthetic process	GO:1902680	266	0.040
spindle organization	GO:0007051	253	0.039
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.039
nucleosome organization	GO:0034728	59	0.039
multi multicellular organism process	GO:0044706	123	0.039
cellular protein localization	GO:0034613	160	0.039
regulation of protein transport	GO:0051223	57	0.039
multi organism reproductive behavior	GO:0044705	121	0.038
axon development	GO:0061564	297	0.038
regulation of nuclear division	GO:0051783	58	0.038
regulation of molecular function	GO:0065009	217	0.038
multicellular organismal reproductive behavior	GO:0033057	110	0.038
positive regulation of developmental process	GO:0051094	143	0.038
cellular component assembly involved in morphogenesis	GO:0010927	151	0.038
negative regulation of response to stimulus	GO:0048585	258	0.037
protein complex assembly	GO:0006461	200	0.037
striated muscle myosin thick filament assembly	GO:0071688	3	0.037
mrna catabolic process	GO:0006402	33	0.036
protein transport	GO:0015031	155	0.036
organic substance catabolic process	GO:1901575	308	0.036
regulation of multi organism process	GO:0043900	131	0.036
regulation of cellular protein metabolic process	GO:0032268	243	0.035
transcription from rna polymerase ii promoter	GO:0006366	368	0.035
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.035
muscle structure development	GO:0061061	224	0.035
regulation of meiotic cell cycle	GO:0051445	9	0.035
snrna processing	GO:0016180	14	0.034
posttranscriptional gene silencing by rna	GO:0035194	45	0.034
positive regulation of cellular component biogenesis	GO:0044089	80	0.034
negative regulation of cell cycle process	GO:0010948	109	0.034
programmed cell death	GO:0012501	257	0.033
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.033
compound eye photoreceptor cell differentiation	GO:0001751	140	0.033
cellular protein complex assembly	GO:0043623	71	0.033
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.033
sister chromatid segregation	GO:0000819	92	0.033
regulation of cell death	GO:0010941	173	0.033
morphogenesis of an epithelium	GO:0002009	276	0.033
digestive system development	GO:0055123	149	0.031
cell motility	GO:0048870	251	0.031
muscle cell development	GO:0055001	50	0.031
rna catabolic process	GO:0006401	37	0.031
protein ubiquitination	GO:0016567	70	0.030
mrna splice site selection	GO:0006376	1	0.030
regulation of translation	GO:0006417	56	0.029
positive regulation of phosphorus metabolic process	GO:0010562	139	0.029
rna 3 end processing	GO:0031123	45	0.029
tissue morphogenesis	GO:0048729	297	0.029
regulation of cell differentiation	GO:0045595	302	0.028
regulation of cellular localization	GO:0060341	136	0.028
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.028
spindle assembly	GO:0051225	80	0.028
cellular nitrogen compound catabolic process	GO:0044270	165	0.028
ncrna metabolic process	GO:0034660	43	0.027
regulation of transport	GO:0051049	181	0.026
macromolecular complex assembly	GO:0065003	256	0.026
eye development	GO:0001654	323	0.026
camera type eye development	GO:0043010	4	0.026
establishment of localization in cell	GO:0051649	402	0.025
muscle cell differentiation	GO:0042692	103	0.025
eye photoreceptor cell differentiation	GO:0001754	145	0.025
positive regulation of developmental growth	GO:0048639	62	0.024
hematopoietic or lymphoid organ development	GO:0048534	57	0.024
cell growth	GO:0016049	108	0.024
positive regulation of cellular biosynthetic process	GO:0031328	316	0.024
regulation of apoptotic process	GO:0042981	130	0.024
multi organism behavior	GO:0051705	175	0.024
appendage development	GO:0048736	401	0.024
genitalia development	GO:0048806	26	0.024	Worm
cellular catabolic process	GO:0044248	372	0.024
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.024	Mouse
regulation of neurogenesis	GO:0050767	158	0.023
photoreceptor cell development	GO:0042461	96	0.023
regulation of dna templated transcription elongation	GO:0032784	17	0.023
rna localization	GO:0006403	115	0.023
purine ribonucleotide metabolic process	GO:0009150	145	0.023
positive regulation of growth	GO:0045927	75	0.023
regulation of protein localization	GO:0032880	76	0.023
regulation of intracellular protein transport	GO:0033157	46	0.023
regulation of behavior	GO:0050795	75	0.023
regulation of cell proliferation	GO:0042127	163	0.023
imaginal disc derived appendage development	GO:0048737	399	0.022
rhabdomere development	GO:0042052	38	0.022
compound eye development	GO:0048749	307	0.022
tripartite regional subdivision	GO:0007351	103	0.022
reproductive structure development	GO:0048608	74	0.022	Worm
positive regulation of nucleocytoplasmic transport	GO:0046824	24	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.022
nucleobase containing compound catabolic process	GO:0034655	165	0.022
dendrite morphogenesis	GO:0048813	199	0.021
negative regulation of meiotic cell cycle	GO:0051447	2	0.021
homeostatic process	GO:0042592	199	0.021
mapk cascade	GO:0000165	107	0.021
aromatic compound catabolic process	GO:0019439	166	0.021
axonogenesis	GO:0007409	290	0.021
organonitrogen compound metabolic process	GO:1901564	318	0.021
negative regulation of organelle organization	GO:0010639	56	0.021
negative regulation of cell cycle phase transition	GO:1901988	103	0.021
regulation of cellular ketone metabolic process	GO:0010565	3	0.021
regulation of synapse organization	GO:0050807	110	0.021
appendage morphogenesis	GO:0035107	397	0.020
catabolic process	GO:0009056	409	0.020
signal transduction by phosphorylation	GO:0023014	107	0.020
positive regulation of multicellular organism growth	GO:0040018	21	0.020
actin cytoskeleton organization	GO:0030036	206	0.020
negative regulation of mitotic cell cycle	GO:0045930	109	0.020
mrna transport	GO:0051028	15	0.020
regulation of intracellular transport	GO:0032386	64	0.020
organic substance transport	GO:0071702	257	0.019
mitotic sister chromatid segregation	GO:0000070	87	0.019
ras protein signal transduction	GO:0007265	88	0.019
epithelial cell differentiation	GO:0030855	322	0.019
negative regulation of cell cycle	GO:0045786	116	0.019
phagocytosis	GO:0006909	215	0.019
cell proliferation	GO:0008283	299	0.019
chromosome segregation	GO:0007059	157	0.019
negative regulation of multicellular organismal process	GO:0051241	142	0.019
spliceosomal complex assembly	GO:0000245	1	0.019
tube morphogenesis	GO:0035239	191	0.019
dna integrity checkpoint	GO:0031570	81	0.019
ribonucleotide metabolic process	GO:0009259	145	0.019
regulation of neuron projection development	GO:0010975	69	0.019
gland development	GO:0048732	191	0.019
regulation of localization	GO:0032879	275	0.019
positive regulation of biosynthetic process	GO:0009891	316	0.018
apoptotic process	GO:0006915	159	0.018
nuclear transport	GO:0051169	72	0.018
cellular protein complex disassembly	GO:0043624	35	0.018
centrosome organization	GO:0051297	163	0.018
meiotic nuclear division	GO:0007126	151	0.018
regulation of nervous system development	GO:0051960	248	0.018
gene silencing by rna	GO:0031047	57	0.018
reproductive behavior	GO:0019098	122	0.018
regulation of neuron differentiation	GO:0045664	103	0.018
snrna metabolic process	GO:0016073	14	0.018
regulation of organelle organization	GO:0033043	196	0.017
gonad development	GO:0008406	50	0.017	Worm
regulation of mapk cascade	GO:0043408	92	0.017
regulation of protein complex assembly	GO:0043254	42	0.017
regulation of response to stress	GO:0080134	200	0.017
purine nucleotide metabolic process	GO:0006163	146	0.017
myofibril assembly	GO:0030239	36	0.017
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.017
negative regulation of signal transduction	GO:0009968	206	0.017
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.017
transcription elongation from rna polymerase ii promoter	GO:0006368	18	0.017
positive regulation of cellular component organization	GO:0051130	156	0.017
nucleoside triphosphate metabolic process	GO:0009141	120	0.017
organelle localization	GO:0051640	148	0.017
striated muscle cell development	GO:0055002	50	0.016
cellular macromolecular complex assembly	GO:0034622	153	0.016
positive regulation of intracellular transport	GO:0032388	42	0.016
posttranscriptional gene silencing	GO:0016441	46	0.016
cuticle pattern formation	GO:0035017	27	0.016
regulation of establishment of protein localization	GO:0070201	61	0.016
cellular macromolecule catabolic process	GO:0044265	136	0.016
positive regulation of erk1 and erk2 cascade	GO:0070374	36	0.016
regulation of proteasomal protein catabolic process	GO:0061136	39	0.016
negative regulation of cellular biosynthetic process	GO:0031327	277	0.016
positive regulation of transport	GO:0051050	92	0.015
positive regulation of phosphorylation	GO:0042327	87	0.015
organonitrogen compound catabolic process	GO:1901565	128	0.015
negative regulation of gene expression	GO:0010629	387	0.015
cellular component disassembly	GO:0022411	46	0.015
single organism catabolic process	GO:0044712	228	0.015
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.015
embryonic development via the syncytial blastoderm	GO:0001700	148	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.015
g1 s transition of mitotic cell cycle	GO:0000082	31	0.015
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.015
striated muscle cell differentiation	GO:0051146	90	0.015
dendrite development	GO:0016358	204	0.015
small gtpase mediated signal transduction	GO:0007264	88	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.014
dendrite guidance	GO:0070983	21	0.014
intracellular transport	GO:0046907	228	0.014
retina development in camera type eye	GO:0060041	4	0.014
meiotic cell cycle	GO:0051321	171	0.014
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.014
multicellular organismal aging	GO:0010259	140	0.014
ribonucleotide catabolic process	GO:0009261	109	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014
muscle system process	GO:0003012	21	0.014
mrna cis splicing via spliceosome	GO:0045292	1	0.014
carbohydrate derivative catabolic process	GO:1901136	118	0.014
notch signaling pathway	GO:0007219	120	0.014
positive regulation of cell death	GO:0010942	69	0.014
glycosyl compound metabolic process	GO:1901657	127	0.014
regulation of synapse structure and activity	GO:0050803	128	0.014
carbohydrate derivative metabolic process	GO:1901135	217	0.014
regulation of anatomical structure morphogenesis	GO:0022603	242	0.014
negative regulation of signaling	GO:0023057	219	0.013
protein catabolic process	GO:0030163	101	0.013
axis specification	GO:0009798	167	0.013
positive regulation of mapk cascade	GO:0043410	63	0.013
spindle assembly involved in mitosis	GO:0090307	50	0.013
cytokinesis	GO:0000910	90	0.013
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.013
organophosphate metabolic process	GO:0019637	195	0.013
rna polyadenylation	GO:0043631	12	0.013
protein localization to nucleus	GO:0034504	55	0.013
establishment of spindle localization	GO:0051293	22	0.013
compound eye morphogenesis	GO:0001745	249	0.013
regulation of erk1 and erk2 cascade	GO:0070372	39	0.013
developmental maturation	GO:0021700	172	0.012
heterochromatin organization	GO:0070828	25	0.012
regulation of catalytic activity	GO:0050790	185	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.012	Mouse
regulation of programmed cell death	GO:0043067	152	0.012
eye photoreceptor cell development	GO:0042462	81	0.012
dna metabolic process	GO:0006259	227	0.012
purine nucleoside metabolic process	GO:0042278	127	0.012
regulation of multicellular organism growth	GO:0040014	40	0.012
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.012
negative regulation of cell communication	GO:0010648	223	0.012
ribonucleoside metabolic process	GO:0009119	127	0.012
anatomical structure homeostasis	GO:0060249	97	0.012
microtubule organizing center organization	GO:0031023	168	0.012
negative regulation of growth	GO:0045926	84	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012
mrna 3 end processing	GO:0031124	28	0.012
regulation of cell cycle phase transition	GO:1901987	130	0.012
embryonic hindgut morphogenesis	GO:0048619	48	0.012
peptidyl amino acid modification	GO:0018193	105	0.012
g2 dna damage checkpoint	GO:0031572	69	0.012
protein maturation	GO:0051604	71	0.012
ribonucleoprotein complex subunit organization	GO:0071826	28	0.011
cellular macromolecule localization	GO:0070727	220	0.011
histone exchange	GO:0043486	21	0.011
regulation of cellular response to stress	GO:0080135	89	0.011
secretion by cell	GO:0032940	101	0.011
cellular amino acid metabolic process	GO:0006520	61	0.011
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	15	0.011
cardiovascular system development	GO:0072358	82	0.011
positive regulation of protein import into nucleus	GO:0042307	21	0.011
regulation of protein catabolic process	GO:0042176	55	0.011
macromolecular complex disassembly	GO:0032984	37	0.011
protein complex disassembly	GO:0043241	36	0.011
negative regulation of biosynthetic process	GO:0009890	277	0.011
heterocycle catabolic process	GO:0046700	166	0.011
cellular protein modification process	GO:0006464	438	0.011
mrna polyadenylation	GO:0006378	11	0.011
immune system development	GO:0002520	57	0.011
microtubule polymerization or depolymerization	GO:0031109	39	0.011
negative regulation of cellular catabolic process	GO:0031330	34	0.011
positive regulation of molecular function	GO:0044093	136	0.011
positive regulation of apoptotic process	GO:0043065	47	0.011
regulation of protein metabolic process	GO:0051246	256	0.011
cellular amine metabolic process	GO:0044106	12	0.011
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.010
nucleoside phosphate metabolic process	GO:0006753	162	0.010
regulation of wnt signaling pathway	GO:0030111	68	0.010
telencephalon development	GO:0021537	2	0.010
negative regulation of cytoskeleton organization	GO:0051494	30	0.010
amine metabolic process	GO:0009308	12	0.010
somatic muscle development	GO:0007525	66	0.010
purine ribonucleoside catabolic process	GO:0046130	112	0.010
nucleotide catabolic process	GO:0009166	109	0.010
regulation of cellular catabolic process	GO:0031329	157	0.010
negative regulation of rna biosynthetic process	GO:1902679	240	0.010
ribose phosphate metabolic process	GO:0019693	145	0.010
mitotic cell cycle checkpoint	GO:0007093	88	0.010

snRNP-U1-70K disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.025
	nervous system disease	DOID:863	0	0.025

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