IMP: Integrative Multi-species Prediction

Drosophila melanogaster

140 known processes

Mpk2 (Dmel_CG5475)

CG5475 gene product from transcript CG5475-RB

(Aliases: DMPK2,Erk2,D-p38,p38A,dMPK2,Dp38,p38a,DmMPK2,Dmel\CG5475,P38,dp38a,dp38,D-p38a,mpk2,CG5475,p38,p38 alpha,D-MPK2,group 2,D-P38a)

FLYBASE: FBgn0015765
Entrez: 42866
UniProtKB: E1JIV6
UniProtKB: O62618

Process Predictions
Disease Predictions

Mpk2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002816	3	0.986
response to oxidative stress	GO:0006979	86	0.977
immune system process	GO:0002376	347	0.946
negative regulation of cellular metabolic process	GO:0031324	382	0.940	Fly
immune response	GO:0006955	246	0.929
intracellular signal transduction	GO:0035556	300	0.903
regulation of response to biotic stimulus	GO:0002831	63	0.885
regulation of anatomical structure morphogenesis	GO:0022603	242	0.855	Yeast Mouse
positive regulation of biosynthetic process	GO:0009891	316	0.835	Yeast Mouse Worm
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.750	Yeast Mouse Worm
regulation of immune response	GO:0050776	118	0.749
regulation of multi organism process	GO:0043900	131	0.747
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.741	Yeast Mouse Worm Fly
regulation of immune system process	GO:0002682	176	0.725
regulation of immune effector process	GO:0002697	52	0.702
positive regulation of gene expression	GO:0010628	290	0.702	Yeast Mouse Worm
defense response to other organism	GO:0098542	225	0.701
regulation of intracellular signal transduction	GO:1902531	236	0.682	Fly
regulation of cellular response to stress	GO:0080135	89	0.677
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.675
response to biotic stimulus	GO:0009607	294	0.674
positive regulation of rna biosynthetic process	GO:1902680	266	0.654	Yeast Mouse Worm
regulation of defense response to virus by host	GO:0050691	10	0.653
immune effector process	GO:0002252	98	0.640
humoral immune response	GO:0006959	117	0.639
lipopolysaccharide mediated signaling pathway	GO:0031663	1	0.609	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	316	0.603	Yeast Mouse Worm
negative regulation of cell communication	GO:0010648	223	0.583	Mouse Fly
memory	GO:0007613	94	0.571
regulation of defense response	GO:0031347	102	0.568	Fly
positive regulation of immune response	GO:0050778	63	0.561
response to abiotic stimulus	GO:0009628	341	0.550
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.549
mucosal immune response	GO:0002385	10	0.541
negative regulation of response to stimulus	GO:0048585	258	0.523
positive regulation of defense response to virus by host	GO:0002230	10	0.519
positive regulation of macromolecule metabolic process	GO:0010604	405	0.517	Yeast Mouse Worm Fly
innate immune response	GO:0045087	144	0.515	Worm Fly
defense response	GO:0006952	300	0.503
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.499	Yeast Mouse Worm
phosphorylation	GO:0016310	294	0.494
response to external biotic stimulus	GO:0043207	293	0.491
regulation of defense response to virus	GO:0050688	14	0.473
defense response to bacterium	GO:0042742	178	0.470
response to bacterium	GO:0009617	198	0.465
response to other organism	GO:0051707	293	0.453
neurological system process	GO:0050877	358	0.450
defense response to fungus	GO:0050832	48	0.443
antimicrobial peptide production	GO:0002775	46	0.430
mapk cascade	GO:0000165	107	0.429
response to oxygen radical	GO:0000305	3	0.427	Worm
negative regulation of cellular biosynthetic process	GO:0031327	277	0.417
gene silencing	GO:0016458	138	0.409
transcription from rna polymerase ii promoter	GO:0006366	368	0.397	Yeast Mouse Worm
homeostatic process	GO:0042592	199	0.392	Mouse
negative regulation of biosynthetic process	GO:0009890	277	0.391
regulation of cell morphogenesis	GO:0022604	163	0.390
cellular response to chemical stimulus	GO:0070887	199	0.382
regulation of humoral immune response	GO:0002920	51	0.369
adult chitin containing cuticle pigmentation	GO:0048085	16	0.361
regulation of antimicrobial humoral response	GO:0002759	50	0.358
cellular response to dna damage stimulus	GO:0006974	223	0.352	Human Mouse
organonitrogen compound biosynthetic process	GO:1901566	117	0.351
cell cycle checkpoint	GO:0000075	95	0.341	Mouse
peptide metabolic process	GO:0006518	80	0.338
dna damage checkpoint	GO:0000077	78	0.331	Mouse
positive regulation of immune system process	GO:0002684	68	0.330	Mouse
paracrine signaling	GO:0038001	7	0.321
cellular response to reactive oxygen species	GO:0034614	14	0.317
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.317	Yeast Mouse Worm
regionalization	GO:0003002	416	0.310
positive regulation of rna metabolic process	GO:0051254	271	0.301	Yeast Mouse Worm
regulation of mapk cascade	GO:0043408	92	0.299	Fly
response to peptidoglycan	GO:0032494	2	0.297
antimicrobial humoral response	GO:0019730	99	0.293
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.293	Yeast Mouse Worm
negative regulation of transcription dna templated	GO:0045892	237	0.289
positive regulation of response to stimulus	GO:0048584	323	0.289
negative regulation of gene expression	GO:0010629	387	0.285
antibacterial humoral response	GO:0019731	44	0.284	Fly
defense response to gram negative bacterium	GO:0050829	94	0.280	Worm
defense response to virus	GO:0051607	23	0.279
regulation of response to stress	GO:0080134	200	0.276
synaptic transmission	GO:0007268	288	0.274	Fly
dna integrity checkpoint	GO:0031570	81	0.272	Mouse
response to inorganic substance	GO:0010035	44	0.268
actin filament based process	GO:0030029	220	0.267
organ or tissue specific immune response	GO:0002251	10	0.264
cellular amide metabolic process	GO:0043603	80	0.261
organonitrogen compound metabolic process	GO:1901564	318	0.258
connective tissue development	GO:0061448	3	0.252	Mouse
positive regulation of transcription dna templated	GO:0045893	266	0.251	Yeast Mouse Worm
negative regulation of response to external stimulus	GO:0032102	22	0.247
positive regulation of immune effector process	GO:0002699	28	0.247
determination of adult lifespan	GO:0008340	137	0.243
regulation of response to external stimulus	GO:0032101	115	0.240
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.239	Yeast Mouse Worm
regulation of cellular component biogenesis	GO:0044087	201	0.239
dna metabolic process	GO:0006259	227	0.233	Yeast
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.230
epithelial cell differentiation	GO:0030855	322	0.228	Fly
regulation of defense response to bacterium	GO:1900424	30	0.228
positive regulation of signaling	GO:0023056	243	0.226
cellular response to oxygen containing compound	GO:1901701	79	0.226
death	GO:0016265	284	0.225	Worm
regulation of multicellular organismal development	GO:2000026	414	0.220
regulation of antibacterial peptide biosynthetic process	GO:0002808	22	0.214
positive regulation of cell communication	GO:0010647	250	0.213
biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002812	14	0.211
antibacterial peptide production	GO:0002778	22	0.210
response to reactive oxygen species	GO:0000302	24	0.205
positive regulation of signal transduction	GO:0009967	223	0.200
regulation of antibacterial peptide production	GO:0002786	22	0.198
regulation of metal ion transport	GO:0010959	15	0.197
epidermal cell differentiation	GO:0009913	51	0.191
negative regulation of rna biosynthetic process	GO:1902679	240	0.188
macromolecular complex assembly	GO:0065003	256	0.187
immune response regulating signaling pathway	GO:0002764	2	0.186
response to oxygen containing compound	GO:1901700	200	0.185
signal transduction by phosphorylation	GO:0023014	107	0.185
positive regulation of cellular component biogenesis	GO:0044089	80	0.184
response to heat	GO:0009408	63	0.179
negative regulation of defense response to bacterium	GO:1900425	7	0.176
positive regulation of defense response	GO:0031349	59	0.174
apoptotic process	GO:0006915	159	0.174
post embryonic appendage morphogenesis	GO:0035120	385	0.173	Fly
heart morphogenesis	GO:0003007	32	0.168
regulation of cell shape	GO:0008360	113	0.168
regulation of jnk cascade	GO:0046328	40	0.168	Fly
response to superoxide	GO:0000303	3	0.167	Worm
regulation of programmed cell death	GO:0043067	152	0.165
regulation of production of molecular mediator of immune response	GO:0002700	44	0.164
regulation of stress activated mapk cascade	GO:0032872	41	0.164	Fly
biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0002815	3	0.161
response to starvation	GO:0042594	97	0.159
positive regulation of defense response to bacterium	GO:1900426	23	0.158
aging	GO:0007568	143	0.157
amide biosynthetic process	GO:0043604	42	0.155
muscle organ development	GO:0007517	127	0.153	Mouse
positive regulation of cellular component organization	GO:0051130	156	0.152	Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.151
regulation of cell differentiation	GO:0045595	302	0.150	Yeast Mouse
regulation of innate immune response	GO:0045088	71	0.149	Fly
response to fungus	GO:0009620	50	0.145
pattern recognition receptor signaling pathway	GO:0002221	2	0.141
vesicle mediated transport	GO:0016192	381	0.139	Fly
imaginal disc derived appendage development	GO:0048737	399	0.139	Fly
regulation of antimicrobial peptide production	GO:0002784	44	0.138
pigmentation	GO:0043473	75	0.136
cellular chemical homeostasis	GO:0055082	40	0.136
regulation of dna metabolic process	GO:0051052	34	0.136	Yeast
antibacterial peptide biosynthetic process	GO:0002780	22	0.133
tube development	GO:0035295	244	0.133	Fly
cell death	GO:0008219	279	0.132	Worm
immune response activating signal transduction	GO:0002757	2	0.130
chemical homeostasis	GO:0048878	92	0.127
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.127
stress activated protein kinase signaling cascade	GO:0031098	55	0.124	Mouse Rat Worm Fly
regulation of cellular amide metabolic process	GO:0034248	39	0.123
multicellular organismal aging	GO:0010259	140	0.122
dorsal ventral pattern formation	GO:0009953	133	0.122
stress activated mapk cascade	GO:0051403	52	0.121	Mouse Rat Worm Fly
regulation of cell death	GO:0010941	173	0.120
response to nutrient levels	GO:0031667	114	0.120
negative regulation of signaling	GO:0023057	219	0.120	Mouse Fly
epithelial cell development	GO:0002064	274	0.119	Fly
response to organophosphorus	GO:0046683	2	0.119
dendrite morphogenesis	GO:0048813	199	0.118
carboxylic acid metabolic process	GO:0019752	92	0.118	Mouse
response to extracellular stimulus	GO:0009991	116	0.117
response to virus	GO:0009615	28	0.117
cellular amino acid metabolic process	GO:0006520	61	0.116
cellular response to ionizing radiation	GO:0071479	15	0.116	Human
skeletal muscle organ development	GO:0060538	48	0.115	Mouse
regulation of phosphorylation	GO:0042325	147	0.113	Fly
heart development	GO:0007507	82	0.109
programmed cell death	GO:0012501	257	0.108	Worm
response to lipopolysaccharide	GO:0032496	4	0.108	Human Mouse
melanization defense response	GO:0035006	45	0.107	Fly
negative regulation of peptidoglycan recognition protein signaling pathway	GO:0061060	3	0.107
muscle attachment	GO:0016203	36	0.107
organic substance transport	GO:0071702	257	0.106	Mouse
regulation of protein kinase activity	GO:0045859	51	0.106	Fly
positive regulation of intracellular signal transduction	GO:1902533	116	0.106
appendage development	GO:0048736	401	0.105	Fly
response to organic substance	GO:0010033	284	0.104	Human Mouse Rat Fly
regulation of neuron death	GO:1901214	26	0.104
bmp signaling pathway	GO:0030509	27	0.104	Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.102	Mouse Fly
peripheral nervous system development	GO:0007422	52	0.102
regulation of anatomical structure size	GO:0090066	163	0.101
positive regulation of phosphorus metabolic process	GO:0010562	139	0.100	Fly
inorganic ion transmembrane transport	GO:0098660	73	0.099
localization of cell	GO:0051674	257	0.097	Fly
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.097	Fly
response to osmotic stress	GO:0006970	14	0.096
ion transmembrane transport	GO:0034220	122	0.096
regulation of gene expression epigenetic	GO:0040029	128	0.096
immune system development	GO:0002520	57	0.095	Mouse
catabolic process	GO:0009056	409	0.095	Fly
regulation of phosphate metabolic process	GO:0019220	210	0.095	Fly
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria	GO:0006965	3	0.094
cell motility	GO:0048870	251	0.094	Fly
jnk cascade	GO:0007254	50	0.093	Fly
nucleobase containing compound catabolic process	GO:0034655	165	0.093
negative regulation of multicellular organismal process	GO:0051241	142	0.092
organic acid metabolic process	GO:0006082	103	0.092	Mouse
negative regulation of rna metabolic process	GO:0051253	251	0.092
oxoacid metabolic process	GO:0043436	103	0.091	Mouse
positive regulation of molecular function	GO:0044093	136	0.091
regulation of developmental pigmentation	GO:0048070	24	0.091
response to endogenous stimulus	GO:0009719	119	0.090	Mouse Fly
positive regulation of cell size	GO:0045793	21	0.089
response to lipid	GO:0033993	38	0.089	Human Mouse
chromatin silencing	GO:0006342	76	0.088
positive regulation of multicellular organismal process	GO:0051240	143	0.087	Human Mouse Fly
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.087	Fly
peptide biosynthetic process	GO:0043043	42	0.086
dendrite development	GO:0016358	204	0.086
purine containing compound catabolic process	GO:0072523	112	0.085
response to temperature stimulus	GO:0009266	106	0.085
cellular cation homeostasis	GO:0030003	38	0.085
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0002813	14	0.085
cellular response to heat	GO:0034605	24	0.085	Yeast
response to monosaccharide	GO:0034284	4	0.085	Rat
response to hexose	GO:0009746	3	0.085	Rat
response to salt stress	GO:0009651	11	0.084	Fly
appendage morphogenesis	GO:0035107	397	0.084	Fly
response to light stimulus	GO:0009416	124	0.083
response to nitrogen compound	GO:1901698	90	0.083	Mouse
regulation of blood circulation	GO:1903522	21	0.083
developmental maturation	GO:0021700	172	0.083
cellular macromolecule localization	GO:0070727	220	0.082	Mouse Worm
regulation of catalytic activity	GO:0050790	185	0.082	Fly
cell adhesion	GO:0007155	136	0.082
negative regulation of intracellular signal transduction	GO:1902532	57	0.080	Fly
imaginal disc derived wing morphogenesis	GO:0007476	337	0.080	Fly
cation homeostasis	GO:0055080	51	0.080
cuticle development	GO:0042335	86	0.079
secretion	GO:0046903	109	0.079
negative regulation of phosphorus metabolic process	GO:0010563	45	0.079	Fly
muscle tissue development	GO:0060537	30	0.079	Mouse
positive regulation of phosphate metabolic process	GO:0045937	139	0.078	Fly
cognition	GO:0050890	141	0.076
protein complex biogenesis	GO:0070271	201	0.076
organic hydroxy compound biosynthetic process	GO:1901617	21	0.075
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.075
endocytosis	GO:0006897	310	0.074	Fly
protein phosphorylation	GO:0006468	169	0.073
cell migration	GO:0016477	238	0.073	Fly
negative regulation of signal transduction	GO:0009968	206	0.072	Mouse Fly
digestive tract development	GO:0048565	149	0.072	Fly
response to metal ion	GO:0010038	23	0.071
regulation of cell development	GO:0060284	215	0.070	Mouse
negative regulation of apoptotic process	GO:0043066	63	0.068
protein localization	GO:0008104	284	0.067	Mouse Worm
regulation of apoptotic process	GO:0042981	130	0.067
regulation of stress activated protein kinase signaling cascade	GO:0070302	42	0.066	Fly
cellular response to biotic stimulus	GO:0071216	4	0.066	Human Mouse
protein localization to nucleus	GO:0034504	55	0.066	Mouse Worm
regulation of cell size	GO:0008361	63	0.066
maintenance of protein location in cell	GO:0032507	26	0.066
wing disc morphogenesis	GO:0007472	344	0.066	Fly
regulation of molecular function	GO:0065009	217	0.065	Fly
cellular response to lipopolysaccharide	GO:0071222	3	0.065	Human Mouse
innate immune response activating signal transduction	GO:0002758	2	0.065
regulation of canonical wnt signaling pathway	GO:0060828	15	0.065	Mouse
ion homeostasis	GO:0050801	55	0.064
production of molecular mediator of immune response	GO:0002440	46	0.064
positive regulation of antibacterial peptide production	GO:0002803	20	0.064
peptidoglycan recognition protein signaling pathway	GO:0061057	16	0.063
muscle fiber development	GO:0048747	12	0.063	Mouse
cell projection assembly	GO:0030031	94	0.063
salivary gland development	GO:0007431	162	0.063
positive regulation of catalytic activity	GO:0043085	118	0.062
nuclear division	GO:0000280	332	0.062
protein modification process	GO:0036211	438	0.061
taxis	GO:0042330	304	0.061	Fly
actin cytoskeleton organization	GO:0030036	206	0.061
salivary gland morphogenesis	GO:0007435	145	0.060
response to glucose	GO:0009749	2	0.059	Rat
positive regulation of programmed cell death	GO:0043068	62	0.059
cellular response to transforming growth factor beta stimulus	GO:0071560	18	0.057	Fly
positive regulation of cell differentiation	GO:0045597	64	0.057	Mouse
cellular nitrogen compound catabolic process	GO:0044270	165	0.057
antimicrobial peptide biosynthetic process	GO:0002777	38	0.057
regulation of heart contraction	GO:0008016	21	0.056
hemopoiesis	GO:0030097	46	0.056	Mouse
amine metabolic process	GO:0009308	12	0.056
regulation of bmp signaling pathway	GO:0030510	23	0.055	Fly
apoptotic signaling pathway	GO:0097190	27	0.055
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.055
ras protein signal transduction	GO:0007265	88	0.055
cell type specific apoptotic process	GO:0097285	38	0.055
muscle structure development	GO:0061061	224	0.054	Human Mouse
negative regulation of neuron death	GO:1901215	18	0.054
positive regulation of nervous system development	GO:0051962	69	0.054
ribose phosphate metabolic process	GO:0019693	145	0.053
positive regulation of dendrite morphogenesis	GO:0050775	9	0.053
regulation of phosphorus metabolic process	GO:0051174	210	0.053	Fly
regulation of protein metabolic process	GO:0051246	256	0.053	Fly
embryonic organ development	GO:0048568	50	0.053	Fly
activation of innate immune response	GO:0002218	4	0.052
cellular response to starvation	GO:0009267	61	0.052
phagocytosis	GO:0006909	215	0.052	Fly
positive regulation of antimicrobial peptide production	GO:0002225	28	0.052
regulation of nervous system development	GO:0051960	248	0.052
carbohydrate derivative metabolic process	GO:1901135	217	0.051
single organism cellular localization	GO:1902580	180	0.051	Mouse
cellular response to nutrient levels	GO:0031669	62	0.051
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.051
negative regulation of phosphorylation	GO:0042326	35	0.050	Fly
forebrain development	GO:0030900	2	0.050
regulation of ion transport	GO:0043269	39	0.050
cellular response to molecule of bacterial origin	GO:0071219	3	0.050	Human Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.049
negative regulation of defense response	GO:0031348	35	0.049
heart contraction	GO:0060047	26	0.049
nucleoside catabolic process	GO:0009164	112	0.049
axon guidance	GO:0007411	233	0.049	Fly
regulation of peptidoglycan recognition protein signaling pathway	GO:0061058	4	0.049
neuron projection guidance	GO:0097485	241	0.049	Fly
aromatic compound catabolic process	GO:0019439	166	0.049
carbohydrate derivative catabolic process	GO:1901136	118	0.049
response to organonitrogen compound	GO:0010243	75	0.048	Mouse
establishment of tissue polarity	GO:0007164	87	0.048
circulatory system process	GO:0003013	37	0.048
regulation of steroid metabolic process	GO:0019218	2	0.048
gtp catabolic process	GO:0006184	72	0.048
regulation of cell substrate adhesion	GO:0010810	2	0.048
positive regulation of developmental process	GO:0051094	143	0.048	Mouse Fly
multi organism behavior	GO:0051705	175	0.047
cellular response to organic substance	GO:0071310	132	0.047	Human Mouse Fly
single organism catabolic process	GO:0044712	228	0.046
regulation of cellular component size	GO:0032535	98	0.046
single organism biosynthetic process	GO:0044711	206	0.046	Yeast
substrate adhesion dependent cell spreading	GO:0034446	2	0.046
myoblast fusion	GO:0007520	43	0.045	Mouse
molting cycle chitin based cuticle	GO:0007591	56	0.045
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria	GO:0006964	12	0.045
purine nucleotide metabolic process	GO:0006163	146	0.045
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.045
actin filament based movement	GO:0030048	26	0.044
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.044
negative regulation of phosphate metabolic process	GO:0045936	45	0.044	Fly
regulation of cellular protein metabolic process	GO:0032268	243	0.044	Fly
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO:0070059	4	0.043
multi organism reproductive behavior	GO:0044705	121	0.043
neuron recognition	GO:0008038	101	0.043
response to organic cyclic compound	GO:0014070	89	0.043
small molecule metabolic process	GO:0044281	305	0.043	Mouse
skin development	GO:0043588	65	0.042
digestive system development	GO:0055123	149	0.042	Fly
response to growth factor	GO:0070848	31	0.042	Human Fly
cell activation	GO:0001775	9	0.042
cellular component assembly involved in morphogenesis	GO:0010927	151	0.042	Yeast Fly
regulation of transferase activity	GO:0051338	58	0.042	Fly
organonitrogen compound catabolic process	GO:1901565	128	0.041
developmental programmed cell death	GO:0010623	138	0.041
regulation of cell proliferation	GO:0042127	163	0.041
positive regulation of antibacterial peptide biosynthetic process	GO:0006963	20	0.041
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.041	Human Mouse Fly
male mating behavior	GO:0060179	70	0.041
positive regulation of cell migration	GO:0030335	2	0.041
purine nucleotide catabolic process	GO:0006195	109	0.041
muscle cell differentiation	GO:0042692	103	0.040	Human Mouse
organic substance catabolic process	GO:1901575	308	0.040
gtp metabolic process	GO:0046039	72	0.040
positive regulation of multi organism process	GO:0043902	40	0.040
regulation of adult chitin containing cuticle pigmentation	GO:0048082	13	0.040
peptidyl amino acid modification	GO:0018193	105	0.040	Human Mouse Worm
small gtpase mediated signal transduction	GO:0007264	88	0.040
cell cycle dna replication	GO:0044786	23	0.039	Yeast
regulation of organelle organization	GO:0033043	196	0.039
signal transduction in response to dna damage	GO:0042770	3	0.038	Human
regulation of cellular amine metabolic process	GO:0033238	3	0.038
negative regulation of gene expression epigenetic	GO:0045814	77	0.038
g protein coupled receptor signaling pathway	GO:0007186	136	0.037
morphogenesis of an epithelium	GO:0002009	276	0.036	Fly
cellular response to endogenous stimulus	GO:0071495	80	0.036	Fly
cellular catabolic process	GO:0044248	372	0.036	Fly
anatomical structure homeostasis	GO:0060249	97	0.036
cellular divalent inorganic cation homeostasis	GO:0072503	23	0.036
response to molecule of bacterial origin	GO:0002237	7	0.035	Human Mouse
long term memory	GO:0007616	62	0.035
axonogenesis	GO:0007409	290	0.035	Fly
single organism intracellular transport	GO:1902582	207	0.035	Mouse
regulation of ras protein signal transduction	GO:0046578	93	0.035
organelle assembly	GO:0070925	198	0.034
nucleotide metabolic process	GO:0009117	161	0.034
hematopoietic or lymphoid organ development	GO:0048534	57	0.034	Mouse
negative regulation of stress activated protein kinase signaling cascade	GO:0070303	20	0.034	Fly
positive regulation of antimicrobial humoral response	GO:0002760	28	0.034
negative regulation of cell death	GO:0060548	81	0.034
ribonucleotide metabolic process	GO:0009259	145	0.034
ion transport	GO:0006811	145	0.034
cation transmembrane transport	GO:0098655	88	0.033
cellular metal ion homeostasis	GO:0006875	31	0.033
response to radiation	GO:0009314	155	0.033	Human
peptidoglycan catabolic process	GO:0009253	3	0.033
purine containing compound metabolic process	GO:0072521	155	0.033
myotube cell development	GO:0014904	3	0.033	Mouse
oocyte development	GO:0048599	124	0.033
mating behavior	GO:0007617	106	0.033
response to wounding	GO:0009611	94	0.033	Mouse Fly
biological adhesion	GO:0022610	138	0.033
reactive oxygen species metabolic process	GO:0072593	22	0.033
negative regulation of cellular component organization	GO:0051129	108	0.032
developmental pigmentation	GO:0048066	68	0.032
positive regulation of antimicrobial peptide biosynthetic process	GO:0002807	26	0.032
learning or memory	GO:0007611	141	0.032
digestive tract morphogenesis	GO:0048546	127	0.032	Fly
cell aging	GO:0007569	2	0.031	Human
organic hydroxy compound metabolic process	GO:1901615	83	0.031	Fly
response to decreased oxygen levels	GO:0036293	58	0.031
positive regulation of protein metabolic process	GO:0051247	128	0.031	Fly
positive regulation of humoral immune response	GO:0002922	28	0.031
regulation of map kinase activity	GO:0043405	17	0.031	Fly
response to hypoxia	GO:0001666	53	0.031
somatic muscle development	GO:0007525	66	0.031
positive regulation of cell development	GO:0010720	61	0.031
ameboidal type cell migration	GO:0001667	151	0.030	Fly
nucleocytoplasmic transport	GO:0006913	72	0.030	Mouse
purine ribonucleotide metabolic process	GO:0009150	145	0.030
purine nucleoside metabolic process	GO:0042278	127	0.030
axon development	GO:0061564	297	0.030	Fly
regulation of protein modification process	GO:0031399	112	0.030	Fly
organic cyclic compound catabolic process	GO:1901361	168	0.030
negative regulation of cell differentiation	GO:0045596	143	0.030	Yeast
cellular response to extracellular stimulus	GO:0031668	64	0.030
circadian rhythm	GO:0007623	105	0.030
gland morphogenesis	GO:0022612	145	0.030
cellular response to nitrogen compound	GO:1901699	51	0.030
extrinsic apoptotic signaling pathway	GO:0097191	1	0.029
negative regulation of kinase activity	GO:0033673	16	0.029	Fly
striated muscle cell development	GO:0055002	50	0.029	Mouse
macromolecule catabolic process	GO:0009057	161	0.029
ovarian follicle cell development	GO:0030707	248	0.029	Fly
glycosaminoglycan catabolic process	GO:0006027	3	0.028
regulation of cell projection organization	GO:0031344	92	0.028
positive regulation of apoptotic signaling pathway	GO:2001235	4	0.028
visual learning	GO:0008542	4	0.028
response to ionizing radiation	GO:0010212	32	0.028	Human
metal ion homeostasis	GO:0055065	44	0.028
sex determination	GO:0007530	18	0.028
regulation of chromosome organization	GO:0033044	64	0.028
heterochromatin organization	GO:0070828	25	0.028
nuclear dna replication	GO:0033260	1	0.028	Yeast
regulation of nucleocytoplasmic transport	GO:0046822	35	0.028	Mouse
regulation of neuron differentiation	GO:0045664	103	0.028
negative regulation of developmental process	GO:0051093	201	0.027	Yeast
regulation of hydrolase activity	GO:0051336	97	0.027
jak stat cascade	GO:0007259	49	0.027
regulation of wnt signaling pathway	GO:0030111	68	0.027	Mouse
glycosyl compound metabolic process	GO:1901657	127	0.027
response to hydrogen peroxide	GO:0042542	11	0.027
eye development	GO:0001654	323	0.027
respiratory system development	GO:0060541	213	0.027
heterocycle catabolic process	GO:0046700	166	0.027
terminal button organization	GO:0072553	19	0.027	Fly
regulation of cellular ketone metabolic process	GO:0010565	3	0.027
positive regulation of reactive oxygen species metabolic process	GO:2000379	0	0.027	Human
nucleotide catabolic process	GO:0009166	109	0.027
cell proliferation	GO:0008283	299	0.027
cuticle pigmentation	GO:0048067	22	0.026
wound healing	GO:0042060	75	0.026	Mouse Fly
purine ribonucleoside catabolic process	GO:0046130	112	0.026
purine ribonucleoside metabolic process	GO:0046128	127	0.026
central nervous system development	GO:0007417	201	0.026
positive regulation of cell motility	GO:2000147	3	0.026
intracellular transport	GO:0046907	228	0.026	Mouse
cell cell junction organization	GO:0045216	55	0.026
regulation of homeostatic process	GO:0032844	7	0.026	Mouse
tissue death	GO:0016271	102	0.026
divalent inorganic cation homeostasis	GO:0072507	29	0.026
regulation of purine nucleotide metabolic process	GO:1900542	62	0.025
cellular response to lipid	GO:0071396	20	0.025	Human Mouse
nucleoside triphosphate metabolic process	GO:0009141	120	0.025
positive regulation of innate immune response	GO:0045089	38	0.025
positive regulation of mapk cascade	GO:0043410	63	0.025
regulation of cell cycle	GO:0051726	291	0.025	Yeast Rat
organophosphate catabolic process	GO:0046434	112	0.025
myotube differentiation	GO:0014902	46	0.025	Mouse
neuron death	GO:0070997	27	0.025
negative regulation of wnt signaling pathway	GO:0030178	28	0.024	Mouse
protein complex assembly	GO:0006461	200	0.024
response to copper ion	GO:0046688	4	0.024
guanosine containing compound metabolic process	GO:1901068	74	0.024
regulation of cellular amino acid metabolic process	GO:0006521	0	0.024
nuclear transport	GO:0051169	72	0.024	Mouse
imaginal disc derived wing margin morphogenesis	GO:0008587	41	0.024
negative regulation of programmed cell death	GO:0043069	72	0.024
carbohydrate metabolic process	GO:0005975	82	0.024	Mouse
ribonucleotide catabolic process	GO:0009261	109	0.024
actin filament organization	GO:0007015	126	0.024

Mpk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.074
cancer	DOID:162	0.024
disease of cellular proliferation	DOID:14566	0.024
organ system cancer	DOID:0050686	0.024

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