IMP: Integrative Multi-species Prediction

Drosophila melanogaster

132 known processes

twf (Dmel_CG3172)

twinfilin

(Aliases: Dmel\CG3172,CG3172,Twf,A6)

Entrez: 41719
FLYBASE: FBgn0038206
UniProtKB: Q9VFM9

Process Predictions
Disease Predictions

twf biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mushroom body development	GO:0016319	70	0.928
regulation of actin filament length	GO:0030832	27	0.826
vesicle mediated transport	GO:0016192	381	0.794
regulation of actin polymerization or depolymerization	GO:0008064	27	0.777
epithelial cell migration	GO:0010631	148	0.687
regulation of actin filament polymerization	GO:0030833	25	0.633
regulation of cellular component size	GO:0032535	98	0.595
ameboidal type cell migration	GO:0001667	151	0.504
cell proliferation	GO:0008283	299	0.488
actin polymerization or depolymerization	GO:0008154	31	0.427
small molecule metabolic process	GO:0044281	305	0.390
actin cytoskeleton organization	GO:0030036	206	0.381
endocytosis	GO:0006897	310	0.371
epithelium migration	GO:0090132	148	0.340
regulation of anatomical structure size	GO:0090066	163	0.334
actin filament polymerization	GO:0030041	27	0.301
regulation of protein polymerization	GO:0032271	28	0.300
cellular macromolecule localization	GO:0070727	220	0.291
actin filament organization	GO:0007015	126	0.290
regulation of actin cytoskeleton organization	GO:0032956	42	0.280
regulation of synaptic growth at neuromuscular junction	GO:0008582	89	0.246
actin filament based process	GO:0030029	220	0.243
regulation of cytoskeleton organization	GO:0051493	89	0.225
neuromuscular junction development	GO:0007528	149	0.220
nucleoside phosphate metabolic process	GO:0006753	162	0.187
protein complex assembly	GO:0006461	200	0.186
positive regulation of cellular component organization	GO:0051130	156	0.179
organophosphate metabolic process	GO:0019637	195	0.172
epithelial cell differentiation	GO:0030855	322	0.168
glycosyl compound metabolic process	GO:1901657	127	0.166
ovarian follicle cell migration	GO:0007297	121	0.165
positive regulation of protein polymerization	GO:0032273	14	0.157
tissue migration	GO:0090130	155	0.157
columnar cuboidal epithelial cell development	GO:0002066	249	0.153
nucleoside phosphate catabolic process	GO:1901292	110	0.142
nucleobase containing small molecule metabolic process	GO:0055086	174	0.140
camera type eye development	GO:0043010	4	0.138
protein localization	GO:0008104	284	0.138	Yeast Mouse
border follicle cell migration	GO:0007298	113	0.137
synaptic growth at neuromuscular junction	GO:0051124	119	0.136
cell migration	GO:0016477	238	0.134
organelle fission	GO:0048285	340	0.132
developmental growth	GO:0048589	280	0.131
cellular macromolecular complex assembly	GO:0034622	153	0.131
regulation of endocytosis	GO:0030100	37	0.131
ribonucleoside catabolic process	GO:0042454	112	0.130
growth	GO:0040007	359	0.130
organonitrogen compound metabolic process	GO:1901564	318	0.128
regulation of protein complex assembly	GO:0043254	42	0.127
epithelial cell development	GO:0002064	274	0.127
head development	GO:0060322	135	0.119
negative regulation of signaling	GO:0023057	219	0.114
cell motility	GO:0048870	251	0.114
cytokinesis	GO:0000910	90	0.110
single organism cellular localization	GO:1902580	180	0.109
positive regulation of actin filament polymerization	GO:0030838	11	0.109
positive regulation of cell projection organization	GO:0031346	29	0.107
positive regulation of cellular component biogenesis	GO:0044089	80	0.105
establishment of localization in cell	GO:0051649	402	0.105
dendrite development	GO:0016358	204	0.104
ovarian follicle cell development	GO:0030707	248	0.104
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.103
cellular response to chemical stimulus	GO:0070887	199	0.103
single organism catabolic process	GO:0044712	228	0.102
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.101
nucleoside catabolic process	GO:0009164	112	0.101
morphogenesis of an epithelium	GO:0002009	276	0.097
regulation of lamellipodium assembly	GO:0010591	15	0.097
appendage development	GO:0048736	401	0.096
protein complex biogenesis	GO:0070271	201	0.091
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.091
regulation of cell projection organization	GO:0031344	92	0.091
regulation of anatomical structure morphogenesis	GO:0022603	242	0.086
male gamete generation	GO:0048232	201	0.085
regulation of notch signaling pathway	GO:0008593	100	0.085
meiotic cell cycle process	GO:1903046	132	0.085
purine ribonucleotide metabolic process	GO:0009150	145	0.085
ribonucleoside metabolic process	GO:0009119	127	0.084
phosphorylation	GO:0016310	294	0.083	Human Mouse
appendage morphogenesis	GO:0035107	397	0.083
regulation of cell cycle process	GO:0010564	181	0.083
actin nucleation	GO:0045010	8	0.082
glycosyl compound catabolic process	GO:1901658	112	0.080
carbohydrate derivative metabolic process	GO:1901135	217	0.080
regulation of vesicle mediated transport	GO:0060627	59	0.079
regulation of organelle organization	GO:0033043	196	0.079
nucleoside metabolic process	GO:0009116	127	0.079
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.079
regulation of phosphorus metabolic process	GO:0051174	210	0.078	Human
regulation of cellular component biogenesis	GO:0044087	201	0.078
positive regulation of cellular amine metabolic process	GO:0033240	0	0.076
regulation of actin filament based process	GO:0032970	42	0.075
phagocytosis	GO:0006909	215	0.074
ribose phosphate metabolic process	GO:0019693	145	0.071
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.071
regulation of lamellipodium organization	GO:1902743	15	0.069
purine nucleotide metabolic process	GO:0006163	146	0.068
axon guidance	GO:0007411	233	0.067
meiotic cytokinesis	GO:0033206	33	0.067
positive regulation of signal transduction	GO:0009967	223	0.067
cellular amine metabolic process	GO:0044106	12	0.067
regulation of developmental growth	GO:0048638	174	0.066
cellular protein localization	GO:0034613	160	0.066
positive regulation of signaling	GO:0023056	243	0.066
nucleoside triphosphate metabolic process	GO:0009141	120	0.065
protein depolymerization	GO:0051261	31	0.065
carboxylic acid metabolic process	GO:0019752	92	0.065
positive regulation of cell communication	GO:0010647	250	0.065
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.064
cellular lipid metabolic process	GO:0044255	83	0.064
purine ribonucleoside metabolic process	GO:0046128	127	0.064
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.063
macromolecular complex assembly	GO:0065003	256	0.063
purine containing compound metabolic process	GO:0072521	155	0.062
post embryonic appendage morphogenesis	GO:0035120	385	0.062
synapse organization	GO:0050808	196	0.061
nucleotide metabolic process	GO:0009117	161	0.060
purine nucleotide catabolic process	GO:0006195	109	0.059
purine nucleoside catabolic process	GO:0006152	112	0.059
cell projection assembly	GO:0030031	94	0.059
purine nucleoside metabolic process	GO:0042278	127	0.059
intracellular signal transduction	GO:0035556	300	0.058
nuclear division	GO:0000280	332	0.058
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.057
organic substance catabolic process	GO:1901575	308	0.056
organonitrogen compound catabolic process	GO:1901565	128	0.056
organic substance transport	GO:0071702	257	0.056
spermatogenesis	GO:0007283	200	0.054
secretion by cell	GO:0032940	101	0.054
protein transport	GO:0015031	155	0.053
proteolysis	GO:0006508	192	0.053
protein modification process	GO:0036211	438	0.052	Human Mouse
regulation of growth	GO:0040008	233	0.051
organelle localization	GO:0051640	148	0.051
single organism intracellular transport	GO:1902582	207	0.049
regulation of cellular ketone metabolic process	GO:0010565	3	0.048
regulation of actin filament depolymerization	GO:0030834	3	0.048	Mouse
ribonucleotide metabolic process	GO:0009259	145	0.047
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.046
cellular catabolic process	GO:0044248	372	0.045
positive regulation of phosphorus metabolic process	GO:0010562	139	0.045
lamellipodium assembly	GO:0030032	21	0.045
cellular protein complex disassembly	GO:0043624	35	0.045
purine ribonucleotide catabolic process	GO:0009154	109	0.045
adult locomotory behavior	GO:0008344	76	0.044
positive regulation of response to stimulus	GO:0048584	323	0.044
positive regulation of cytoskeleton organization	GO:0051495	21	0.043
regulation of phosphate metabolic process	GO:0019220	210	0.042	Human
locomotory behavior	GO:0007626	176	0.042
endomembrane system organization	GO:0010256	119	0.042
imaginal disc derived appendage development	GO:0048737	399	0.042
regulation of programmed cell death	GO:0043067	152	0.041
cellular component assembly involved in morphogenesis	GO:0010927	151	0.040
response to organic substance	GO:0010033	284	0.040
organelle assembly	GO:0070925	198	0.040
positive regulation of nucleotide metabolic process	GO:0045981	55	0.039
cell death	GO:0008219	279	0.039
response to alcohol	GO:0097305	95	0.038
negative regulation of cellular catabolic process	GO:0031330	34	0.038
chemotaxis	GO:0006935	249	0.038
positive regulation of phosphate metabolic process	GO:0045937	139	0.037
response to endogenous stimulus	GO:0009719	119	0.037
protein phosphorylation	GO:0006468	169	0.037	Human Mouse
cellular ketone metabolic process	GO:0042180	24	0.037
positive regulation of notch signaling pathway	GO:0045747	34	0.036
single organism behavior	GO:0044708	391	0.036
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	4	0.035
regionalization	GO:0003002	416	0.035
ribonucleotide catabolic process	GO:0009261	109	0.034
cortical actin cytoskeleton organization	GO:0030866	24	0.034
death	GO:0016265	284	0.034
nucleoside triphosphate catabolic process	GO:0009143	108	0.034
wing disc morphogenesis	GO:0007472	344	0.034
cellular response to organic substance	GO:0071310	132	0.034
positive regulation of lipid metabolic process	GO:0045834	4	0.033
regulation of phosphorylation	GO:0042325	147	0.033	Human
protein polymerization	GO:0051258	42	0.033
regulation of cellular amine metabolic process	GO:0033238	3	0.033
taxis	GO:0042330	304	0.032
positive regulation of response to external stimulus	GO:0032103	44	0.032
purine ribonucleoside catabolic process	GO:0046130	112	0.031
purine containing compound catabolic process	GO:0072523	112	0.030
programmed cell death	GO:0012501	257	0.030
single organism carbohydrate metabolic process	GO:0044723	72	0.030
carbohydrate derivative catabolic process	GO:1901136	118	0.030
membrane budding	GO:0006900	4	0.030
tissue morphogenesis	GO:0048729	297	0.030
establishment of proximal distal cell polarity	GO:0022606	4	0.030
intracellular transport	GO:0046907	228	0.029
regulation of cell shape	GO:0008360	113	0.029
establishment of nucleus localization	GO:0040023	26	0.029
guanosine containing compound catabolic process	GO:1901069	74	0.028
homeostatic process	GO:0042592	199	0.028
regulation of cell morphogenesis	GO:0022604	163	0.028
membrane organization	GO:0061024	112	0.027
negative regulation of signal transduction	GO:0009968	206	0.027
single fertilization	GO:0007338	24	0.027
positive regulation of protein complex assembly	GO:0031334	22	0.027
cytoskeleton dependent cytokinesis	GO:0061640	81	0.027
atp metabolic process	GO:0046034	49	0.027
imaginal disc derived wing morphogenesis	GO:0007476	337	0.026
regulation of apoptotic process	GO:0042981	130	0.026
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.026
organic acid metabolic process	GO:0006082	103	0.026
regulation of cell development	GO:0060284	215	0.026
nucleotide catabolic process	GO:0009166	109	0.026
endosomal transport	GO:0016197	44	0.026
mapk cascade	GO:0000165	107	0.026
regulation of synapse organization	GO:0050807	110	0.025
central nervous system development	GO:0007417	201	0.025
cytoplasmic transport	GO:0016482	130	0.025
apoptotic process	GO:0006915	159	0.024
biological adhesion	GO:0022610	138	0.024
cell adhesion	GO:0007155	136	0.024
cellular protein modification process	GO:0006464	438	0.024	Human Mouse
positive regulation of multicellular organismal process	GO:0051240	143	0.023
sphingolipid metabolic process	GO:0006665	19	0.023
regulation of filopodium assembly	GO:0051489	24	0.023
localization of cell	GO:0051674	257	0.023
golgi organization	GO:0007030	66	0.023
reproductive structure development	GO:0048608	74	0.022
cellular amino acid metabolic process	GO:0006520	61	0.022
positive regulation of organelle organization	GO:0010638	65	0.021
intracellular protein transport	GO:0006886	104	0.021
cellular protein complex assembly	GO:0043623	71	0.021
negative regulation of proteolysis	GO:0045861	31	0.021
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.020
guanosine containing compound metabolic process	GO:1901068	74	0.020
positive regulation of gtpase activity	GO:0043547	43	0.020
maintenance of protein location in cell	GO:0032507	26	0.020
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.020
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.019
positive regulation of protein metabolic process	GO:0051247	128	0.019
regulation of proteolysis	GO:0030162	87	0.019
body morphogenesis	GO:0010171	2	0.019
negative regulation of cell communication	GO:0010648	223	0.019
negative regulation of gene expression	GO:0010629	387	0.019
negative regulation of apoptotic process	GO:0043066	63	0.019
establishment of protein localization	GO:0045184	163	0.019
small gtpase mediated signal transduction	GO:0007264	88	0.019
positive regulation of cell motility	GO:2000147	3	0.019
cytoplasmic transport nurse cell to oocyte	GO:0007303	12	0.018
amine metabolic process	GO:0009308	12	0.018
regulation of cell death	GO:0010941	173	0.018
lamellipodium organization	GO:0097581	21	0.018
female meiotic division	GO:0007143	70	0.018
instar larval development	GO:0002168	55	0.018
stem cell proliferation	GO:0072089	88	0.018
cellular nitrogen compound catabolic process	GO:0044270	165	0.018
cell recognition	GO:0008037	102	0.017
establishment or maintenance of cytoskeleton polarity	GO:0030952	44	0.017
positive regulation of lamellipodium organization	GO:1902745	7	0.017
regulation of stress activated mapk cascade	GO:0032872	41	0.017
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.017
regulation of hydrolase activity	GO:0051336	97	0.017
establishment of organelle localization	GO:0051656	122	0.017
negative regulation of cytoskeleton organization	GO:0051494	30	0.017	Yeast Mouse
neuron projection extension	GO:1990138	32	0.017
regulation of cell projection assembly	GO:0060491	30	0.017
negative regulation of cell cycle	GO:0045786	116	0.016
regulation of cell substrate adhesion	GO:0010810	2	0.016
establishment of monopolar cell polarity	GO:0061162	15	0.016
cilium assembly	GO:0042384	38	0.016
arp2 3 complex mediated actin nucleation	GO:0034314	3	0.016
cation transport	GO:0006812	110	0.016
mitotic nuclear division	GO:0007067	213	0.016
regulation of phosphatase activity	GO:0010921	3	0.016
chromosome organization	GO:0051276	360	0.016
response to oxygen containing compound	GO:1901700	200	0.015
regulation of nervous system development	GO:0051960	248	0.015
positive regulation of cell proliferation	GO:0008284	47	0.015
embryonic development via the syncytial blastoderm	GO:0001700	148	0.015
regulation of cellular amino acid metabolic process	GO:0006521	0	0.015
positive regulation of protein secretion	GO:0050714	9	0.015
meiotic cell cycle	GO:0051321	171	0.015
synapse assembly	GO:0007416	143	0.015
cellular component disassembly	GO:0022411	46	0.015
retrograde transport endosome to golgi	GO:0042147	3	0.015
carbohydrate metabolic process	GO:0005975	82	0.015
neural precursor cell proliferation	GO:0061351	75	0.014
secretion	GO:0046903	109	0.014
cellular response to oxygen containing compound	GO:1901701	79	0.014
regulation of cell cycle	GO:0051726	291	0.014
response to abiotic stimulus	GO:0009628	341	0.014
positive regulation of nucleotide catabolic process	GO:0030813	46	0.014
regulation of protein processing	GO:0070613	32	0.014
embryo development ending in birth or egg hatching	GO:0009792	152	0.014
regulation of molecular function	GO:0065009	217	0.014
aromatic compound catabolic process	GO:0019439	166	0.014
regulation of protein depolymerization	GO:1901879	27	0.014	Mouse
imaginal disc derived wing hair site selection	GO:0035320	4	0.014
spermatid differentiation	GO:0048515	114	0.014
regulation of catalytic activity	GO:0050790	185	0.014
ceramide metabolic process	GO:0006672	7	0.013
establishment of mitochondrion localization	GO:0051654	7	0.013
larval development	GO:0002164	104	0.013
catabolic process	GO:0009056	409	0.013
anatomical structure homeostasis	GO:0060249	97	0.013
regulation of multicellular organismal development	GO:2000026	414	0.013
exocytosis	GO:0006887	28	0.013
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.013
regulation of peptidyl tyrosine phosphorylation	GO:0050730	10	0.013
eye photoreceptor cell differentiation	GO:0001754	145	0.013
sex differentiation	GO:0007548	81	0.013
peptidyl tyrosine modification	GO:0018212	24	0.012	Mouse
cell division	GO:0051301	248	0.012
glycoprotein biosynthetic process	GO:0009101	41	0.012
actin filament bundle assembly	GO:0051017	26	0.012
positive regulation of intracellular signal transduction	GO:1902533	116	0.012
spermatid development	GO:0007286	98	0.012
lipid biosynthetic process	GO:0008610	46	0.012
regulation of wnt signaling pathway	GO:0030111	68	0.012
notch signaling pathway	GO:0007219	120	0.012
regulation of cell division	GO:0051302	72	0.012
cytoplasmic microtubule organization	GO:0031122	22	0.012
protein kinase b signaling	GO:0043491	1	0.012
membrane depolarization	GO:0051899	4	0.012
oocyte microtubule cytoskeleton polarization	GO:0008103	22	0.012
nucleus localization	GO:0051647	34	0.012
regulation of peptidase activity	GO:0052547	39	0.011
lipid metabolic process	GO:0006629	121	0.011
axonogenesis	GO:0007409	290	0.011
regulation of protein kinase activity	GO:0045859	51	0.011
establishment or maintenance of apical basal cell polarity	GO:0035088	34	0.011
protein targeting	GO:0006605	64	0.011
regulation of protein maturation	GO:1903317	32	0.011
positive regulation of developmental process	GO:0051094	143	0.011
nucleoside monophosphate metabolic process	GO:0009123	52	0.011
regulation of nucleoside metabolic process	GO:0009118	50	0.011
macromolecular complex disassembly	GO:0032984	37	0.011
organic cyclic compound catabolic process	GO:1901361	168	0.011
secondary metabolic process	GO:0019748	75	0.011
eggshell formation	GO:0030703	105	0.011
spindle assembly	GO:0051225	80	0.011
establishment or maintenance of microtubule cytoskeleton polarity	GO:0030951	41	0.011
regulation of embryonic development	GO:0045995	68	0.011
organophosphate catabolic process	GO:0046434	112	0.011
actomyosin contractile ring assembly	GO:0000915	10	0.011
neuron projection guidance	GO:0097485	241	0.010
pronuclear migration	GO:0035046	4	0.010
brain development	GO:0007420	120	0.010
protein processing	GO:0016485	68	0.010
protein localization to organelle	GO:0033365	82	0.010
muscle cell differentiation	GO:0042692	103	0.010
negative regulation of programmed cell death	GO:0043069	72	0.010
non sensory hair organization	GO:0035316	47	0.010
gtp metabolic process	GO:0046039	72	0.010
positive regulation of filopodium assembly	GO:0051491	15	0.010
spindle assembly involved in mitosis	GO:0090307	50	0.010

twf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.018
	nervous system disease	DOID:863	0	0.010

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