IMP: Integrative Multi-species Prediction

Drosophila melanogaster

128 known processes

Crk (Dmel_CG1587)

CG1587 gene product from transcript CG1587-RC

(Aliases: dCrk,dCRK,CG1587,D-Crk,DCrk,Dmel\CG1587,crk,D-CRK,CRK,Dcrk)

FLYBASE: FBgn0024811
Entrez: 43775
UniProtKB: Q9XYM0
UniProtKB: H9XVM6
UniProtKB: H9XVM7
UniProtKB: Q95RW2
UniProtKB: X2JD84
UniProtKB: X2JCS2

Process Predictions
Disease Predictions

Crk biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular catabolic process	GO:0044248	372	0.271	Human
protein localization	GO:0008104	284	0.176
cellular response to dna damage stimulus	GO:0006974	223	0.168
regulation of cell morphogenesis	GO:0022604	163	0.126
heterocycle catabolic process	GO:0046700	166	0.118	Human
cgmp metabolic process	GO:0046068	11	0.117
organic substance catabolic process	GO:1901575	308	0.109	Human
regulation of cellular protein metabolic process	GO:0032268	243	0.105
catabolic process	GO:0009056	409	0.097	Human
endocytosis	GO:0006897	310	0.096
chromosome organization	GO:0051276	360	0.096
regulation of cellular response to stress	GO:0080135	89	0.093
negative regulation of cellular biosynthetic process	GO:0031327	277	0.090
posttranscriptional regulation of gene expression	GO:0010608	145	0.089
regulation of protein metabolic process	GO:0051246	256	0.089
single organism intracellular transport	GO:1902582	207	0.085
single organism cellular localization	GO:1902580	180	0.078
cellular macromolecule catabolic process	GO:0044265	136	0.077
protein modification process	GO:0036211	438	0.076
regulation of cell shape	GO:0008360	113	0.074
organic cyclic compound catabolic process	GO:1901361	168	0.071	Human
single organism catabolic process	GO:0044712	228	0.071	Human
regulation of localization	GO:0032879	275	0.066
compound eye development	GO:0048749	307	0.063
regulation of response to stress	GO:0080134	200	0.062
eye development	GO:0001654	323	0.058
vesicle mediated transport	GO:0016192	381	0.054
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.052
regulation of anatomical structure morphogenesis	GO:0022603	242	0.046
compound eye morphogenesis	GO:0001745	249	0.045
regulation of neuron differentiation	GO:0045664	103	0.045
photoreceptor cell differentiation	GO:0046530	170	0.043
establishment of protein localization	GO:0045184	163	0.043
carbohydrate derivative metabolic process	GO:1901135	217	0.043	Human
lateral inhibition	GO:0046331	206	0.039
stem cell differentiation	GO:0048863	117	0.039
nucleoside metabolic process	GO:0009116	127	0.039	Human
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.038
developmental growth	GO:0048589	280	0.037
body morphogenesis	GO:0010171	2	0.037
cellular nitrogen compound catabolic process	GO:0044270	165	0.036	Human
negative regulation of cellular metabolic process	GO:0031324	382	0.035
regulation of cellular component biogenesis	GO:0044087	201	0.033
cell cycle phase transition	GO:0044770	140	0.033
nucleobase containing compound catabolic process	GO:0034655	165	0.033	Human
nucleotide catabolic process	GO:0009166	109	0.033	Human
regulation of translation	GO:0006417	56	0.033
regulation of organelle organization	GO:0033043	196	0.033	Human Mouse
compound eye photoreceptor cell differentiation	GO:0001751	140	0.032
nucleobase containing small molecule metabolic process	GO:0055086	174	0.032	Human
negative regulation of cell communication	GO:0010648	223	0.031
positive regulation of multicellular organismal process	GO:0051240	143	0.031
positive regulation of developmental process	GO:0051094	143	0.031
membrane organization	GO:0061024	112	0.030
covalent chromatin modification	GO:0016569	106	0.030
modification dependent protein catabolic process	GO:0019941	78	0.029
cellular response to starvation	GO:0009267	61	0.029
mitotic cell cycle phase transition	GO:0044772	138	0.028
negative regulation of signaling	GO:0023057	219	0.028
macromolecular complex assembly	GO:0065003	256	0.028
photoreceptor cell development	GO:0042461	96	0.028
regionalization	GO:0003002	416	0.027	Mouse
spermatogenesis	GO:0007283	200	0.027
aromatic compound catabolic process	GO:0019439	166	0.027	Human
negative regulation of rna biosynthetic process	GO:1902679	240	0.026
glycoprotein metabolic process	GO:0009100	41	0.026
response to organic substance	GO:0010033	284	0.026
vesicle organization	GO:0016050	44	0.026
protein complex assembly	GO:0006461	200	0.025
intracellular transport	GO:0046907	228	0.024
hematopoietic or lymphoid organ development	GO:0048534	57	0.024	Mouse
ribonucleotide catabolic process	GO:0009261	109	0.023	Human
negative regulation of gene expression	GO:0010629	387	0.023
cell cycle checkpoint	GO:0000075	95	0.023
dendrite development	GO:0016358	204	0.022
macromolecule catabolic process	GO:0009057	161	0.022
organonitrogen compound metabolic process	GO:1901564	318	0.022	Human
ribonucleotide metabolic process	GO:0009259	145	0.021	Human
regulation of multicellular organismal development	GO:2000026	414	0.021
histone modification	GO:0016570	106	0.021
actin cytoskeleton organization	GO:0030036	206	0.020	Human Mouse
small gtpase mediated signal transduction	GO:0007264	88	0.020	Rat
purine containing compound metabolic process	GO:0072521	155	0.020	Human
cellular response to organic substance	GO:0071310	132	0.020
cell death	GO:0008219	279	0.020
chromatin modification	GO:0016568	147	0.019
negative regulation of rna metabolic process	GO:0051253	251	0.019
programmed cell death	GO:0012501	257	0.019
negative regulation of biosynthetic process	GO:0009890	277	0.019
cell motility	GO:0048870	251	0.019
intracellular signal transduction	GO:0035556	300	0.019
protein localization to organelle	GO:0033365	82	0.019
regulation of cell cycle phase transition	GO:1901987	130	0.019
localization of cell	GO:0051674	257	0.019
cellular macromolecular complex assembly	GO:0034622	153	0.018
establishment of protein localization to organelle	GO:0072594	62	0.018
actin filament organization	GO:0007015	126	0.018
negative regulation of response to stimulus	GO:0048585	258	0.018
cgmp biosynthetic process	GO:0006182	8	0.018
stem cell development	GO:0048864	79	0.018
regulation of transport	GO:0051049	181	0.017
positive regulation of molecular function	GO:0044093	136	0.017
eye morphogenesis	GO:0048592	260	0.017
single organism behavior	GO:0044708	391	0.017
death	GO:0016265	284	0.017
camera type eye development	GO:0043010	4	0.017
sensory organ morphogenesis	GO:0090596	260	0.017
retrograde transport endosome to golgi	GO:0042147	3	0.017
cellular response to chemical stimulus	GO:0070887	199	0.017
anterior posterior pattern specification	GO:0009952	136	0.017	Mouse
carbohydrate derivative biosynthetic process	GO:1901137	85	0.017
regulation of purine nucleotide biosynthetic process	GO:1900371	14	0.017
protein transport	GO:0015031	155	0.017
organelle assembly	GO:0070925	198	0.017
muscle structure development	GO:0061061	224	0.016	Zebrafish
positive regulation of cell communication	GO:0010647	250	0.016
embryo development ending in birth or egg hatching	GO:0009792	152	0.016
regulation of hemocyte proliferation	GO:0035206	37	0.016
phagocytosis	GO:0006909	215	0.016
proteasomal protein catabolic process	GO:0010498	59	0.016
rrna processing	GO:0006364	3	0.016
atp metabolic process	GO:0046034	49	0.016
actin filament based process	GO:0030029	220	0.016	Human Mouse
male gamete generation	GO:0048232	201	0.016
cellular macromolecule localization	GO:0070727	220	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.016
regulation of mrna metabolic process	GO:1903311	72	0.016
response to extracellular stimulus	GO:0009991	116	0.015
negative regulation of signal transduction	GO:0009968	206	0.015
eye photoreceptor cell differentiation	GO:0001754	145	0.015
protein modification by small protein conjugation or removal	GO:0070647	106	0.015
cellular protein localization	GO:0034613	160	0.015
response to lipopolysaccharide	GO:0032496	4	0.015
ribose phosphate metabolic process	GO:0019693	145	0.015	Human
regulation of cellular localization	GO:0060341	136	0.015
positive regulation of catalytic activity	GO:0043085	118	0.014
regulation of cell development	GO:0060284	215	0.014
regulation of protein stability	GO:0031647	43	0.014
single organism membrane organization	GO:0044802	93	0.014
regulation of response to external stimulus	GO:0032101	115	0.014
meiotic cell cycle	GO:0051321	171	0.014
establishment of localization in cell	GO:0051649	402	0.014
immune system development	GO:0002520	57	0.014	Mouse
positive regulation of cellular component organization	GO:0051130	156	0.014
positive regulation of protein metabolic process	GO:0051247	128	0.014
endomembrane system organization	GO:0010256	119	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.013	Human
ribonucleoside catabolic process	GO:0042454	112	0.013	Human
organic substance transport	GO:0071702	257	0.013
ovulation cycle	GO:0042698	1	0.013
cellular response to nitrogen compound	GO:1901699	51	0.013
organelle fission	GO:0048285	340	0.012
regulation of photoreceptor cell differentiation	GO:0046532	34	0.012
cellular protein complex assembly	GO:0043623	71	0.012
larval development	GO:0002164	104	0.012
scf dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031146	1	0.012
response to axon injury	GO:0048678	12	0.012
single organism biosynthetic process	GO:0044711	206	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.011	Human
hemopoiesis	GO:0030097	46	0.011
regulation of phosphorus metabolic process	GO:0051174	210	0.011
regulation of protein modification process	GO:0031399	112	0.011
nucleoside triphosphate metabolic process	GO:0009141	120	0.011	Human
maintenance of location	GO:0051235	73	0.011
positive regulation of cell projection organization	GO:0031346	29	0.011
mitotic cell cycle checkpoint	GO:0007093	88	0.011
translation	GO:0006412	69	0.011
cytoplasmic transport	GO:0016482	130	0.011
compound eye photoreceptor development	GO:0042051	78	0.011
tor signaling	GO:0031929	32	0.011
cytoskeleton dependent intracellular transport	GO:0030705	44	0.011
response to radiation	GO:0009314	155	0.011
cellular protein modification process	GO:0006464	438	0.011
cellular response to nutrient levels	GO:0031669	62	0.011
positive regulation of cgmp biosynthetic process	GO:0030828	1	0.011
homeostatic process	GO:0042592	199	0.010
ncrna processing	GO:0034470	30	0.010
cellular protein catabolic process	GO:0044257	83	0.010
intermediate filament based process	GO:0045103	1	0.010
ncrna metabolic process	GO:0034660	43	0.010
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.010
nucleoside triphosphate catabolic process	GO:0009143	108	0.010	Human
dendrite morphogenesis	GO:0048813	199	0.010
protein complex biogenesis	GO:0070271	201	0.010
positive regulation of biosynthetic process	GO:0009891	316	0.010
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.010
positive regulation of cell cycle	GO:0045787	43	0.010

Crk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
bone development disease	DOID:0080006	0.014
osteochondrodysplasia	DOID:2256	0.014
bone disease	DOID:0080001	0.014
disease of anatomical entity	DOID:7	0.014
osteogenesis imperfecta	DOID:12347	0.014
connective tissue disease	DOID:65	0.014
musculoskeletal system disease	DOID:17	0.014

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