Drosophila melanogaster

108 known processes

ple (Dmel_CG10118)

pale

(Aliases: Th,DTH,pale/ple,DH65B,dTH65B,CG10118,VII,Dmel\CG10118,TH,Pale)

ple biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cuticle pigmentationGO:0048067220.997
circadian rhythmGO:00076231050.995
Fly
single organism behaviorGO:00447083910.985
phenol containing compound biosynthetic processGO:004618960.981
adult chitin containing cuticle pigmentationGO:0048085160.954
molting cycle chitin based cuticleGO:0007591560.883
locomotory behaviorGO:00076261760.873
regulation of cuticle pigmentationGO:0048079160.830
molting cycle processGO:0022404290.829
rhythmic processGO:00485111060.802
Fly
dopamine biosynthetic processGO:004241630.747
chitin based cuticle sclerotizationGO:0007593190.735
circadian sleep wake cycle processGO:0022410240.731
Fly
adult behaviorGO:00305341370.701
olfactory behaviorGO:0042048970.694
tyrosine metabolic processGO:000657010.694
Mouse
regulation of developmental pigmentationGO:0048070240.690
molting cycleGO:0042303560.678
catecholamine biosynthetic processGO:004242330.671
regulation of chitin based cuticle tanningGO:0007564140.651
dopamine metabolic processGO:004241770.647
indole containing compound biosynthetic processGO:004243540.646
Zebrafish Fly
aromatic amino acid family metabolic processGO:000907230.635
Mouse
regulation of circadian rhythmGO:0042752490.634
Fly
learning or memoryGO:00076111410.612
Mouse Worm
sensory perceptionGO:00076001960.607
Mouse
serotonin metabolic processGO:004242820.546
Zebrafish Fly
regulation of adult chitin containing cuticle pigmentationGO:0048082130.520
cognitionGO:00508901410.514
Mouse Worm
multi organism behaviorGO:00517051750.479
appendage morphogenesisGO:00351073970.443
long term memoryGO:0007616620.421
adult locomotory behaviorGO:0008344760.408
rhythmic behaviorGO:0007622760.390
Fly
cuticle developmentGO:0042335860.367
positive regulation of rna metabolic processGO:00512542710.363
primary amino compound biosynthetic processGO:190116220.361
Zebrafish Fly
growthGO:00400073590.359
regulation of multicellular organismal developmentGO:20000264140.331
chemosensory behaviorGO:00076351060.330
memoryGO:0007613940.325
Mouse
catechol containing compound metabolic processGO:0009712100.325
negative regulation of cellular metabolic processGO:00313243820.325
phenol containing compound metabolic processGO:0018958570.303
developmental growthGO:00485892800.302
respiratory system developmentGO:00605412130.297
regulation of transcription from rna polymerase ii promoterGO:00063573780.295
negative regulation of cell communicationGO:00106482230.290
imaginal disc derived appendage developmentGO:00487373990.285
regulation of developmental growthGO:00486381740.273
catechol containing compound biosynthetic processGO:000971330.264
positive regulation of nucleobase containing compound metabolic processGO:00459353320.241
response to temperature stimulusGO:00092661060.227
negative regulation of cellular biosynthetic processGO:00313272770.224
regulation of response to external stimulusGO:00321011150.222
sleepGO:0030431490.218
Fly
cellular response to chemical stimulusGO:00708871990.214
positive regulation of nitrogen compound metabolic processGO:00511733540.212
circadian sleep wake cycle sleepGO:0050802230.212
Fly
neurological system processGO:00508773580.211
Mouse Worm
negative regulation of response to stimulusGO:00485852580.207
response to nitrogen compoundGO:1901698900.207
regulation of cell differentiationGO:00455953020.206
organic hydroxy compound biosynthetic processGO:1901617210.203
chitin based cuticle developmentGO:0040003490.201
organonitrogen compound biosynthetic processGO:19015661170.194
malpighian tubule morphogenesisGO:0007443440.194
epithelial tube morphogenesisGO:0060562880.190
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.188
positive regulation of multicellular organismal processGO:00512401430.187
negative regulation of biosynthetic processGO:00098902770.181
olfactory learningGO:0008355560.173
positive regulation of nucleic acid templated transcriptionGO:19035082660.169
open tracheal system developmentGO:00074242040.162
positive regulation of gene expressionGO:00106282900.162
locomotor rhythmGO:0045475560.160
positive regulation of response to stimulusGO:00485843230.158
regulation of immune system processGO:00026821760.157
circadian behaviorGO:0048512760.156
Fly
response to mechanical stimulusGO:0009612280.148
Worm
response to oxygen containing compoundGO:19017002000.144
synaptic transmissionGO:00072682880.143
Mouse
regulation of localizationGO:00328792750.143
organic hydroxy compound metabolic processGO:1901615830.141
regulation of circadian sleep wake cycle sleepGO:0045187210.138
Fly
regulation of protein metabolic processGO:00512462560.137
embryo development ending in birth or egg hatchingGO:00097921520.135
response to toxic substanceGO:0009636220.131
regulation of growthGO:00400082330.130
negative regulation of macromolecule biosynthetic processGO:00105582700.129
response to gravityGO:0009629260.128
imaginal disc derived appendage morphogenesisGO:00351143950.128
toxin metabolic processGO:000940420.126
regulation of cellular protein metabolic processGO:00322682430.123
single organism biosynthetic processGO:00447112060.120
Mouse
response to insecticideGO:0017085140.117
extracellular structure organizationGO:0043062460.114
chromosome organizationGO:00512763600.114
epithelial cell migration open tracheal systemGO:0007427320.114
wing disc morphogenesisGO:00074723440.112
gravitaxisGO:0042332260.108
tube morphogenesisGO:00352391910.107
regulation of molecular functionGO:00650092170.104
multi organism reproductive behaviorGO:00447051210.102
homeostatic processGO:00425921990.099
establishment of organelle localizationGO:00516561220.099
response to organonitrogen compoundGO:0010243750.098
cellular homeostasisGO:0019725800.096
positive regulation of transcription from rna polymerase ii promoterGO:00459442040.093
organic substance catabolic processGO:19015753080.092
regulation of catalytic activityGO:00507901850.092
transcription from rna polymerase ii promoterGO:00063663680.091
positive regulation of transcription dna templatedGO:00458932660.090
positive regulation of macromolecule biosynthetic processGO:00105572830.089
intracellular signal transductionGO:00355563000.089
regulation of multi organism processGO:00439001310.088
regulation of response to biotic stimulusGO:0002831630.087
immune system processGO:00023763470.087
response to organic cyclic compoundGO:0014070890.087
regulation of anatomical structure sizeGO:00900661630.083
small molecule metabolic processGO:00442813050.083
Mouse
multi multicellular organism processGO:00447061230.083
immune response activating signal transductionGO:000275720.083
synapse assemblyGO:00074161430.082
negative regulation of gene expressionGO:00106293870.080
positive regulation of cellular biosynthetic processGO:00313283160.078
negative regulation of transcription dna templatedGO:00458922370.078
regulation of neuron differentiationGO:00456641030.076
positive regulation of rna biosynthetic processGO:19026802660.076
imaginal disc derived wing morphogenesisGO:00074763370.076
chemical homeostasisGO:0048878920.075
anesthesia resistant memoryGO:000761560.075
pigmentationGO:0043473750.073
reproductive behaviorGO:00190981220.072
post embryonic appendage morphogenesisGO:00351203850.070
regulation of synaptic growth at neuromuscular junctionGO:0008582890.068
male mating behaviorGO:0060179700.067
positive regulation of immune system processGO:0002684680.066
response to endogenous stimulusGO:00097191190.064
response to alkaloidGO:0043279260.064
neuron neuron synaptic transmissionGO:0007270140.063
Mouse
cellular catabolic processGO:00442483720.063
regulation of anatomical structure morphogenesisGO:00226032420.062
peptide metabolic processGO:0006518800.062
positive regulation of biosynthetic processGO:00098913160.059
defense responseGO:00069523000.059
immune response regulating signaling pathwayGO:000276420.058
positive regulation of macromolecule metabolic processGO:00106044050.057
organonitrogen compound metabolic processGO:19015643180.057
taxisGO:00423303040.056
neuromuscular synaptic transmissionGO:0007274670.054
amine metabolic processGO:0009308120.054
lateral inhibitionGO:00463312060.052
negative regulation of signalingGO:00230572190.052
ion homeostasisGO:0050801550.051
regulation of mapk cascadeGO:0043408920.051
regulation of secretion by cellGO:1903530390.050
cation homeostasisGO:0055080510.050
negative regulation of developmental processGO:00510932010.050
positive regulation of cellular protein metabolic processGO:00322701180.048
catabolic processGO:00090564090.048
negative regulation of nucleobase containing compound metabolic processGO:00459342610.048
regulation of synaptic transmissionGO:0050804690.048
synaptic vesicle transportGO:0048489500.048
regulation of tube sizeGO:0035150460.047
regulation of cellular localizationGO:00603411360.047
positive regulation of cell communicationGO:00106472500.047
intraspecies interaction between organismsGO:005170340.046
enzyme linked receptor protein signaling pathwayGO:00071671790.046
regulation of response to stressGO:00801342000.046
regulation of blood circulationGO:1903522210.046
Mouse
cellular response to nitrogen compoundGO:1901699510.045
positive regulation of signalingGO:00230562430.045
divalent inorganic cation homeostasisGO:0072507290.043
chitin based embryonic cuticle biosynthetic processGO:0008362160.043
negative regulation of nitrogen compound metabolic processGO:00511722650.042
translationGO:0006412690.042
g protein coupled receptor signaling pathwayGO:00071861360.041
amide biosynthetic processGO:0043604420.041
matingGO:00076181200.040
aggressive behaviorGO:0002118630.040
positive regulation of signal transductionGO:00099672230.039
protein catabolic processGO:00301631010.039
regulation of secretionGO:0051046440.039
response to extracellular stimulusGO:00099911160.038
Worm
eye developmentGO:00016543230.038
Mouse
compound eye photoreceptor cell differentiationGO:00017511400.038
zygotic determination of anterior posterior axis embryoGO:0007354270.038
response to nutrient levelsGO:00316671140.038
Worm
response to organic substanceGO:00100332840.037
blood circulationGO:0008015260.037
Mouse
metal ion transportGO:0030001740.037
positive regulation of developmental growthGO:0048639620.036
negative regulation of multicellular organismal processGO:00512411420.036
regulation of phosphorus metabolic processGO:00511742100.036
immune responseGO:00069552460.036
eye photoreceptor cell differentiationGO:00017541450.035
Mouse
positive regulation of developmental processGO:00510941430.035
cellular response to endogenous stimulusGO:0071495800.035
regulation of neurotransmitter levelsGO:0001505380.035
response to metal ionGO:0010038230.035
multicellular organismal agingGO:00102591400.034
negative regulation of rna metabolic processGO:00512532510.033
transition metal ion transportGO:0000041160.033
cellular ion homeostasisGO:0006873390.033
establishment of synaptic vesicle localizationGO:0097480500.033
amino sugar metabolic processGO:0006040100.033
tissue morphogenesisGO:00487292970.032
morphogenesis of an epitheliumGO:00020092760.032
cellular response to organic substanceGO:00713101320.032
feeding behaviorGO:0007631500.031
Mouse
cellular amide metabolic processGO:0043603800.031
appendage developmentGO:00487364010.030
positive regulation of phosphorus metabolic processGO:00105621390.029
hematopoietic or lymphoid organ developmentGO:0048534570.029
negative regulation of signal transductionGO:00099682060.029
nuclear transportGO:0051169720.029
regulation of nervous system developmentGO:00519602480.029
negative regulation of protein metabolic processGO:0051248850.029
signal transduction by phosphorylationGO:00230141070.028
carbohydrate derivative metabolic processGO:19011352170.028
nucleocytoplasmic transportGO:0006913720.027
cellular response to organonitrogen compoundGO:0071417360.027
regulation of protein modification processGO:00313991120.027
epithelial cell differentiationGO:00308553220.026
vitamin metabolic processGO:000676620.026
regulation of synapse structure and activityGO:00508031280.026
response to drugGO:0042493170.026
imaginal disc growthGO:0007446370.025
regulation of circadian sleep wake cycleGO:0042749250.025
Fly
regulation of intracellular signal transductionGO:19025312360.025
extracellular matrix organizationGO:0030198320.025
eye photoreceptor cell developmentGO:0042462810.025
Mouse
response to light stimulusGO:00094161240.025
epithelial cell migrationGO:00106311480.025
neuromuscular processGO:0050905210.025
negative regulation of cellular protein metabolic processGO:0032269850.025
regulation of membrane potentialGO:0042391350.024
synaptic vesicle endocytosisGO:0048488280.024
cellular response to mechanical stimulusGO:007126020.024
cellular chemical homeostasisGO:0055082400.024
heart contractionGO:0060047260.024
Mouse
rhabdomere developmentGO:0042052380.024
embryonic pattern specificationGO:00098801740.024
cellular protein modification processGO:00064644380.024
developmental pigmentationGO:0048066680.024
positive regulation of molecular functionGO:00440931360.023
hindbrain developmentGO:003090220.023
eye morphogenesisGO:00485922600.023
Mouse
cellular amine metabolic processGO:0044106120.023
regulation of tube diameterGO:0035296140.023
regulation of system processGO:0044057360.023
Mouse
glucosamine containing compound metabolic processGO:190107190.022
negative regulation of intracellular signal transductionGO:1902532570.022
terminal branching open tracheal systemGO:0007430170.022
regulation of translationGO:0006417560.022
membrane depolarizationGO:005189940.022
agingGO:00075681430.022
response to other organismGO:00517072930.022
phosphorylationGO:00163102940.022
forebrain developmentGO:003090020.022
regulation of excitatory postsynaptic membrane potentialGO:006007930.022
neuromuscular junction developmentGO:00075281490.022
regulation of immune responseGO:00507761180.022
receptor clusteringGO:004311330.021
cell fate determinationGO:0001709910.021
protein targeting to nucleusGO:0044744510.021
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.021
indole containing compound metabolic processGO:004243050.021
Zebrafish Fly
establishment of vesicle localizationGO:0051650510.021
striated muscle cell developmentGO:0055002500.021
regulation of tube architecture open tracheal systemGO:0035152680.021
positive regulation of secretion by cellGO:1903532200.021
secretion by cellGO:00329401010.021
regulation of cell morphogenesis involved in differentiationGO:0010769610.021
blastoderm segmentationGO:00073501590.021
muscle organ developmentGO:00075171270.020
regulation of synapse organizationGO:00508071100.020
photoreceptor cell differentiationGO:00465301700.020
Mouse
regulation of defense responseGO:00313471020.020
signal releaseGO:0023061490.020
response to hexoseGO:000974630.020
ameboidal type cell migrationGO:00016671510.020
male courtship behaviorGO:0008049630.020
deathGO:00162652840.020
cellular amino acid metabolic processGO:0006520610.019
Mouse
morphogenesis of a branching epitheliumGO:0061138450.019
sensory perception of smellGO:0007608800.019
organic substance transportGO:00717022570.019
negative regulation of translationGO:0017148280.019
developmental maturationGO:00217001720.019
organonitrogen compound catabolic processGO:19015651280.019
dendrite morphogenesisGO:00488131990.019
regulation of photoreceptor cell differentiationGO:0046532340.019
protein import into nucleusGO:0006606510.019
cellular response to carbohydrate stimulusGO:007132240.018
mating behaviorGO:00076171060.018
cation transportGO:00068121100.018
regulation of cell cycleGO:00517262910.018
response to woundingGO:0009611940.018
reproductive system developmentGO:0061458740.018
purine nucleoside metabolic processGO:00422781270.018
negative regulation of cell differentiationGO:00455961430.018
thermotaxisGO:0043052160.018
muscle cell developmentGO:0055001500.018
regulation of epithelial cell proliferationGO:005067840.018
nucleobase containing compound catabolic processGO:00346551650.018
regulation of cell developmentGO:00602842150.018
response to abiotic stimulusGO:00096283410.018
peptide biosynthetic processGO:0043043420.018
protein modification processGO:00362114380.018
intracellular transportGO:00469072280.017
nitrogen compound transportGO:0071705850.017
carbohydrate derivative catabolic processGO:19011361180.017
embryonic hindgut morphogenesisGO:0048619480.017
autophagyGO:00069141080.017
cellular response to hexose stimulusGO:007133110.017
associative learningGO:0008306650.017
immune effector processGO:0002252980.017
renal tubule developmentGO:0061326640.017
macromolecule catabolic processGO:00090571610.017
synapse organizationGO:00508081960.016
regulation of transportGO:00510491810.016
sensory perception of chemical stimulusGO:00076061160.016
stem cell differentiationGO:00488631170.016
purine containing compound metabolic processGO:00725211550.016
protein importGO:0017038550.016
positive regulation of pathway restricted smad protein phosphorylationGO:001086210.016
protein complex biogenesisGO:00702712010.016
learningGO:0007612750.016
Mouse Worm
cell motilityGO:00488702510.016
regulation of cellular amide metabolic processGO:0034248390.016
positive regulation of protein localization to nucleusGO:1900182210.015
carbohydrate metabolic processGO:0005975820.015
renal tubule morphogenesisGO:0061333440.015
response to hormoneGO:0009725450.015
cellular response to organic cyclic compoundGO:0071407320.015
anatomical structure homeostasisGO:0060249970.015
cellular component assembly involved in morphogenesisGO:00109271510.015
positive regulation of nucleocytoplasmic transportGO:0046824240.015
secretionGO:00469031090.015
positive regulation of synapse assemblyGO:0051965290.014
synaptic vesicle localizationGO:0097479530.014
regulation of cellular component biogenesisGO:00440872010.014
response to insulinGO:0032868290.014
positive regulation of transportGO:0051050920.014
embryonic morphogenesisGO:00485982060.014
Mouse
nucleoside phosphate metabolic processGO:00067531620.014
notch signaling pathwayGO:00072191200.014
organic cyclic compound catabolic processGO:19013611680.014
connective tissue developmentGO:006144830.014
synaptic transmission gabaergicGO:005193210.014
positive regulation of synaptic transmissionGO:0050806150.014
cellular nitrogen compound catabolic processGO:00442701650.014
response to inorganic substanceGO:0010035440.014
terminal region determinationGO:0007362250.013
positive regulation of intracellular protein transportGO:0090316300.013
regulation of behaviorGO:0050795750.013
Fly
regulation of r7 cell differentiationGO:0045676150.013
oxoacid metabolic processGO:00434361030.013
Mouse
regulation of tube diameter open tracheal systemGO:0035158110.013
regulation of cytoskeleton organizationGO:0051493890.013
segmentationGO:00352822070.013
striated muscle adaptationGO:001488810.013
pteridine containing compound metabolic processGO:004255860.013
regulation of hydrolase activityGO:0051336970.013
spermatogenesisGO:00072832000.013
protein transportGO:00150311550.013
regulation of nucleocytoplasmic transportGO:0046822350.013
body morphogenesisGO:001017120.013
cellular macromolecular complex assemblyGO:00346221530.013
cellular response to hormone stimulusGO:0032870440.012
cellular metal ion homeostasisGO:0006875310.012
compound eye pigmentationGO:0048072170.012
compound eye morphogenesisGO:00017452490.012
cellular biogenic amine metabolic processGO:000657690.012
ribonucleotide metabolic processGO:00092591450.012
positive regulation of growthGO:0045927750.012
protein phosphorylationGO:00064681690.012
cardiovascular system developmentGO:0072358820.012
Mouse
antimicrobial peptide productionGO:0002775460.012
spiracle morphogenesis open tracheal systemGO:0035277220.012
positive regulation of immune responseGO:0050778630.012
cell type specific apoptotic processGO:0097285380.012
carbohydrate derivative biosynthetic processGO:1901137850.012
single organism nuclear importGO:1902593510.012
neurotransmitter transportGO:0006836370.012
dormancy processGO:002261120.012
regulation of synapse assemblyGO:0051963940.012
dendrite developmentGO:00163582040.012
chitin metabolic processGO:000603070.012
positive regulation of protein transportGO:0051222370.012
sensory organ morphogenesisGO:00905962600.011
Mouse
mesoderm developmentGO:0007498780.011
thermosensory behaviorGO:0040040190.011
oocyte microtubule cytoskeleton polarizationGO:0008103220.011
cell proliferationGO:00082832990.011
immune system developmentGO:0002520570.011
phagocytosisGO:00069092150.011
regulation of neurogenesisGO:00507671580.011
nuclear importGO:0051170510.011
cellular macromolecule localizationGO:00707272200.011
response to oxygen radicalGO:000030530.011
larval feeding behaviorGO:0030536150.011
mitotic cytokinesisGO:0000281500.011
positive regulation of i kappab kinase nf kappab signalingGO:004312310.011
regionalizationGO:00030024160.011
negative regulation of nucleic acid templated transcriptionGO:19035072400.011
central nervous system developmentGO:00074172010.011
Zebrafish
vesicle mediated transportGO:00161923810.011
synaptic transmission cholinergicGO:000727190.011
activation of innate immune responseGO:000221840.011
catecholamine metabolic processGO:0006584100.011
branching morphogenesis of an epithelial tubeGO:0048754450.011
regulation of cellular component sizeGO:0032535980.011
regulation of protein import into nucleusGO:0042306280.011
positive regulation of phosphate metabolic processGO:00459371390.011
cellular cation homeostasisGO:0030003380.011
regulation of intracellular protein transportGO:0033157460.011
digestive tract morphogenesisGO:00485461270.011
cellular response to insulin stimulusGO:0032869280.010
mapk cascadeGO:00001651070.010
developmental programmed cell deathGO:00106231380.010
columnar cuboidal epithelial cell developmentGO:00020662490.010
visual learningGO:000854240.010
regulation of cellular response to stressGO:0080135890.010
retinal cell programmed cell deathGO:0046666250.010
branch fusion open tracheal systemGO:0035147170.010
mesenchymal cell differentiationGO:004876210.010
organic acid metabolic processGO:00060821030.010
Mouse
limb developmentGO:006017310.010
medium term memoryGO:007237580.010
response to peptideGO:1901652290.010
protein maturationGO:0051604710.010
protein complex assemblyGO:00064612000.010
regulation of tube length open tracheal systemGO:0035159240.010
rna 3 end processingGO:0031123450.010
neuron apoptotic processGO:0051402170.010

ple disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.050
nervous system diseaseDOID:86300.037
neuropathyDOID:87000.022
cancerDOID:16200.012
disease of cellular proliferationDOID:1456600.012