IMP: Integrative Multi-species Prediction

Drosophila melanogaster

214 known processes

Acf1 (Dmel_CG1966)

ATP-dependent chromatin assembly factor large subunit

(Aliases: Acf,p170/p185,ACF1,acf1,Acf-1,ACF/CHRAC,dACF,CHRAC,CHRAC-175,Dmel\CG1966,CG1966,dCHRAC,CAF,ACF)

Entrez: 43751
FLYBASE: FBgn0027620
UniProtKB: Q9V9T4

Process Predictions
Disease Predictions

Acf1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of gene expression epigenetic	GO:0040029	128	0.995
gene silencing	GO:0016458	138	0.986
chromatin silencing	GO:0006342	76	0.967
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.950
negative regulation of gene expression	GO:0010629	387	0.904
nuclear division	GO:0000280	332	0.900
organelle fission	GO:0048285	340	0.854
embryo development ending in birth or egg hatching	GO:0009792	152	0.854
negative regulation of rna metabolic process	GO:0051253	251	0.847
mitotic nuclear division	GO:0007067	213	0.843
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.842
negative regulation of rna biosynthetic process	GO:1902679	240	0.777
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.768
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.760
negative regulation of transcription dna templated	GO:0045892	237	0.727
meiotic nuclear division	GO:0007126	151	0.715
eye development	GO:0001654	323	0.578
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.542
negative regulation of biosynthetic process	GO:0009890	277	0.517
positive regulation of macromolecule metabolic process	GO:0010604	405	0.458
cell proliferation	GO:0008283	299	0.457
chromosome organization	GO:0051276	360	0.433
chromosome separation	GO:0051304	42	0.426
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.406
dna conformation change	GO:0071103	105	0.373
positive regulation of gene expression	GO:0010628	290	0.372
spindle organization	GO:0007051	253	0.371
meiotic cell cycle	GO:0051321	171	0.359
negative regulation of cell differentiation	GO:0045596	143	0.339
negative regulation of cellular biosynthetic process	GO:0031327	277	0.300
regulation of cell cycle	GO:0051726	291	0.290
mitotic g2 dna damage checkpoint	GO:0007095	69	0.288
regulation of mitotic cell cycle	GO:0007346	190	0.287
mitotic dna integrity checkpoint	GO:0044774	75	0.280
mitotic sister chromatid segregation	GO:0000070	87	0.265
regulation of cell cycle process	GO:0010564	181	0.258
chromosome segregation	GO:0007059	157	0.252
larval development	GO:0002164	104	0.241	Worm
mitotic sister chromatid separation	GO:0051306	30	0.234
stem cell differentiation	GO:0048863	117	0.231
posttranscriptional gene silencing	GO:0016441	46	0.229
negative regulation of developmental process	GO:0051093	201	0.225	Worm
positive regulation of cellular biosynthetic process	GO:0031328	316	0.219
heterochromatin organization	GO:0070828	25	0.198
regulation of response to stress	GO:0080134	200	0.190
chromatin organization	GO:0006325	207	0.186
eye morphogenesis	GO:0048592	260	0.186
cellular protein modification process	GO:0006464	438	0.183
dna methylation or demethylation	GO:0044728	4	0.174
immune response	GO:0006955	246	0.173
regulation of cell cycle phase transition	GO:1901987	130	0.171
cell cycle phase transition	GO:0044770	140	0.170
transcription from rna polymerase ii promoter	GO:0006366	368	0.167
regulation of meiosis	GO:0040020	3	0.166
imaginal disc derived appendage development	GO:0048737	399	0.162
regulation of cell death	GO:0010941	173	0.159
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.154
nucleoside metabolic process	GO:0009116	127	0.153
regulation of nuclear division	GO:0051783	58	0.149
ribose phosphate metabolic process	GO:0019693	145	0.149
mitotic cell cycle phase transition	GO:0044772	138	0.149
heterochromatin organization involved in chromatin silencing	GO:0070868	9	0.140
sensory organ morphogenesis	GO:0090596	260	0.137
positive regulation of rna biosynthetic process	GO:1902680	266	0.128
appendage development	GO:0048736	401	0.125
regulation of cell division	GO:0051302	72	0.117
dna metabolic process	GO:0006259	227	0.116
negative regulation of gene expression epigenetic	GO:0045814	77	0.115
small molecule metabolic process	GO:0044281	305	0.114
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.109
nucleobase containing compound catabolic process	GO:0034655	165	0.107
positive regulation of programmed cell death	GO:0043068	62	0.105
glycosyl compound catabolic process	GO:1901658	112	0.103
innate immune response	GO:0045087	144	0.101
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.098
reproductive system development	GO:0061458	74	0.097
negative regulation of cellular metabolic process	GO:0031324	382	0.094
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.089
embryonic organ development	GO:0048568	50	0.081
apoptotic process	GO:0006915	159	0.081
reproductive structure development	GO:0048608	74	0.079
organonitrogen compound catabolic process	GO:1901565	128	0.078
macromolecular complex assembly	GO:0065003	256	0.077
sister chromatid segregation	GO:0000819	92	0.077
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.076
regulation of cell proliferation	GO:0042127	163	0.075
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.072
tube morphogenesis	GO:0035239	191	0.071
immune system process	GO:0002376	347	0.069
atp metabolic process	GO:0046034	49	0.068
regulation of cellular response to stress	GO:0080135	89	0.068
positive regulation of biosynthetic process	GO:0009891	316	0.067
negative regulation of cell cycle phase transition	GO:1901988	103	0.066
immune system development	GO:0002520	57	0.065
peptidyl amino acid modification	GO:0018193	105	0.065
positive regulation of transcription dna templated	GO:0045893	266	0.065
gland development	GO:0048732	191	0.064
organonitrogen compound metabolic process	GO:1901564	318	0.064
nucleosome organization	GO:0034728	59	0.064
compound eye development	GO:0048749	307	0.063
purine ribonucleotide metabolic process	GO:0009150	145	0.063
photoreceptor cell differentiation	GO:0046530	170	0.062
dna methylation	GO:0006306	4	0.061
response to other organism	GO:0051707	293	0.060
regulation of apoptotic process	GO:0042981	130	0.060
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.059
posttranscriptional gene silencing by rna	GO:0035194	45	0.058
chromosome condensation	GO:0030261	41	0.057
positive regulation of rna metabolic process	GO:0051254	271	0.056
nucleoside triphosphate catabolic process	GO:0009143	108	0.055
maintenance of protein location in cell	GO:0032507	26	0.054
negative regulation of mitotic sister chromatid separation	GO:2000816	13	0.054
camera type eye development	GO:0043010	4	0.052
dna integrity checkpoint	GO:0031570	81	0.052
dna damage checkpoint	GO:0000077	78	0.050
response to external biotic stimulus	GO:0043207	293	0.050
negative regulation of cell cycle	GO:0045786	116	0.049
negative regulation of apoptotic process	GO:0043066	63	0.047
regulation of protein metabolic process	GO:0051246	256	0.047
regulation of programmed cell death	GO:0043067	152	0.047
telomere maintenance	GO:0000723	21	0.046
regulation of catabolic process	GO:0009894	170	0.044
regulation of chromosome organization	GO:0033044	64	0.043
cell cycle checkpoint	GO:0000075	95	0.042
regulation of intracellular signal transduction	GO:1902531	236	0.042
dendrite development	GO:0016358	204	0.042
regulation of chromatin silencing	GO:0031935	36	0.041
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.040
carbohydrate derivative metabolic process	GO:1901135	217	0.040
regulation of cell differentiation	GO:0045595	302	0.040
regulation of transcription by chromatin organization	GO:0034401	3	0.040
stem cell division	GO:0017145	69	0.039
gene silencing by rna	GO:0031047	57	0.039
positive regulation of response to stimulus	GO:0048584	323	0.038
cellular macromolecular complex assembly	GO:0034622	153	0.038
nuclear dna replication	GO:0033260	1	0.038
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.038
anatomical structure homeostasis	GO:0060249	97	0.038
meiotic cell cycle process	GO:1903046	132	0.037
meiosis i	GO:0007127	59	0.037
organic cyclic compound catabolic process	GO:1901361	168	0.036
metaphase anaphase transition of cell cycle	GO:0044784	28	0.036
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.034
development of primary sexual characteristics	GO:0045137	50	0.034
compound eye morphogenesis	GO:0001745	249	0.034
organic substance catabolic process	GO:1901575	308	0.033
salivary gland morphogenesis	GO:0007435	145	0.033
negative regulation of chromosome segregation	GO:0051985	14	0.032
eye photoreceptor cell differentiation	GO:0001754	145	0.032
chromatin modification	GO:0016568	147	0.032
mitotic dna damage checkpoint	GO:0044773	74	0.032
dna alkylation	GO:0006305	4	0.031
receptor mediated endocytosis	GO:0006898	21	0.031
organ formation	GO:0048645	39	0.030
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.030
cellular amino acid metabolic process	GO:0006520	61	0.029
positive regulation of cell death	GO:0010942	69	0.029
digestive system development	GO:0055123	149	0.029
cell cycle dna replication	GO:0044786	23	0.029
programmed cell death	GO:0012501	257	0.029
purine containing compound metabolic process	GO:0072521	155	0.029
gland morphogenesis	GO:0022612	145	0.029
vesicle mediated transport	GO:0016192	381	0.029
body morphogenesis	GO:0010171	2	0.029
epithelial cell differentiation	GO:0030855	322	0.029
cellular catabolic process	GO:0044248	372	0.029
single organism biosynthetic process	GO:0044711	206	0.028
positive regulation of apoptotic process	GO:0043065	47	0.028
protein modification process	GO:0036211	438	0.028
endocytosis	GO:0006897	310	0.028
nucleoside catabolic process	GO:0009164	112	0.027
cellular nitrogen compound catabolic process	GO:0044270	165	0.027
histone h3 k27 methylation	GO:0070734	6	0.027
purine ribonucleotide catabolic process	GO:0009154	109	0.027
mitotic cell cycle checkpoint	GO:0007093	88	0.026
eggshell chorion gene amplification	GO:0007307	9	0.026
nucleobase containing small molecule metabolic process	GO:0055086	174	0.026
post embryonic appendage morphogenesis	GO:0035120	385	0.026
organic acid metabolic process	GO:0006082	103	0.026
regulation of mitosis	GO:0007088	56	0.025
nucleotide catabolic process	GO:0009166	109	0.025
ribonucleoside catabolic process	GO:0042454	112	0.025
cell division	GO:0051301	248	0.025
regulation of phosphatase activity	GO:0010921	3	0.024
compound eye photoreceptor cell differentiation	GO:0001751	140	0.024
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.024
purine nucleotide metabolic process	GO:0006163	146	0.024
r7 cell differentiation	GO:0045466	43	0.024
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.024
positive regulation of multicellular organismal process	GO:0051240	143	0.024
purine ribonucleoside catabolic process	GO:0046130	112	0.023
regulation of phosphate metabolic process	GO:0019220	210	0.023
ribonucleoside metabolic process	GO:0009119	127	0.022
regulation of mitotic sister chromatid separation	GO:0010965	28	0.022
glycosyl compound metabolic process	GO:1901657	127	0.022
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.022
ribonucleotide catabolic process	GO:0009261	109	0.022
response to oxygen containing compound	GO:1901700	200	0.022
regulation of anatomical structure morphogenesis	GO:0022603	242	0.022
chromatin remodeling	GO:0006338	72	0.022
ribonucleotide metabolic process	GO:0009259	145	0.021
regulation of hemocyte proliferation	GO:0035206	37	0.021
salivary gland development	GO:0007431	162	0.021
intracellular signal transduction	GO:0035556	300	0.020
appendage morphogenesis	GO:0035107	397	0.020
connective tissue development	GO:0061448	3	0.020
purine nucleotide catabolic process	GO:0006195	109	0.020
negative regulation of neurogenesis	GO:0050768	53	0.020
sex differentiation	GO:0007548	81	0.020
positive regulation of cellular catabolic process	GO:0031331	95	0.020
cellular response to chemical stimulus	GO:0070887	199	0.020
regulation of cellular amino acid metabolic process	GO:0006521	0	0.020
regulation of immune system process	GO:0002682	176	0.019
organophosphate catabolic process	GO:0046434	112	0.019
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.019
purine nucleoside catabolic process	GO:0006152	112	0.019
posttranscriptional regulation of gene expression	GO:0010608	145	0.019
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.019
response to biotic stimulus	GO:0009607	294	0.018
regulation of organelle organization	GO:0033043	196	0.018
regulation of gene silencing	GO:0060968	63	0.018
female meiotic division	GO:0007143	70	0.018
positive regulation of developmental process	GO:0051094	143	0.018
cell adhesion	GO:0007155	136	0.018
positive regulation of molecular function	GO:0044093	136	0.017
digestive tract development	GO:0048565	149	0.017
purine containing compound catabolic process	GO:0072523	112	0.017
regionalization	GO:0003002	416	0.017
response to lipid	GO:0033993	38	0.017
regulation of sister chromatid segregation	GO:0033045	28	0.017
positive regulation of mitotic cell cycle	GO:0045931	34	0.016
single organism catabolic process	GO:0044712	228	0.016
mitotic g2 m transition checkpoint	GO:0044818	70	0.016
positive regulation of cell development	GO:0010720	61	0.016
embryonic development via the syncytial blastoderm	GO:0001700	148	0.016
male meiosis	GO:0007140	52	0.016
axon development	GO:0061564	297	0.016
protein import into nucleus	GO:0006606	51	0.016
regulation of gliogenesis	GO:0014013	11	0.015
columnar cuboidal epithelial cell development	GO:0002066	249	0.015
embryonic morphogenesis	GO:0048598	206	0.015
response to organic substance	GO:0010033	284	0.015
g2 dna damage checkpoint	GO:0031572	69	0.015
regulation of neurogenesis	GO:0050767	158	0.015
autophagic cell death	GO:0048102	83	0.015
tissue morphogenesis	GO:0048729	297	0.015
dna endoreduplication	GO:0042023	22	0.015
positive regulation of cell proliferation	GO:0008284	47	0.014
cellular response to dna damage stimulus	GO:0006974	223	0.014
stem cell development	GO:0048864	79	0.014
positive regulation of gene expression epigenetic	GO:0045815	16	0.014
positive regulation of neuron projection regeneration	GO:0070572	3	0.014
induction of programmed cell death by ecdysone	GO:0035078	12	0.014
carbohydrate derivative catabolic process	GO:1901136	118	0.014
regulation of cellular amine metabolic process	GO:0033238	3	0.013
sister chromatid cohesion	GO:0007062	18	0.013
cellular response to organic substance	GO:0071310	132	0.013
homeostatic process	GO:0042592	199	0.013
cytoplasmic microtubule organization	GO:0031122	22	0.013
purine nucleoside metabolic process	GO:0042278	127	0.013
negative regulation of signal transduction	GO:0009968	206	0.013
exocrine system development	GO:0035272	162	0.012
defense response	GO:0006952	300	0.012
regulation of innate immune response	GO:0045088	71	0.012
mitochondrial membrane organization	GO:0007006	3	0.012
purine ribonucleoside metabolic process	GO:0046128	127	0.012
negative regulation of wnt signaling pathway	GO:0030178	28	0.012
dna amplification	GO:0006277	11	0.012
mitotic cell cycle embryonic	GO:0045448	38	0.012
carboxylic acid metabolic process	GO:0019752	92	0.012
defense response to other organism	GO:0098542	225	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
regulation of cellular protein metabolic process	GO:0032268	243	0.012
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.012
digestive tract morphogenesis	GO:0048546	127	0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.012
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
imaginal disc derived wing morphogenesis	GO:0007476	337	0.011
regulation of immune response	GO:0050776	118	0.011
negative regulation of multicellular organismal process	GO:0051241	142	0.011	Worm
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.011
mrna metabolic process	GO:0016071	124	0.011
catabolic process	GO:0009056	409	0.011
negative regulation of cell development	GO:0010721	62	0.011
nucleoside triphosphate metabolic process	GO:0009141	120	0.011
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.011
jak stat cascade	GO:0007259	49	0.011
positive regulation of proteasomal protein catabolic process	GO:1901800	20	0.011
forebrain development	GO:0030900	2	0.011
negative regulation of mitotic cell cycle	GO:0045930	109	0.011
dna packaging	GO:0006323	91	0.011
gonad development	GO:0008406	50	0.011
nucleosome positioning	GO:0016584	3	0.011
cleavage furrow formation	GO:0036089	2	0.011
photoreceptor cell fate commitment	GO:0046552	41	0.011
nucleosome mobilization	GO:0042766	9	0.011
localization of cell	GO:0051674	257	0.011
peptidyl lysine methylation	GO:0018022	16	0.010
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.010
response to organic cyclic compound	GO:0014070	89	0.010
negative regulation of chromosome organization	GO:2001251	19	0.010
regulation of chromosome segregation	GO:0051983	32	0.010
macromolecule methylation	GO:0043414	45	0.010
regulation of peptidyl lysine acetylation	GO:2000756	7	0.010
ovulation cycle	GO:0042698	1	0.010

Acf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.012
disease of cellular proliferation	DOID:14566	0.012
cancer	DOID:162	0.012

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