IMP: Integrative Multi-species Prediction

Drosophila melanogaster

134 known processes

Orc6 (Dmel_CG1584)

Origin recognition complex subunit 6

(Aliases: ORC6,CG1584,rDmORC,orc6,DmORC6,Dmel\CG1584,DmORC 6,ORC)

FLYBASE: FBgn0023180
Entrez: 36017
UniProtKB: Q9Y1B2

Process Predictions
Disease Predictions

Orc6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
compound eye development	GO:0048749	307	0.378
negative regulation of transcription dna templated	GO:0045892	237	0.339
eye development	GO:0001654	323	0.296
chromosome segregation	GO:0007059	157	0.224
sensory organ morphogenesis	GO:0090596	260	0.208
lateral inhibition	GO:0046331	206	0.204
regulation of multicellular organismal development	GO:2000026	414	0.195
nuclear division	GO:0000280	332	0.187
neuron projection guidance	GO:0097485	241	0.185
chromosome organization	GO:0051276	360	0.177
sister chromatid segregation	GO:0000819	92	0.174
dendrite morphogenesis	GO:0048813	199	0.168
organelle fission	GO:0048285	340	0.160
asymmetric neuroblast division	GO:0055059	33	0.148
regulation of cell cycle phase transition	GO:1901987	130	0.142
multi organism behavior	GO:0051705	175	0.141
anterior posterior axis specification	GO:0009948	109	0.130
mitotic sister chromatid separation	GO:0051306	30	0.128
body morphogenesis	GO:0010171	2	0.125
regulation of cell development	GO:0060284	215	0.113
dendrite development	GO:0016358	204	0.111
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.101
central nervous system development	GO:0007417	201	0.099
growth	GO:0040007	359	0.096
establishment of organelle localization	GO:0051656	122	0.095
positive regulation of mitotic cell cycle	GO:0045931	34	0.091
stem cell proliferation	GO:0072089	88	0.091
neural precursor cell proliferation	GO:0061351	75	0.090
appendage development	GO:0048736	401	0.089
taxis	GO:0042330	304	0.087
negative regulation of cell cycle	GO:0045786	116	0.087
mitotic sister chromatid segregation	GO:0000070	87	0.086
negative regulation of cellular metabolic process	GO:0031324	382	0.085
regulation of mitotic sister chromatid segregation	GO:0033047	28	0.084
negative regulation of multicellular organismal process	GO:0051241	142	0.084
axon guidance	GO:0007411	233	0.083
negative regulation of biosynthetic process	GO:0009890	277	0.083
regulation of mitotic cell cycle	GO:0007346	190	0.081
axon development	GO:0061564	297	0.077
compound eye morphogenesis	GO:0001745	249	0.077
neuronal stem cell division	GO:0036445	35	0.076
regulation of cell morphogenesis	GO:0022604	163	0.076
meiotic chromosome segregation	GO:0045132	59	0.074
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.073
macromolecular complex assembly	GO:0065003	256	0.072
regulation of cytoskeleton organization	GO:0051493	89	0.071
developmental growth	GO:0048589	280	0.071
establishment of localization in cell	GO:0051649	402	0.070
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.069
dna conformation change	GO:0071103	105	0.069
regulation of r7 cell differentiation	GO:0045676	15	0.068
regulation of cellular catabolic process	GO:0031329	157	0.066
eye photoreceptor cell differentiation	GO:0001754	145	0.064
regulation of canonical wnt signaling pathway	GO:0060828	15	0.062
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.062
regulation of anatomical structure morphogenesis	GO:0022603	242	0.058
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.057
spindle organization	GO:0007051	253	0.057
negative regulation of response to stimulus	GO:0048585	258	0.056
eggshell chorion gene amplification	GO:0007307	9	0.054
appendage morphogenesis	GO:0035107	397	0.054
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.054
dna packaging	GO:0006323	91	0.052
positive regulation of cell communication	GO:0010647	250	0.052
regulation of circadian rhythm	GO:0042752	49	0.051
camera type eye development	GO:0043010	4	0.051
vesicle mediated transport	GO:0016192	381	0.051
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.046
positive regulation of signal transduction	GO:0009967	223	0.046
regulation of cell cycle	GO:0051726	291	0.046
positive regulation of molecular function	GO:0044093	136	0.046
eye morphogenesis	GO:0048592	260	0.045
protein localization	GO:0008104	284	0.044
cell cycle checkpoint	GO:0000075	95	0.044
neuroblast proliferation	GO:0007405	74	0.044
rho protein signal transduction	GO:0007266	14	0.044
regulation of phosphate metabolic process	GO:0019220	210	0.043
axonogenesis	GO:0007409	290	0.042
negative regulation of rna metabolic process	GO:0051253	251	0.042
dna endoreduplication	GO:0042023	22	0.041
proteolysis	GO:0006508	192	0.041
negative regulation of rna biosynthetic process	GO:1902679	240	0.040
circadian rhythm	GO:0007623	105	0.040
macromolecule catabolic process	GO:0009057	161	0.040
stem cell division	GO:0017145	69	0.039
spermatogenesis	GO:0007283	200	0.039
cellular catabolic process	GO:0044248	372	0.039
metaphase anaphase transition of cell cycle	GO:0044784	28	0.038
negative regulation of cellular biosynthetic process	GO:0031327	277	0.038
chemotaxis	GO:0006935	249	0.038
response to alcohol	GO:0097305	95	0.037
anterior posterior pattern specification	GO:0009952	136	0.037
columnar cuboidal epithelial cell development	GO:0002066	249	0.037
regulation of catabolic process	GO:0009894	170	0.037
regulation of cellular component biogenesis	GO:0044087	201	0.037
mitotic chromosome condensation	GO:0007076	22	0.037
negative regulation of cell division	GO:0051782	17	0.036
muscle organ development	GO:0007517	127	0.035
segmentation	GO:0035282	207	0.035
regulation of cell cycle process	GO:0010564	181	0.034
digestive tract morphogenesis	GO:0048546	127	0.033
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.033
mitotic nuclear division	GO:0007067	213	0.033
purine ribonucleotide metabolic process	GO:0009150	145	0.033
positive regulation of cell proliferation	GO:0008284	47	0.033
hindgut morphogenesis	GO:0007442	58	0.032
mitotic cell cycle phase transition	GO:0044772	138	0.032
regulation of mitotic sister chromatid separation	GO:0010965	28	0.032
positive regulation of multicellular organismal process	GO:0051240	143	0.032
r7 cell differentiation	GO:0045466	43	0.032
compound eye photoreceptor cell differentiation	GO:0001751	140	0.032
dna replication	GO:0006260	48	0.032
chorion containing eggshell formation	GO:0007304	105	0.031
mitotic spindle organization	GO:0007052	220	0.031
regulation of organ morphogenesis	GO:2000027	78	0.031
telomere capping	GO:0016233	11	0.031
tripartite regional subdivision	GO:0007351	103	0.031
meiotic cell cycle process	GO:1903046	132	0.031
negative regulation of cellular component organization	GO:0051129	108	0.030
cell division	GO:0051301	248	0.030
regulation of organelle organization	GO:0033043	196	0.029
negative regulation of signal transduction	GO:0009968	206	0.029
secretion by cell	GO:0032940	101	0.029
brain development	GO:0007420	120	0.029
positive regulation of cellular protein metabolic process	GO:0032270	118	0.028
phosphorylation	GO:0016310	294	0.028
positive regulation of cellular component biogenesis	GO:0044089	80	0.028
regulation of molecular function	GO:0065009	217	0.028
blastoderm segmentation	GO:0007350	159	0.028
chromosome separation	GO:0051304	42	0.027
negative regulation of cell cycle process	GO:0010948	109	0.027
rhythmic process	GO:0048511	106	0.027
negative regulation of mitotic cell cycle phase transition	GO:1901991	103	0.027
negative regulation of mitotic cell cycle	GO:0045930	109	0.027
regulation of mitosis	GO:0007088	56	0.027
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	30	0.026
negative regulation of developmental process	GO:0051093	201	0.026
somatic stem cell division	GO:0048103	37	0.026
cell type specific apoptotic process	GO:0097285	38	0.026
malpighian tubule morphogenesis	GO:0007443	44	0.026
response to external biotic stimulus	GO:0043207	293	0.026
plasma membrane organization	GO:0007009	26	0.026
regulation of nuclear division	GO:0051783	58	0.025
negative regulation of gene expression epigenetic	GO:0045814	77	0.025
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.025
gland development	GO:0048732	191	0.025
secretion	GO:0046903	109	0.025
regulation of intracellular signal transduction	GO:1902531	236	0.025
epithelial cell differentiation	GO:0030855	322	0.024
regulation of neurogenesis	GO:0050767	158	0.024
regulation of metaphase anaphase transition of cell cycle	GO:1902099	26	0.024
cellular macromolecule catabolic process	GO:0044265	136	0.024
regulation of chromosome organization	GO:0033044	64	0.024
regulation of cell differentiation	GO:0045595	302	0.024
embryonic morphogenesis	GO:0048598	206	0.024
chromosome condensation	GO:0030261	41	0.024
oocyte differentiation	GO:0009994	145	0.023
single organism membrane organization	GO:0044802	93	0.023
meiotic cell cycle	GO:0051321	171	0.023
negative regulation of developmental growth	GO:0048640	64	0.023
cell cycle phase transition	GO:0044770	140	0.023
ras protein signal transduction	GO:0007265	88	0.023
negative regulation of signaling	GO:0023057	219	0.023
cell cell junction organization	GO:0045216	55	0.023
membrane organization	GO:0061024	112	0.023
nucleoside metabolic process	GO:0009116	127	0.022
response to bacterium	GO:0009617	198	0.022
epithelial tube morphogenesis	GO:0060562	88	0.022
endomembrane system organization	GO:0010256	119	0.022
regulation of epithelial cell differentiation	GO:0030856	4	0.022
photoreceptor cell fate commitment	GO:0046552	41	0.022
neurological system process	GO:0050877	358	0.022
cell cycle dna replication	GO:0044786	23	0.022
positive regulation of mitotic cell cycle phase transition	GO:1901992	20	0.022
mitotic cell cycle checkpoint	GO:0007093	88	0.022
positive regulation of protein metabolic process	GO:0051247	128	0.021
meiosis i	GO:0007127	59	0.021
imaginal disc growth	GO:0007446	37	0.021
mesoderm development	GO:0007498	78	0.021
regulation of growth	GO:0040008	233	0.021
phagocytosis	GO:0006909	215	0.021
programmed cell death	GO:0012501	257	0.021
mitotic g2 dna damage checkpoint	GO:0007095	69	0.021
post embryonic appendage morphogenesis	GO:0035120	385	0.021
negative regulation of growth	GO:0045926	84	0.021
tube development	GO:0035295	244	0.021
regulation of phosphorus metabolic process	GO:0051174	210	0.021
eye photoreceptor cell fate commitment	GO:0042706	37	0.021
positive regulation of r7 cell differentiation	GO:0045678	7	0.021
regulation of sister chromatid segregation	GO:0033045	28	0.021
cell proliferation	GO:0008283	299	0.021
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.021
response to organic substance	GO:0010033	284	0.020
biological adhesion	GO:0022610	138	0.020
regulation of heterochromatin assembly	GO:0031445	8	0.020
protein catabolic process	GO:0030163	101	0.020
photoreceptor cell differentiation	GO:0046530	170	0.020
dna metabolic process	GO:0006259	227	0.020
protein modification process	GO:0036211	438	0.020
reproductive system development	GO:0061458	74	0.020
cell fate determination	GO:0001709	91	0.020
cellular nitrogen compound catabolic process	GO:0044270	165	0.019
cellular response to dna damage stimulus	GO:0006974	223	0.019
nuclear dna replication	GO:0033260	1	0.019
female meiosis chromosome segregation	GO:0016321	33	0.019
neuron recognition	GO:0008038	101	0.019
positive regulation of cellular catabolic process	GO:0031331	95	0.019
regulation of cellular component size	GO:0032535	98	0.019
positive regulation of phosphorus metabolic process	GO:0010562	139	0.019
positive regulation of macromolecule metabolic process	GO:0010604	405	0.019
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.019
embryonic axis specification	GO:0000578	107	0.019
positive regulation of catabolic process	GO:0009896	105	0.019
telencephalon development	GO:0021537	2	0.019
digestive system development	GO:0055123	149	0.018
wing disc morphogenesis	GO:0007472	344	0.018
catabolic process	GO:0009056	409	0.018
regulation of cellular protein metabolic process	GO:0032268	243	0.018
positive regulation of neurogenesis	GO:0050769	41	0.018
positive regulation of response to stimulus	GO:0048584	323	0.018
regulation of neuron projection development	GO:0010975	69	0.018
cell cycle comprising mitosis without cytokinesis	GO:0033301	25	0.018
meiotic dna double strand break formation	GO:0042138	1	0.018
positive regulation of dna endoreduplication	GO:0032877	4	0.018
sensory perception	GO:0007600	196	0.018
organ growth	GO:0035265	56	0.018
sex differentiation	GO:0007548	81	0.018
neuroblast division	GO:0055057	35	0.018
organonitrogen compound metabolic process	GO:1901564	318	0.018
epidermal cell differentiation	GO:0009913	51	0.018
embryonic hindgut morphogenesis	GO:0048619	48	0.018
positive regulation of signaling	GO:0023056	243	0.018
single organism behavior	GO:0044708	391	0.018
negative regulation of notch signaling pathway	GO:0045746	41	0.017
tissue morphogenesis	GO:0048729	297	0.017
ovarian follicle cell development	GO:0030707	248	0.017
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.017
epithelial cell development	GO:0002064	274	0.017
response to anesthetic	GO:0072347	9	0.017
positive regulation of gene expression	GO:0010628	290	0.017
asymmetric stem cell division	GO:0098722	49	0.017
cellular macromolecular complex assembly	GO:0034622	153	0.017
negative regulation of cell proliferation	GO:0008285	69	0.017
dna amplification	GO:0006277	11	0.017
aromatic compound catabolic process	GO:0019439	166	0.017
dna damage checkpoint	GO:0000077	78	0.017
cell cycle g1 s phase transition	GO:0044843	31	0.017
forebrain development	GO:0030900	2	0.017
single organism catabolic process	GO:0044712	228	0.017
small gtpase mediated signal transduction	GO:0007264	88	0.017
positive regulation of cell cycle process	GO:0090068	28	0.016
regulation of ras protein signal transduction	GO:0046578	93	0.016
eggshell formation	GO:0030703	105	0.016
positive regulation of mitotic sister chromatid separation	GO:1901970	10	0.016
dna recombination	GO:0006310	32	0.016
protein complex biogenesis	GO:0070271	201	0.016
negative regulation of nervous system development	GO:0051961	92	0.016
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.016
malpighian tubule development	GO:0072002	64	0.016
positive regulation of cell cycle	GO:0045787	43	0.016
asymmetric protein localization	GO:0008105	33	0.016
positive regulation of cell projection organization	GO:0031346	29	0.016
positive regulation of cellular biosynthetic process	GO:0031328	316	0.016
proteasomal protein catabolic process	GO:0010498	59	0.016
negative regulation of chromosome segregation	GO:0051985	14	0.016
regulation of protein catabolic process	GO:0042176	55	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.015
regulation of immune response	GO:0050776	118	0.015
regulation of mitotic metaphase anaphase transition	GO:0030071	26	0.015
stem cell differentiation	GO:0048863	117	0.015
dna replication initiation	GO:0006270	6	0.015
synapse assembly	GO:0007416	143	0.015
endocytosis	GO:0006897	310	0.015
single organism cellular localization	GO:1902580	180	0.015
organelle localization	GO:0051640	148	0.015
actin filament based process	GO:0030029	220	0.015
developmental growth involved in morphogenesis	GO:0060560	65	0.015
positive regulation of cell development	GO:0010720	61	0.015
regionalization	GO:0003002	416	0.015
regulation of cell projection organization	GO:0031344	92	0.014
intracellular signal transduction	GO:0035556	300	0.014
neuron fate commitment	GO:0048663	50	0.014
mitotic cell cycle embryonic	GO:0045448	38	0.014
positive regulation of cell differentiation	GO:0045597	64	0.014
renal tubule development	GO:0061326	64	0.014
gene silencing	GO:0016458	138	0.014
mitotic g2 m transition checkpoint	GO:0044818	70	0.014
male gamete generation	GO:0048232	201	0.014
response to biotic stimulus	GO:0009607	294	0.014
neuroblast fate determination	GO:0007400	12	0.014
muscle structure development	GO:0061061	224	0.014
regulation of response to stress	GO:0080134	200	0.014
defense response to bacterium	GO:0042742	178	0.014
response to organophosphorus	GO:0046683	2	0.014
positive regulation of biosynthetic process	GO:0009891	316	0.013
cell death	GO:0008219	279	0.013
establishment or maintenance of cell polarity	GO:0007163	167	0.013
regulation of axon guidance	GO:1902667	10	0.013
positive regulation of cellular component organization	GO:0051130	156	0.013
dna integrity checkpoint	GO:0031570	81	0.013
regulation of immune system process	GO:0002682	176	0.013
regulation of notch signaling pathway	GO:0008593	100	0.013
negative regulation of cell development	GO:0010721	62	0.013
renal tubule morphogenesis	GO:0061333	44	0.013
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.013
gliogenesis	GO:0042063	80	0.013
regulation of phosphorylation	GO:0042325	147	0.013
glial cell migration	GO:0008347	31	0.013
response to oxygen containing compound	GO:1901700	200	0.013
regulation of cell proliferation	GO:0042127	163	0.013
regulation of protein deacetylation	GO:0090311	2	0.013
protein transport	GO:0015031	155	0.013
oocyte development	GO:0048599	124	0.013
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.013
ameboidal type cell migration	GO:0001667	151	0.012
regulation of cell morphogenesis involved in differentiation	GO:0010769	61	0.012
regulation of photoreceptor cell differentiation	GO:0046532	34	0.012
regulation of axonogenesis	GO:0050770	32	0.012
negative regulation of intracellular signal transduction	GO:1902532	57	0.012
negative regulation of gene expression	GO:0010629	387	0.012
positive regulation of neuron differentiation	GO:0045666	26	0.012
oocyte maturation	GO:0001556	3	0.012
cell motility	GO:0048870	251	0.012
negative regulation of cell differentiation	GO:0045596	143	0.012
sister chromatid cohesion	GO:0007062	18	0.012
notch signaling pathway	GO:0007219	120	0.012
nucleobase containing compound catabolic process	GO:0034655	165	0.012
regulation of gene expression epigenetic	GO:0040029	128	0.012
cellular protein localization	GO:0034613	160	0.012
reproductive structure development	GO:0048608	74	0.012
hindgut development	GO:0061525	58	0.012
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.012
chromatin assembly or disassembly	GO:0006333	52	0.012
regulation of neuron differentiation	GO:0045664	103	0.012
multi organism reproductive behavior	GO:0044705	121	0.012
branching involved in open tracheal system development	GO:0060446	45	0.012
reciprocal dna recombination	GO:0035825	19	0.012
anterior posterior axis specification embryo	GO:0008595	103	0.012
protein polymerization	GO:0051258	42	0.012
digestive tract development	GO:0048565	149	0.012
single organismal cell cell adhesion	GO:0016337	45	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
mesenchymal cell differentiation	GO:0048762	1	0.011
regulation of localization	GO:0032879	275	0.011
regulation of cell death	GO:0010941	173	0.011
regulation of protein metabolic process	GO:0051246	256	0.011
asymmetric protein localization involved in cell fate determination	GO:0045167	9	0.011
pole plasm assembly	GO:0007315	61	0.011
positive regulation of metaphase anaphase transition of cell cycle	GO:1902101	10	0.011
positive regulation of cell death	GO:0010942	69	0.011
eye antennal disc development	GO:0035214	60	0.011
mapk cascade	GO:0000165	107	0.011
innate immune response	GO:0045087	144	0.011
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.011
intracellular transport	GO:0046907	228	0.011
locomotory behavior	GO:0007626	176	0.011
regulation of cell size	GO:0008361	63	0.011
modification dependent protein catabolic process	GO:0019941	78	0.011
regulation of catalytic activity	GO:0050790	185	0.011
regulation of wnt signaling pathway	GO:0030111	68	0.011
dna dependent dna replication	GO:0006261	17	0.011
imaginal disc derived appendage development	GO:0048737	399	0.011
negative regulation of molecular function	GO:0044092	51	0.011
negative regulation of dna metabolic process	GO:0051053	12	0.011
protein complex assembly	GO:0006461	200	0.011
cell junction organization	GO:0034330	57	0.011
negative regulation of organelle organization	GO:0010639	56	0.011
dosage compensation	GO:0007549	16	0.010
regulation of microtubule based process	GO:0032886	49	0.010
positive regulation of cytoskeleton organization	GO:0051495	21	0.010
memory	GO:0007613	94	0.010
actin cytoskeleton organization	GO:0030036	206	0.010

Orc6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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