IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Sirt4 (Dmel_CG3187)

CG3187 gene product from transcript CG3187-RC

(Aliases: Dmel\CG3187,dSIRT4,CG3187,D.mel3,dmSRT407)

FLYBASE: FBgn0029783
Entrez: 31480
UniProtKB: Q8IRR5

Process Predictions
Disease Predictions

Sirt4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
small molecule metabolic process	GO:0044281	305	0.080
protein modification process	GO:0036211	438	0.071
organonitrogen compound metabolic process	GO:1901564	318	0.065
negative regulation of response to stimulus	GO:0048585	258	0.060
phosphorylation	GO:0016310	294	0.050
regulation of intracellular signal transduction	GO:1902531	236	0.049
detection of stimulus	GO:0051606	156	0.047
negative regulation of signal transduction	GO:0009968	206	0.044
nucleobase containing small molecule metabolic process	GO:0055086	174	0.044
regulation of cellular protein metabolic process	GO:0032268	243	0.042	Rat
vesicle mediated transport	GO:0016192	381	0.041
nucleotide metabolic process	GO:0009117	161	0.041
lateral inhibition	GO:0046331	206	0.035
intracellular signal transduction	GO:0035556	300	0.034
regulation of immune response	GO:0050776	118	0.034
endocytosis	GO:0006897	310	0.030
locomotory behavior	GO:0007626	176	0.028
macromolecular complex assembly	GO:0065003	256	0.028
cellular protein modification process	GO:0006464	438	0.027
negative regulation of signaling	GO:0023057	219	0.027	Human
response to monosaccharide	GO:0034284	4	0.026
nucleoside phosphate metabolic process	GO:0006753	162	0.026
single organism cellular localization	GO:1902580	180	0.026	Rat
regulation of cellular amine metabolic process	GO:0033238	3	0.025
response to glucose	GO:0009749	2	0.025
response to biotic stimulus	GO:0009607	294	0.025
regulation of cell cycle	GO:0051726	291	0.025
response to external biotic stimulus	GO:0043207	293	0.025
positive regulation of cell migration	GO:0030335	2	0.025
organic substance catabolic process	GO:1901575	308	0.024
negative regulation of gene expression	GO:0010629	387	0.024	Rat
organophosphate metabolic process	GO:0019637	195	0.024
regulation of organelle organization	GO:0033043	196	0.024	Rat
regulation of immune system process	GO:0002682	176	0.023
regulation of cell death	GO:0010941	173	0.023	Rat
endomembrane system organization	GO:0010256	119	0.023
response to other organism	GO:0051707	293	0.022
regulation of phosphorus metabolic process	GO:0051174	210	0.022
catabolic process	GO:0009056	409	0.022
cellular response to chemical stimulus	GO:0070887	199	0.022	Rat
ion homeostasis	GO:0050801	55	0.022
phenol containing compound metabolic process	GO:0018958	57	0.022
secretion	GO:0046903	109	0.022	Human
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.021
single organism intracellular transport	GO:1902582	207	0.021	Rat
epithelial cell migration	GO:0010631	148	0.021
activation of innate immune response	GO:0002218	4	0.021
protein complex biogenesis	GO:0070271	201	0.020
regulation of phosphorylation	GO:0042325	147	0.020
regulation of phosphate metabolic process	GO:0019220	210	0.020
phagocytosis	GO:0006909	215	0.020
tissue migration	GO:0090130	155	0.020
protein localization	GO:0008104	284	0.020	Rat
regulation of cellular component biogenesis	GO:0044087	201	0.019
death	GO:0016265	284	0.019	Rat
defense response	GO:0006952	300	0.019
positive regulation of phosphate metabolic process	GO:0045937	139	0.019
apoptotic process	GO:0006915	159	0.019	Rat
positive regulation of response to stimulus	GO:0048584	323	0.019
programmed cell death	GO:0012501	257	0.019	Rat
innate immune response	GO:0045087	144	0.019
ribonucleoside metabolic process	GO:0009119	127	0.019
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.019
carbohydrate derivative metabolic process	GO:1901135	217	0.019
nucleoside triphosphate metabolic process	GO:0009141	120	0.019
response to organic substance	GO:0010033	284	0.018
response to oxygen containing compound	GO:1901700	200	0.018
carboxylic acid metabolic process	GO:0019752	92	0.018
regulation of transport	GO:0051049	181	0.018	Human Rat
immune response activating signal transduction	GO:0002757	2	0.018
nucleoside metabolic process	GO:0009116	127	0.018
purine ribonucleotide metabolic process	GO:0009150	145	0.018
camera type eye development	GO:0043010	4	0.018
organic acid metabolic process	GO:0006082	103	0.018
response to hexose	GO:0009746	3	0.018
immune response regulating signaling pathway	GO:0002764	2	0.017
single organism behavior	GO:0044708	391	0.017
positive regulation of signal transduction	GO:0009967	223	0.017
protein complex assembly	GO:0006461	200	0.017
establishment of localization in cell	GO:0051649	402	0.017	Human Rat
regulation of catalytic activity	GO:0050790	185	0.017
negative regulation of cell death	GO:0060548	81	0.017	Rat
epithelial cell differentiation	GO:0030855	322	0.017
cellular response to organic substance	GO:0071310	132	0.017
energy derivation by oxidation of organic compounds	GO:0015980	32	0.017
organelle assembly	GO:0070925	198	0.017
single organism catabolic process	GO:0044712	228	0.017
regionalization	GO:0003002	416	0.016
determination of adult lifespan	GO:0008340	137	0.016
cell division	GO:0051301	248	0.016
positive regulation of phosphorus metabolic process	GO:0010562	139	0.016
regulation of programmed cell death	GO:0043067	152	0.016	Rat
generation of precursor metabolites and energy	GO:0006091	42	0.016
response to organophosphorus	GO:0046683	2	0.016
regulation of apoptotic process	GO:0042981	130	0.015	Rat
actin filament based process	GO:0030029	220	0.015
purine nucleotide metabolic process	GO:0006163	146	0.015
cellular macromolecular complex assembly	GO:0034622	153	0.015
cell proliferation	GO:0008283	299	0.015
single organism biosynthetic process	GO:0044711	206	0.015
regulation of response to stress	GO:0080134	200	0.015
cellular protein complex assembly	GO:0043623	71	0.015
ribonucleotide metabolic process	GO:0009259	145	0.015
mitotic nuclear division	GO:0007067	213	0.015
response to abiotic stimulus	GO:0009628	341	0.015	Rat
purine ribonucleoside metabolic process	GO:0046128	127	0.014
protein phosphorylation	GO:0006468	169	0.014
regulation of multicellular organismal development	GO:2000026	414	0.014
positive regulation of multicellular organismal process	GO:0051240	143	0.014
response to radiation	GO:0009314	155	0.014
cellular ion homeostasis	GO:0006873	39	0.014
homeostatic process	GO:0042592	199	0.014
axonogenesis	GO:0007409	290	0.014
aging	GO:0007568	143	0.014
immune response	GO:0006955	246	0.014
epithelium migration	GO:0090132	148	0.014
actin filament organization	GO:0007015	126	0.014
cellular cation homeostasis	GO:0030003	38	0.014
chemical homeostasis	GO:0048878	92	0.013
immune system process	GO:0002376	347	0.013
positive regulation of cell communication	GO:0010647	250	0.013
purine nucleoside metabolic process	GO:0042278	127	0.013
detection of stimulus involved in sensory perception	GO:0050906	92	0.013
developmental programmed cell death	GO:0010623	138	0.013
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.013
organic substance transport	GO:0071702	257	0.013	Human Rat
organonitrogen compound biosynthetic process	GO:1901566	117	0.013
positive regulation of phosphorylation	GO:0042327	87	0.013
cell death	GO:0008219	279	0.013	Rat
cellular amine metabolic process	GO:0044106	12	0.013
amine metabolic process	GO:0009308	12	0.013
regulation of multi organism process	GO:0043900	131	0.013
golgi organization	GO:0007030	66	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
intracellular transport	GO:0046907	228	0.013	Rat
autophagic cell death	GO:0048102	83	0.013
glycosyl compound metabolic process	GO:1901657	127	0.013
negative regulation of programmed cell death	GO:0043069	72	0.013	Rat
response to nitrogen compound	GO:1901698	90	0.012
positive regulation of exocytosis	GO:0045921	4	0.012
regulation of anatomical structure size	GO:0090066	163	0.012
purine containing compound metabolic process	GO:0072521	155	0.012
positive regulation of cell motility	GO:2000147	3	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012
macromolecule catabolic process	GO:0009057	161	0.012
chemotaxis	GO:0006935	249	0.012
positive regulation of mapk cascade	GO:0043410	63	0.012
cellular response to monosaccharide stimulus	GO:0071326	2	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.012
response to organic cyclic compound	GO:0014070	89	0.012
cellular metal ion homeostasis	GO:0006875	31	0.012
histolysis	GO:0007559	102	0.012
membrane organization	GO:0061024	112	0.012
oxidation reduction process	GO:0055114	123	0.012
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.012
ribose phosphate metabolic process	GO:0019693	145	0.012
protein modification by small protein conjugation	GO:0032446	79	0.012
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.012
detection of chemical stimulus	GO:0009593	93	0.012
sensory perception	GO:0007600	196	0.012
endosomal transport	GO:0016197	44	0.012
negative regulation of developmental process	GO:0051093	201	0.012
ovarian follicle cell development	GO:0030707	248	0.012
positive regulation of macromolecule metabolic process	GO:0010604	405	0.011
response to alcohol	GO:0097305	95	0.011
positive regulation of immune system process	GO:0002684	68	0.011
signal transduction by phosphorylation	GO:0023014	107	0.011
ras protein signal transduction	GO:0007265	88	0.011
cellular ketone metabolic process	GO:0042180	24	0.011
carbohydrate derivative biosynthetic process	GO:1901137	85	0.011
sensory perception of pain	GO:0019233	4	0.011
actin cytoskeleton organization	GO:0030036	206	0.011
response to bacterium	GO:0009617	198	0.011
protein processing	GO:0016485	68	0.011	Rat
response to lipopolysaccharide	GO:0032496	4	0.011
protein ubiquitination	GO:0016567	70	0.011
neurological system process	GO:0050877	358	0.011
regulation of cell differentiation	GO:0045595	302	0.011
cellular response to ethanol	GO:0071361	4	0.011
response to endogenous stimulus	GO:0009719	119	0.011
regulation of defense response	GO:0031347	102	0.011
establishment of protein localization	GO:0045184	163	0.011	Rat
protein transport	GO:0015031	155	0.011	Rat
regulation of innate immune response	GO:0045088	71	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.011
regulation of cellular localization	GO:0060341	136	0.011	Human Rat
protein modification by small protein conjugation or removal	GO:0070647	106	0.011
cellular catabolic process	GO:0044248	372	0.011
compound eye development	GO:0048749	307	0.011
negative regulation of cellular metabolic process	GO:0031324	382	0.011	Rat
negative regulation of apoptotic process	GO:0043066	63	0.010	Rat
protein maturation	GO:0051604	71	0.010	Rat
autophagy	GO:0006914	108	0.010
nuclear division	GO:0000280	332	0.010
germarium derived egg chamber formation	GO:0007293	101	0.010
organic hydroxy compound metabolic process	GO:1901615	83	0.010
dorsal ventral pattern formation	GO:0009953	133	0.010
nucleoside monophosphate metabolic process	GO:0009123	52	0.010
pattern recognition receptor signaling pathway	GO:0002221	2	0.010
wound healing	GO:0042060	75	0.010
response to hormone	GO:0009725	45	0.010
response to extracellular stimulus	GO:0009991	116	0.010
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.010
negative regulation of cellular protein metabolic process	GO:0032269	85	0.010	Rat
defense response to other organism	GO:0098542	225	0.010

Sirt4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.047
nervous system disease	DOID:863	0.016
disease of cellular proliferation	DOID:14566	0.013
cancer	DOID:162	0.011
organ system cancer	DOID:0050686	0.011
sensory system disease	DOID:0050155	0.010

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