IMP: Integrative Multi-species Prediction

Drosophila melanogaster

5 known processes

fy (Dmel_CG13396)

fuzzy

(Aliases: CG13396,Dmel\CG13396)

Entrez: 34166
FLYBASE: FBgn0001084
UniProtKB: O16868
UniProtKB: M9PCK4

Process Predictions
Disease Predictions

fy biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
tissue morphogenesis	GO:0048729	297	0.705	Mouse
imaginal disc derived wing hair organization	GO:0035317	45	0.411
regionalization	GO:0003002	416	0.411	Mouse
morphogenesis of an epithelium	GO:0002009	276	0.379	Mouse
hair cell differentiation	GO:0035315	47	0.373
establishment of tissue polarity	GO:0007164	87	0.364	Mouse
embryonic morphogenesis	GO:0048598	206	0.359	Mouse
positive regulation of signal transduction	GO:0009967	223	0.326
appendage development	GO:0048736	401	0.299
imaginal disc derived wing morphogenesis	GO:0007476	337	0.247
imaginal disc derived appendage development	GO:0048737	399	0.233
skin development	GO:0043588	65	0.227	Mouse
post embryonic appendage morphogenesis	GO:0035120	385	0.225
positive regulation of cell communication	GO:0010647	250	0.222
actin cytoskeleton organization	GO:0030036	206	0.215
morphogenesis of a polarized epithelium	GO:0001738	93	0.198	Mouse
positive regulation of response to stimulus	GO:0048584	323	0.196
positive regulation of signaling	GO:0023056	243	0.189
epidermis development	GO:0008544	65	0.186	Mouse
establishment or maintenance of cell polarity	GO:0007163	167	0.175
eye development	GO:0001654	323	0.162
spinal cord patterning	GO:0021511	1	0.144	Mouse
proteolysis	GO:0006508	192	0.143
regulation of wnt signaling pathway	GO:0030111	68	0.129	Mouse
synaptic transmission	GO:0007268	288	0.125
appendage morphogenesis	GO:0035107	397	0.120
wing disc morphogenesis	GO:0007472	344	0.118
establishment of planar polarity	GO:0001736	87	0.115	Mouse
regulation of catabolic process	GO:0009894	170	0.112
positive regulation of phosphate metabolic process	GO:0045937	139	0.099
guanosine containing compound metabolic process	GO:1901068	74	0.096
non sensory hair organization	GO:0035316	47	0.090
mapk cascade	GO:0000165	107	0.088
macromolecular complex assembly	GO:0065003	256	0.088
organic substance catabolic process	GO:1901575	308	0.083
phosphorylation	GO:0016310	294	0.083
regulation of cellular component biogenesis	GO:0044087	201	0.079	Mouse
cell division	GO:0051301	248	0.077
camera type eye development	GO:0043010	4	0.074
embryonic development via the syncytial blastoderm	GO:0001700	148	0.074
organelle assembly	GO:0070925	198	0.073	Mouse
wnt signaling pathway	GO:0016055	98	0.073	Mouse
circulatory system development	GO:0072359	82	0.069
protein modification process	GO:0036211	438	0.068
epidermal cell differentiation	GO:0009913	51	0.068
establishment of organelle localization	GO:0051656	122	0.067
actin filament based process	GO:0030029	220	0.066
signal transduction by phosphorylation	GO:0023014	107	0.066
negative regulation of response to stimulus	GO:0048585	258	0.066	Mouse
intracellular signal transduction	GO:0035556	300	0.065
open tracheal system development	GO:0007424	204	0.063
regulation of phosphate metabolic process	GO:0019220	210	0.062
cellular macromolecule catabolic process	GO:0044265	136	0.062
cellular catabolic process	GO:0044248	372	0.062
regulation of protein metabolic process	GO:0051246	256	0.061
modification dependent macromolecule catabolic process	GO:0043632	79	0.060
regulation of molecular function	GO:0065009	217	0.057
asymmetric stem cell division	GO:0098722	49	0.056
regulation of phosphorus metabolic process	GO:0051174	210	0.056
negative regulation of cell communication	GO:0010648	223	0.055	Mouse
regulation of smoothened signaling pathway	GO:0008589	28	0.055	Mouse
carbohydrate derivative metabolic process	GO:1901135	217	0.053
tube development	GO:0035295	244	0.052	Mouse
muscle structure development	GO:0061061	224	0.051
negative regulation of signal transduction	GO:0009968	206	0.051	Mouse
ameboidal type cell migration	GO:0001667	151	0.051
enzyme linked receptor protein signaling pathway	GO:0007167	179	0.051	Mouse
cellular protein catabolic process	GO:0044257	83	0.051
imaginal disc derived wing hair site selection	GO:0035320	4	0.051
negative regulation of notch signaling pathway	GO:0045746	41	0.051
imaginal disc derived appendage morphogenesis	GO:0035114	395	0.051
dorsal ventral pattern formation	GO:0009953	133	0.050	Mouse
compound eye morphogenesis	GO:0001745	249	0.049
membrane organization	GO:0061024	112	0.048
tube morphogenesis	GO:0035239	191	0.047	Mouse
regulation of multicellular organismal development	GO:2000026	414	0.046	Mouse
anterior posterior axis specification	GO:0009948	109	0.045
regulation of apoptotic process	GO:0042981	130	0.044
phagocytosis	GO:0006909	215	0.044
tissue migration	GO:0090130	155	0.044
cell projection assembly	GO:0030031	94	0.043	Mouse
negative regulation of signaling	GO:0023057	219	0.041	Mouse
vesicle mediated transport	GO:0016192	381	0.040
regulation of cellular protein metabolic process	GO:0032268	243	0.040
protein maturation	GO:0051604	71	0.040
protein processing	GO:0016485	68	0.040
cytokinesis	GO:0000910	90	0.040
negative regulation of gene expression	GO:0010629	387	0.040
regulation of notch signaling pathway	GO:0008593	100	0.039
convergent extension involved in gastrulation	GO:0060027	2	0.039
cell cell junction assembly	GO:0007043	38	0.039
epithelium migration	GO:0090132	148	0.039
cell motility	GO:0048870	251	0.039
single organism intracellular transport	GO:1902582	207	0.038
epithelial cell migration	GO:0010631	148	0.038
endocytosis	GO:0006897	310	0.038
negative regulation of cellular metabolic process	GO:0031324	382	0.038
digestive tract development	GO:0048565	149	0.036
regulation of endopeptidase activity	GO:0052548	36	0.036
proteolysis involved in cellular protein catabolic process	GO:0051603	83	0.036
regulation of catalytic activity	GO:0050790	185	0.036
intracellular transport	GO:0046907	228	0.035
segmentation	GO:0035282	207	0.034
organonitrogen compound metabolic process	GO:1901564	318	0.034
protein transport	GO:0015031	155	0.034
small molecule metabolic process	GO:0044281	305	0.033
cellular response to dna damage stimulus	GO:0006974	223	0.033
establishment of localization in cell	GO:0051649	402	0.033
synapse organization	GO:0050808	196	0.032
regulation of embryonic development	GO:0045995	68	0.032	Mouse
cellular protein localization	GO:0034613	160	0.032
establishment of imaginal disc derived wing hair orientation	GO:0001737	24	0.031
cell cell junction organization	GO:0045216	55	0.031
positive regulation of macromolecule metabolic process	GO:0010604	405	0.030
sensory organ morphogenesis	GO:0090596	260	0.030
ubiquitin dependent protein catabolic process	GO:0006511	78	0.030
protein catabolic process	GO:0030163	101	0.030
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	54	0.029
retina development in camera type eye	GO:0060041	4	0.029
regulation of peptidase activity	GO:0052547	39	0.029
notch signaling pathway	GO:0007219	120	0.029
positive regulation of nucleobase containing compound metabolic process	GO:0045935	332	0.029
protein polymerization	GO:0051258	42	0.029
double strand break repair	GO:0006302	26	0.028
positive regulation of molecular function	GO:0044093	136	0.028
regulation of hydrolase activity	GO:0051336	97	0.028
positive regulation of phosphorus metabolic process	GO:0010562	139	0.028
aromatic compound catabolic process	GO:0019439	166	0.028
cell migration	GO:0016477	238	0.028
epithelial cell differentiation	GO:0030855	322	0.027
actomyosin structure organization	GO:0031032	56	0.027
positive regulation of gtpase activity	GO:0043547	43	0.027
limb development	GO:0060173	1	0.026
cellular nitrogen compound catabolic process	GO:0044270	165	0.026
mitotic dna damage checkpoint	GO:0044773	74	0.026
negative regulation of phosphate metabolic process	GO:0045936	45	0.026
protein complex assembly	GO:0006461	200	0.026
localization of cell	GO:0051674	257	0.026
cytoplasmic transport	GO:0016482	130	0.025
positive regulation of hydrolase activity	GO:0051345	78	0.025
epidermal growth factor receptor signaling pathway	GO:0007173	58	0.025
convergent extension	GO:0060026	2	0.025
ribonucleoside triphosphate catabolic process	GO:0009203	108	0.025
regulation of phosphorylation	GO:0042325	147	0.025
stem cell differentiation	GO:0048863	117	0.025	Mouse
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	65	0.025
positive regulation of protein metabolic process	GO:0051247	128	0.025
catabolic process	GO:0009056	409	0.024
asymmetric protein localization	GO:0008105	33	0.024
protein localization	GO:0008104	284	0.024
nuclear division	GO:0000280	332	0.024
response to organic substance	GO:0010033	284	0.024	Mouse
nucleobase containing compound catabolic process	GO:0034655	165	0.024
erbb signaling pathway	GO:0038127	58	0.024
positive regulation of wnt signaling pathway	GO:0030177	25	0.023
endomembrane system organization	GO:0010256	119	0.023
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	116	0.022	Mouse
eye morphogenesis	GO:0048592	260	0.022
regulation of gtpase activity	GO:0043087	44	0.022
determination of adult lifespan	GO:0008340	137	0.022
organic cyclic compound catabolic process	GO:1901361	168	0.022
protein modification by small protein conjugation or removal	GO:0070647	106	0.022
chromosome organization	GO:0051276	360	0.021
striated muscle cell differentiation	GO:0051146	90	0.021
small gtpase mediated signal transduction	GO:0007264	88	0.021
regulation of cell division	GO:0051302	72	0.021
protein modification by small protein conjugation	GO:0032446	79	0.021
peptidyl amino acid modification	GO:0018193	105	0.021
cellular component assembly involved in morphogenesis	GO:0010927	151	0.021	Mouse
modification dependent protein catabolic process	GO:0019941	78	0.021
macromolecule catabolic process	GO:0009057	161	0.020
regulation of cellular component size	GO:0032535	98	0.020
regulation of cell differentiation	GO:0045595	302	0.020	Mouse
response to organophosphorus	GO:0046683	2	0.020
epithelial tube morphogenesis	GO:0060562	88	0.020	Mouse
circulatory system process	GO:0003013	37	0.019
gtp metabolic process	GO:0046039	72	0.019
regulation of mitotic cell cycle phase transition	GO:1901990	130	0.019
somatic stem cell division	GO:0048103	37	0.019
rna localization	GO:0006403	115	0.019
cell junction organization	GO:0034330	57	0.019
cell death	GO:0008219	279	0.019
ovarian follicle cell development	GO:0030707	248	0.019
cilium assembly	GO:0042384	38	0.018	Mouse
negative regulation of protein metabolic process	GO:0051248	85	0.018
regulation of vesicle mediated transport	GO:0060627	59	0.018
compound eye development	GO:0048749	307	0.018
ras protein signal transduction	GO:0007265	88	0.018
regulation of epithelial cell proliferation	GO:0050678	4	0.018
jnk cascade	GO:0007254	50	0.018
organelle fission	GO:0048285	340	0.017
spinal cord dorsal ventral patterning	GO:0021513	1	0.017	Mouse
mitotic nuclear division	GO:0007067	213	0.017
protein complex disassembly	GO:0043241	36	0.017
regulation of cytoskeleton organization	GO:0051493	89	0.017
establishment of monopolar cell polarity	GO:0061162	15	0.017
regulation of cell development	GO:0060284	215	0.017	Mouse
chaeta development	GO:0022416	97	0.017
positive regulation of phosphorylation	GO:0042327	87	0.017
purine nucleoside metabolic process	GO:0042278	127	0.016
cell junction assembly	GO:0034329	42	0.016
positive regulation of mapk cascade	GO:0043410	63	0.016
organic substance transport	GO:0071702	257	0.016
purine containing compound catabolic process	GO:0072523	112	0.016
organophosphate metabolic process	GO:0019637	195	0.016
stem cell division	GO:0017145	69	0.016
sister chromatid segregation	GO:0000819	92	0.016
regulation of protein complex assembly	GO:0043254	42	0.016
regulation of proteolysis	GO:0030162	87	0.016
protein ubiquitination	GO:0016567	70	0.016
purine containing compound metabolic process	GO:0072521	155	0.016
neurological system process	GO:0050877	358	0.016
positive regulation of gtp catabolic process	GO:0033126	43	0.016
neuron recognition	GO:0008038	101	0.016
digestive tract morphogenesis	GO:0048546	127	0.016
regulation of localization	GO:0032879	275	0.015
embryonic heart tube development	GO:0035050	22	0.015
single organism cellular localization	GO:1902580	180	0.015
negative regulation of developmental process	GO:0051093	201	0.015	Mouse
regulation of synapse structure and activity	GO:0050803	128	0.015
response to external biotic stimulus	GO:0043207	293	0.015
heart development	GO:0007507	82	0.015
developmental growth involved in morphogenesis	GO:0060560	65	0.015
embryo development ending in birth or egg hatching	GO:0009792	152	0.015	Mouse
peripheral nervous system development	GO:0007422	52	0.014
axis elongation	GO:0003401	3	0.014
regulation of anatomical structure size	GO:0090066	163	0.014
regulation of synaptic transmission	GO:0050804	69	0.014
epithelial cell development	GO:0002064	274	0.014
spermatid development	GO:0007286	98	0.014
regulation of protein catabolic process	GO:0042176	55	0.014
organelle localization	GO:0051640	148	0.014
kidney development	GO:0001822	3	0.014
establishment of proximal distal cell polarity	GO:0022606	4	0.014
positive regulation of intracellular signal transduction	GO:1902533	116	0.014
eye photoreceptor cell differentiation	GO:0001754	145	0.014
cellular amino acid metabolic process	GO:0006520	61	0.014
smoothened signaling pathway	GO:0007224	49	0.014	Mouse
cellular response to growth factor stimulus	GO:0071363	30	0.014	Mouse
muscle cell differentiation	GO:0042692	103	0.013
regulation of cellular catabolic process	GO:0031329	157	0.013
golgi vesicle transport	GO:0048193	27	0.013
protein heterooligomerization	GO:0051291	4	0.013
neuroblast division	GO:0055057	35	0.013
regulation of tube size	GO:0035150	46	0.013
myoblast fusion	GO:0007520	43	0.013
blastoderm segmentation	GO:0007350	159	0.013
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
proteasomal protein catabolic process	GO:0010498	59	0.013
cellular lipid metabolic process	GO:0044255	83	0.013
establishment of protein localization	GO:0045184	163	0.013
carboxylic acid metabolic process	GO:0019752	92	0.013
positive regulation of catabolic process	GO:0009896	105	0.013
positive regulation of canonical wnt signaling pathway	GO:0090263	7	0.012
neuron projection guidance	GO:0097485	241	0.012
dna metabolic process	GO:0006259	227	0.012
developmental maturation	GO:0021700	172	0.012
cardiovascular system development	GO:0072358	82	0.012
negative regulation of rna metabolic process	GO:0051253	251	0.012
nucleotide metabolic process	GO:0009117	161	0.012
meiosis i	GO:0007127	59	0.012
single organism biosynthetic process	GO:0044711	206	0.012
cellular protein modification process	GO:0006464	438	0.012
negative regulation of multicellular organismal process	GO:0051241	142	0.012	Mouse
negative regulation of cell proliferation	GO:0008285	69	0.012	Mouse
axis specification	GO:0009798	167	0.012
neural retina development	GO:0003407	4	0.012
syncytium formation	GO:0006949	43	0.012
chromosome segregation	GO:0007059	157	0.012
ovarian nurse cell to oocyte transport	GO:0007300	27	0.012
vesicle organization	GO:0016050	44	0.012
regulation of cell death	GO:0010941	173	0.012
gtp catabolic process	GO:0006184	72	0.012
transcription initiation from rna polymerase ii promoter	GO:0006367	25	0.012
negative regulation of epithelial cell proliferation	GO:0050680	4	0.012
eggshell chorion assembly	GO:0007306	66	0.012
single organism membrane organization	GO:0044802	93	0.012
sensory perception of chemical stimulus	GO:0007606	116	0.012
compound eye photoreceptor cell differentiation	GO:0001751	140	0.012
regulation of actin filament length	GO:0030832	27	0.011
negative regulation of programmed cell death	GO:0043069	72	0.011
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	37	0.011
regulation of organelle organization	GO:0033043	196	0.011	Mouse
positive regulation of protein kinase activity	GO:0045860	25	0.011
cellularization	GO:0007349	90	0.011
activation of cysteine type endopeptidase activity	GO:0097202	17	0.011
single organism catabolic process	GO:0044712	228	0.011
aggressive behavior	GO:0002118	63	0.011
establishment of ommatidial planar polarity	GO:0042067	49	0.011
regulation of nervous system development	GO:0051960	248	0.011
guanosine containing compound catabolic process	GO:1901069	74	0.011
multicellular organismal aging	GO:0010259	140	0.011
organonitrogen compound catabolic process	GO:1901565	128	0.011
regulation of protein localization	GO:0032880	76	0.011
regulation of transcription from rna polymerase ii promoter	GO:0006357	378	0.011
stress activated mapk cascade	GO:0051403	52	0.011
appendage segmentation	GO:0035285	26	0.011
stress activated protein kinase signaling cascade	GO:0031098	55	0.011
cellular response to chemical stimulus	GO:0070887	199	0.011	Mouse
glycosyl compound metabolic process	GO:1901657	127	0.011
positive regulation of catalytic activity	GO:0043085	118	0.011
response to biotic stimulus	GO:0009607	294	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	108	0.011
positive regulation of gene expression	GO:0010628	290	0.011
multi organism behavior	GO:0051705	175	0.011
establishment of body hair or bristle planar orientation	GO:0048104	6	0.011
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	44	0.011
negative regulation of phosphorylation	GO:0042326	35	0.011
ovarian follicle cell migration	GO:0007297	121	0.011
negative regulation of cell differentiation	GO:0045596	143	0.011	Mouse
columnar cuboidal epithelial cell differentiation	GO:0002065	256	0.011
respiratory system development	GO:0060541	213	0.011
regulation of intracellular signal transduction	GO:1902531	236	0.010
cellular macromolecular complex assembly	GO:0034622	153	0.010
chromatin modification	GO:0016568	147	0.010
dephosphorylation	GO:0016311	51	0.010
regulation of immune system process	GO:0002682	176	0.010
negative regulation of protein processing	GO:0010955	31	0.010
regulation of nucleoside metabolic process	GO:0009118	50	0.010
head involution	GO:0008258	35	0.010
formation of organ boundary	GO:0010160	30	0.010
notch receptor processing	GO:0007220	13	0.010
skeletal muscle fiber development	GO:0048741	3	0.010
regulation of cysteine type endopeptidase activity	GO:2000116	27	0.010
cilium organization	GO:0044782	41	0.010	Mouse
response to other organism	GO:0051707	293	0.010
establishment of cell polarity	GO:0030010	40	0.010
actin filament organization	GO:0007015	126	0.010
defense response	GO:0006952	300	0.010
peptidyl lysine modification	GO:0018205	57	0.010
negative regulation of proteolysis	GO:0045861	31	0.010
negative regulation of protein maturation	GO:1903318	31	0.010

fy disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.034

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