IMP: Integrative Multi-species Prediction

Drosophila melanogaster

97 known processes

geminin (Dmel_CG3183)

CG3183 gene product from transcript CG3183-RA

(Aliases: v(2)k09107,Dm Geminin,Dm geminin,anon-WO0257455.1,l(2)k14019,gem,Geminin,CG3183,Dmel\CG3183,Gem)

FLYBASE: FBgn0033081
Entrez: 35563
UniProtKB: Q7JX41

Process Predictions
Disease Predictions

geminin biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
protein complex biogenesis	GO:0070271	201	0.967	Mouse
spindle organization	GO:0007051	253	0.958
mitotic spindle organization	GO:0007052	220	0.777
positive regulation of transcription dna templated	GO:0045893	266	0.766
organelle fission	GO:0048285	340	0.702
neuronal stem cell division	GO:0036445	35	0.678
mitotic sister chromatid separation	GO:0051306	30	0.647
nuclear division	GO:0000280	332	0.619
mitotic nuclear division	GO:0007067	213	0.543
regulation of mitosis	GO:0007088	56	0.528
meiotic nuclear division	GO:0007126	151	0.526
transcription from rna polymerase ii promoter	GO:0006366	368	0.522
cell division	GO:0051301	248	0.519
phosphorylation	GO:0016310	294	0.517
small molecule metabolic process	GO:0044281	305	0.477
chromosome segregation	GO:0007059	157	0.476
sex differentiation	GO:0007548	81	0.377
positive regulation of rna metabolic process	GO:0051254	271	0.369
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.343
positive regulation of cellular biosynthetic process	GO:0031328	316	0.282
reproductive structure development	GO:0048608	74	0.278
positive regulation of biosynthetic process	GO:0009891	316	0.276
programmed cell death	GO:0012501	257	0.273
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.262
development of primary sexual characteristics	GO:0045137	50	0.255
genitalia development	GO:0048806	26	0.254
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.254
regulation of mitotic cell cycle	GO:0007346	190	0.230
cell cycle phase transition	GO:0044770	140	0.221
reproductive system development	GO:0061458	74	0.219
macromolecular complex assembly	GO:0065003	256	0.217	Mouse
regulation of cell division	GO:0051302	72	0.214
protein complex assembly	GO:0006461	200	0.208	Mouse
compound eye development	GO:0048749	307	0.205
regulation of cell cycle phase transition	GO:1901987	130	0.199
mitotic cell cycle phase transition	GO:0044772	138	0.195
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.192
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.185
spindle assembly involved in mitosis	GO:0090307	50	0.185
chromosome organization	GO:0051276	360	0.184
regulation of organelle organization	GO:0033043	196	0.180
proteasomal protein catabolic process	GO:0010498	59	0.178
cellular macromolecule catabolic process	GO:0044265	136	0.174
regulation of cell cycle process	GO:0010564	181	0.174
negative regulation of gene expression	GO:0010629	387	0.173	Human Mouse
meiotic cell cycle process	GO:1903046	132	0.173
spindle assembly	GO:0051225	80	0.167
meiotic cell cycle	GO:0051321	171	0.150
chromosome separation	GO:0051304	42	0.148
positive regulation of macromolecule metabolic process	GO:0010604	405	0.144
positive regulation of gene expression	GO:0010628	290	0.143
regulation of programmed cell death	GO:0043067	152	0.137
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.136
chromosome localization	GO:0050000	20	0.133
neuroblast proliferation	GO:0007405	74	0.132
modification dependent protein catabolic process	GO:0019941	78	0.131
regulation of nuclear division	GO:0051783	58	0.130
single organism biosynthetic process	GO:0044711	206	0.130
regulation of gene silencing	GO:0060968	63	0.130
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.126
neuroblast division	GO:0055057	35	0.125
mitotic sister chromatid segregation	GO:0000070	87	0.121
regulation of sister chromatid segregation	GO:0033045	28	0.120
positive regulation of rna biosynthetic process	GO:1902680	266	0.119
gonad development	GO:0008406	50	0.116
translation	GO:0006412	69	0.114
vesicle mediated transport	GO:0016192	381	0.112
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.112
regulation of dna metabolic process	GO:0051052	34	0.111
regulation of cell death	GO:0010941	173	0.096
digestive system development	GO:0055123	149	0.092
ubiquitin dependent protein catabolic process	GO:0006511	78	0.091
catabolic process	GO:0009056	409	0.090
regulation of mitotic sister chromatid separation	GO:0010965	28	0.090
regulation of protein metabolic process	GO:0051246	256	0.087
gene silencing by rna	GO:0031047	57	0.086
regulation of chromosome segregation	GO:0051983	32	0.086
sister chromatid segregation	GO:0000819	92	0.086
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.083
regulation of cell cycle	GO:0051726	291	0.079
regulation of meiosis	GO:0040020	3	0.078
regulation of chromosome organization	GO:0033044	64	0.078
cellular protein modification process	GO:0006464	438	0.076
dendrite morphogenesis	GO:0048813	199	0.074
establishment of localization in cell	GO:0051649	402	0.072
negative regulation of phosphorus metabolic process	GO:0010563	45	0.071
carboxylic acid metabolic process	GO:0019752	92	0.067
negative regulation of cell cycle	GO:0045786	116	0.067	Human Mouse
oocyte differentiation	GO:0009994	145	0.067
negative regulation of cellular metabolic process	GO:0031324	382	0.065
regulation of cellular protein metabolic process	GO:0032268	243	0.065
intracellular signal transduction	GO:0035556	300	0.062
modification dependent macromolecule catabolic process	GO:0043632	79	0.059
negative regulation of phosphate metabolic process	GO:0045936	45	0.059
positive regulation of phosphorylation	GO:0042327	87	0.055
positive regulation of signal transduction	GO:0009967	223	0.054
g2 m transition of mitotic cell cycle	GO:0000086	19	0.054
posttranscriptional gene silencing	GO:0016441	46	0.054
endocytosis	GO:0006897	310	0.053
regulation of cellular catabolic process	GO:0031329	157	0.053
positive regulation of cell communication	GO:0010647	250	0.051
regulation of heterochromatin assembly	GO:0031445	8	0.050
organic substance catabolic process	GO:1901575	308	0.050
chromosome movement towards spindle pole	GO:0051305	4	0.050
positive regulation of signaling	GO:0023056	243	0.049
positive regulation of protein metabolic process	GO:0051247	128	0.049
oxoacid metabolic process	GO:0043436	103	0.047
cytoplasmic microtubule organization	GO:0031122	22	0.044
organelle assembly	GO:0070925	198	0.043	Zebrafish
posttranscriptional regulation of gene expression	GO:0010608	145	0.040
negative regulation of organelle organization	GO:0010639	56	0.039
negative regulation of mitotic cell cycle	GO:0045930	109	0.039
stem cell division	GO:0017145	69	0.037
stem cell proliferation	GO:0072089	88	0.037
single organism catabolic process	GO:0044712	228	0.037
small gtpase mediated signal transduction	GO:0007264	88	0.036
metaphase anaphase transition of cell cycle	GO:0044784	28	0.036
positive regulation of response to stimulus	GO:0048584	323	0.036
body morphogenesis	GO:0010171	2	0.035
protein catabolic process	GO:0030163	101	0.035
regulation of apoptotic process	GO:0042981	130	0.034
signal transduction by phosphorylation	GO:0023014	107	0.034
negative regulation of intrinsic apoptotic signaling pathway	GO:2001243	1	0.034
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.033
organic acid metabolic process	GO:0006082	103	0.033
posttranscriptional gene silencing by rna	GO:0035194	45	0.032
proteolysis	GO:0006508	192	0.032
regionalization	GO:0003002	416	0.030
protein phosphorylation	GO:0006468	169	0.030
establishment of chromosome localization	GO:0051303	20	0.028
purine ribonucleotide catabolic process	GO:0009154	109	0.027
morphogenesis of an epithelium	GO:0002009	276	0.027
regulation of molecular function	GO:0065009	217	0.026
positive regulation of cellular catabolic process	GO:0031331	95	0.026
mitotic cell cycle checkpoint	GO:0007093	88	0.026
response to abiotic stimulus	GO:0009628	341	0.026
organelle localization	GO:0051640	148	0.026
eye development	GO:0001654	323	0.026
neural precursor cell proliferation	GO:0061351	75	0.025
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.025
nucleus organization	GO:0006997	45	0.025
regulation of gene expression epigenetic	GO:0040029	128	0.025
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.025
microtubule organizing center organization	GO:0031023	168	0.024
anatomical structure homeostasis	GO:0060249	97	0.024
aromatic compound catabolic process	GO:0019439	166	0.023
tube morphogenesis	GO:0035239	191	0.023
macromolecule catabolic process	GO:0009057	161	0.023
negative regulation of signaling	GO:0023057	219	0.023
regulation of intracellular signal transduction	GO:1902531	236	0.022
positive regulation of cell proliferation	GO:0008284	47	0.022
endomitotic cell cycle	GO:0007113	7	0.022
mitotic sister chromatid cohesion	GO:0007064	6	0.022
regulation of phosphatase activity	GO:0010921	3	0.022
regulation of phosphorus metabolic process	GO:0051174	210	0.022
cellular macromolecular complex assembly	GO:0034622	153	0.022
regulation of catabolic process	GO:0009894	170	0.022
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.021
cell death	GO:0008219	279	0.021
organophosphate catabolic process	GO:0046434	112	0.021
g1 s transition of mitotic cell cycle	GO:0000082	31	0.021
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.021
regulation of phosphorylation	GO:0042325	147	0.021
regulation of transport	GO:0051049	181	0.020
oocyte development	GO:0048599	124	0.020
negative regulation of apoptotic process	GO:0043066	63	0.020
carbohydrate derivative metabolic process	GO:1901135	217	0.019
developmental programmed cell death	GO:0010623	138	0.019
phagocytosis	GO:0006909	215	0.019
positive regulation of lipid catabolic process	GO:0050996	1	0.018
larval development	GO:0002164	104	0.017
organophosphate metabolic process	GO:0019637	195	0.017
response to biotic stimulus	GO:0009607	294	0.017
gene silencing	GO:0016458	138	0.017
regulation of cellular response to stress	GO:0080135	89	0.017
purine ribonucleotide metabolic process	GO:0009150	145	0.017
eye photoreceptor cell differentiation	GO:0001754	145	0.017
dna metabolic process	GO:0006259	227	0.016
reactive nitrogen species metabolic process	GO:2001057	0	0.016
regulation of cell cycle g1 s phase transition	GO:1902806	23	0.016
mitotic spindle elongation	GO:0000022	81	0.016
receptor mediated endocytosis	GO:0006898	21	0.016
establishment or maintenance of cell polarity	GO:0007163	167	0.016
nucleoside triphosphate metabolic process	GO:0009141	120	0.016
ribose phosphate metabolic process	GO:0019693	145	0.016
regulation of proteasomal protein catabolic process	GO:0061136	39	0.016
organic cyclic compound catabolic process	GO:1901361	168	0.016
regulation of localization	GO:0032879	275	0.016
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.016
regulation of catalytic activity	GO:0050790	185	0.015
purine nucleotide metabolic process	GO:0006163	146	0.015
negative regulation of transcription factor import into nucleus	GO:0042992	4	0.015
death	GO:0016265	284	0.015
negative regulation of cell cycle phase transition	GO:1901988	103	0.015
gland development	GO:0048732	191	0.014	Zebrafish
negative regulation of protein metabolic process	GO:0051248	85	0.014
spindle elongation	GO:0051231	83	0.014
nucleus localization	GO:0051647	34	0.014
positive regulation of phosphate metabolic process	GO:0045937	139	0.014
cell cycle dna replication	GO:0044786	23	0.014
negative regulation of cell communication	GO:0010648	223	0.014
organonitrogen compound metabolic process	GO:1901564	318	0.013
intracellular transport	GO:0046907	228	0.013
peptidyl amino acid modification	GO:0018193	105	0.013
protein modification process	GO:0036211	438	0.013
ribonucleoside catabolic process	GO:0042454	112	0.013
nitric oxide metabolic process	GO:0046209	1	0.013
regulation of proteolysis	GO:0030162	87	0.013
centrosome organization	GO:0051297	163	0.013
reproductive behavior	GO:0019098	122	0.013
dna hypermethylation	GO:0044026	3	0.013
salivary gland development	GO:0007431	162	0.013
reactive oxygen species biosynthetic process	GO:1903409	0	0.012
positive regulation of catalytic activity	GO:0043085	118	0.012
positive regulation of cellular protein metabolic process	GO:0032270	118	0.012
cell cycle checkpoint	GO:0000075	95	0.012
purine containing compound metabolic process	GO:0072521	155	0.012
negative regulation of transcription dna templated	GO:0045892	237	0.012	Human Mouse
regulation of syncytial blastoderm mitotic cell cycle	GO:0007348	4	0.012
negative regulation of programmed cell death	GO:0043069	72	0.012
dna replication initiation	GO:0006270	6	0.012
regulation of striated muscle contraction	GO:0006942	2	0.012
covalent chromatin modification	GO:0016569	106	0.012
purine nucleoside catabolic process	GO:0006152	112	0.012
positive regulation of cell death	GO:0010942	69	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.012
cellular response to nutrient	GO:0031670	1	0.012
epithelial tube morphogenesis	GO:0060562	88	0.012
anterior posterior pattern specification	GO:0009952	136	0.012
regulation of kinase activity	GO:0043549	53	0.012
regulation of transferase activity	GO:0051338	58	0.012
positive regulation of cellular component organization	GO:0051130	156	0.012
immune system development	GO:0002520	57	0.012
positive regulation of binding	GO:0051099	4	0.011
gene silencing by mirna	GO:0035195	22	0.011
regulation of cyclin dependent protein serine threonine kinase activity	GO:0000079	3	0.011
embryo development ending in birth or egg hatching	GO:0009792	152	0.011
positive regulation of apoptotic process	GO:0043065	47	0.011
apoptotic process	GO:0006915	159	0.011
negative regulation of cell death	GO:0060548	81	0.011
cellular catabolic process	GO:0044248	372	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.011	Human Mouse
dorsal vessel heart proper cell fate commitment	GO:0035053	2	0.011
mitochondrial membrane organization	GO:0007006	3	0.011
negative regulation of phosphorylation	GO:0042326	35	0.011
meiotic cell cycle phase transition	GO:0044771	4	0.011
demethylation	GO:0070988	6	0.011
dendrite development	GO:0016358	204	0.011
multi multicellular organism process	GO:0044706	123	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.011
muscle cell differentiation	GO:0042692	103	0.010
prostanoid biosynthetic process	GO:0046457	1	0.010
nucleoside monophosphate metabolic process	GO:0009123	52	0.010
negative regulation of gtp catabolic process	GO:0033125	1	0.010
regulation of hydrolase activity	GO:0051336	97	0.010
ovarian follicle cell development	GO:0030707	248	0.010
cell proliferation	GO:0008283	299	0.010

geminin disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
syndrome	DOID:225	0.014
musculoskeletal system disease	DOID:17	0.011
dysostosis	DOID:1934	0.011
bone disease	DOID:0080001	0.011
connective tissue disease	DOID:65	0.011
bone development disease	DOID:0080006	0.011
brachydactyly	DOID:0050581	0.011
disease of anatomical entity	DOID:7	0.011

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network