Drosophila melanogaster

18 known processes

Sk1 (Dmel_CG1747)

Sphingosine kinase 1

(Aliases: Dmel\CG1747,Sphk1,CG1747,SK1)

Sk1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
small molecule metabolic processGO:00442813050.093
Rat
organonitrogen compound metabolic processGO:19015643180.080
response to abiotic stimulusGO:00096283410.078
Yeast
positive regulation of nitrogen compound metabolic processGO:00511733540.061
wing disc morphogenesisGO:00074723440.061
organic substance transportGO:00717022570.060
single organism biosynthetic processGO:00447112060.057
Rat
photoreceptor cell differentiationGO:00465301700.054
lipid metabolic processGO:00066291210.052
imaginal disc derived appendage morphogenesisGO:00351143950.052
intracellular signal transductionGO:00355563000.051
Yeast
post embryonic appendage morphogenesisGO:00351203850.050
actin filament based processGO:00300292200.050
appendage developmentGO:00487364010.050
positive regulation of nucleobase containing compound metabolic processGO:00459353320.049
transcription from rna polymerase ii promoterGO:00063663680.048
g protein coupled receptor signaling pathwayGO:00071861360.048
cell migrationGO:00164772380.048
Rat
positive regulation of gene expressionGO:00106282900.046
imaginal disc derived wing morphogenesisGO:00074763370.046
cellular protein modification processGO:00064644380.046
Rat
imaginal disc derived appendage developmentGO:00487373990.045
positive regulation of rna metabolic processGO:00512542710.044
cellular amine metabolic processGO:0044106120.043
positive regulation of macromolecule biosynthetic processGO:00105572830.043
amine metabolic processGO:0009308120.042
photoreceptor cell developmentGO:0042461960.042
cellular catabolic processGO:00442483720.041
detection of stimulusGO:00516061560.040
vesicle mediated transportGO:00161923810.040
appendage morphogenesisGO:00351073970.040
positive regulation of cellular biosynthetic processGO:00313283160.039
regulation of transcription from rna polymerase ii promoterGO:00063573780.039
carboxylic acid metabolic processGO:0019752920.038
Rat
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.038
compound eye developmentGO:00487493070.038
chemotaxisGO:00069352490.037
catabolic processGO:00090564090.037
negative regulation of response to stimulusGO:00485852580.037
cellular response to chemical stimulusGO:00708871990.037
Rat
protein modification processGO:00362114380.037
Rat
regulation of multicellular organismal developmentGO:20000264140.037
Rat
organophosphate metabolic processGO:00196371950.036
cell motilityGO:00488702510.036
Rat
regulation of cellular amino acid metabolic processGO:000652100.036
epithelial cell differentiationGO:00308553220.036
negative regulation of nitrogen compound metabolic processGO:00511722650.036
regulation of cellular ketone metabolic processGO:001056530.036
taxisGO:00423303040.035
epithelial cell developmentGO:00020642740.035
camera type eye developmentGO:004301040.035
endocytosisGO:00068973100.035
detection of light stimulusGO:0009583580.035
response to radiationGO:00093141550.034
central nervous system developmentGO:00074172010.034
positive regulation of response to stimulusGO:00485843230.034
negative regulation of nucleobase containing compound metabolic processGO:00459342610.034
eye developmentGO:00016543230.034
positive regulation of macromolecule metabolic processGO:00106044050.033
Rat
organic substance catabolic processGO:19015753080.033
regulation of phosphorus metabolic processGO:00511742100.033
Rat
synapse assemblyGO:00074161430.033
nucleotide metabolic processGO:00091171610.033
cellular amino acid metabolic processGO:0006520610.032
positive regulation of nucleic acid templated transcriptionGO:19035082660.032
positive regulation of transcription dna templatedGO:00458932660.032
phagocytosisGO:00069092150.032
positive regulation of cell communicationGO:00106472500.032
Rat
compound eye photoreceptor developmentGO:0042051780.031
single organism catabolic processGO:00447122280.031
negative regulation of gene expressionGO:00106293870.031
kidney developmentGO:000182230.031
programmed cell deathGO:00125012570.030
Rat
axonogenesisGO:00074092900.030
nucleoside phosphate metabolic processGO:00067531620.030
nuclear divisionGO:00002803320.030
purine nucleoside metabolic processGO:00422781270.030
cell deathGO:00082192790.030
Rat
sensory organ morphogenesisGO:00905962600.029
purine containing compound metabolic processGO:00725211550.029
ribonucleotide metabolic processGO:00092591450.029
morphogenesis of an epitheliumGO:00020092760.029
regulation of cellular protein metabolic processGO:00322682430.029
Rat
negative regulation of cell communicationGO:00106482230.029
oxoacid metabolic processGO:00434361030.029
Rat
synapse organizationGO:00508081960.029
organic acid metabolic processGO:00060821030.029
Rat
negative regulation of signal transductionGO:00099682060.028
positive regulation of phosphorus metabolic processGO:00105621390.028
Rat
regulation of cell cycleGO:00517262910.028
compound eye morphogenesisGO:00017452490.028
growthGO:00400073590.028
ion transportGO:00068111450.028
regulation of intracellular signal transductionGO:19025312360.028
negative regulation of signalingGO:00230572190.028
regulation of cellular catabolic processGO:00313291570.028
regulation of response to stressGO:00801342000.027
purine nucleotide metabolic processGO:00061631460.027
matingGO:00076181200.027
regulation of anatomical structure morphogenesisGO:00226032420.027
tube developmentGO:00352952440.027
positive regulation of signalingGO:00230562430.027
Rat
peripheral nervous system developmentGO:0007422520.027
eye photoreceptor cell developmentGO:0042462810.026
positive regulation of rna biosynthetic processGO:19026802660.026
synaptic transmissionGO:00072682880.026
Rat
response to organic substanceGO:00100332840.026
Rat
regulation of phosphate metabolic processGO:00192202100.026
Rat
regulation of protein metabolic processGO:00512462560.026
Rat
purine nucleoside catabolic processGO:00061521120.026
phosphorylationGO:00163102940.026
regulation of molecular functionGO:00650092170.026
regulation of localizationGO:00328792750.026
Rat
positive regulation of phosphate metabolic processGO:00459371390.025
Rat
regulation of cellular component biogenesisGO:00440872010.025
aromatic compound catabolic processGO:00194391660.025
multi multicellular organism processGO:00447061230.025
Rat
purine ribonucleoside metabolic processGO:00461281270.025
purine nucleoside triphosphate metabolic processGO:00091441190.025
regulation of synapse structure and activityGO:00508031280.025
negative regulation of cellular metabolic processGO:00313243820.025
response to light stimulusGO:00094161240.025
establishment of planar polarityGO:0001736870.025
tissue morphogenesisGO:00487292970.025
ribose phosphate metabolic processGO:00196931450.025
cellular ketone metabolic processGO:0042180240.025
nucleobase containing small molecule metabolic processGO:00550861740.025
regulation of catalytic activityGO:00507901850.025
organic cyclic compound catabolic processGO:19013611680.025
enzyme linked receptor protein signaling pathwayGO:00071671790.025
regulation of transportGO:00510491810.024
Rat
positive regulation of signal transductionGO:00099672230.024
purine ribonucleotide metabolic processGO:00091501450.024
regulation of cellular amine metabolic processGO:003323830.024
regulation of catabolic processGO:00098941700.024
regulation of cell deathGO:00109411730.024
Rat
response to lipopolysaccharideGO:003249640.024
developmental growthGO:00485892800.023
lateral inhibitionGO:00463312060.023
membrane organizationGO:00610241120.023
ribonucleoside catabolic processGO:00424541120.023
regulation of organelle organizationGO:00330431960.023
nucleoside metabolic processGO:00091161270.023
chromosome organizationGO:00512763600.023
compound eye photoreceptor cell differentiationGO:00017511400.023
ameboidal type cell migrationGO:00016671510.023
cell cell signaling involved in cell fate commitmentGO:00451682100.023
glycosyl compound metabolic processGO:19016571270.023
regionalizationGO:00030024160.023
eye pigment metabolic processGO:0042441330.023
tissue migrationGO:00901301550.022
nucleobase containing compound catabolic processGO:00346551650.022
digestive system developmentGO:00551231490.022
carbohydrate derivative metabolic processGO:19011352170.022
actin cytoskeleton organizationGO:00300362060.022
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.022
carbohydrate derivative catabolic processGO:19011361180.022
germ cell migrationGO:0008354430.022
eye photoreceptor cell differentiationGO:00017541450.022
establishment of tissue polarityGO:0007164870.022
protein localizationGO:00081042840.022
positive regulation of catalytic activityGO:00430851180.022
regulation of cellular localizationGO:00603411360.022
Rat
regulation of apoptotic processGO:00429811300.022
Rat
body morphogenesisGO:001017120.021
negative regulation of developmental processGO:00510932010.021
ribonucleoside metabolic processGO:00091191270.021
heterocycle catabolic processGO:00467001660.021
ribonucleoside triphosphate metabolic processGO:00091991190.021
response to extracellular stimulusGO:00099911160.021
Rat
positive regulation of biosynthetic processGO:00098913160.021
determination of adult lifespanGO:00083401370.021
negative regulation of cellular biosynthetic processGO:00313272770.021
eye morphogenesisGO:00485922600.021
negative regulation of rna metabolic processGO:00512532510.021
organonitrogen compound catabolic processGO:19015651280.021
negative regulation of biosynthetic processGO:00098902770.021
regulation of cell differentiationGO:00455953020.020
Rat
cation transportGO:00068121100.020
cellular nitrogen compound catabolic processGO:00442701650.020
positive regulation of programmed cell deathGO:0043068620.020
deathGO:00162652840.020
Rat
ras protein signal transductionGO:0007265880.020
embryonic morphogenesisGO:00485982060.020
positive regulation of catabolic processGO:00098961050.020
positive regulation of intracellular signal transductionGO:19025331160.020
guanosine containing compound metabolic processGO:1901068740.020
axon developmentGO:00615642970.019
purine containing compound catabolic processGO:00725231120.019
protein phosphorylationGO:00064681690.019
Rat
rhabdomere developmentGO:0042052380.019
signal transduction by phosphorylationGO:00230141070.019
negative regulation of cell differentiationGO:00455961430.019
regulation of programmed cell deathGO:00430671520.019
Rat
rna processingGO:00063961470.019
response to oxygen containing compoundGO:19017002000.019
Rat
axon guidanceGO:00074112330.019
signal releaseGO:0023061490.018
Rat
nucleoside triphosphate catabolic processGO:00091431080.018
gland developmentGO:00487321910.018
proteolysisGO:00065081920.018
purine ribonucleoside catabolic processGO:00461301120.018
positive regulation of multicellular organismal processGO:00512401430.018
Rat
cellular macromolecule localizationGO:00707272200.018
organophosphate catabolic processGO:00464341120.018
apoptotic processGO:00069151590.018
Rat
cell proliferationGO:00082832990.018
rho protein signal transductionGO:0007266140.018
forebrain developmentGO:003090020.018
defense responseGO:00069523000.018
metal ion transportGO:0030001740.018
nucleoside triphosphate metabolic processGO:00091411200.017
regulation of defense responseGO:00313471020.017
regulation of nucleotide metabolic processGO:0006140620.017
response to other organismGO:00517072930.017
positive regulation of molecular functionGO:00440931360.017
columnar cuboidal epithelial cell differentiationGO:00020652560.017
regulation of growthGO:00400082330.017
tube morphogenesisGO:00352391910.017
negative regulation of cellular protein metabolic processGO:0032269850.017
organelle fissionGO:00482853400.017
open tracheal system developmentGO:00074242040.017
positive regulation of cellular catabolic processGO:0031331950.017
phototransductionGO:0007602520.017
digestive tract developmentGO:00485651490.017
regulation of hydrolase activityGO:0051336970.017
negative regulation of organelle organizationGO:0010639560.017
regulation of nervous system developmentGO:00519602480.017
Rat
posttranscriptional regulation of gene expressionGO:00106081450.017
nucleotide catabolic processGO:00091661090.017
nucleoside phosphate catabolic processGO:19012921100.017
organic hydroxy compound metabolic processGO:1901615830.017
nucleoside catabolic processGO:00091641120.016
localization of cellGO:00516742570.016
Rat
organelle assemblyGO:00709251980.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
stem cell differentiationGO:00488631170.016
salivary gland morphogenesisGO:00074351450.016
purine ribonucleoside triphosphate metabolic processGO:00092051190.016
columnar cuboidal epithelial cell developmentGO:00020662490.016
developmental pigmentationGO:0048066680.016
mapk cascadeGO:00001651070.016
salivary gland developmentGO:00074311620.016
peptidyl amino acid modificationGO:00181931050.016
negative regulation of cell cycleGO:00457861160.016
response to temperature stimulusGO:00092661060.016
Yeast
regulation of small gtpase mediated signal transductionGO:0051056930.016
nitrogen compound transportGO:0071705850.016
ethanolamine containing compound metabolic processGO:004243940.016
neuromuscular junction developmentGO:00075281490.016
negative regulation of nucleic acid templated transcriptionGO:19035072400.016
negative regulation of rna biosynthetic processGO:19026792400.016
gtp catabolic processGO:0006184720.016
ribonucleotide catabolic processGO:00092611090.016
regulation of mapk cascadeGO:0043408920.016
response to external biotic stimulusGO:00432072930.016
hormone catabolic processGO:004244730.016
chromatin organizationGO:00063252070.015
gtp metabolic processGO:0046039720.015
mesoderm developmentGO:0007498780.015
detection of abiotic stimulusGO:0009582660.015
positive regulation of purine nucleotide metabolic processGO:1900544550.015
glycosyl compound catabolic processGO:19016581120.015
exocrine system developmentGO:00352721620.015
immune response activating signal transductionGO:000275720.015
immune system processGO:00023763470.015
small gtpase mediated signal transductionGO:0007264880.015
single organism cellular localizationGO:19025801800.015
positive regulation of cell motilityGO:200014730.015
Rat
regulation of organ morphogenesisGO:2000027780.015
regulation of purine nucleotide metabolic processGO:1900542620.015
regulation of anatomical structure sizeGO:00900661630.015
positive regulation of cellular amine metabolic processGO:003324000.015
establishment of localization in cellGO:00516494020.015
Rat
mitotic cell cycle phase transitionGO:00447721380.015
regulation of protein modification processGO:00313991120.015
Rat
cellular response to organic substanceGO:00713101320.015
Rat
positive regulation of cellular component organizationGO:00511301560.015
Rat
retina development in camera type eyeGO:006004140.015
macromolecular complex assemblyGO:00650032560.015
hindbrain developmentGO:003090220.015
endomembrane system organizationGO:00102561190.015
positive regulation of nucleotide metabolic processGO:0045981550.015
negative regulation of transcription dna templatedGO:00458922370.015
autophagyGO:00069141080.015
regulation of epithelial cell differentiationGO:003085640.015
digestive tract morphogenesisGO:00485461270.015
gastrulationGO:0007369700.015
positive regulation of transportGO:0051050920.015
Rat
meiotic cell cycleGO:00513211710.015
regulation of cell cycle processGO:00105641810.015
neuron projection guidanceGO:00974852410.014
morphogenesis of a polarized epitheliumGO:0001738930.014
vitamin metabolic processGO:000676620.014
negative regulation of cellular component organizationGO:00511291080.014
negative regulation of macromolecule biosynthetic processGO:00105582700.014
pigment metabolic process involved in pigmentationGO:0043474330.014
mrna metabolic processGO:00160711240.014
nephron epithelium developmentGO:007200930.014
eye antennal disc developmentGO:0035214600.014
cellular response to extracellular stimulusGO:0031668640.014
Rat
guanosine containing compound catabolic processGO:1901069740.014
autophagic cell deathGO:0048102830.014
cellular response to carbohydrate stimulusGO:007132240.014
developmental maturationGO:00217001720.014
response to woundingGO:0009611940.014
vitamin biosynthetic processGO:000911010.014
regulation of immune system processGO:00026821760.014
actin filament based movementGO:0030048260.014
response to endogenous stimulusGO:00097191190.014
Rat
positive regulation of cell deathGO:0010942690.014
epithelium migrationGO:00901321480.014
regulation of gene expression epigeneticGO:00400291280.014
cuticle developmentGO:0042335860.014
regulation of response to external stimulusGO:00321011150.014
positive regulation of nucleoside metabolic processGO:0045979470.014
embryonic development via the syncytial blastodermGO:00017001480.014
positive regulation of cellular protein metabolic processGO:00322701180.014
Rat
purine nucleotide catabolic processGO:00061951090.014
response to starvationGO:0042594970.014
Rat
immune response regulating signaling pathwayGO:000276420.014
synaptic growth at neuromuscular junctionGO:00511241190.014
spermatogenesisGO:00072832000.014
purine nucleoside triphosphate catabolic processGO:00091461080.014
regulation of proteolysisGO:0030162870.014
telencephalon developmentGO:002153720.013
pigmentationGO:0043473750.013
mrna processingGO:00063971040.013
agingGO:00075681430.013
cellular response to oxygen containing compoundGO:1901701790.013
Rat
regulation of cell developmentGO:00602842150.013
Rat
regulation of phosphorylationGO:00423251470.013
Rat
nephron developmentGO:007200630.013
anatomical structure homeostasisGO:0060249970.013
regulation of synaptic growth at neuromuscular junctionGO:0008582890.013
positive regulation of apoptotic processGO:0043065470.013
purine ribonucleotide catabolic processGO:00091541090.013
circulatory system developmentGO:0072359820.013
camera type eye morphogenesisGO:004859320.013
purine ribonucleoside triphosphate catabolic processGO:00092071080.013
epithelial cell migrationGO:00106311480.013
pigment metabolic processGO:0042440840.013
multicellular organismal agingGO:00102591400.013
neuropeptide signaling pathwayGO:0007218450.013
chaeta developmentGO:0022416970.013
oocyte differentiationGO:00099941450.013
response to heatGO:0009408630.013
Yeast
mesodermal cell migrationGO:000807870.013
ribonucleoside triphosphate catabolic processGO:00092031080.013
regulation of synapse organizationGO:00508071100.013
cellular response to endogenous stimulusGO:0071495800.013
mesenchymal cell differentiationGO:004876210.013
regulation of ras protein signal transductionGO:0046578930.013
ovarian follicle cell developmentGO:00307072480.013
connective tissue developmentGO:006144830.013
salivary gland cell autophagic cell deathGO:0035071830.013
segmentationGO:00352822070.013
cellular response to starvationGO:0009267610.013
Rat
protein processingGO:0016485680.013
response to monosaccharideGO:003428440.013
regulation of mitotic cell cycleGO:00073461900.013
peptidyl threonine phosphorylationGO:001810720.013
negative regulation of protein metabolic processGO:0051248850.013
cellular protein localizationGO:00346131600.013
leg disc developmentGO:0035218920.012
protein complex biogenesisGO:00702712010.012
epidermal cell differentiationGO:0009913510.012
notch signaling pathwayGO:00072191200.012
cellular response to biotic stimulusGO:007121640.012
regulation of neurogenesisGO:00507671580.012
Rat
lipid localizationGO:0010876540.012
negative regulation of gene expression epigeneticGO:0045814770.012
kidney epithelium developmentGO:007207330.012
gland morphogenesisGO:00226121450.012
leg disc morphogenesisGO:0007478800.012
response to glucoseGO:000974920.012
regulation of epithelial cell proliferationGO:005067840.012
meiotic nuclear divisionGO:00071261510.012
mitotic nuclear divisionGO:00070672130.012
response to biotic stimulusGO:00096072940.012
nephron tubule developmentGO:007208030.012
cell projection assemblyGO:0030031940.012
negative regulation of multicellular organismal processGO:00512411420.012
single organism membrane fusionGO:0044801420.012
regulation of developmental growthGO:00486381740.012
regulation of cell morphogenesis involved in differentiationGO:0010769610.012
cell divisionGO:00513012480.012
gene silencingGO:00164581380.012
regulation of multi organism processGO:00439001310.012
positive regulation of hydrolase activityGO:0051345780.011
chemosensory behaviorGO:00076351060.011
rna localizationGO:00064031150.011
cellular response to ethanolGO:007136140.011
protein maturationGO:0051604710.011
cellular response to lipopolysaccharideGO:007122230.011
sensory perception of painGO:001923340.011
somatic muscle developmentGO:0007525660.011
regulation of notch signaling pathwayGO:00085931000.011
dna metabolic processGO:00062592270.011
sterol homeostasisGO:005509240.011
rhythmic behaviorGO:0007622760.011
protein transportGO:00150311550.011
positive regulation of nucleotide catabolic processGO:0030813460.011
response to hexoseGO:000974630.011
regulation of hormone levelsGO:0010817400.011
salivary gland histolysisGO:0035070880.011
nephron epithelium morphogenesisGO:007208830.011
cellular response to molecule of bacterial originGO:007121930.011
establishment of protein localizationGO:00451841630.011
histolysisGO:00075591020.011
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.011
cell maturationGO:00484691440.011
macromolecule catabolic processGO:00090571610.011
respiratory system developmentGO:00605412130.011
positive regulation of cell migrationGO:003033520.011
Rat
carbohydrate metabolic processGO:0005975820.011
intracellular transportGO:00469072280.011
response to organic cyclic compoundGO:0014070890.011
Rat
negative regulation of transcription from rna polymerase ii promoterGO:00001221190.011
androgen metabolic processGO:000820910.011
regulation of cell substrate adhesionGO:001081020.011
response to nutrient levelsGO:00316671140.011
Rat
limb developmentGO:006017310.011
defense response to other organismGO:00985422250.011
developmental programmed cell deathGO:00106231380.011
single organism intracellular transportGO:19025822070.011
negative regulation of defense responseGO:0031348350.011
regulation of cell proliferationGO:00421271630.011
regulation of neuron differentiationGO:00456641030.011
Rat
single organism membrane organizationGO:0044802930.011
regulation of synapse assemblyGO:0051963940.011
cellularizationGO:0007349900.011
dendrite developmentGO:00163582040.011
regulation of gtp catabolic processGO:0033124440.011
multi organism behaviorGO:00517051750.011
regulation of nucleotide catabolic processGO:0030811480.011
activation of innate immune responseGO:000221840.010
dendrite morphogenesisGO:00488131990.010
regulation of mrna metabolic processGO:1903311720.010
positive regulation of gtpase activityGO:0043547430.010
positive regulation of phosphorylationGO:0042327870.010
Rat
pigment biosynthetic processGO:0046148360.010
innate immune response activating signal transductionGO:000275820.010
regulation of purine nucleotide catabolic processGO:0033121480.010
sensory perception of smellGO:0007608800.010
regulation of cell morphogenesisGO:00226041630.010
secretion by cellGO:00329401010.010
Rat
organelle localizationGO:00516401480.010
regulation of mrna processingGO:0050684710.010
meiotic cell cycle processGO:19030461320.010
epithelial tube morphogenesisGO:0060562880.010
neurological system processGO:00508773580.010
mitochondrion organizationGO:0007005650.010
response to organonitrogen compoundGO:0010243750.010
Rat
cholesterol homeostasisGO:004263230.010
organonitrogen compound biosynthetic processGO:19015661170.010
morphogenesis of embryonic epitheliumGO:0016331940.010
eye pigment biosynthetic processGO:0006726320.010

Sk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.062
disease of metabolismDOID:001466700.027
nervous system diseaseDOID:86300.021
musculoskeletal system diseaseDOID:1700.017
inherited metabolic disorderDOID:65500.017
sensory system diseaseDOID:005015500.013
eye and adnexa diseaseDOID:149200.010
disease of cellular proliferationDOID:1456600.010