IMP: Integrative Multi-species Prediction

Drosophila melanogaster

33 known processes

fax (Dmel_CG4609)

failed axon connections

(Aliases: Fax,CG4609,clone 1.34,anon-EST:Liang-1.34,anon-WO0172774.68,anon-WO0172774.69,fac,anon-WO0172774.65,anon-WO0172774.66,anon-WO0172774.67,Dmel\CG4609,anon-WO0172774.62,anon-WO0172774.63)

Entrez: 39826
FLYBASE: FBgn0014163
UniProtKB: M9PFH6
UniProtKB: Q86BI4
UniProtKB: Q95RI5
UniProtKB: Q59E30
UniProtKB: Q59E29
UniProtKB: M9PFW1

Process Predictions
Disease Predictions

fax biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
neurological system process	GO:0050877	358	0.303
regulation of gene expression epigenetic	GO:0040029	128	0.292
negative regulation of nucleobase containing compound metabolic process	GO:0045934	261	0.274
positive regulation of macromolecule biosynthetic process	GO:0010557	283	0.250
positive regulation of nitrogen compound metabolic process	GO:0051173	354	0.219
axonogenesis	GO:0007409	290	0.210
positive regulation of cellular biosynthetic process	GO:0031328	316	0.207
negative regulation of gene expression	GO:0010629	387	0.185
dendrite development	GO:0016358	204	0.183
negative regulation of rna biosynthetic process	GO:1902679	240	0.181
response to abiotic stimulus	GO:0009628	341	0.175
neuron projection guidance	GO:0097485	241	0.171
dendrite morphogenesis	GO:0048813	199	0.159
negative regulation of cellular biosynthetic process	GO:0031327	277	0.153
negative regulation of transcription dna templated	GO:0045892	237	0.150
negative regulation of rna metabolic process	GO:0051253	251	0.147
neuron recognition	GO:0008038	101	0.143
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	267	0.143
axon guidance	GO:0007411	233	0.142
positive regulation of nucleic acid templated transcription	GO:1903508	266	0.130
intracellular transport	GO:0046907	228	0.123
positive regulation of macromolecule metabolic process	GO:0010604	405	0.122
embryonic development via the syncytial blastoderm	GO:0001700	148	0.122
negative regulation of nitrogen compound metabolic process	GO:0051172	265	0.115
negative regulation of macromolecule biosynthetic process	GO:0010558	270	0.112
negative regulation of cellular metabolic process	GO:0031324	382	0.105
adult behavior	GO:0030534	137	0.104
positive regulation of gene expression	GO:0010628	290	0.100
sensory perception	GO:0007600	196	0.098
positive regulation of transcription dna templated	GO:0045893	266	0.097
imaginal disc derived appendage development	GO:0048737	399	0.096
sensory organ morphogenesis	GO:0090596	260	0.094
camera type eye development	GO:0043010	4	0.092
negative regulation of nucleic acid templated transcription	GO:1903507	240	0.087
gene silencing by rna	GO:0031047	57	0.082
positive regulation of rna metabolic process	GO:0051254	271	0.081
negative regulation of biosynthetic process	GO:0009890	277	0.080
regulation of cell development	GO:0060284	215	0.078
regulation of multicellular organismal development	GO:2000026	414	0.076
single organism behavior	GO:0044708	391	0.074
embryo development ending in birth or egg hatching	GO:0009792	152	0.074
positive regulation of cellular component organization	GO:0051130	156	0.067
immune system process	GO:0002376	347	0.062
tissue morphogenesis	GO:0048729	297	0.060
forebrain development	GO:0030900	2	0.060
appendage morphogenesis	GO:0035107	397	0.059
positive regulation of rna biosynthetic process	GO:1902680	266	0.059
sensory perception of mechanical stimulus	GO:0050954	72	0.057
positive regulation of response to external stimulus	GO:0032103	44	0.057
embryonic morphogenesis	GO:0048598	206	0.056
positive regulation of biosynthetic process	GO:0009891	316	0.056
learning or memory	GO:0007611	141	0.056
response to wounding	GO:0009611	94	0.056
muscle organ development	GO:0007517	127	0.055
memory	GO:0007613	94	0.054
gene silencing	GO:0016458	138	0.053
epithelial cell differentiation	GO:0030855	322	0.052
axon development	GO:0061564	297	0.051
intracellular signal transduction	GO:0035556	300	0.050
regulation of cell proliferation	GO:0042127	163	0.049
positive regulation of developmental process	GO:0051094	143	0.049
organonitrogen compound metabolic process	GO:1901564	318	0.048
regulation of immune system process	GO:0002682	176	0.048
cell recognition	GO:0008037	102	0.048
stem cell differentiation	GO:0048863	117	0.048
regulation of intracellular signal transduction	GO:1902531	236	0.047
posttranscriptional regulation of gene expression	GO:0010608	145	0.044
regulation of response to stress	GO:0080134	200	0.044
wound healing	GO:0042060	75	0.044
response to temperature stimulus	GO:0009266	106	0.044
long term memory	GO:0007616	62	0.043
retina development in camera type eye	GO:0060041	4	0.043
response to organic substance	GO:0010033	284	0.042
regulation of cell differentiation	GO:0045595	302	0.041
heterocycle catabolic process	GO:0046700	166	0.041
telencephalon development	GO:0021537	2	0.038
apoptotic process	GO:0006915	159	0.038
regulation of cell cycle	GO:0051726	291	0.038
sensory perception of sound	GO:0007605	56	0.037
regulation of response to external stimulus	GO:0032101	115	0.037
regulation of programmed cell death	GO:0043067	152	0.037
lateral inhibition	GO:0046331	206	0.035
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.035
taxis	GO:0042330	304	0.035
wing disc morphogenesis	GO:0007472	344	0.034
response to decreased oxygen levels	GO:0036293	58	0.034
synaptic transmission	GO:0007268	288	0.034
regulation of nervous system development	GO:0051960	248	0.034
appendage development	GO:0048736	401	0.034
spindle organization	GO:0007051	253	0.034
immune effector process	GO:0002252	98	0.034
endocytosis	GO:0006897	310	0.033
endomembrane system organization	GO:0010256	119	0.033
translation	GO:0006412	69	0.032
regulation of i kappab kinase nf kappab signaling	GO:0043122	2	0.032
regulation of anatomical structure morphogenesis	GO:0022603	242	0.032
vesicle mediated transport	GO:0016192	381	0.032
male gamete generation	GO:0048232	201	0.032
protein localization	GO:0008104	284	0.031
striated muscle tissue development	GO:0014706	27	0.031
regulation of neurogenesis	GO:0050767	158	0.031
programmed cell death	GO:0012501	257	0.030
actin cytoskeleton organization	GO:0030036	206	0.030
eye development	GO:0001654	323	0.030
regulation of localization	GO:0032879	275	0.030
posttranscriptional gene silencing by rna	GO:0035194	45	0.030
aromatic compound catabolic process	GO:0019439	166	0.029
post embryonic appendage morphogenesis	GO:0035120	385	0.029
regulation of catabolic process	GO:0009894	170	0.029
ovarian follicle cell development	GO:0030707	248	0.028
skeletal muscle organ development	GO:0060538	48	0.028
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.028
organic cyclic compound catabolic process	GO:1901361	168	0.028
cellular protein localization	GO:0034613	160	0.027
midgut development	GO:0007494	23	0.027
catabolic process	GO:0009056	409	0.027
mitotic spindle organization	GO:0007052	220	0.026
negative regulation of cell differentiation	GO:0045596	143	0.026
regulation of cellular catabolic process	GO:0031329	157	0.026
wnt signaling pathway	GO:0016055	98	0.026
organic substance transport	GO:0071702	257	0.026
mitotic nuclear division	GO:0007067	213	0.026
motor neuron axon guidance	GO:0008045	58	0.025
gene silencing by mirna	GO:0035195	22	0.025
protein modification by small protein conjugation	GO:0032446	79	0.025
negative regulation of gene expression epigenetic	GO:0045814	77	0.025
regionalization	GO:0003002	416	0.025
myoblast fusion	GO:0007520	43	0.025
cell proliferation	GO:0008283	299	0.024
cognition	GO:0050890	141	0.024
spermatogenesis	GO:0007283	200	0.024
regulation of cellular protein metabolic process	GO:0032268	243	0.023
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.023
chemotaxis	GO:0006935	249	0.023
negative regulation of developmental process	GO:0051093	201	0.023
salivary gland development	GO:0007431	162	0.023
protein ubiquitination	GO:0016567	70	0.023
growth	GO:0040007	359	0.023
cation homeostasis	GO:0055080	51	0.023
gland development	GO:0048732	191	0.023
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.022
inter male aggressive behavior	GO:0002121	60	0.022
regeneration	GO:0031099	16	0.022
single organism intracellular transport	GO:1902582	207	0.022
phagocytosis	GO:0006909	215	0.022
response to radiation	GO:0009314	155	0.022
cytoplasmic transport	GO:0016482	130	0.022
morphogenesis of an epithelium	GO:0002009	276	0.022
regulation of wnt signaling pathway	GO:0030111	68	0.021
localization of cell	GO:0051674	257	0.021
aggressive behavior	GO:0002118	63	0.021
protein complex disassembly	GO:0043241	36	0.021
nucleotide catabolic process	GO:0009166	109	0.021
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	204	0.021
exocrine system development	GO:0035272	162	0.020
chromatin silencing	GO:0006342	76	0.020
rna processing	GO:0006396	147	0.020
single organism catabolic process	GO:0044712	228	0.020
transcription from rna polymerase ii promoter	GO:0006366	368	0.020
muscle structure development	GO:0061061	224	0.020
regulation of synapse assembly	GO:0051963	94	0.020
peripheral nervous system development	GO:0007422	52	0.020
cell death	GO:0008219	279	0.020
morphogenesis of embryonic epithelium	GO:0016331	94	0.019
negative regulation of signal transduction	GO:0009968	206	0.019
cellular nitrogen compound catabolic process	GO:0044270	165	0.019
regulation of cellular ketone metabolic process	GO:0010565	3	0.019
macromolecular complex assembly	GO:0065003	256	0.019
organonitrogen compound catabolic process	GO:1901565	128	0.019
chorion containing eggshell formation	GO:0007304	105	0.019
digestive tract development	GO:0048565	149	0.019
positive regulation of multicellular organismal process	GO:0051240	143	0.019
positive regulation of signal transduction	GO:0009967	223	0.019
amine metabolic process	GO:0009308	12	0.018
negative regulation of protein processing	GO:0010955	31	0.018
regulation of catalytic activity	GO:0050790	185	0.018
response to heat	GO:0009408	63	0.018
response to hypoxia	GO:0001666	53	0.018
chromosome organization	GO:0051276	360	0.018
immune response activating signal transduction	GO:0002757	2	0.018
purine ribonucleotide catabolic process	GO:0009154	109	0.018
purine nucleoside metabolic process	GO:0042278	127	0.018
central nervous system development	GO:0007417	201	0.018
regulation of defense response	GO:0031347	102	0.018
organonitrogen compound biosynthetic process	GO:1901566	117	0.018
cellular homeostasis	GO:0019725	80	0.018
cellular ketone metabolic process	GO:0042180	24	0.018
small molecule metabolic process	GO:0044281	305	0.018
regulation of molecular function	GO:0065009	217	0.018
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	16	0.017
jak stat cascade	GO:0007259	49	0.017
posttranscriptional gene silencing	GO:0016441	46	0.017
organic substance catabolic process	GO:1901575	308	0.017
cardiovascular system development	GO:0072358	82	0.017
cellular catabolic process	GO:0044248	372	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017
negative regulation of signaling	GO:0023057	219	0.017
regulation of mrna metabolic process	GO:1903311	72	0.017
ion homeostasis	GO:0050801	55	0.017
response to extracellular stimulus	GO:0009991	116	0.017
response to lipopolysaccharide	GO:0032496	4	0.017
positive regulation of signaling	GO:0023056	243	0.017
death	GO:0016265	284	0.017
nucleobase containing small molecule metabolic process	GO:0055086	174	0.017
regulation of mitotic cell cycle	GO:0007346	190	0.016
detection of stimulus	GO:0051606	156	0.016
wing disc pattern formation	GO:0035222	66	0.016
chromosome segregation	GO:0007059	157	0.016
regulation of mrna processing	GO:0050684	71	0.016
organophosphate catabolic process	GO:0046434	112	0.016
immune response	GO:0006955	246	0.016
cellular metal ion homeostasis	GO:0006875	31	0.016
nucleoside triphosphate catabolic process	GO:0009143	108	0.016
non canonical wnt signaling pathway	GO:0035567	8	0.016
regulation of circadian rhythm	GO:0042752	49	0.016
golgi organization	GO:0007030	66	0.016
actomyosin structure organization	GO:0031032	56	0.016
imaginal disc derived wing morphogenesis	GO:0007476	337	0.016
regulation of cell death	GO:0010941	173	0.016
cellular response to dna damage stimulus	GO:0006974	223	0.016
cellular response to chemical stimulus	GO:0070887	199	0.016
nucleoside phosphate catabolic process	GO:1901292	110	0.016
homeostatic process	GO:0042592	199	0.016
purine containing compound metabolic process	GO:0072521	155	0.016
regulation of neuron differentiation	GO:0045664	103	0.016
glycosyl compound catabolic process	GO:1901658	112	0.016
positive regulation of protein metabolic process	GO:0051247	128	0.016
mrna metabolic process	GO:0016071	124	0.015
purine nucleoside triphosphate catabolic process	GO:0009146	108	0.015
synaptic vesicle transport	GO:0048489	50	0.015
negative regulation of cellular component organization	GO:0051129	108	0.015
spindle elongation	GO:0051231	83	0.015
negative regulation of catalytic activity	GO:0043086	42	0.015
regulation of small gtpase mediated signal transduction	GO:0051056	93	0.015
wing disc dorsal ventral pattern formation	GO:0048190	47	0.015
g protein coupled receptor signaling pathway	GO:0007186	136	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.015
regulation of cellular amine metabolic process	GO:0033238	3	0.015
epithelial cell development	GO:0002064	274	0.015
ras protein signal transduction	GO:0007265	88	0.015
positive regulation of response to stimulus	GO:0048584	323	0.015
regulation of transport	GO:0051049	181	0.015
purine ribonucleoside metabolic process	GO:0046128	127	0.015
regulation of hydrolase activity	GO:0051336	97	0.015
ubiquitin dependent protein catabolic process	GO:0006511	78	0.015
cellular response to external stimulus	GO:0071496	66	0.015
nucleoside triphosphate metabolic process	GO:0009141	120	0.015
purine ribonucleoside catabolic process	GO:0046130	112	0.015
organophosphate metabolic process	GO:0019637	195	0.015
rrna processing	GO:0006364	3	0.015
body morphogenesis	GO:0010171	2	0.015
muscle tissue development	GO:0060537	30	0.015
negative regulation of cell death	GO:0060548	81	0.014
centrosome duplication	GO:0051298	121	0.014
purine containing compound catabolic process	GO:0072523	112	0.014
negative regulation of protein metabolic process	GO:0051248	85	0.014
ribonucleoside triphosphate metabolic process	GO:0009199	119	0.014
protein k48 linked ubiquitination	GO:0070936	3	0.014
digestive system development	GO:0055123	149	0.014
muscle attachment	GO:0016203	36	0.014
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.014
negative regulation of response to stimulus	GO:0048585	258	0.014
erbb signaling pathway	GO:0038127	58	0.014
positive regulation of cell development	GO:0010720	61	0.014
carboxylic acid metabolic process	GO:0019752	92	0.014
tube morphogenesis	GO:0035239	191	0.014
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.014
ribonucleoside metabolic process	GO:0009119	127	0.014
antimicrobial peptide production	GO:0002775	46	0.014
hindbrain development	GO:0030902	2	0.014
single organism biosynthetic process	GO:0044711	206	0.014
regulation of cell cycle process	GO:0010564	181	0.014
locomotory behavior	GO:0007626	176	0.014
circulatory system development	GO:0072359	82	0.013
synaptic growth at neuromuscular junction	GO:0051124	119	0.013
ribose phosphate metabolic process	GO:0019693	145	0.013
regulation of chromosome organization	GO:0033044	64	0.013
organic acid metabolic process	GO:0006082	103	0.013
pigment metabolic process	GO:0042440	84	0.013
nucleocytoplasmic transport	GO:0006913	72	0.013
regulation of behavior	GO:0050795	75	0.013
cell cell signaling involved in cell fate commitment	GO:0045168	210	0.013
cellular response to organic substance	GO:0071310	132	0.013
hematopoietic progenitor cell differentiation	GO:0002244	1	0.013
negative regulation of catabolic process	GO:0009895	36	0.013
regulation of cell shape	GO:0008360	113	0.013
gliogenesis	GO:0042063	80	0.013
proteolysis	GO:0006508	192	0.013
nucleoside phosphate metabolic process	GO:0006753	162	0.013
salivary gland morphogenesis	GO:0007435	145	0.013
gtp metabolic process	GO:0046039	72	0.013
formation of anatomical boundary	GO:0048859	37	0.013
morphogenesis of a polarized epithelium	GO:0001738	93	0.013
regulation of apoptotic process	GO:0042981	130	0.013
centrosome cycle	GO:0007098	137	0.013
compound eye morphogenesis	GO:0001745	249	0.012
head development	GO:0060322	135	0.012
single organism carbohydrate metabolic process	GO:0044723	72	0.012
imaginal disc pattern formation	GO:0007447	91	0.012
stem cell fate commitment	GO:0048865	25	0.012
actin filament based process	GO:0030029	220	0.012
glial cell migration	GO:0008347	31	0.012
cellular amide metabolic process	GO:0043603	80	0.012
camera type eye morphogenesis	GO:0048593	2	0.012
mesenchymal cell differentiation	GO:0048762	1	0.012
cellular macromolecular complex assembly	GO:0034622	153	0.012
negative regulation of cellular catabolic process	GO:0031330	34	0.012
response to oxygen levels	GO:0070482	59	0.012
stem cell development	GO:0048864	79	0.012
positive regulation of catabolic process	GO:0009896	105	0.012
rhythmic process	GO:0048511	106	0.012
semaphorin plexin signaling pathway	GO:0071526	4	0.012
ribonucleotide metabolic process	GO:0009259	145	0.012
striated muscle cell differentiation	GO:0051146	90	0.012
regulation of endocytosis	GO:0030100	37	0.012
negative regulation of growth	GO:0045926	84	0.012
meiotic nuclear division	GO:0007126	151	0.012
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	119	0.012
response to mechanical stimulus	GO:0009612	28	0.012
biological adhesion	GO:0022610	138	0.012
regulation of immune response	GO:0050776	118	0.012
convergent extension involved in gastrulation	GO:0060027	2	0.012
mesenchymal cell development	GO:0014031	1	0.012
nucleoside catabolic process	GO:0009164	112	0.012
regulation of organ morphogenesis	GO:2000027	78	0.012
cellular component assembly involved in morphogenesis	GO:0010927	151	0.011
positive regulation of intracellular signal transduction	GO:1902533	116	0.011
positive regulation of cell migration	GO:0030335	2	0.011
stem cell maintenance	GO:0019827	67	0.011
antimicrobial humoral response	GO:0019730	99	0.011
response to paraquat	GO:1901562	4	0.011
chromatin organization	GO:0006325	207	0.011
negative regulation of cell communication	GO:0010648	223	0.011
nuclear division	GO:0000280	332	0.011
blood circulation	GO:0008015	26	0.011
intracellular protein transport	GO:0006886	104	0.011
organelle fission	GO:0048285	340	0.011
negative regulation of cell cycle process	GO:0010948	109	0.011
positive regulation of apoptotic process	GO:0043065	47	0.011
regulation of cellular protein catabolic process	GO:1903362	44	0.011
purine nucleotide catabolic process	GO:0006195	109	0.011
salivary gland cell autophagic cell death	GO:0035071	83	0.011
gland morphogenesis	GO:0022612	145	0.011
syncytium formation	GO:0006949	43	0.011
regulation of cell substrate adhesion	GO:0010810	2	0.011
positive regulation of hydrolase activity	GO:0051345	78	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
protein modification by small protein conjugation or removal	GO:0070647	106	0.011
regulation of organelle organization	GO:0033043	196	0.011
carbohydrate derivative catabolic process	GO:1901136	118	0.011
response to other organism	GO:0051707	293	0.011
regulation of antimicrobial peptide biosynthetic process	GO:0002805	38	0.011
axon choice point recognition	GO:0016198	26	0.011
ncrna metabolic process	GO:0034660	43	0.011
guanosine containing compound metabolic process	GO:1901068	74	0.011
positive regulation of cell proliferation	GO:0008284	47	0.010
developmental growth	GO:0048589	280	0.010
chemical homeostasis	GO:0048878	92	0.010
negative regulation of organelle organization	GO:0010639	56	0.010
nucleotide metabolic process	GO:0009117	161	0.010
negative regulation of cell cycle	GO:0045786	116	0.010
leg disc development	GO:0035218	92	0.010
tube development	GO:0035295	244	0.010
dorsal ventral pattern formation	GO:0009953	133	0.010
chondroitin sulfate proteoglycan biosynthetic process	GO:0050650	3	0.010
regulation of defense response to bacterium	GO:1900424	30	0.010
regulation of proteolysis	GO:0030162	87	0.010
establishment of rna localization	GO:0051236	47	0.010
axon midline choice point recognition	GO:0016199	26	0.010
carbohydrate derivative metabolic process	GO:1901135	217	0.010
regulation of response to wounding	GO:1903034	19	0.010

fax disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.029
nervous system disease	DOID:863	0.014
cancer	DOID:162	0.010
disease of cellular proliferation	DOID:14566	0.010
organ system cancer	DOID:0050686	0.010

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