Drosophila melanogaster

215 known processes

Parp (Dmel_CG40411)

Poly-(ADP-ribose) polymerase

(Aliases: Dmel\CG40411,PARP-1,CG17718,D.PARP,LD21673.3prime,PARP1,CG17696,dPARP,CG17685,PARP,BEST:LD21673,CG40411)

Parp biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
negative regulation of cellular macromolecule biosynthetic processGO:20001132670.718
negative regulation of cellular metabolic processGO:00313243820.655
negative regulation of nitrogen compound metabolic processGO:00511722650.637
chromatin silencingGO:0006342760.616
defense responseGO:00069523000.596
regulation of gene expression epigeneticGO:00400291280.537
negative regulation of rna metabolic processGO:00512532510.525
compound eye morphogenesisGO:00017452490.517
columnar cuboidal epithelial cell developmentGO:00020662490.511
eye developmentGO:00016543230.496
sensory organ morphogenesisGO:00905962600.431
compound eye developmentGO:00487493070.398
myoblast fusionGO:0007520430.387
negative regulation of gene expression epigeneticGO:0045814770.378
morphogenesis of a polarized epitheliumGO:0001738930.375
chromatin organizationGO:00063252070.367
gene silencingGO:00164581380.362
negative regulation of developmental processGO:00510932010.339
response to biotic stimulusGO:00096072940.337
growthGO:00400073590.337
Mouse
eye morphogenesisGO:00485922600.335
negative regulation of gene expressionGO:00106293870.332
innate immune responseGO:00450871440.310
female meiotic divisionGO:0007143700.302
morphogenesis of an epitheliumGO:00020092760.289
immune responseGO:00069552460.287
establishment of planar polarityGO:0001736870.279
embryo development ending in birth or egg hatchingGO:00097921520.270
negative regulation of biosynthetic processGO:00098902770.266
ovarian follicle cell developmentGO:00307072480.258
imaginal disc derived appendage developmentGO:00487373990.256
negative regulation of rna biosynthetic processGO:19026792400.249
positive regulation of autophagyGO:0010508210.241
negative regulation of macromolecule biosynthetic processGO:00105582700.238
response to external biotic stimulusGO:00432072930.236
defense response to bacteriumGO:00427421780.235
negative regulation of cellular biosynthetic processGO:00313272770.226
developmental programmed cell deathGO:00106231380.225
response to temperature stimulusGO:00092661060.218
establishment of tissue polarityGO:0007164870.217
nucleus organizationGO:0006997450.214
dorsal appendage formationGO:0046843470.210
response to other organismGO:00517072930.210
regulation of growthGO:00400082330.205
Mouse
negative regulation of transcription dna templatedGO:00458922370.204
chromosome organizationGO:00512763600.200
compound eye cone cell differentiationGO:0042675130.195
response to bacteriumGO:00096171980.194
nuclear divisionGO:00002803320.193
tissue morphogenesisGO:00487292970.185
negative regulation of nucleobase containing compound metabolic processGO:00459342610.182
digestive tract developmentGO:00485651490.178
autophagyGO:00069141080.176
appendage developmentGO:00487364010.175
regulation of protein metabolic processGO:00512462560.174
appendage morphogenesisGO:00351073970.165
immune effector processGO:0002252980.162
developmental pigmentationGO:0048066680.161
immune system processGO:00023763470.160
negative regulation of nucleic acid templated transcriptionGO:19035072400.159
digestive system developmentGO:00551231490.155
protein localization to nucleusGO:0034504550.154
regulation of proteolysisGO:0030162870.154
dorsal closureGO:0007391790.149
syncytium formationGO:0006949430.148
regulation of mitotic cell cycle phase transitionGO:19019901300.147
tube morphogenesisGO:00352391910.147
chromosome segregationGO:00070591570.136
regulation of immune responseGO:00507761180.135
meiotic chromosome segregationGO:0045132590.131
regulation of autophagyGO:0010506620.129
imaginal disc derived wing morphogenesisGO:00074763370.127
establishment of ommatidial planar polarityGO:0042067490.123
epithelial cell developmentGO:00020642740.118
ovarian follicle cell migrationGO:00072971210.118
regulation of cellular protein metabolic processGO:00322682430.116
negative regulation of cell differentiationGO:00455961430.116
regulation of cell differentiationGO:00455953020.115
positive regulation of macromolecule metabolic processGO:00106044050.113
organic substance catabolic processGO:19015753080.113
establishment of localization in cellGO:00516494020.111
regulation of chromosome organizationGO:0033044640.110
inter male aggressive behaviorGO:0002121600.104
nuclear body organizationGO:003057560.104
positive regulation of biosynthetic processGO:00098913160.103
telomere organizationGO:0032200210.103
Mouse
columnar cuboidal epithelial cell differentiationGO:00020652560.102
defense response to other organismGO:00985422250.101
regionalizationGO:00030024160.100
muscle organ developmentGO:00075171270.098
regulation of anatomical structure morphogenesisGO:00226032420.098
regulation of cell cycle phase transitionGO:19019871300.096
post embryonic appendage morphogenesisGO:00351203850.094
embryonic development via the syncytial blastodermGO:00017001480.093
organelle fissionGO:00482853400.092
regulation of organelle organizationGO:00330431960.091
intracellular signal transductionGO:00355563000.090
epithelial cell differentiationGO:00308553220.089
regulation of dna metabolic processGO:0051052340.088
dna damage checkpointGO:0000077780.086
eggshell formationGO:00307031050.086
response to heatGO:0009408630.084
myotube differentiationGO:0014902460.084
embryonic morphogenesisGO:00485982060.083
proteolysisGO:00065081920.082
cellular catabolic processGO:00442483720.082
regulation of defense responseGO:00313471020.080
regulation of establishment of planar polarityGO:0090175220.079
organonitrogen compound metabolic processGO:19015643180.077
eggshell chorion assemblyGO:0007306660.075
transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071691160.075
programmed cell deathGO:00125012570.075
syncytium formation by plasma membrane fusionGO:0000768430.075
cellular response to heatGO:0034605240.073
chorion containing eggshell formationGO:00073041050.073
catabolic processGO:00090564090.072
developmental growthGO:00485892800.072
response to organic substanceGO:00100332840.072
photoreceptor cell differentiationGO:00465301700.070
jnk cascadeGO:0007254500.066
deathGO:00162652840.065
regulation of cell developmentGO:00602842150.064
gland developmentGO:00487321910.063
regulation of response to oxidative stressGO:190288240.063
regulation of organ morphogenesisGO:2000027780.061
head developmentGO:00603221350.060
positive regulation of macromolecule biosynthetic processGO:00105572830.060
aggressive behaviorGO:0002118630.059
morphogenesis of embryonic epitheliumGO:0016331940.059
determination of adult lifespanGO:00083401370.058
germarium derived egg chamber formationGO:00072931010.057
photoreceptor cell developmentGO:0042461960.056
muscle cell differentiationGO:00426921030.056
chromosome separationGO:0051304420.056
phosphorylationGO:00163102940.055
stem cell differentiationGO:00488631170.054
regulation of epithelial cell differentiationGO:003085640.054
negative regulation of cell fate specificationGO:0009996150.054
response to oxygen containing compoundGO:19017002000.054
Mouse
regulation of cellular catabolic processGO:00313291570.052
regulation of catabolic processGO:00098941700.052
chromatin assemblyGO:0031497480.051
tissue deathGO:00162711020.051
macroautophagyGO:0016236420.051
macromolecule catabolic processGO:00090571610.051
positive regulation of nitrogen compound metabolic processGO:00511733540.050
apoptotic processGO:00069151590.050
regulation of cellular component biogenesisGO:00440872010.049
regulation of endopeptidase activityGO:0052548360.049
meiotic cell cycle processGO:19030461320.049
epithelial cell migrationGO:00106311480.048
molting cycle chitin based cuticleGO:0007591560.048
compound eye retinal cell programmed cell deathGO:0046667230.047
adult chitin based cuticle developmentGO:000836520.047
anatomical structure homeostasisGO:0060249970.047
Mouse
positive regulation of programmed cell deathGO:0043068620.046
cellular macromolecule catabolic processGO:00442651360.046
regulation of immune system processGO:00026821760.046
positive regulation of response to stimulusGO:00485843230.046
dna metabolic processGO:00062592270.045
Mouse
negative regulation of photoreceptor cell differentiationGO:004653380.045
single organism catabolic processGO:00447122280.044
cuticle developmentGO:0042335860.044
agingGO:00075681430.043
ommatidial rotationGO:0016318200.043
regulation of cellular response to stressGO:0080135890.043
positive regulation of protein metabolic processGO:00512471280.043
cell proliferationGO:00082832990.042
cell growthGO:00160491080.042
regulation of innate immune responseGO:0045088710.041
central nervous system developmentGO:00074172010.040
positive regulation of compound eye retinal cell programmed cell deathGO:004667290.040
regulation of chromatin organizationGO:1902275320.040
positive regulation of metaphase anaphase transition of cell cycleGO:1902101100.040
cytoplasmic transportGO:00164821300.040
regulation of peptidase activityGO:0052547390.040
modification dependent macromolecule catabolic processGO:0043632790.040
cell cycle checkpointGO:0000075950.040
multicellular organismal agingGO:00102591400.040
meiotic cell cycleGO:00513211710.040
positive regulation of organelle organizationGO:0010638650.039
meiotic nuclear divisionGO:00071261510.039
histolysisGO:00075591020.039
defense response to gram negative bacteriumGO:0050829940.039
cellular ketone metabolic processGO:0042180240.038
camera type eye morphogenesisGO:004859320.038
stress activated mapk cascadeGO:0051403520.038
wing disc morphogenesisGO:00074723440.038
circadian rhythmGO:00076231050.037
compound eye photoreceptor fate commitmentGO:0001752360.037
cell deathGO:00082192790.037
ubiquitin dependent protein catabolic processGO:0006511780.037
regulation of multicellular organismal developmentGO:20000264140.036
regulation of photoreceptor cell differentiationGO:0046532340.036
behavioral response to ethanolGO:0048149490.036
regulation of developmental growthGO:00486381740.036
brain developmentGO:00074201200.035
regulation of catalytic activityGO:00507901850.035
regulation of neurogenesisGO:00507671580.035
negative regulation of cell cycleGO:00457861160.035
modification dependent protein catabolic processGO:0019941780.035
cellular protein catabolic processGO:0044257830.035
positive regulation of cell sizeGO:0045793210.035
striated muscle cell differentiationGO:0051146900.034
mapk cascadeGO:00001651070.033
negative regulation of cell communicationGO:00106482230.033
phagocytosisGO:00069092150.033
multi organism behaviorGO:00517051750.033
visceral muscle developmentGO:0007522140.033
positive regulation of proteolysisGO:0045862520.033
positive regulation of cellular component organizationGO:00511301560.032
biological adhesionGO:00226101380.032
cell cycle phase transitionGO:00447701400.031
mitotic spindle organizationGO:00070522200.031
small molecule metabolic processGO:00442813050.031
camera type eye developmentGO:004301040.031
regulation of response to stressGO:00801342000.031
regulation of apoptotic processGO:00429811300.030
negative regulation of multicellular organismal processGO:00512411420.030
positive regulation of immune responseGO:0050778630.030
endocytosisGO:00068973100.029
macromolecular complex assemblyGO:00650032560.029
regulation of cellular amine metabolic processGO:003323830.029
positive regulation of endopeptidase activityGO:0010950260.029
lateral inhibitionGO:00463312060.028
hindbrain developmentGO:003090220.028
response to extracellular stimulusGO:00099911160.028
autophagic cell deathGO:0048102830.028
negative regulation of molecular functionGO:0044092510.028
lipid localizationGO:0010876540.028
imaginal disc derived wing hair organizationGO:0035317450.028
regulation of programmed cell deathGO:00430671520.028
regulation of nervous system developmentGO:00519602480.028
dna replicationGO:0006260480.028
regulation of compound eye retinal cell programmed cell deathGO:0046669180.027
regulation of phosphorylationGO:00423251470.027
imaginal disc derived appendage morphogenesisGO:00351143950.027
positive regulation of cellular protein metabolic processGO:00322701180.027
regulation of anatomical structure sizeGO:00900661630.027
regulation of cellular response to oxidative stressGO:190040740.026
retinal cell programmed cell deathGO:0046666250.026
cellular response to peptideGO:1901653280.026
regulation of neuron differentiationGO:00456641030.026
negative regulation of growthGO:0045926840.026
establishment or maintenance of cell polarityGO:00071631670.026
response to woundingGO:0009611940.026
regulation of developmental pigmentationGO:0048070240.026
regulation of phosphate metabolic processGO:00192202100.026
protein maturationGO:0051604710.025
regulation of proteasomal ubiquitin dependent protein catabolic processGO:0032434370.025
border follicle cell migrationGO:00072981130.025
nucleocytoplasmic transportGO:0006913720.025
regulation of mapk cascadeGO:0043408920.025
regulation of epidermal cell differentiationGO:004560430.025
regulation of immune effector processGO:0002697520.025
regulation of stress activated mapk cascadeGO:0032872410.024
epidermal growth factor receptor signaling pathwayGO:0007173580.024
translationGO:0006412690.024
adult chitin containing cuticle pigmentationGO:0048085160.024
positive regulation of catalytic activityGO:00430851180.024
purine nucleoside metabolic processGO:00422781270.024
retina development in camera type eyeGO:006004140.024
innate immune response activating signal transductionGO:000275820.024
muscle structure developmentGO:00610612240.024
positive regulation of gene expressionGO:00106282900.024
posttranscriptional regulation of gene expressionGO:00106081450.024
epithelium migrationGO:00901321480.023
exocrine system developmentGO:00352721620.023
immune response activating signal transductionGO:000275720.023
pigmentationGO:0043473750.023
wound healingGO:0042060750.023
response to nutrient levelsGO:00316671140.023
positive regulation of cellular catabolic processGO:0031331950.022
open tracheal system developmentGO:00074242040.022
protein modification processGO:00362114380.022
regulation of antimicrobial humoral responseGO:0002759500.022
cell agingGO:000756920.022
positive regulation of signalingGO:00230562430.022
dna integrity checkpointGO:0031570810.022
nuclear transportGO:0051169720.022
positive regulation of catabolic processGO:00098961050.022
positive regulation of cellular biosynthetic processGO:00313283160.022
proteasome mediated ubiquitin dependent protein catabolic processGO:0043161540.022
regulation of chromatin modificationGO:1903308280.022
positive regulation of nucleic acid templated transcriptionGO:19035082660.021
cellular amino acid metabolic processGO:0006520610.021
chitin based cuticle developmentGO:0040003490.021
female meiosis chromosome segregationGO:0016321330.021
regulation of circadian rhythmGO:0042752490.021
protein localizationGO:00081042840.021
positive regulation of nucleobase containing compound metabolic processGO:00459353320.021
negative regulation of cellular protein metabolic processGO:0032269850.020
regulation of multi organism processGO:00439001310.020
regulation of cellular component sizeGO:0032535980.020
lipid metabolic processGO:00066291210.020
regulation of jnk cascadeGO:0046328400.020
nuclear importGO:0051170510.020
regulation of phosphatase activityGO:001092130.020
protein catabolic processGO:00301631010.020
response to lipopolysaccharideGO:003249640.020
enzyme linked receptor protein signaling pathwayGO:00071671790.020
regulation of cuticle pigmentationGO:0048079160.020
salivary gland cell autophagic cell deathGO:0035071830.020
mitotic sister chromatid segregationGO:0000070870.020
regulation of notch signaling pathwayGO:00085931000.020
amine metabolic processGO:0009308120.019
regulation of cell cycleGO:00517262910.019
chromatin remodelingGO:0006338720.019
negative regulation of cell developmentGO:0010721620.019
forebrain developmentGO:003090020.019
regulation of mitotic metaphase anaphase transitionGO:0030071260.019
retina morphogenesis in camera type eyeGO:006004220.019
cellular response to biotic stimulusGO:007121640.019
regulation of transcription from rna polymerase ii promoterGO:00063573780.018
positive regulation of r7 cell differentiationGO:004567870.018
negative regulation of response to stimulusGO:00485852580.018
positive regulation of cellular component biogenesisGO:0044089800.018
regulation of translationGO:0006417560.018
organic hydroxy compound metabolic processGO:1901615830.018
fusion cell fate specificationGO:003515640.018
carboxylic acid metabolic processGO:0019752920.018
regulation of stress activated protein kinase signaling cascadeGO:0070302420.018
non sensory hair organizationGO:0035316470.018
negative regulation of developmental growthGO:0048640640.017
regulation of dna replicationGO:0006275130.017
regulation of organ growthGO:0046620420.017
homeostatic processGO:00425921990.017
Mouse
cellular lipid metabolic processGO:0044255830.017
response to organonitrogen compoundGO:0010243750.017
response to endogenous stimulusGO:00097191190.017
regulation of defense response to virusGO:0050688140.017
establishment of protein localizationGO:00451841630.017
skin developmentGO:0043588650.017
digestive tract morphogenesisGO:00485461270.017
regulation of cellular amino acid metabolic processGO:000652100.017
negative regulation of apoptotic processGO:0043066630.017
positive regulation of rna biosynthetic processGO:19026802660.016
single organism intracellular transportGO:19025822070.016
intracellular protein transportGO:00068861040.016
regulation of nucleocytoplasmic transportGO:0046822350.016
regulation of gene silencingGO:0060968630.016
developmental maturationGO:00217001720.016
regulation of mrna processingGO:0050684710.016
regulation of syncytium formation by plasma membrane fusionGO:006014260.016
cellular response to oxygen containing compoundGO:1901701790.016
Mouse
positive regulation of cellular amine metabolic processGO:003324000.016
regulation of chromatin silencingGO:0031935360.016
vesicle mediated transportGO:00161923810.016
cellular component assembly involved in morphogenesisGO:00109271510.016
salivary gland morphogenesisGO:00074351450.016
spermatogenesisGO:00072832000.016
protein importGO:0017038550.016
regulation of cell sizeGO:0008361630.016
oxoacid metabolic processGO:00434361030.016
skeletal muscle fiber developmentGO:004874130.016
stress activated protein kinase signaling cascadeGO:0031098550.016
cognitionGO:00508901410.016
mitotic sister chromatid separationGO:0051306300.015
genital disc developmentGO:0035215440.015
protein complex biogenesisGO:00702712010.015
cellular response to chemical stimulusGO:00708871990.015
Mouse
protein phosphorylationGO:00064681690.015
regulation of macroautophagyGO:0016241150.015
positive regulation of molecular functionGO:00440931360.015
negative regulation of mitotic cell cycleGO:00459301090.015
ameboidal type cell migrationGO:00016671510.015
notch signaling pathwayGO:00072191200.015
negative regulation of neurogenesisGO:0050768530.015
response to ecdysoneGO:0035075340.015
negative regulation of signal transductionGO:00099682060.015
regulation of heterochromatin assemblyGO:003144580.015
compound eye photoreceptor cell differentiationGO:00017511400.015
single organism biosynthetic processGO:00447112060.015
positive regulation of mitotic metaphase anaphase transitionGO:0045842100.015
rna 3 end processingGO:0031123450.015
regulation of adult chitin containing cuticle pigmentationGO:0048082130.015
eye photoreceptor cell fate commitmentGO:0042706370.015
stem cell maintenanceGO:0019827670.015
synaptic transmissionGO:00072682880.015
metaphase anaphase transition of cell cycleGO:0044784280.014
protein processingGO:0016485680.014
chromatin assembly or disassemblyGO:0006333520.014
intracellular transportGO:00469072280.014
regulation of cell morphogenesisGO:00226041630.014
regulation of mitotic sister chromatid separationGO:0010965280.014
positive regulation of epithelial cell differentiationGO:003085810.014
proteolysis involved in cellular protein catabolic processGO:0051603830.014
antimicrobial humoral responseGO:0019730990.014
salivary gland histolysisGO:0035070880.014
pattern recognition receptor signaling pathwayGO:000222120.014
compound eye cone cell fate commitmentGO:004267650.014
cellular protein localizationGO:00346131600.014
heterocycle catabolic processGO:00467001660.014
regulation of chitin based cuticle tanningGO:0007564140.014
negative regulation of nervous system developmentGO:0051961920.014
regulation of mitotic cell cycleGO:00073461900.014
positive regulation of hydrolase activityGO:0051345780.013
response to abiotic stimulusGO:00096283410.013
myotube cell developmentGO:001490430.013
cellular protein modification processGO:00064644380.013
male gamete generationGO:00482322010.013
positive regulation of immune system processGO:0002684680.013
positive regulation of peptidase activityGO:0010952290.013
striated muscle cell developmentGO:0055002500.013
protein complex assemblyGO:00064612000.013
regulation of execution phase of apoptosisGO:190011750.013
transcription from rna polymerase ii promoterGO:00063663680.013
chromatin modificationGO:00165681470.013
response to starvationGO:0042594970.013
protein import into nucleusGO:0006606510.013
positive regulation of cell deathGO:0010942690.013
humoral immune responseGO:00069591170.013
positive regulation of phosphorus metabolic processGO:00105621390.013
regulation of response to external stimulusGO:00321011150.013
detection of external biotic stimulusGO:009858120.013
regulation of i kappab kinase nf kappab signalingGO:004312220.013
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005940.013
erbb signaling pathwayGO:0038127580.012
mitotic dna integrity checkpointGO:0044774750.012
single organism cellular localizationGO:19025801800.012
response to fungusGO:0009620500.012
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280230.012
regulation of proteasomal protein catabolic processGO:0061136390.012
spermatid developmentGO:0007286980.012
positive regulation of retinal cell programmed cell deathGO:004667090.012
regulation of multicellular organism growthGO:0040014400.012
negative regulation of catabolic processGO:0009895360.012
positive regulation of response to extracellular stimulusGO:003210680.012
nephrocyte diaphragm assemblyGO:003605930.012
regulation of response to nutrient levelsGO:0032107180.012
regulation of cellular ketone metabolic processGO:001056530.012
regulation of embryonic developmentGO:0045995680.012
positive regulation of cysteine type endopeptidase activityGO:2001056240.012
cellular response to peptide hormone stimulusGO:0071375280.012
adult behaviorGO:00305341370.012
organic acid metabolic processGO:00060821030.012
mitotic cell cycle phase transitionGO:00447721380.011
rna processingGO:00063961470.011
cellular macromolecule localizationGO:00707272200.011
respiratory system developmentGO:00605412130.011
protein targetingGO:0006605640.011
cell maturationGO:00484691440.011
regulation of erbb signaling pathwayGO:1901184420.011
immune response regulating signaling pathwayGO:000276420.011
regulation of cell deathGO:00109411730.011
positive regulation of rna metabolic processGO:00512542710.011
cellular response to lipopolysaccharideGO:007122230.011
negative regulation of epidermal growth factor receptor signaling pathwayGO:0042059290.011
negative regulation of protein processingGO:0010955310.011
cellular response to nutrient levelsGO:0031669620.011
positive regulation of transcription dna templatedGO:00458932660.011
signal transduction in response to dna damageGO:004277030.011
paracrine signalingGO:003800170.011
cell cell signaling involved in cell fate commitmentGO:00451682100.011
regulation of chromosome segregationGO:0051983320.011
regulation of intracellular signal transductionGO:19025312360.011
cellular response to extracellular stimulusGO:0031668640.011
ras protein signal transductionGO:0007265880.011
regulation of retinal cell programmed cell deathGO:0046668180.011
anion transportGO:0006820410.010
cuticle pattern formationGO:0035017270.010
cell motilityGO:00488702510.010
small gtpase mediated signal transductionGO:0007264880.010
dna conformation changeGO:00711031050.010
negative regulation of cell cycle processGO:00109481090.010
carbohydrate metabolic processGO:0005975820.010
response to sterolGO:0036314340.010
negative regulation of cell cycle phase transitionGO:19019881030.010
micropyle formationGO:004684440.010
cellular response to starvationGO:0009267610.010
negative regulation of immune system processGO:0002683500.010
positive regulation of defense responseGO:0031349590.010
regulation of lipid transportGO:003236830.010
generation of precursor metabolites and energyGO:0006091420.010
negative regulation of programmed cell deathGO:0043069720.010
regulation of epidermal growth factor receptor signaling pathwayGO:0042058420.010

Parp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.016
organ system cancerDOID:005068600.016
disease of cellular proliferationDOID:1456600.016