IMP: Integrative Multi-species Prediction

Drosophila melanogaster

0 known processes

Hsc70Cb (Dmel_CG6603)

CG6603 gene product from transcript CG6603-RG

(Aliases: l(3)S134802,Hsc70,0041/12,l(3)S148513,l(3)134217,1485/13,l(3)07621,Dmel\CG6603,HSC70,anon-WO0118547.302,l(3)00082,1348/02,BEST:LD32772,1342/17,CG6603,dHsp110,l(3)148513,0318/20,hsc70Cb,l(3)70Ca,l(3)70Cb,LD32772,HSP110-1,l(3)S134217,HSC-70)

Entrez: 39557
FLYBASE: FBgn0026418
UniProtKB: M9MSL3
UniProtKB: Q9VUC1

Process Predictions
Disease Predictions

Hsc70Cb biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
nuclear division	GO:0000280	332	0.787
mitotic nuclear division	GO:0007067	213	0.410
posttranscriptional regulation of gene expression	GO:0010608	145	0.292
positive regulation of gene expression	GO:0010628	290	0.258	Rat
organelle fission	GO:0048285	340	0.255
growth	GO:0040007	359	0.235
embryo development ending in birth or egg hatching	GO:0009792	152	0.209
protein complex assembly	GO:0006461	200	0.188	Human
larval development	GO:0002164	104	0.174
aging	GO:0007568	143	0.171
single organism intracellular transport	GO:1902582	207	0.150	Human
multicellular organismal aging	GO:0010259	140	0.143
organic substance catabolic process	GO:1901575	308	0.111	Yeast
positive regulation of biosynthetic process	GO:0009891	316	0.106
protein modification by small protein conjugation or removal	GO:0070647	106	0.104
gene silencing by rna	GO:0031047	57	0.100
male gamete generation	GO:0048232	201	0.098
regulation of cellular protein metabolic process	GO:0032268	243	0.093	Rat
positive regulation of cellular biosynthetic process	GO:0031328	316	0.093
positive regulation of macromolecule metabolic process	GO:0010604	405	0.093	Rat
dna repair	GO:0006281	54	0.092
microtubule cytoskeleton organization involved in mitosis	GO:1902850	52	0.092
nucleoside triphosphate metabolic process	GO:0009141	120	0.085	Yeast
reproductive system development	GO:0061458	74	0.084
rna processing	GO:0006396	147	0.081
immune response	GO:0006955	246	0.080
spindle organization	GO:0007051	253	0.079
cellular catabolic process	GO:0044248	372	0.077	Yeast
macromolecule catabolic process	GO:0009057	161	0.073
cell proliferation	GO:0008283	299	0.071
spindle assembly involved in mitosis	GO:0090307	50	0.071
taxis	GO:0042330	304	0.070
positive regulation of protein metabolic process	GO:0051247	128	0.069
atp metabolic process	GO:0046034	49	0.068	Yeast
embryonic axis specification	GO:0000578	107	0.068
positive regulation of rna biosynthetic process	GO:1902680	266	0.068
purine containing compound metabolic process	GO:0072521	155	0.067	Yeast
embryonic morphogenesis	GO:0048598	206	0.066
regulation of mrna metabolic process	GO:1903311	72	0.065
single organism nuclear import	GO:1902593	51	0.063
posttranscriptional gene silencing	GO:0016441	46	0.062
organelle assembly	GO:0070925	198	0.062
glycosyl compound catabolic process	GO:1901658	112	0.061	Yeast
protein modification by small protein removal	GO:0070646	28	0.060
posttranscriptional gene silencing by rna	GO:0035194	45	0.059
cellular macromolecule catabolic process	GO:0044265	136	0.059
sex differentiation	GO:0007548	81	0.058
anterior posterior axis specification	GO:0009948	109	0.058
purine nucleoside monophosphate metabolic process	GO:0009126	50	0.056	Yeast
organophosphate metabolic process	GO:0019637	195	0.055	Yeast
protein transport	GO:0015031	155	0.055	Human
heterocycle catabolic process	GO:0046700	166	0.054	Yeast
mitotic g2 m transition checkpoint	GO:0044818	70	0.054
axon guidance	GO:0007411	233	0.054
ribonucleoside monophosphate metabolic process	GO:0009161	51	0.052	Yeast
regulation of mitotic cell cycle	GO:0007346	190	0.052
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.052	Yeast
response to organic substance	GO:0010033	284	0.052	Rat
positive regulation of rna metabolic process	GO:0051254	271	0.051
aromatic compound catabolic process	GO:0019439	166	0.051	Yeast
regulation of mrna processing	GO:0050684	71	0.051
nucleoside triphosphate catabolic process	GO:0009143	108	0.050	Yeast
vesicle mediated transport	GO:0016192	381	0.050
single organism behavior	GO:0044708	391	0.049
microtubule organizing center organization	GO:0031023	168	0.049
regulation of mrna 3 end processing	GO:0031440	7	0.047
nucleoside monophosphate metabolic process	GO:0009123	52	0.047	Yeast
response to nitrogen compound	GO:1901698	90	0.047
cellular response to chemical stimulus	GO:0070887	199	0.047
regulation of protein metabolic process	GO:0051246	256	0.045	Rat
regulation of organelle organization	GO:0033043	196	0.044
genitalia development	GO:0048806	26	0.044
nucleocytoplasmic transport	GO:0006913	72	0.044
response to abiotic stimulus	GO:0009628	341	0.044	Rat
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.044
gene silencing	GO:0016458	138	0.043
organonitrogen compound metabolic process	GO:1901564	318	0.043	Yeast
protein catabolic process	GO:0030163	101	0.043
endocytosis	GO:0006897	310	0.043
cellular nitrogen compound catabolic process	GO:0044270	165	0.043	Yeast
single organism cellular localization	GO:1902580	180	0.042	Human
establishment of protein localization	GO:0045184	163	0.041	Human
regulation of intracellular signal transduction	GO:1902531	236	0.041
cellular response to dna damage stimulus	GO:0006974	223	0.041
regulation of rna splicing	GO:0043484	69	0.041
intracellular transport	GO:0046907	228	0.040	Human
cell motility	GO:0048870	251	0.040
detection of stimulus	GO:0051606	156	0.040
ribonucleoside monophosphate catabolic process	GO:0009158	39	0.039	Yeast
nucleobase containing compound catabolic process	GO:0034655	165	0.039	Yeast
eye development	GO:0001654	323	0.039
cell division	GO:0051301	248	0.039
intracellular signal transduction	GO:0035556	300	0.039
rna localization	GO:0006403	115	0.039
regulation of phosphorus metabolic process	GO:0051174	210	0.038	Rat
protein complex biogenesis	GO:0070271	201	0.038	Human
protein localization	GO:0008104	284	0.038	Human
imaginal disc derived wing morphogenesis	GO:0007476	337	0.038
establishment of tissue polarity	GO:0007164	87	0.038
response to oxygen containing compound	GO:1901700	200	0.037
organic cyclic compound catabolic process	GO:1901361	168	0.037	Yeast
transcription from rna polymerase ii promoter	GO:0006366	368	0.037
intracellular mrna localization	GO:0008298	66	0.037
regulation of alternative mrna splicing via spliceosome	GO:0000381	60	0.036
catabolic process	GO:0009056	409	0.035	Yeast
intracellular protein transport	GO:0006886	104	0.035	Human
response to radiation	GO:0009314	155	0.034
gonad development	GO:0008406	50	0.033
regulation of cell differentiation	GO:0045595	302	0.033
axis specification	GO:0009798	167	0.032
nucleotide catabolic process	GO:0009166	109	0.032	Yeast
immune system process	GO:0002376	347	0.032
nucleobase containing small molecule metabolic process	GO:0055086	174	0.032	Yeast
mrna metabolic process	GO:0016071	124	0.032
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.032
nucleoside phosphate metabolic process	GO:0006753	162	0.031	Yeast
appendage development	GO:0048736	401	0.031
purine ribonucleotide catabolic process	GO:0009154	109	0.031	Yeast
rna splicing	GO:0008380	83	0.031
reproductive structure development	GO:0048608	74	0.031
response to oxidative stress	GO:0006979	86	0.031
mrna processing	GO:0006397	104	0.030
snrna metabolic process	GO:0016073	14	0.030
nucleoside phosphate catabolic process	GO:1901292	110	0.029	Yeast
mitotic g2 dna damage checkpoint	GO:0007095	69	0.029
nuclear transport	GO:0051169	72	0.029
protein import	GO:0017038	55	0.029	Human
spindle assembly	GO:0051225	80	0.028
chaperone mediated protein folding	GO:0061077	2	0.028	Mouse
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.028	Yeast
single organism biosynthetic process	GO:0044711	206	0.028
cytokinesis	GO:0000910	90	0.027
developmental growth	GO:0048589	280	0.027
cytoplasmic transport	GO:0016482	130	0.027	Human
negative regulation of gene expression	GO:0010629	387	0.027	Rat
regulation of localization	GO:0032879	275	0.027
determination of adult lifespan	GO:0008340	137	0.027
nucleus organization	GO:0006997	45	0.027
organelle localization	GO:0051640	148	0.027
regulation of growth	GO:0040008	233	0.027
response to other organism	GO:0051707	293	0.027
phagocytosis	GO:0006909	215	0.027
anterior posterior pattern specification	GO:0009952	136	0.027
protein targeting	GO:0006605	64	0.026	Human
dna replication	GO:0006260	48	0.026
nuclear import	GO:0051170	51	0.026
purine nucleoside metabolic process	GO:0042278	127	0.026	Yeast
spermatogenesis	GO:0007283	200	0.026
lipid storage	GO:0019915	38	0.025
glycosyl compound metabolic process	GO:1901657	127	0.025	Yeast
positive regulation of transcription dna templated	GO:0045893	266	0.024
negative regulation of cell differentiation	GO:0045596	143	0.024
ribonucleotide metabolic process	GO:0009259	145	0.024	Yeast
carbohydrate derivative catabolic process	GO:1901136	118	0.024	Yeast
carbohydrate derivative metabolic process	GO:1901135	217	0.024	Yeast
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.024	Yeast
ribonucleoprotein complex subunit organization	GO:0071826	28	0.024
establishment of localization in cell	GO:0051649	402	0.024	Human
rna splicing via transesterification reactions	GO:0000375	73	0.024
response to light stimulus	GO:0009416	124	0.024
mrna splicing via spliceosome	GO:0000398	73	0.024
purine ribonucleoside metabolic process	GO:0046128	127	0.023	Yeast
cellular macromolecule localization	GO:0070727	220	0.023	Human
neurological system process	GO:0050877	358	0.023
translation	GO:0006412	69	0.023
atp catabolic process	GO:0006200	38	0.023	Yeast
mrna polyadenylation	GO:0006378	11	0.023
regulation of catalytic activity	GO:0050790	185	0.023	Yeast
modification dependent macromolecule catabolic process	GO:0043632	79	0.023
ubiquitin dependent protein catabolic process	GO:0006511	78	0.023
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.022
protein modification by small protein conjugation	GO:0032446	79	0.022
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.022
negative regulation of cellular metabolic process	GO:0031324	382	0.022	Rat
molting cycle	GO:0042303	56	0.022
mitotic spindle organization	GO:0007052	220	0.022
histolysis	GO:0007559	102	0.022
nucleotide metabolic process	GO:0009117	161	0.022	Yeast
adult behavior	GO:0030534	137	0.022
nucleoside metabolic process	GO:0009116	127	0.021	Yeast
alternative mrna splicing via spliceosome	GO:0000380	60	0.021
single organism membrane organization	GO:0044802	93	0.021	Human
localization of cell	GO:0051674	257	0.021
small molecule metabolic process	GO:0044281	305	0.021	Yeast
regulation of meiosis	GO:0040020	3	0.021
regulation of cell proliferation	GO:0042127	163	0.021
regulation of nucleocytoplasmic transport	GO:0046822	35	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	119	0.020	Yeast
regulation of establishment of protein localization	GO:0070201	61	0.020
translational initiation	GO:0006413	11	0.020
purine nucleoside triphosphate metabolic process	GO:0009144	119	0.020	Yeast
digestive tract development	GO:0048565	149	0.020
regulation of cell division	GO:0051302	72	0.020
purine ribonucleoside monophosphate metabolic process	GO:0009167	50	0.020	Yeast
gastrulation	GO:0007369	70	0.020
positive regulation of developmental growth	GO:0048639	62	0.020
cellular protein catabolic process	GO:0044257	83	0.020
cellular macromolecular complex assembly	GO:0034622	153	0.019	Human
camera type eye development	GO:0043010	4	0.019
response to organonitrogen compound	GO:0010243	75	0.019
meiotic cytokinesis	GO:0033206	33	0.019
ribonucleotide catabolic process	GO:0009261	109	0.019	Yeast
purine ribonucleoside catabolic process	GO:0046130	112	0.019	Yeast
purine nucleotide catabolic process	GO:0006195	109	0.019	Yeast
dna metabolic process	GO:0006259	227	0.019
purine ribonucleotide metabolic process	GO:0009150	145	0.019	Yeast
body morphogenesis	GO:0010171	2	0.019
modification dependent protein catabolic process	GO:0019941	78	0.018
purine nucleotide metabolic process	GO:0006163	146	0.018	Yeast
negative regulation of cellular biosynthetic process	GO:0031327	277	0.018
positive regulation of cellular protein metabolic process	GO:0032270	118	0.018
response to dsrna	GO:0043331	15	0.018
chromatin organization	GO:0006325	207	0.018
lateral inhibition	GO:0046331	206	0.018
response to biotic stimulus	GO:0009607	294	0.018
stem cell maintenance	GO:0019827	67	0.018
nucleoside catabolic process	GO:0009164	112	0.018	Yeast
regulation of response to stress	GO:0080134	200	0.018
cell migration	GO:0016477	238	0.018
gene silencing by mirna	GO:0035195	22	0.018
regulation of molecular function	GO:0065009	217	0.018	Yeast Rat
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017	Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.017
positive regulation of response to stimulus	GO:0048584	323	0.017
multi organism behavior	GO:0051705	175	0.017
pole plasm oskar mrna localization	GO:0045451	46	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.016
cell aging	GO:0007569	2	0.016
protein import into nucleus	GO:0006606	51	0.016
regulation of cell cycle	GO:0051726	291	0.016
g2 dna damage checkpoint	GO:0031572	69	0.016
defense response	GO:0006952	300	0.016
eye antennal disc development	GO:0035214	60	0.016
regulation of catabolic process	GO:0009894	170	0.016
purine ribonucleoside monophosphate catabolic process	GO:0009169	38	0.016	Yeast
organic substance transport	GO:0071702	257	0.016	Human
cellular protein complex assembly	GO:0043623	71	0.016	Human
cellular response to organic substance	GO:0071310	132	0.016
defense response to bacterium	GO:0042742	178	0.016
nucleoside monophosphate catabolic process	GO:0009125	39	0.015	Yeast
regulation of transport	GO:0051049	181	0.015
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.015
cellular protein modification process	GO:0006464	438	0.015	Rat
rna catabolic process	GO:0006401	37	0.015
segmentation	GO:0035282	207	0.015
cellular response to dsrna	GO:0071359	15	0.015
ribose phosphate metabolic process	GO:0019693	145	0.015	Yeast
negative regulation of mitotic cell cycle	GO:0045930	109	0.015
protein deubiquitination	GO:0016579	17	0.015
phosphorylation	GO:0016310	294	0.015	Rat
response to heat	GO:0009408	63	0.015	Rat
ribonucleoside metabolic process	GO:0009119	127	0.015	Yeast
positive regulation of growth	GO:0045927	75	0.014
cellular homeostasis	GO:0019725	80	0.014
proteasomal protein catabolic process	GO:0010498	59	0.014
apoptotic process	GO:0006915	159	0.014	Rat
regulation of protein complex disassembly	GO:0043244	29	0.014
appendage morphogenesis	GO:0035107	397	0.014
cell death	GO:0008219	279	0.014	Rat
regulation of defense response	GO:0031347	102	0.014
stem cell differentiation	GO:0048863	117	0.014
protein phosphorylation	GO:0006468	169	0.014	Rat
regulation of developmental growth	GO:0048638	174	0.014
embryonic pattern specification	GO:0009880	174	0.014
dna geometric change	GO:0032392	16	0.014
tripartite regional subdivision	GO:0007351	103	0.014
regulation of cellular catabolic process	GO:0031329	157	0.013
centrosome cycle	GO:0007098	137	0.013
eye morphogenesis	GO:0048592	260	0.013
response to external biotic stimulus	GO:0043207	293	0.013
regulation of protein localization	GO:0032880	76	0.013
proteolysis	GO:0006508	192	0.013
positive regulation of intracellular signal transduction	GO:1902533	116	0.013
rhythmic process	GO:0048511	106	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013	Rat
sensory organ morphogenesis	GO:0090596	260	0.013
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.013
hemopoiesis	GO:0030097	46	0.013
regulation of cell cycle phase transition	GO:1901987	130	0.013
establishment of protein localization to organelle	GO:0072594	62	0.012	Human
retina development in camera type eye	GO:0060041	4	0.012
cytoskeleton dependent cytokinesis	GO:0061640	81	0.012
ribonucleoprotein complex biogenesis	GO:0022613	31	0.012
rna interference	GO:0016246	27	0.012
epidermis development	GO:0008544	65	0.012
smoothened signaling pathway	GO:0007224	49	0.012
anterior posterior axis specification embryo	GO:0008595	103	0.012
defense response to gram negative bacterium	GO:0050829	94	0.012
negative regulation of signaling	GO:0023057	219	0.012
purine nucleoside monophosphate catabolic process	GO:0009128	38	0.012	Yeast
dna duplex unwinding	GO:0032508	16	0.012
regulation of hydrolase activity	GO:0051336	97	0.012
innate immune response	GO:0045087	144	0.012
digestive tract morphogenesis	GO:0048546	127	0.012
chemotaxis	GO:0006935	249	0.012
regulation of gene expression epigenetic	GO:0040029	128	0.012
development of primary sexual characteristics	GO:0045137	50	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.011
death	GO:0016265	284	0.011	Rat
striated muscle myosin thick filament assembly	GO:0071688	3	0.011
regulation of mitosis	GO:0007088	56	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.011	Yeast
rna phosphodiester bond hydrolysis exonucleolytic	GO:0090503	4	0.011
negative regulation of developmental process	GO:0051093	201	0.011
regulation of multicellular organism growth	GO:0040014	40	0.011
urogenital system development	GO:0001655	72	0.011	Rat
response to lipid	GO:0033993	38	0.011
oocyte differentiation	GO:0009994	145	0.011
protein targeting to nucleus	GO:0044744	51	0.011
mrna catabolic process	GO:0006402	33	0.011
response to alcohol	GO:0097305	95	0.011
rna 3 end processing	GO:0031123	45	0.011
protein localization to organelle	GO:0033365	82	0.011	Human
positive regulation of multicellular organism growth	GO:0040018	21	0.011
regulation of nuclear division	GO:0051783	58	0.011
protein localization to nucleus	GO:0034504	55	0.010
centrosome duplication	GO:0051298	121	0.010
regulation of protein processing	GO:0070613	32	0.010
regulation of phosphate metabolic process	GO:0019220	210	0.010	Rat
multi multicellular organism process	GO:0044706	123	0.010
response to wounding	GO:0009611	94	0.010
meiotic cell cycle	GO:0051321	171	0.010
dna amplification	GO:0006277	11	0.010
reproductive behavior	GO:0019098	122	0.010
negative regulation of cell cycle	GO:0045786	116	0.010
oocyte microtubule cytoskeleton organization	GO:0016325	35	0.010

Hsc70Cb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.037
nervous system disease	DOID:863	0.021
cancer	DOID:162	0.016
disease of cellular proliferation	DOID:14566	0.016

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